Search Results - "SWISTOK, Joseph"

The N-terminal Domain of RGS4 Confers Receptor-selective Inhibition of G Protein Signaling by Zeng, W, Xu, X, Popov, S, Mukhopadhyay, S, Chidiac, P, Swistok, J, Danho, W, Yagaloff, K A, Fisher, S L, Ross, E M, Muallem, S, Wilkie, T M

“…Regulators of heterotrimeric G protein signaling (RGS) proteins are GTPase-activating proteins (GAPs) that accelerate GTP hydrolysis by G q and G i α…”
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Structure-activity relationship of linear peptide Bu-His-DPhe-Arg-Trp-Gly-NH2 at the human melanocortin-1 and -4 receptors: Arginine substitution by CHEUNG, Adrian Wai-Hing, DANHO, Waleed, SWISTOK, Joseph, QI, Lida, KURYLKO, Grazyna, FRANCO, Lucia, YAGALOFF, Keith, LI CHEN

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A predictive pharmacophore model of human melanocortin-4 receptor as derived from the solution structures of cyclic peptides by Sun, Hongmao, Greeley, David N., Chu, Xin-Jie, Cheung, Adrian, Danho, Waleed, Swistok, Joseph, Wang, Yao, Zhao, Chunlin, Chen, Li, Fry, David C.

“…A predictive pharmacophore model of human melanocortin-4 receptor (hMC4R) was derived from the NMR structures of a series of rigidified MT-II related cyclic…”
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Discovery of 1-amino-4-phenylcyclohexane-1-carboxylic acid and its influence on agonist selectivity between human melanocortin-4 and -1 receptors in linear pentapeptides by Chu, Xin-Jie, Bartkovitz, David, Danho, Waleed, Swistok, Joseph, Cheung, Adrian Wai-Hing, Kurylko, Grazyna, Rowan, Karen, Yeon, Mitch, Franco, Lucia, Qi, Lida, Chen, Li, Yagaloff, Keith

“…A design and synthesis of cis-Apc as new histidine surrogate and its incorporation into linear pentapeptides (Penta- cis-Apc-DPhe-Arg-Trp-Gly-NH 2) and related…”
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Structure-activity relationship of linear peptide Bu-His-DPhe-Arg-Trp-Gly-NH2 at the human melanocortin-1 and -4 receptors: Histidine substitution by CHEUNG, Adrian Wai-Hing, DANHO, Waleed, YAGALOFF, Keith, SWISTOK, Joseph, LIDA QI, KURYLKO, Grazyna, ROWAN, Karen, YEON, Mitch, FRANCO, Lucia, CHU, Xin-Jie, LI CHEN

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Preparation of human Melanocortin-4 receptor agonist libraries : Linear peptides X-Y-DPhe7-Arg8-Trp(or 2-Nal)9-Z-NH2 by CHEUNG, Adrian Wai-Hing, LIDA QI, GORE, Vijay, CHU, Xin-Jie, BARTKOVITZ, David, KURYLKO, Grazyna, SWISTOK, Joseph, DANHO, Waleed, LI CHEN, YAGALOFF, Keith

“…Two libraries of hMC4R agonists, X-Y-DPhe(7)-Arg(8)-2-Nal(9)-Z-NH(2) and X-Y-DPhe(7)-Arg(8)-Trp(9)-Z-NH(2), totaling 185 peptides were prepared using Irori…”
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Structure-activity relationship of cyclic peptide Penta-c[Asp-His6-DPhe7-Arg8-Trp9-Lys]-NH2 at the human melanocortin-1 and -4 receptors: His6 substitution by WAI-HING CHEUNG, Adrian, DANHO, Waleed, YAGALOFF, Keith, SWISTOK, Joseph, QI, Lida, KURYLKO, Grazyna, ROWAN, Karen, YEON, Mitch, FRANCO, Lucia, CHU, Xin-Jie, LI CHEN

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Structure-activity relationship of linear peptide Bu-His6-DPhe7-Arg8-Trp9-Gly10-NH2 at the human melanocortin-1 and -4 receptors : DPhe7 and Trp9 substitution by DANHO, Waleed, SWISTOK, Joseph, CHEUNG, Adrian Wai-Hing, KURYLKO, Grazyna, FRANCO, Lucia, CHU, Xin-Jie, LI CHEN, YAGALOFF, Keith

“…A series of pentapeptides, based on hMC4R pentapeptide agonist (Bu-His(6)-DPhe(7)-Arg(8)-Trp(9)-Gly(10)-NH(2)), was prepared in which either DPhe(7) or Trp(9)…”
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Opportunities and challenges of developing peptide drugs in the pharmaceutical industry by Danho, Waleed, Swistok, Joseph, Khan, Wajiha, Chu, Xin-Jie, Cheung, Adrian, Fry, David, Sun, Hongmao, Kurylko, Grazyna, Rumennik, Leonid, Cefalu, Joseph, Cefalu, Gretchen, Nunn, Philip

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Carboxylic acids and tetrazoles as isosteric replacements for sulfate in cholecystokinin analogs by Tilley, Jefferson W, Danho, Waleed, Lovey, Kathleen, Wagner, Rolf, Swistok, Joseph, Makofske, Raymond, Michalewsky, Joseph, Triscari, Joseph, Nelson, David, Weatherford, Sally

“…A series of analogues of the satiety-inducing peptide cholecystokinin (CCK-8) was prepared in which the sulfated tyrosine required for activation of peripheral…”
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Structure activity studies of tryptophan30 modified analogs of Ac-CCK-7 by Danho, W, Tilley, J W, Shiuey, S J, Kulesha, I, Swistok, J, Makofske, R, Michalewsky, J, Wagner, R, Triscari, J, Nelson, D

