Search Results - "SYKES, David B"

Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment by Kfoury, Youmna, Baryawno, Ninib, Severe, Nicolas, Mei, Shenglin, Gustafsson, Karin, Hirz, Taghreed, Brouse, Thomas, Scadden, Elizabeth W., Igolkina, Anna A., Kokkaliaris, Konstantinos, Choi, Bryan D., Barkas, Nikolas, Randolph, Mark A., Shin, John H., Saylor, Philip J., Scadden, David T., Sykes, David B., Kharchenko, Peter V.

“…Bone metastases are devastating complications of cancer. They are particularly common in prostate cancer (PCa), represent incurable disease, and are refractory…”
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Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin by Palchaudhuri, Rahul, Saez, Borja, Hoggatt, Jonathan, Schajnovitz, Amir, Sykes, David B, Tate, Tiffany A, Czechowicz, Agnieszka, Kfoury, Youmna, Ruchika, FNU, Rossi, Derrick J, Verdine, Gregory L, Mansour, Michael K, Scadden, David T

“…An antibody-based conditioning agent enables hematopoietic stem cell transplantation in immunocompetent mice with less toxicity than irradiation. Hematopoietic…”
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Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53 by Yoon, Kyoung Wan, Byun, Sanguine, Kwon, Eunjeong, Hwang, So-Young, Chu, Kiki, Hiraki, Masatsugu, Jo, Seung-Hee, Weins, Astrid, Hakroush, Samy, Cebulla, Angelika, Sykes, David B., Greka, Anna, Mundel, Peter, Fisher, David E., Mandinova, Anna, Lee, Sam W.

“…The inefficient clearance of dying cells can lead to abnormal immune responses, such as unresolved inflammation and autoimmune conditions. We show that tumor…”
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Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses by Hirz, Taghreed, Mei, Shenglin, Sarkar, Hirak, Kfoury, Youmna, Wu, Shulin, Verhoeven, Bronte M., Subtelny, Alexander O., Zlatev, Dimitar V., Wszolek, Matthew W., Salari, Keyan, Murray, Evan, Chen, Fei, Macosko, Evan Z., Wu, Chin-Lee, Scadden, David T., Dahl, Douglas M., Baryawno, Ninib, Saylor, Philip J., Kharchenko, Peter V., Sykes, David B.

“…The treatment of low-risk primary prostate cancer entails active surveillance only, while high-risk disease requires multimodal treatment including surgery,…”
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Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney by Simic, Petra, Kim, Wondong, Zhou, Wen, Pierce, Kerry A, Chang, Wenhan, Sykes, David B, Aziz, Najihah B, Elmariah, Sammy, Ngo, Debby, Pajevic, Paola Divieti, Govea, Nicolas, Kestenbaum, Bryan R, de Boer, Ian H, Cheng, Zhiqiang, Christov, Marta, Chun, Jerold, Leaf, David E, Waikar, Sushrut S, Tager, Andrew M, Gerszten, Robert E, Thadhani, Ravi I, Clish, Clary B, Jüppner, Harald, Wein, Marc N, Rhee, Eugene P

“…Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that controls blood phosphate levels by increasing renal phosphate excretion and reducing…”
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SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin by Simic, Petra, Zainabadi, Kayvan, Bell, Eric, Sykes, David B., Saez, Borja, Lotinun, Sutada, Baron, Roland, Scadden, David, Schipani, Ernestina, Guarente, Leonard

“…Mesenchymal stem cells (MSCs) are multi‐potent cells that can differentiate into osteoblasts, adipocytes, chondrocytes and myocytes. This potential declines…”
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Severe autoimmune hemolytic anemia following receipt of SARS‐CoV‐2 mRNA vaccine by Gadi, Sanjay R. V., Brunker, Patricia A. R., Al‐Samkari, Hanny, Sykes, David B., Saff, Rebecca R., Lo, Janet, Bendapudi, Pavan, Leaf, David E., Leaf, Rebecca Karp

