Infectious diseases and secondary antibody deficiency in patients from a mesoregion of Sao Paulo State, Brazil

Infectious diseases and secondary antibody deficiency in patients from a mesoregion of Sao Paulo State, Brazil

Our aim was to determine the secondary antibody deficiency (SAD) profiles of patients in a mesoregion of Sao Paulo state, Brazil, focusing on infectious diseases. Demographic characteristics, and clinical and laboratory data were obtained from electronic files; infections were classified as organ-sp...

Full description

Saved in:
Bibliographic Details
Published in:Tropical medicine and infectious disease Vol. 9; no. 5; pp. 1 - 13
Main Authors: Prestes-Carneiro, Luiz Euribel, Carrilho, Paula Andreia Martins, Torelli, Danielle Francisco Honorato de Barros, Bressa, Jose Antonio Nascimento, Parizi, Ana Carolina Gomes, Vieira, Pedro Henrique Meireles, Sa, Fernanda Miranda Caliani, Ferreira, Mauricio Domingues
Format: Journal Article
Language:English
Published: Basel, Switzerland MDPI 01-05-2024
MDPI AG
Subjects:
Agammaglobulinemia
Anemia
Antibodies
Autoimmune diseases
B cells
Bacterial infections
Biological products
Blood diseases
Chemotherapy
Communicable diseases
Disease susceptibility
Hematology
Hospitals
hypo-γ-globulinemia
Immune system
Immunodeficiency
Immunosuppressive agents
Immunotherapy
Infections
Infectious diseases
Metabolic disorders
Methodology
Monoclonal antibodies
Patients
secondary antibody deficiency
Statistical analysis
Viral antibodies
Viral infections
Brazil
Canada
Belgium
United States > US
hypo-γ-globulinemia
secondary antibody deficiency
infectious diseases
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Our aim was to determine the secondary antibody deficiency (SAD) profiles of patients in a mesoregion of Sao Paulo state, Brazil, focusing on infectious diseases. Demographic characteristics, and clinical and laboratory data were obtained from electronic files; infections were classified as organ-specific and graded as mild, moderate, life-threatening, and fatal. Non-Hodgkin's lymphoma (NHL) accounted for 30% of patients, nephrotic syndrome (NS) 25%, chronic lymphocyte leukemia 20%, and multiple myeloma 15%. Patients with NS were younger than those in other groups, and hypo-gamma-globulinemia was detected in 94.1%, IgG < 400 mg/dL in 60.0%, IgA < 40 mg/dL in 55.0%, and CD19 < 20 cells/mm3 in 30.0%. One hundred and one infections were found; 82.1% were classified as mild or moderate, 7.9% as life-threatening, and 3.0% as fatal. Respiratory tract infections were more prevalent (41.5%), and pneumonia accounted for 19.8%. Lower levels of infections were found in patients with NS compared with NHL (p equivalent 0.0001). Most patients progressed to hypo-gamma- globulinemia and SAD after treatment with immunosuppressants, and mild and moderate infections were predominant. These therapies are increasing in patients with different diseases; therefore, monitoring hypo-gamma-globulinemia and infections May help to identify patients at high risk for severe complications, antibiotic prophylaxis or treatment, and immunoglobulin replacement.
Bibliography:Tropical Medicine and Infectious Disease, Vol. 9, No. 5, May 2024, 1-13
Informit, Melbourne (Vic)
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2414-6366
2414-6366
DOI:10.3390/tropicalmed9050104