Search Results - "SZOLCSANYI, Janos"

A CRPS-IgG-transfer-trauma model reproducing inflammatory and positive sensory signs associated with complex regional pain syndrome by Tékus, Valéria, Hajna, Zsófia, Borbély, Éva, Markovics, Adrienn, Bagoly, Teréz, Szolcsányi, János, Thompson, Victoria, Kemény, Ágnes, Helyes, Zsuzsanna, Goebel, Andreas

“…The transfer of serum IgG from patients with long-standing complex regional pain syndrome (CRPS) to mice, followed by mild hind paw trauma, causes typical…”
Get full text

Alterations in PACAP-38-like immunoreactivity in the plasma during ictal and interictal periods of migraine patients by Tuka, Bernadett, Helyes, Zsuzsanna, Markovics, Adrienn, Bagoly, Teréz, Szolcsányi, János, Szabó, Nikoletta, Tóth, Eszter, Kincses, Zsigmond Tamás, Vécsei, László, Tajti, János

“…Recent studies on migraineurs and our own animal experiments have revealed that pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) has an…”
Get more information

Pituitary adenylate cyclase-activating polypeptide plays a key role in nitroglycerol-induced trigeminovascular activation in mice by Markovics, Adrienn, Kormos, Viktoria, Gaszner, Balazs, Lashgarara, Arvin, Szoke, Eva, Sandor, Katalin, Szabadfi, Krisztina, Tuka, Bernadett, Tajti, Janos, Szolcsanyi, Janos, Pinter, Erika, Hashimoto, Hitoshi, Kun, Jozsef, Reglodi, Dora, Helyes, Zsuzsanna

“…Abstract Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors (PAC1, VPAC) are present in sensory neurons and vascular smooth muscle…”
Get full text

Small molecule somatostatin receptor subtype 4 (sst4) agonists are novel anti-inflammatory and analgesic drug candidates by Szőke, Éva, Bálint, Mónika, Hetényi, Csaba, Markovics, Adrienn, Elekes, Krisztián, Pozsgai, Gábor, Szűts, Tamás, Kéri, György, Őrfi, László, Sándor, Zoltán, Szolcsányi, János, Pintér, Erika, Helyes, Zsuzsanna

“…We provided strong proof of concept evidence that somatostatin mediates potent analgesic and anti-inflammatory actions via its receptor subtype 4 (sst4)…”
Get full text

The role of transient receptor potential ankyrin 1 (TRPA1) receptor activation in hydrogen-sulphide-induced CGRP-release and vasodilation by Pozsgai, Gábor, Hajna, Zsófia, Bagoly, Teréz, Boros, Melinda, Kemény, Ágnes, Materazzi, Serena, Nassini, Romina, Helyes, Zsuzsanna, Szolcsányi, János, Pintér, Erika

“…Activation of transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) channels on capsaicin-sensitive sensory neurons causes release of…”
Get full text

Capsaicin-sensitive sensory nerves exert complex regulatory functions in the serum-transfer mouse model of autoimmune arthritis by Borbély, Éva, Botz, Bálint, Bölcskei, Kata, Kenyér, Tibor, Kereskai, László, Kiss, Tamás, Szolcsányi, János, Pintér, Erika, Csepregi, Janka Zsófia, Mócsai, Attila, Helyes, Zsuzsanna

“…Highlights • Capsaicin-sensitive sensory nerves are protective against autoimmune arthritis. • Desensitization of these fibers increase immune cell activation…”
Get full text

Peripheral and central alterations of pituitary adenylate cyclase activating polypeptide-like immunoreactivity in the rat in response to activation of the trigeminovascular system by Tuka, Bernadett, Helyes, Zsuzsanna, Markovics, Adrienn, Bagoly, Teréz, Németh, József, Márk, László, Brubel, Réka, Reglődi, Dóra, Párdutz, Árpád, Szolcsányi, János, Vécsei, László, Tajti, János

“…► We examined the PACAP-27/38-LI in the activated trigeminovascular system. ► Blood plasma, nerve tissues and liquor were analyzed in two rat models. ►…”
Get full text

Effect of Surgical and Chemical Sensory Denervation on Non-neural Expression of the Transient Receptor Potential Vanilloid 1 (TRPV1) Receptors in the Rat by Kun, József, Helyes, Zsuzsanna, Perkecz, Anikó, Bán, Ágnes, Polgár, Beáta, Szolcsányi, János, Pintér, Erika

“…Pretreatment with the ultrapotent capsaicin analog resiniferatoxin (RTX) has been applied as a selective pharmacological tool in inflammation and pain studies…”
Get full text

Evidence for a novel, neurohumoral antinociceptive mechanism mediated by peripheral capsaicin-sensitive nociceptors in conscious rats by Pethő, Gábor, Bölcskei, Kata, Füredi, Réka, Botz, Bálint, Bagoly, Teréz, Pintér, Erika, Szolcsányi, János

“…Abstract Stimulation of capsaicin-sensitive peripheral sensory nerve terminals induces remote anti-inflammatory effects throughout the body of anesthetized…”
Get full text

The Role of Transient Receptor Potential Vanilloid 1 (Trpv1) Receptors in Dextran Sulfate-Induced Colitis in Mice by Szitter, Istvan, Pozsgai, Gabor, Sandor, Katalin, Elekes, Krisztian, Kemeny, Agnes, Perkecz, Aniko, Szolcsanyi, Janos, Helyes, Zsuzsanna, Pinter, Erika

