Search Results - "SZUMLINSKI, KAREN K."

Selective Inhibition of PDE4B Reduces Methamphetamine Reinforcement in Two C57BL/6 Substrains by Honeywell, Kevin M, Doren, Eliyana Van, Szumlinski, Karen K

“…Methamphetamine (MA) is a highly addictive psychostimulant drug, and the number of MA-related overdose deaths has reached epidemic proportions. Repeated MA…”
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Strain Differences in Alcohol-Induced Neurochemical Plasticity: A Role for Accumbens Glutamate in Alcohol Intake by Kapasova, Zuzana, Szumlinski, Karen K.

“…Background:  Repeated alcohol administration alters nucleus accumbens (NAC) basal glutamate content and sensitizes the capacity of alcohol to increase NAC…”
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Negative Affect and Excessive Alcohol Intake Incubate during Protracted Withdrawal from Binge-Drinking in Adolescent, But Not Adult, Mice by Lee, Kaziya M, Coehlo, Michal A, Solton, Noah R, Szumlinski, Karen K

“…Binge-drinking is common in underage alcohol users, yet we know little regarding the biopsychological impact of binge-drinking during early periods of…”
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Neuropharmacological Evidence Implicating Drug-Induced Glutamate Receptor Dysfunction in Affective and Cognitive Sequelae of Subchronic Methamphetamine Self-Administration in Mice by Denning, Christopher J E, Madory, Lauren E, Herbert, Jessica N, Cabrera, Ryan A, Szumlinski, Karen K

“…Methamphetamine (MA) is a highly addictive drug, and MA use disorder is often comorbid with anxiety and cognitive impairment. These comorbid conditions are…”
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Selective Inhibition of PDE4B Reduces Binge Drinking in Two C57BL/6 Substrains by Jimenez Chavez, C. Leonardo, Bryant, Camron D., Munn-Chernoff, Melissa A., Szumlinski, Karen K.

“…Cyclic AMP (cAMP)-dependent signaling is highly implicated in the pathophysiology of alcohol use disorder (AUD), with evidence supporting the efficacy of…”
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mGluR1 within the nucleus accumbens regulates alcohol intake in mice under limited-access conditions by Lum, Emily N., Campbell, Rianne R., Rostock, Charlotte, Szumlinski, Karen K.

“…Idiopathic or alcohol-induced increases in the expression and function of the Group1 metabotropic glutamate receptor subtype 1 (mGluR1) within the extended…”
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Homers regulate drug-induced neuroplasticity: Implications for addiction by Szumlinski, Karen K., Ary, Alexis W., Lominac, Kevin D.

“…Drug addiction is a chronic, relapsing disorder, characterized by an uncontrollable motivation to seek and use drugs. Converging clinical and preclinical…”
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Homer proteins: implications for neuropsychiatric disorders by Szumlinski, Karen K, Kalivas, Peter W, Worley, Paul F

“…Homer proteins regulate signal transduction, synaptogenesis and receptor trafficking, in addition to maintaining and regulating extracellular glutamate levels…”
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Sex‐dependent effects of an Hnrnph1 mutation on fentanyl addiction‐relevant behaviors but not antinociception in mice by Bryant, Camron D., Healy, Aidan F., Ruan, Qiu T., Coehlo, Michal A., Lustig, Elijah, Yazdani, Neema, Luttik, Kimberly P., Tran, Tori, Swancy, Isaiah, Brewin, Lindsey W., Chen, Melanie M., Szumlinski, Karen K.

“…Opioid Use Disorder (OUD) and opioid‐related deaths remain a major public health concern in the United States. Both environmental and genetic factors influence…”
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Effects of systemic pretreatment with the NAALADase inhibitor 2-PMPA on oral methamphetamine reinforcement in C57BL/6J mice by Fultz, Elissa K, Nei, Andrea Y T, Chi, Joyce C, Lichter, Jacqueline N, Szumlinski, Karen K

“…Repeated exposure to methamphetamine (MA) in laboratory rodents induces a sensitization of glutamate release within the corticoaccumbens pathway that drives…”
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p10, the N-terminal domain of p35, protects against CDK5/p25-induced neurotoxicity by Zhang, Lingyan, Liu, Wen, Szumlinski, Karen K, Lew, John

“…Cyclin-dependent kinase 5(CDK5) in complex with its activator, p35 (protein of 35 kDa), is essential for early neurodevelopment in mammals. However, endogenous…”
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A subchronic history of binge-drinking elicits mild, age- and sex-selective, affective, and cognitive anomalies in C57BL/6J mice by Jimenez Chavez, C. Leonardo, Van Doren, Eliyana, Scheldrup, Gavin, Rivera, Emely, Torres-Gonzalez, Jose, Herbert, Jessica N., Denning, Christopher J. E., Khorsandi, Sarah, Garcia, Andrew, Castro, Marian, Szumlinski, Karen K.

