Search Results - "SZETO, Linda"

Exenatide, a Glucagon-like Peptide-1 Receptor Agonist, Acutely Inhibits Intestinal Lipoprotein Production in Healthy Humans by Xiao, Changting, Bandsma, Robert H J, Dash, Satya, Szeto, Linda, Lewis, Gary F

“…OBJECTIVES—Incretin-based therapies for the treatment of type 2 diabetes mellitus improve plasma lipid profiles and postprandial lipemia, but their exact…”
Get full text

Insulin Acutely Inhibits Intestinal Lipoprotein Secretion in Humans in Part by Suppressing Plasma Free Fatty Acids by PAVLIC, Mirjana, CHANGTING XIAO, SZETO, Linda, PATTERSON, Bruce W, LEWIS, Gary F

“…Intestinal lipoprotein production has recently been shown to be increased in insulin resistance, but it is not known whether it is regulated by insulin in…”
Get full text

Both Intestinal and Hepatic Lipoprotein Production Are Stimulated by an Acute Elevation of Plasma Free Fatty Acids in Humans by DUEZ, Hélène, LAMARCHE, Benoit, VALERO, René, PAVLIC, Mirjana, PROCTOR, Spencer, CHANGTING XIAO, SZETO, Linda, PATTERSON, Bruce W, LEWIS, Gary F

“…Hepatic lipoprotein production has been shown previously to be regulated by free fatty acid (FFA) flux to the liver, whereas intestinal lipoprotein production…”
Get full text

Intestinal Lipoprotein Overproduction, a Newly Recognized Component of Insulin Resistance, Is Ameliorated by the Insulin Sensitizer Rosiglitazone: Studies in the Fructose-Fed Syrian Golden Hamster by Lewis, Gary F, Uffelman, Kristine, Naples, Mark, Szeto, Linda, Haidari, Mehran, Adeli, Khosrow

“…We investigated whether intestinal lipoprotein overproduction in a fructose-fed, insulin-resistant hamster model is prevented with insulin sensitization…”
Get full text

Atorvastatin induces insulin sensitization in Zucker lean and fatty rats by Wong, Victor, Stavar, Laura, Szeto, Linda, Uffelman, Kristine, Wang, Chao-Hung, Fantus, I George, Lewis, Gary F.

“…The 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitors (‘statins’) have been implicated in preventing new onset type 2 diabetes, whereas the…”
Get full text

Hepatic Lipase mRNA, Protein, and Plasma Enzyme Activity Is Increased in the Insulin-Resistant, Fructose-Fed Syrian Golden Hamster and Is Partially Normalized by the Insulin Sensitizer Rosiglitazone by LEWIS, Gary F, MURDOCH, Susan, UFFELMAN, Kristine, NAPLES, Mark, SZETO, Linda, ALBERS, Alegria, ADELI, Khosrow, BRUNZELL, John D

“…Hepatic Lipase mRNA, Protein, and Plasma Enzyme Activity Is Increased in the Insulin-Resistant, Fructose-Fed Syrian Golden Hamster and Is Partially Normalized…”
Get full text

Ameliorated Hepatic Insulin Resistance Is Associated with Normalization of Microsomal Triglyceride Transfer Protein Expression and Reduction in Very Low Density Lipoprotein Assembly and Secretion in the Fructose-fed Hamster by Carpentier, Andre, Taghibiglou, Changiz, Leung, Nathalie, Szeto, Linda, Van Iderstine, Stephen C, Uffelman, Kristine D, Buckingham, Robin, Adeli, Khosrow, Lewis, Gary F

“…To determine whether reduction of insulin resistance could ameliorate fructose-induced very low density lipoprotein (VLDL) oversecretion and to explore the…”
Get full text

Intestinal Lipoprotein Production Is Stimulated by an Acute Elevation of Plasma Free Fatty Acids in the Fasting State: Studies in Insulin-Resistant and Insulin-Sensitized Syrian Golden Hamsters by Lewis, Gary F, Naples, Mark, Uffelman, Kristine, Leung, Nathalie, Szeto, Linda, Adeli, Khosrow

“…It is not known whether intestinal lipoprotein production is stimulated by an acute elevation of plasma free fatty acids (FFA). We examined the effect of an…”
Get full text

Effects of acute hyperinsulinemia on VLDL triglyceride and VLDL ApoB production in normal weight and obese individuals by LEWIS, G. F, UFFELMAN, K. D, SZETO, L. W, STEINER, G

“…The effects of short-term hyperinsulinemia on the production of both VLDL triglyceride and VLDL apoB were determined semiquantitatively before and during a 6-h…”
Get full text

Enhancement of muscle glucose uptake by the vasopeptidase inhibitor, omapatrilat, is independent of insulin signaling and the AMP kinase pathway by Wong, Victor, Szeto, Linda, Uffelman, Kristine, Fantus, I George, Lewis, Gary F

