Search Results - "SYBERTZ, E. J"

Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663 by Van Heek, Margaret, Farley, Constance, Compton, Douglas S, Hoos, Lizbeth, Alton, Kevin B, Sybertz, Edmund J, Davis, Harry R

“…Previous studies described the metabolism‐based discovery of a potent, selective inhibitor of intestinal absorption of cholesterol, SCH58235 (Ezetimibe). Here…”
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SCH 39370, a neutral metalloendopeptidase inhibitor, potentiates biological responses to atrial natriuretic factor and lowers blood pressure in desoxycorticosterone acetate-sodium hypertensive rats by Sybertz, E J, Chiu, P J, Vemulapalli, S, Pitts, B, Foster, C J, Watkins, R W, Barnett, A, Haslanger, M F

“…SCH 39370 (N-[N-[1-(S)-carboxyl-3-phenylpropyl]-(S)-phenyl-alanyl]-(S)-isoserin e) is a potent and specific inhibitor of neutral metalloendopeptidase (NEP)…”
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Atrial Natriuretic Factor-Potentiating and Antihypertensive Activity of SCH 34826: An Orally Active Neutral Metalloendopeptidase Inhibitor by Sybertz, Edmund J, Chiu, Peter J.S, Vemulapalli, Subbarao, Watkins, Robert, Haslanger, Martin F

“…The effects of SCH 34826, an orally active neutral metalloendopeptidase inhibitor, on responses to atrial natriuretic factor-(103–125) or -(99–126) and on…”
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Influence of C-ANF receptor and neutral endopeptidase on pharmacokinetics of ANF in rats by Chiu, P J, Tetzloff, G, Romano, M T, Foster, C J, Sybertz, E J

“…The role of C-atrial natriuretic factor (ANF) receptors and neutral endopeptidase (NEP) in the pharmacokinetics and hydrolysis of 125I-labeled ANF was…”
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Diet-induced obese mice develop peripheral, but not central, resistance to leptin by Van Heek, M, Compton, D S, France, C F, Tedesco, R P, Fawzi, A B, Graziano, M P, Sybertz, E J, Strader, C D, Davis, Jr, H R

“…Leptin administration reduces obesity in leptin-deficient ob/ob mice; its effects in obese humans, who have high circulating leptin levels, remain to be…”
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Antiplatelet and Antiproliferative Effects of SCH 51866, a Novel Type 1 and Type 5 Phosphodiesterase Inhibitor by Vemulapalli, Subbarao, Watkins, Robert W, Chintala, Madhu, Davis, Harry, Ahn, Ho-Sam, Fawzi, Ahmad, Tulshian, Deen, Chiu, Peter, Chatterjee, Meeta, Lin, Chin-Chung, Sybertz, Edmund J

“…SUMMARYSCH 51866 is a potent and selective PDE1 and PDE5 inhibitor. The antiplatelet, antiproliferative, and hemodynamic effects of SCH 51866 were compared…”
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Neutral metalloendopeptidase inhibition: a novel means of circulatory modulation by Sybertz, Jr, E J, Chiu, P J, Watkins, R W, Vemulapalli, S

“…Inhibition of the enzyme neutral metalloendopeptidase (NEP) potentiates responses to atrial natriuretic factor (ANF) and elicits reductions in blood pressure…”
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Phorbol dibutyrate contractions in rabbit aorta: calcium dependence and sensitivity to nitrovasodilators and 8-BR-cyclic GMP by Sybertz, E J, Desiderio, D M, Tetzloff, G, Chiu, P J

“…Phorbol esters activate protein kinase C and induce contraction in vascular smooth muscle. The role of Ca and the sensitivity of this response to…”
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Sympathoadrenal stimulation, not endothelin, plays a role in acute pressor response to cyclosporine in anesthetized rats by Chiu, P J, Vemulapalli, S, Sabin, C, Rivelli, M, Bernardino, V, Sybertz, E J

“…The possible role of sympathoadrenal stimulation and endothelin release in cyclosporine (CS)-induced hypertension was ascertained in intact and pithed rats. CS…”
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Inhibition of endothelial derived relaxing factor (EDRF) aggravates ischemic acute renal failure in anesthetized rats by CHINTALA, M. S, CHIU, P. J. S, SUBBARAO VEMULAPALLI, WATKINS, R. W, SYBERTZ, E. J