“…Introduction Alcohol abuse is a risk factor for affective and cognitive disorders, with evidence indicating that adolescent-onset excessive drinking can result…”
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ERK-Directed Phosphorylation of mGlu5 Gates Methamphetamine Reward and Reinforcement in Mouse by Fultz, Elissa K, Quadir, Sema G, Martin, Douglas, Flaherty, Daniel M, Worley, Paul F, Kippin, Tod E, Szumlinski, Karen K

“…Methamphetamine (MA) is a highly addictive psychomotor stimulant drug. In recent years, MA use has increased exponentially on a global scale, with the number…”
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Nucleus Accumbens mGluR5-Associated Signaling Regulates Binge Alcohol Drinking Under Drinking-in-the-Dark Procedures by Cozzoli, Debra K., Courson, Justin, Caruana, Amanda L., Miller, Bailey W., Greentree, Daniel I., Thompson, Andrew B., Wroten, Melissa G., Zhang, Ping-Wu, Xiao, Bo, Hu, Jia-Hua, Klugmann, Matthias, Metten, Pamela, Worley, Paul F., Crabbe, John C., Szumlinski, Karen K.

“…Background Alcohol increases the expression of Group 1 metabotropic glutamate receptors (mGluRs) and their associated scaffolding protein Homer2 and stimulates…”
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Alcohol-Drinking Under Limited-Access Procedures During Mature Adulthood Accelerates the Onset of Cognitive Impairment in Mice by Jimenez Chavez, C Leonardo, Van Doren, Eliyana, Matalon, Jacob, Ogele, Nneoma, Kharwa, Aadithya, Madory, Lauren, Kazerani, Ida, Herbert, Jessica, Torres-Gonzalez, Jose, Rivera, Emely, Szumlinski, Karen K

“…A history of heavy drinking increases vulnerability to, and the severity of, Alzheimer's disease (AD) and related dementias, with alcohol use disorder…”
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Adolescent Mice Are Resilient to Alcohol Withdrawal-Induced Anxiety and Changes in Indices of Glutamate Function within the Nucleus Accumbens by Lee, Kaziya M, Coelho, Michal A, McGregor, Hadley A, Solton, Noah R, Cohen, Matan, Szumlinski, Karen K

“…Binge-drinking is the most prevalent form of alcohol abuse and while an early life history of binge-drinking is a significant risk factor for subsequent…”
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Profiling prefrontal cortex protein expression in rats exhibiting an incubation of cocaine craving following short-access self-administration procedures by Huerta Sanchez, Laura L, Sankaran, Mathangi, Li, Taylor L, Doan, Hoa, Chiu, Alvin, Shulman, Eleanora, Shab, Gabriella, Kippin, Tod E, Szumlinski, Karen K

“…Incubation of drug-craving refers to a time-dependent increase in drug cue-elicited craving that occurs during protracted withdrawal. Historically, rat models…”
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Nerve injury-induced changes in Homer/glutamate receptor signaling contribute to the development and maintenance of neuropathic pain by Obara, Ilona, Goulding, Scott P., Hu, Jia-Hua, Klugmann, Matthias, Worley, Paul F., Szumlinski, Karen K.

“…While group 1 metabotropic glutamate receptors (mGluRs) and ionotropic N-methyl-d-aspartate (NMDA) receptors regulate nociception, the precise molecular…”
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mGlu5 Receptor Blockade Within the Nucleus Accumbens Shell Reduces Behavioral Indices of Alcohol Withdrawal-Induced Anxiety in Mice by Lee, Kaziya M, Coelho, Michal A, Class, MacKayla A, Sern, Kimberly R, Bocz, Mark D, Szumlinski, Karen K

“…Withdrawal from binge-drinking increases negative affect, coinciding with increased expression of the metabotropic glutamate receptor 5 (mGlu5) within the…”
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Prefrontal glutamate correlates of methamphetamine sensitization and preference by Lominac, Kevin D., Quadir, Sema G., Barrett, Hannah M., McKenna, Courtney L., Schwartz, Lisa M., Ruiz, Paige N., Wroten, Melissa G., Campbell, Rianne R., Miller, Bailey W., Holloway, John J., Travis, Katherine O., Rajasekar, Ganesh, Maliniak, Dan, Thompson, Andrew B., Urman, Lawrence E., Kippin, Tod E., Phillips, Tamara J., Szumlinski, Karen K.

“…Methamphetamine (MA) is a widely misused, highly addictive psychostimulant that elicits pronounced deficits in neurocognitive function related to…”
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