Search Results - "SZECSI, Mihály"

Synthesis of regioisomeric 17β-N-phenylpyrazolyl steroid derivatives and their inhibitory effect on 17α-hydroxylase/C17,20-lyase by Iványi, Zoltán, Wölfling, János, Görbe, Tamás, Szécsi, Mihály, Wittmann, Tibor, Schneider, Gyula

“…The reaction of 3β-hydroxy-21-hydroxymethylidenepregn-5-en-3β-ol-20-one (1) with phenylhydrazine (2a) affords two regioisomers,…”
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Novel series of 17β-pyrazolylandrosta-5,16-diene derivatives and their inhibitory effect on 17α-hydroxylase/C17,20-lyase by Iványi, Zoltán, Szabó, Nikoletta, Wölfling, János, Szécsi, Mihály, Julesz, János, Schneider, Gyula

“…► Novel steroidal pyrazole regioisomers were synthesized. ► These compounds contain a double bond in position 16. ► The regioisomers were tested for their…”
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Steroselective synthesis of some steroidal oxazolines, as novel potential inhibitors of 17α-hydroxylase-C17,20-lyase by ONDRE, Dóra, WÖLFLING, János, TOTH, István, SZECSI, Mihály, JULESZ, János, SCHNEIDER, Gyula

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Non-genomic actions of sex hormones on pregnant uterine contractility in rats: An in vitro study at term by Mirdamadi, Mohsen, Kothencz, Anna, Szűcs, Edina, Benyhe, Sándor, Szécsi, Mihály, Gáspár, Róbert

“…The non-genomic (prompt) actions of sex steroids on pregnant uterine contractility are not fully explored yet, the aim of our study was to clarify such effects…”
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Non-genomic uterorelaxant actions of corticosteroid hormones in rats: An in vitro and in vivo study by Mirdamadi, Mohsen, Schaffer, Annamaria, Barna, Tamara, Samavati, Reza, Szűcs, Kálmán F., Szűcs, Edina, Benyhe, Sándor, Szécsi, Mihály, Gáspár, Róbert

“…We aimed to identify the short-term effects of a glucocorticoid (GC) and a mineralocorticoid (MC) on non-pregnant and late pregnant rat uterine contractions to…”
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Synthesis, Biological Evaluation and Docking Studies of 13-Epimeric 10-fluoro- and 10-Chloroestra-1,4-dien-3-ones as Potential Aromatase Inhibitors by Jójárt, Rebeka, Traj, Péter, Kovács, Édua, Horváth, Ágnes, Schneider, Gyula, Szécsi, Mihály, Pál, Attila, Paragi, Gábor, Mernyák, Erzsébet

“…Fluorination of 13-epimeric estrones and their 17-deoxy counterparts was performed with Selectfluor as the reagent. In acetonitrile or trifluoroacetic acid…”
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Synthesis of D-ring-substituted (5′R)- and (5′S)-17β-pyrazolinylandrostene epimers and comparison of their potential anticancer activities by Iványi, Zoltán, Szabó, Nikoletta, Huber, Judit, Wölfling, János, Zupkó, István, Szécsi, Mihály, Wittmann, Tibor, Schneider, Gyula

“…► Steroidal 17β-pyrazolines were prepared from 21-benzalpregnenolone derivatives. ► The reaction afforded a mixture of 5′R and 5′S pyrazolinylandrostene…”
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Synthesis of novel 13α-estrone derivatives by Sonogashira coupling as potential 17β-HSD1 inhibitors by Bacsa, Ildikó, Jójárt, Rebeka, Wölfling, János, Schneider, Gyula, Herman, Bianka Edina, Szécsi, Mihály, Mernyák, Erzsébet

“…Novel 13α-estrone derivatives were synthesized by Sonogashira coupling. Transformations of 2- or 4-iodo regioisomers of 13α-estrone and its 3-methyl ether were…”
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Heterocyclic androstane and estrane d-ring modified steroids: Microwave-assisted synthesis, steroid-converting enzyme inhibition, apoptosis induction, and effects on genes encoding estrogen inactivating enzymes by Kulmány, Ágnes Erika, Herman, Bianka Edina, Zupkó, István, Sinreih, Masa, Rižner, Tea Lanišnik, Savić, Marina, Oklješa, Aleksandar, Nikolić, Andrea, Nagy, Viktória, Ocsovszki, Imre, Szécsi, Mihály, Jovanović-Šanta, Suzana

“…[Display omitted] •d-ring–modified heterocyclic steroids are synthesized by microwave-assisted reactions.•d-ring–fused triazole estrone analog, compound 24,…”
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Synthesis and structure-activity relationships of 2- and/or 4-halogenated 13β- and 13α-estrone derivatives as enzyme inhibitors of estrogen biosynthesis by Bacsa, Ildikó, Herman, Bianka Edina, Jójárt, Rebeka, Herman, Kevin Stefán, Wölfling, János, Schneider, Gyula, Varga, Mónika, Tömböly, Csaba, Rižner, Tea Lanišnik, Szécsi, Mihály, Mernyák, Erzsébet

“…Ring A halogenated 13α-, 13β-, and 17-deoxy-13α-estrone derivatives were synthesised with N-halosuccinimides as electrophile triggers. Substitutions occurred…”
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Efficient access to novel androsteno-17-(1′,3′,4′)-oxadiazoles and 17β-(1′,3′,4′)-thiadiazoles via N-substituted hydrazone and N,N′-disubstituted hydrazine intermediates, and their pharmacological evaluation in vitro by Kovács, Dóra, Wölfling, János, Szabó, Nikoletta, Szécsi, Mihály, Minorics, Renáta, Zupkó, István, Frank, Éva