“…The aim of this study was to investigate the involvement of transient receptor potential vanilloid 1 (TRPV1) receptors in oral dextran sulfate sodium-induced…”
Get full text

Effects of Reference Analgesics and Psychoactive Drugs on the Noxious Heat Threshold of Mice Measured by an Increasing‐Temperature Water Bath by Boros, Melinda, Benkó, Rita, Bölcskei, Kata, Szolcsányi, János, Barthó, Loránd, Pethő, Gábor

“…The study aimed at validating an increasing‐temperature water bath suitable for determining the noxious heat threshold for use in mice. The noxious heat…”
Get full text

Comparison of the Anti-inflammatory and Anti-nociceptive Effects of Cortistatin-14 and Somatostatin-14 in Distinct In Vitro and In Vivo Model Systems by Markovics, Adrienn, Szőke, Éva, Sándor, Katalin, Börzsei, Rita, Bagoly, Teréz, Kemény, Ágnes, Elekes, Krisztián, Pintér, Erika, Szolcsányi, János, Helyes, Zsuzsanna

“…We showed that somatostatin (SST) exerts anti-inflammatory and anti-nociceptive effects through somatostatin receptor subtypes 4 and 1 (sst 4 /sst 1 ). Since…”
Get full text

Effects of analgesics on the plantar incision-induced drop of the noxious heat threshold measured with an increasing-temperature water bath in the rat by FÜREDI, Réka, BÖLCSKEI, Kata, SZOLCSANYI, Janos, PETHÖ, Gabor

“…The behavioural noxious heat threshold i.e. the lowest temperature evoking nocifensive behaviour was previously shown to decrease in short-lasting, but not in…”
Get full text

Heat injury-induced drop of the noxious heat threshold measured with an increasing-temperature water bath: A novel rat thermal hyperalgesia model by Bölcskei, Kata, Horváth, Dóra, Szolcsányi, János, Pethő, Gábor

“…Conventional thermonociceptive tests are based on measurement of the latency of nocifensive reactions evoked by constant, suprathreshold heat stimuli. In the…”
Get full text

Pharmacological characterization of the TRPV1 receptor antagonist JYL1421 (SC0030) in vitro and in vivo in the rat by Jakab, Balázs, Helyes, Zsuzsanna, Varga, Angelika, Bölcskei, Kata, Szabó, Árpád, Sándor, Katalin, Elekes, Krisztián, Börzsei, Rita, Keszthelyi, Dániel, Pintér, Erika, Pethő, Gábor, Németh, József, Szolcsányi, János

“…The TRPV1 capsaicin receptor is an integrator molecule on primary afferent neurones participating in inflammatory and nociceptive processes. The present paper…”
Get full text

Differential Regulatory Role of Pituitary Adenylate Cyclase–Activating Polypeptide in the Serum‐Transfer Arthritis Model by Botz, Bálint, Bölcskei, Kata, Kereskai, László, Kovács, Miklós, Németh, Tamás, Szigeti, Krisztián, Horváth, Ildikó, Máthé, Domokos, Kovács, Noémi, Hashimoto, Hitoshi, Reglődi, Dóra, Szolcsányi, János, Pintér, Erika, Mócsai, Attila, Helyes, Zsuzsanna

“…Objective Pituitary adenylate cyclase–activating polypeptide (PACAP) expressed in capsaicin‐sensitive sensory neurons and immune cells has divergent functions…”
Get full text

Immunohistochemical distribution of vanilloid receptor, calcitonin-gene related peptide and substance P in gastrointestinal mucosa of patients with different gastrointestinal disorders by Dömötör, András, Peidl, Zsanett, Vincze, Aron, Hunyady, Béla, Szolcsányi, János, Kereskay, László, Szekeres, György, Mózsik, Gyula

“…The immunohistochemical distribution of capsaicin/vanilloid (transient receptor potential vanilloid 1, TRPV1) receptors and neuropeptides (CGRP, SP) was…”
Get full text

Pituitary Adenylate Cyclase-Activating Polypeptide Is Upregulated in Murine Skin Inflammation and Mediates Transient Receptor Potential Vanilloid-1-Induced Neurogenic Edema by Helyes, Zsuzsanna, Kun, Jozsef, Dobrosi, Nora, Sándor, Katalin, Németh, Jozsef, Perkecz, Aniko, Pintér, Erika, Szabadfi, Krisztina, Gaszner, Balazs, Tékus, Valeria, Szolcsányi, Janos, Steinhoff, Martin, Hashimoto, Hitoshi, Reglődi, Dora, Bíró, Tamas

“…Although pituitary adenylate cyclase-activating polypeptide (PACAP) was described as a key vasoregulator in human skin, little is known about its expression in…”
Get full text

Molecular pharmacological approaches to effects of capsaicinoids and of classical antisecretory drugs on gastric basal acid secretion and on indomethacin-induced gastric mucosal damage in human healthy subjects (mini review) by Szabó, Imre Laszlo, Czimmer, Jozsef, Szolcsányi, Janos, Mózsik, Gyula

“…Actions of various drugs have been tested on the gastric acid basal secretion and on the drug (Indomethacin)- induced gastric mucosal damage; however their…”
Get more information

The sensory nitrergic nature of the hepatic insulin sensitizing substance mechanism in conscious rabbits by Porszasz, Robert, Legvari, Gyorgyi, Nemeth, Jozsef, Literati, Peter N., Szolcsanyi, Janos, Szilvassy, Zoltan

“…Functional deterioration of sensory fibres in the anterior hepatic plexus or intraportal administration of 7-nitro indazole (1 mg/kg), a selective inhibitor of…”
Get full text