“…Background Large clinical trials have demonstrated the overall safety of vaccines for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). However,…”
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Inhibiting the biogenesis of myeloid-derived suppressor cells enhances immunotherapy efficacy against mammary tumor progression by Colligan, Sean H, Amitrano, Andrea M, Zollo, Robert A, Peresie, Jennifer, Kramer, Elliot D, Morreale, Brian, Barbi, Joseph, Singh, Prashant K, Yu, Han, Wang, Jianmin, Opyrchal, Mateusz, Sykes, David B, Nemeth, Michael J, Abrams, Scott I

“…While immune checkpoint inhibitors (ICIs) have transformed the therapeutic landscape in oncology, they are effective in select subsets of patients. Efficacy…”
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KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs by Yan, Fangxue, Li, Jinyang, Milosevic, Jelena, Petroni, Ricardo, Liu, Suying, Shi, Zhennan, Yuan, Salina, Reynaga, Janice M, Qi, Yuwei, Rico, Joshua, Yu, Sixiang, Liu, Yiman, Rokudai, Susumu, Palmisiano, Neil, Meyer, Sara E, Sung, Pamela J, Wan, Liling, Lan, Fei, Garcia, Benjamin A, Stanger, Ben Z, Sykes, David B, Blanco, M Andrés

“…Epigenetic programs are dysregulated in acute myeloid leukemia (AML) and help enforce an oncogenic state of differentiation arrest. To identify key epigenetic…”
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Modulating Cell Fate as a Therapeutic Strategy by Lin, Brian, Srikanth, Priya, Castle, Alison C., Nigwekar, Sagar, Malhotra, Rajeev, Galloway, Jenna L., Sykes, David B., Rajagopal, Jayaraj

“…In injured tissues, regeneration is often associated with cell fate plasticity, in that cells deviate from their normal lineage paths. It is becoming…”
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A transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma by Alchahin, Adele M., Mei, Shenglin, Tsea, Ioanna, Hirz, Taghreed, Kfoury, Youmna, Dahl, Douglas, Wu, Chin-Lee, Subtelny, Alexander O., Wu, Shulin, Scadden, David T., Shin, John H., Saylor, Philip J., Sykes, David B., Kharchenko, Peter V., Baryawno, Ninib

“…Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer in adults. When ccRCC is localized to the kidney, surgical resection or…”
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An unappreciated role for neutrophil-DC hybrids in immunity to invasive fungal infections by Fites, J Scott, Gui, Michael, Kernien, John F, Negoro, Paige, Dagher, Zeina, Sykes, David B, Nett, Jeniel E, Mansour, Michael K, Klein, Bruce S

“…Neutrophils are classically defined as terminally differentiated, short-lived cells; however, neutrophils can be long-lived with phenotypic plasticity. During…”
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Host defense against fungal pathogens: Adaptable neutrophil responses and the promise of therapeutic opportunities? by Scherer, Allison K, Hopke, Alex, Sykes, David B, Irimia, Daniel, Mansour, Michael K

“…While short lived, neutrophils rapidly deploy a variety of mechanisms to eradicate microbial pathogens including phagocytosis, the release of antimicrobial…”
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Prenylcysteine oxidase 1 like protein is required for neutrophil bactericidal activities by Petenkova, Anastasiia, Auger, Shelby A., Lamb, Jeffrey, Quellier, Daisy, Carter, Cody, To, On Tak, Milosevic, Jelena, Barghout, Rana, Kugadas, Abirami, Lu, Xiaoxiao, Geddes-McAlister, Jennifer, Fichorova, Raina, Sykes, David B., Distefano, Mark D., Gadjeva, Mihaela

“…The bactericidal function of neutrophils is dependent on a myriad of intrinsic and extrinsic stimuli. Using systems immunology approaches we identify…”
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Chromatin accessibility promotes hematopoietic and leukemia stem cell activity by Cabal-Hierro, Lucia, van Galen, Peter, Prado, Miguel A., Higby, Kelly J., Togami, Katsuhiro, Mowery, Cody T., Paulo, Joao A., Xie, Yingtian, Cejas, Paloma, Furusawa, Takashi, Bustin, Michael, Long, Henry W., Sykes, David B., Gygi, Steven P., Finley, Daniel, Bernstein, Bradley E., Lane, Andrew A.