“…A series of novel 17-exo-oxadiazoles and -thiadiazoles in the Δ5 androstene series were efficiently synthesized from pregnenolone acetate and pregnadienolone…”
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Synthesis and Biological Evaluation of Triazolyl 13α-Estrone-Nucleoside Bioconjugates by Bodnár, Brigitta, Mernyák, Erzsébet, Wölfling, János, Schneider, Gyula, Herman, Bianka Edina, Szécsi, Mihály, Sinka, Izabella, Zupkó, István, Kupihár, Zoltán, Kovács, Lajos

“…2'-Deoxynucleoside conjugates of 13α-estrone were synthesized by applying the copper-catalyzed alkyne-azide click reaction (CuAAC). For the introduction of the…”
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Synthesis of substituted 15β-alkoxy estrone derivatives and their cofactor-dependent inhibitory effect on 17β-HSD1 by Herman, Bianka Edina, Kiss, Anita, Wölfling, János, Mernyák, Erzsébet, Szécsi, Mihály, Schneider, Gyula

“…17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) is a key enzyme in the biosynthesis of 17β-estradiol. Novel estrone-based compounds bearing various…”
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Pd-Catalyzed microwave-assisted synthesis of phosphonated 13α-estrones as potential OATP2B1, 17β-HSD1 and/or STS inhibitors by Jójárt, Rebeka, Pécsy, Szabolcs, Keglevich, György, Szécsi, Mihály, Rigó, Réka, Özvegy-Laczka, Csilla, Kecskeméti, Gábor, Mernyák, Erzsébet

“…Novel 2- or 4-phosphonated 13α-estrone derivatives were synthesized via the Hirao reaction. Bromo regioisomers (2- or 4-) of 13α-estrone and its 3-benzyl or…”
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Synthesis and in vitro pharmacological evaluation of N-[(1-benzyl-1,2,3-triazol-4-yl)methyl]-carboxamides on d-secoestrone scaffolds by Szabó, Johanna, Bacsa, Ildikó, Wölfling, János, Schneider, Gyula, Zupkó, István, Varga, Mónika, Herman, Bianka E, Kalmár, László, Szécsi, Mihály, Mernyák, Erzsébet

“…An efficient synthesis of several N-[(1-benzyl-1,2,3-triazol-4-yl)methyl]carboxamides in the 13β- and 13α-d-secoestrone series is reported. Novel triazoles…”
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Synthesis of A-ring halogenated 13α-estrone derivatives as potential 17β-HSD1 inhibitors by Bacsa, Ildikó, Jójárt, Rebeka, Schneider, Gyula, Wölfling, János, Maróti, Péter, Herman, Bianka Edina, Szécsi, Mihály, Mernyák, Erzsébet

“…[Display omitted] •13α-Estrone and some of its 3-ethers were subjected to aromatic halogenations.•The substituent on C-3 greatly affected the chemo- and the…”
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Synthesis of methoxycarbonylpyrazolylandrostene derivatives, and their potential inhibitory effect on androgen biosynthesis and cell proliferation by Szabó, Nikoletta, Iványi, Zoltán, Szécsi, Mihály, Julesz, János, Mernyák, Erzsébet, Huber, Judit, Wölfling, János, Minorics, Renáta, Zupkó, István, Schneider, Gyula

“…[Display omitted] •Synthesis of 3-methoxycarbonyl-1-phenyl-5-pyrazolylandrostene derivatives.•Inhibition of the enzyme Δ5-3β-HSD by 17β-pyrazolylandrost-5-ene…”
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Antihormonal potential of selected D-homo and D-seco estratriene derivatives by Jovanović-Šanta, Suzana S., Petri, Edward T., Klisurić, Olivera R., Szécsi, Mihály, Kovačević, Radmila, Petrović, Julijana A.

“…•New D-homo and 16,17-seco-estratriene compounds were synthesised and characterized.•Docking studies were performed for protein targets of steroidal…”
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Steroidal ferrocenes as potential enzyme inhibitors of the estrogen biosynthesis by Herman, Bianka Edina, Gardi, János, Julesz, János, Tömböly, Csaba, Szánti-Pintér, Eszter, Fehér, Klaudia, Skoda-Földes, Rita, Szécsi, Mihály

“…The potential inhibitory effect of diverse triazolyl-ferrocene steroids on key enzymes of the estrogen biosynthesis was investigated. Test compounds were…”
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Microwave assisted synthesis and biomedical potency of salicyloyloxy and 2-methoxybenzoyloxy androstane and stigmastane derivatives by Penov Gaši, Katarina M., Djurendić, Evgenija A., Szécsi, Mihály, Gardi, János, Csanádi, János J., Klisurić, Olivera R., Dojčinović-Vujašković, Sanja V., Nikolić, Andrea R., Savić, Marina P., Ajduković, Jovana J., Oklješa, Aleksandar M., Kojić, Vesna V., Sakač, Marija N., Jovanović-Šanta, Suzana S.

“…[Display omitted] •New steroidal salicyloyl esters were synthesized by MW and conventional methods.•Antioxidant and cytotoxic activity of new compounds was…”
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