Search Results - "SZABO, Gyongyi"

Gut‐Liver Axis Beyond the Microbiome: How the Fungal Mycobiome Contributes to Alcoholic Liver Disease by Szabo, Gyongyi

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Hypoxia and hypoxia inducible factors: Diverse roles in liver diseases by Nath, Bharath, Szabo, Gyongyi

“…Hypoxia has been shown to have a role in the pathogenesis of several forms of liver disease. The hypoxia inducible factors (HIFs) are a family of…”
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Alcoholic liver disease and the gut-liver axis by Szabo, Gyongyi, Bala, Shashi

“…Alcoholic liver disease (ALD) is one of the leading causes of liver diseases and liver-related death worldwide. Of the many factors that contribute to the…”
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Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors by Francque, Sven, Szabo, Gyongyi, Abdelmalek, Manal F., Byrne, Christopher D., Cusi, Kenneth, Dufour, Jean-François, Roden, Michael, Sacks, Frank, Tacke, Frank

“…The increasing epidemic of obesity worldwide is linked to serious health effects, including increased prevalence of type 2 diabetes mellitus, cardiovascular…”
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Pathophysiology of decompensated cirrhosis: Portal hypertension, circulatory dysfunction, inflammation, metabolism and mitochondrial dysfunction by Engelmann, Cornelius, Clària, Joan, Szabo, Gyongyi, Bosch, Jaume, Bernardi, Mauro

“…Patients with acutely decompensated cirrhosis have a dismal prognosis and frequently progress to acute-on-chronic liver failure, which is characterised by…”
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Interleukin‐1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis by Tilg, Herbert, Moschen, Alexander R., Szabo, Gyongyi

“…Both alcoholic liver disease (ALD) and nonalcoholic fatty liver disease are characterized by massive lipid accumulation in the liver accompanied by…”
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Diagnosis and Treatment of Alcohol‐Associated Liver Diseases: 2019 Practice Guidance From the American Association for the Study of Liver Diseases by Crabb, David W., Im, Gene Y., Szabo, Gyongyi, Mellinger, Jessica L., Lucey, Michael R.

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A Recent Perspective on Alcohol, Immunity, and Host Defense by Szabo, Gyongyi, Mandrekar, Pranoti

“…Background:  Multiple line of clinical and experimental evidence demonstrates that both acute, moderate, and chronic, excessive alcohol use result in various…”
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Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS by Momen-Heravi, Fatemeh, Bala, Shashi, Kodys, Karen, Szabo, Gyongyi

“…Hepatocyte damage and inflammation in monocytes/macrophages are central to the pathogenesis of alcoholic hepatitis (AH). MicroRNAs (miRNAs) regulate all of…”
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Acute binge drinking increases serum endotoxin and bacterial DNA levels in healthy individuals by Bala, Shashi, Marcos, Miguel, Gattu, Arijeet, Catalano, Donna, Szabo, Gyongyi

“…Binge drinking, the most common form of alcohol consumption, is associated with increased mortality and morbidity; yet, its biological consequences are poorly…”
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Gut-liver axis and sterile signals in the development of alcoholic liver disease by Szabo, Gyongyi, Petrasek, Jan

“…Innate immunity plays a critical role in the development of alcohol-induced liver inflammation. Understanding the inter-relationship of signals from within and…”
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Hepatology Communications Achieves First Impact Factor and MEDLINE Indexing by Szabo, Gyongyi

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Dysregulated Autophagy and Lysosome Function Are Linked to Exosome Production by Micro‐RNA 155 in Alcoholic Liver Disease by Babuta, Mrigya, Furi, Istvan, Bala, Shashi, Bukong, Terence N., Lowe, Patrick, Catalano, Donna, Calenda, Charles, Kodys, Karen, Szabo, Gyongyi

“…Cellular homeostais, that is normally maintained through autophagy, is disrupted in alcoholic liver disease (ALD). Because autophagy and exosome biogenesis…”
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The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis by Bala, Shashi, Csak, Timea, Saha, Banishree, Zatsiorsky, James, Kodys, Karen, Catalano, Donna, Satishchandran, Abhishek, Szabo, Gyongyi

“…Graphical abstract…”
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An essential role for monocyte chemoattractant protein‐1 in alcoholic liver injury: Regulation of proinflammatory cytokines and hepatic steatosis in mice by Mandrekar, Pranoti, Ambade, Aditya, Lim, Arlene, Szabo, Gyongyi, Catalano, Donna

“…The importance of chemokines in alcoholic liver injury has been implicated. The role of the chemokine, monocyte chemoattractant protein‐1 (MCP‐1), elevated in…”
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Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90 by Bukong, Terence N, Momen-Heravi, Fatemeh, Kodys, Karen, Bala, Shashi, Szabo, Gyongyi

“…Antibodies targeting receptor-mediated entry of HCV into hepatocytes confer limited therapeutic benefits. Evidence suggests that exosomes can transfer genetic…”
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Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases by Bala, Shashi, Petrasek, Jan, Mundkur, Shiv, Catalano, Donna, Levin, Ivan, Ward, Jeanine, Alao, Hawau, Kodys, Karen, Szabo, Gyongyi

“…MicroRNAs are fine tuners of diverse biological responses and are expressed in various cell types of the liver. Here we hypothesized that circulating microRNAs…”
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Exosome-mediated delivery of functionally active miRNA-155 inhibitor to macrophages by Momen-Heravi, Fatemeh, DDS, Bala, Shashi, PhD, Bukong, Terence, PhD, Szabo, Gyongyi, MD PhD

“…Abstract Exosomes, membranous nanovesicles, naturally carry bio-macromolecules and play pivotal roles in both physiological intercellular crosstalk and disease…”
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Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease by Grander, Christoph, Adolph, Timon E, Wieser, Verena, Lowe, Patrick, Wrzosek, Laura, Gyongyosi, Benedek, Ward, Doyle V, Grabherr, Felix, Gerner, Romana R, Pfister, Alexandra, Enrich, Barbara, Ciocan, Dragos, Macheiner, Sophie, Mayr, Lisa, Drach, Matthias, Moser, Patrizia, Moschen, Alexander R, Perlemuter, Gabriel, Szabo, Gyongyi, Cassard, Anne Marie, Tilg, Herbert

“…Alcoholic liver disease (ALD) is a global health problem with limited therapeutic options. Intestinal barrier integrity and the microbiota modulate…”
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Alcohol‐induced miR‐155 and HDAC11 inhibit negative regulators of the TLR4 pathway and lead to increased LPS responsiveness of Kupffer cells in alcoholic liver disease by Bala, Shashi, Csak, Timea, Kodys, Karen, Catalano, Donna, Ambade, Aditya, Furi, Istvan, Lowe, Patrick, Cho, Yeonhee, Iracheta‐Vellve, Arvin, Szabo, Gyongyi

“…Alcohol downregulates IRAK‐M, SHIP1, SOCS1, and IL‐10, inhibitors of TLR4 signaling, via NF‐κB‐induced miR‐155 and HDAC11 in Kupffer cells. Inflammation…”
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