“…Omapatrilat (OMA), a vasopeptidase inhibitor (VPI), presently being tested in clinical trials for its antihypertensive properties, inhibits both…”
Get full text

High-Dose Resveratrol Treatment for 2 Weeks Inhibits Intestinal and Hepatic Lipoprotein Production in Overweight/Obese Men by Dash, Satya, Xiao, Changting, Morgantini, Cecilia, Szeto, Linda, Lewis, Gary F

“…OBJECTIVE—Overproduction of hepatic apolipoprotein B (apoB)-100 containing very low-density lipoprotein particles and intestinal apoB-48 containing…”
Get full text

Effects of Acute Hyperglucagonemia on Hepatic and Intestinal Lipoprotein Production and Clearance in Healthy Humans by CHANGTING XIAO, PAVLIC, Mirjana, SZETO, Linda, PATTERSON, Bruce W, LEWIS, Gary F

“…The metabolism of hepatic- and intestinally derived lipoproteins is regulated in a complex fashion by nutrients, hormones, and neurologic and other factors…”
Get full text

Triglyceride-Rich Lipoprotein-Associated Apolipoprotein C-III Production Is Stimulated by Plasma Free Fatty Acids in Humans by Pavlic, Mirjana, Valéro, René, Duez, Hélène, Xiao, Changting, Szeto, Linda, Patterson, Bruce W, Lewis, Gary F

“…OBJECTIVE—Insulin resistant states are associated with increased fatty acid flux to liver and intestine, which stimulates the production of triglyceride-rich…”
Get full text

Partial characterization of the fructose-induced defect in very-low-density lipoprotein triglyceride metabolism by Mamo, J C, Hirano, T, James, L, Szeto, L, Steiner, G

“…Very-low-density lipoprotein triglyceride (VLDL-TG) catabolism was studied in rats receiving either fructose or glucose as a 10% drinking solution. Consumption…”
Get more information

Enhanced Cellular Uptake of Remnant High-Density Lipoprotein Particles: A Mechanism for High-Density Lipoprotein Lowering in Insulin Resistance and Hypertriglyceridemia by Xiao, Changting, Watanabe, Takehiko, Zhang, Yi, Trigatti, Bernardo, Szeto, Linda, Connelly, Phil W, Marcovina, Santica, Vaisar, Tomas, Heinecke, Jay W, Lewis, Gary F

“…A low level of high-density lipoprotein (HDL) cholesterol is characteristic of insulin resistance and hypertriglyceridemia and likely contributes to the…”
Get full text

Acute Dipeptidyl Peptidase-4 Inhibition Rapidly Enhances Insulin-Mediated Suppression of Endogenous Glucose Production in Mice by Duez, Hélène, Smith, Angela C, Xiao, C, Giacca, Adria, Szeto, Linda, Drucker, Daniel J, Lewis, Gary F

“…Pharmacological approaches that enhance incretin action for the treatment of type 2 diabetes mellitus have recently been developed, i.e. injectable…”
Get full text

Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans by Lewis, G F, Uffelman, K D, Szeto, L W, Weller, B, Steiner, G

“…Changes in VLDL triglyceride and VLDL apo B production were determined semiquantitatively in healthy young men by examining the effect of altering plasma…”
Get full text

Dissociation between the Insulin-Sensitizing Effect of Rosiglitazone and Its Effect on Hepatic and Intestinal Lipoprotein Production by Duez, Hélène, Lamarche, Benoît, Uffelman, Kristine D., Valéro, René, Szeto, Linda, Lemieux, Simone, Cohn, Jeffrey S., Lewis, Gary F.

“…Context: Despite its potent, well-documented insulin-sensitizing effects, rosiglitazone (RSG) does not effectively ameliorate the hypertriglyceridemia of…”
Get full text

Vasopeptidase inhibitor omapatrilat induces profound insulin sensitization and increases myocardial glucose uptake in Zucker fatty rats: Studies comparing a vasopeptidase inhibitor, angiotensin-converting enzyme inhibitor, and angiotensin II type I receptor blocker by WANG, Chao-Hung, LEUNG, Nathalie, LAPOINTE, Nathalie, SZETO, Linda, UFFELMAN, Kristine D, GIACCA, Adria, ROULEAU, Jean L, LEWIS, Gary F

“…ACE inhibitors (ACEIs) improve insulin resistance and prevent type 2 diabetes, possibly mediated by inhibition of bradykinin (BK) degradation. The…”
Get full text

Rosiglitazone improves intestinal lipoprotein overproduction in the fat-fed Syrian Golden hamster, an animal model of nutritionally-induced insulin resistance by Leung, Nathalie, Naples, Mark, Uffelman, Kristine, Szeto, Linda, Adeli, Khosrow, Lewis, Gary F

“…We have recently shown that the fructose-fed Syrian Golden hamster, a non-diabetic animal model of nutritionally-induced insulin resistance and hyperlipidemia,…”
Get full text