“…The relative importance of endothelial derived relaxing factor (EDRF)/nitric oxide (NO) in maintaining kidney function in normal condition and in acute renal…”
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Phorbol dibutyrate inhibits release and action of endothelium-derived relaxing factor(s) in canine blood vessels by Rubanyi, G M, Desiderio, D, Luisi, A, Johns, A, Sybertz, E J

“…The effects of phorbol esters on endothelium-dependent relaxations evoked by ACh and the calcium ionophore A23187 were analyzed in isolated canine femoral and…”
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SCH 34826: an overview of its profile as a neutral endopeptidase inhibitor and ANF potentiator by Sybertz, E J

“…Our studies with the prototypical NEP inhibitor SCH 34826 indicate the potential role of this class of compounds in cardiovascular modulation. The data…”
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In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461 by Van Heek, M, France, C F, Compton, D S, McLeod, R L, Yumibe, N P, Alton, K B, Sybertz, E J, Davis, Jr, H R

“…SCH48461 is a selective and highly potent inhibitor of cholesterol absorption. In rats, SCH48461 is rapidly and completely metabolized in the first pass…”
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Elevation of plasma atrial natriuretic peptide in rats with chronic heart failure by SCH 39370, a neutral metalloendopeptidase inhibitor by Tikkanen, I, Helin, K, Tikkanen, T, Sybertz, E J, Vemulapalli, S, Sariola, H, Näveri, H, Fyhrquist, F

“…Hormonal, renal and blood pressure effects of SCH 39370, a selective inhibitor of neutral metalloendopeptidase (endopeptidase 24.11, NEP), were studied in a…”
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Cardiac, coronary and peripheral vascular effects of acetyl glyceryl ether phosphoryl choline in the anesthetized dog by Sybertz, E J, Watkins, R W, Baum, T, Pula, K, Rivelli, M

“…Acetyl glyceryl ether phosphoryl choline (AGEPC) is a potent vasodilator, platelet activator and inflammatory agent. The cardiac and peripheral vascular…”
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Phosphoramidon does not inhibit endogenous endothelin-1 release stimulated by hemorrhage, cytokines and hypoxia in rats by Vemulapalli, S, Chiu, P J, Griscti, K, Brown, A, Kurowski, S, Sybertz, E J

“…The role of phosphoramidon-sensitive endothelin converting enzyme in the release of endogenous endothelin-1 was investigated in anesthetized rats. Intravenous…”
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Modulation of circulating endothelin levels in hypertension and endotoxemia in rats by Vemulapalli, S, Chiu, P J, Rivelli, M, Foster, C J, Sybertz, E J

“…We have developed separate radioimmunoassays to measure circulating ET-1 and ET-3 levels in normotensive and different hypertensive rat models so that the role…”
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Localization and characterization of neutral metalloendopeptidase (EC 3.4.24.11), the degradative enzyme for atrial natriuretic peptide, in rat kidney using a radioiodinated neutral metalloendopeptidase inhibitor by Kanazawa, M, Casley, D J, Sybertz, E J, Haslanger, M F, Johnston, C I

“…Atrial natriuretic peptide (ANP) is rapidly degraded by neutral metalloendopeptidase (EC 3.4.24.11, NEP), with the kidney being a major site of ANP clearance…”
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Disparate effects of thrombin receptor activating peptide on platelets and peripheral vasculature in rats by Chintala, Madhu S, Chiu, Peter J.S, Bernadino, Vernon, Tetzloff, Glen G, Tedesco, Richard, Sabin, Crawford, Watkins, Robert W, Sybertz, Edmund J

“…The hemodynamic and platelet effects of the thrombin receptor activating peptide SFLLRN (TRAP) were evaluated in rats. TRAP failed to aggregate rat platelets…”
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Characterization of in vitro and in vivo platelet responses to thrombin and thrombin receptor-activating peptides in guinea pigs by Chiu, Peter J.S., Tetzloff, Glen G., Foster, Carolyn, Chintala, Madhu, Sybertz, Edmund J.

“…Guinea pig platelets are similar to human platelets in their responsiveness to thrombin receptor-activating peptides and other agonists. Therefore, guinea pigs…”
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