“…Chromatin organization is a highly orchestrated process that influences gene expression, in part by modulating access of regulatory factors to DNA and…”
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mTORC1 links pathology in experimental models of Still’s disease and macrophage activation syndrome by Huang, Zhengping, You, Xiaomeng, Chen, Liang, Du, Yan, Brodeur, Kailey, Jee, Hyuk, Wang, Qiang, Linder, Grace, Darbousset, Roxane, Cunin, Pierre, Chang, Margaret H., Wactor, Alexandra, Wauford, Brian M., Todd, Marc J. C., Wei, Kevin, Li, Ying, Levescot, Anais, Iwakura, Yoichiro, Pascual, Virginia, Baldwin, Nicole E., Quartier, Pierre, Li, Tianwang, Gianatasio, Maria T., Hasserjian, Robert P., Henderson, Lauren A., Sykes, David B., Mellins, Elizabeth D., Canna, Scott W., Charles, Julia F., Nigrovic, Peter A., Lee, Pui Y.

“…Still’s disease is a severe inflammatory syndrome characterized by fever, skin rash and arthritis affecting children and adults. Patients with Still’s disease…”
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The Successful Use of Apixaban in Dialysis Patients with Calciphylaxis Who Require Anticoagulation: A Retrospective Analysis by Garza-Mayers, Anna C, Shah, Radhika, Sykes, David B, Nigwekar, Sagar U, Kroshinsky, Daniela

“…Calciphylaxis is a disease of dermal arteriolar calcification that results in necrosis. It commonly occurs in individuals with end-stage renal disease (ESRD)…”
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Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity by Franklin, Reuben, Guo, Yiming, He, Shiyang, Chen, Meijuan, Ji, Fei, Zhou, Xinyue, Frankhouser, David, Do, Brian T., Chiem, Carmen, Jang, Mihyun, Blanco, M. Andres, Vander Heiden, Matthew G., Rockne, Russell C., Ninova, Maria, Sykes, David B., Hochedlinger, Konrad, Lu, Rui, Sadreyev, Ruslan I., Murn, Jernej, Volk, Andrew, Cheloufi, Sihem

“…Cell fate commitment is driven by dynamic changes in chromatin architecture and activity of lineage-specific transcription factors (TFs). The chromatin…”
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SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst by Nguyen, Giang T, Shaban, Lamyaa, Mack, Matthias, Swanson, Kenneth D, Bunnell, Stephen C, Sykes, David B, Mecsas, Joan

“…is a respiratory, blood, liver, and bladder pathogen of significant clinical concern. We show that the adaptor protein, SKAP2, is required for protection…”
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The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG by Kugler, Eitan, Madiwale, Shreyas, Yong, Darren, Thoms, Julie A. I., Birger, Yehudit, Sykes, David B., Schmoellerl, Johannes, Drakul, Aneta, Priebe, Valdemar, Yassin, Muhammad, Aqaqe, Nasma, Rein, Avigail, Fishman, Hila, Geron, Ifat, Chen, Chun-Wei, Raught, Brian, Liu, Qiao, Ogana, Heather, Liedke, Elisabeth, Bourquin, Jean-Pierre, Zuber, Johannes, Milyavsky, Michael, Pimanda, John, Privé, Gilbert G., Izraeli, Shai

“…The ERG (ETS-related gene) transcription factor is linked to various types of cancer, including leukemia. However, the specific ERG domains and co-factors…”
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