“…Cholecystokinin represents a family of gut hormones which among other activities, have been proposed to participate in satiety signaling…”
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Preparation of human Melanocortin-4 receptor agonist libraries: Linear peptides X-Y-DPhe 7-Arg 8-Trp(or 2-Nal) 9-Z-NH 2 by Cheung, Adrian Wai-Hing, Qi, Lida, Gore, Vijay, Chu, Xin-Jie, Bartkovitz, David, Kurylko, Grazyna, Swistok, Joseph, Danho, Waleed, Chen, Li, Yagaloff, Keith

“…Two libraries of hMC4R agonists, X- Y-DPhe 7-Arg 8-2-Nal 9- Z-NH 2 and X- Y-DPhe 7-Arg 8-Trp 9- Z-NH 2, totaling 185 peptides were prepared using Irori tagging…”
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Structure–Activity relationship of linear peptide Bu-His 6-DPhe 7-Arg 8-Trp 9-Gly 10-NH 2 at the human melanocortin-1 and -4 receptors: DPhe 7 and Trp 9 substitution by Danho, Waleed, Swistok, Joseph, Wai-Hing Cheung, Adrian, Kurylko, Grazyna, Franco, Lucia, Chu, Xin-Jie, Chen, Li, Yagaloff, Keith

“…A series of pentapeptides, based on hMC4R pentapeptide agonist (Bu-His 6-DPhe 7-Arg 8-Trp 9-Gly 10-NH 2), was prepared in which either DPhe 7 or Trp 9 residue…”
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Structure-activity relationship of linear peptide Bu-His-DPhe-Arg-Trp-Gly-NH(2) at the human melanocortin-1 and -4 receptors: arginine substitution by Cheung, Adrian Wai-Hing, Danho, Waleed, Swistok, Joseph, Qi, Lida, Kurylko, Grazyna, Franco, Lucia, Yagaloff, Keith, Chen, Li

“…A series of pentapeptides, based on Bu-His(6)-DPhe(7)-Arg(8)-Trp(9)-Gly(10)-NH(2) and modified at the Arg(8) position, was prepared and pharmacologically…”
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Structure-activity relationship of cyclic peptide penta-c[Asp-His(6)-DPhe(7)-Arg(8)-Trp(9)-Lys]-NH(2) at the human melanocortin-1 and -4 receptors: His(6) substitution by Cheung, Adrian Wai-Hing, Danho, Waleed, Swistok, Joseph, Qi, Lida, Kurylko, Grazyna, Rowan, Karen, Yeon, Mitch, Franco, Lucia, Chu, Xin-Jie, Chen, Li, Yagaloff, Keith

“…A series of MT-II related cyclic peptides, based on potent but non-selective hMC4R agonist (Penta-c[Asp-His(6)-DPhe(7)-Arg(8)-Trp(9)-Lys]-NH(2)) was prepared…”
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Structure-activity relationship of linear peptide Bu-His-DPhe-Arg-Trp-Gly-NH(2) at the human melanocortin-1 and -4 receptors: histidine substitution by Cheung, Adrian Wai-Hing, Danho, Waleed, Swistok, Joseph, Qi, Lida, Kurylko, Grazyna, Rowan, Karen, Yeon, Mitch, Franco, Lucia, Chu, Xin-Jie, Chen, Li, Yagaloff, Keith

“…Systematic substitution of His(6) residue using non-selective hMC4R pentapeptide agonist (Bu-His(6)-DPhe(7)-Arg(8)-Trp(9)-Gly(10)-NH(2)) as the template led to…”
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Structure–Activity relationship of linear peptide Bu-His-DPhe-Arg-Trp-Gly-NH 2 at the human melanocortin-1 and -4 receptors: histidine substitution by Cheung, Adrian Wai-Hing, Danho, Waleed, Swistok, Joseph, Qi, Lida, Kurylko, Grazyna, Rowan, Karen, Yeon, Mitch, Franco, Lucia, Chu, Xin-Jie, Chen, Li, Yagaloff, Keith

“…Systematic substitution of His 6 residue using non-selective hMC4R pentapeptide agonist (Bu-His 6-DPhe 7-Arg 8-Trp 9-Gly 10-NH 2) as the template led to the…”
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Structure–activity relationship of cyclic peptide penta-c[Asp-His 6-DPhe 7-Arg 8-Trp 9-Lys]-NH 2 at the human melanocortin-1 and -4 receptors: His 6 substitution by Cheung, Adrian Wai-Hing, Danho, Waleed, Swistok, Joseph, Qi, Lida, Kurylko, Grazyna, Rowan, Karen, Yeon, Mitch, Franco, Lucia, Chu, Xin-Jie, Chen, Li, Yagaloff, Keith

“…A series of MT-II related cyclic peptides, based on potent but non-selective hMC4R agonist (Penta-c[Asp-His 6-DPhe 7-Arg 8-Trp 9-Lys]-NH 2) was prepared in…”
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Structure–Activity relationship of linear peptide Bu-His-DPhe-Arg-Trp-Gly-NH 2 at the human melanocortin-1 and -4 receptors: arginine substitution by Cheung, Adrian Wai-Hing, Danho, Waleed, Swistok, Joseph, Qi, Lida, Kurylko, Grazyna, Franco, Lucia, Yagaloff, Keith, Chen, Li

“…A series of pentapeptides, based on Bu-His 6-DPhe 7-Arg 8-Trp 9-Gly 10-NH 2 and modified at the Arg 8 position, was prepared and pharmacologically…”
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Analogs of CCK incorporating conformationally constrained replacements for Asp32 by Tilley, Jefferson W, Danho, Waleed, Madison, Vincent, Fry, David, Swistok, Joseph, Makofske, Raymond, Michalewsky, Joseph, Schwartz, Allan, Weatherford, Sally

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