Search Results - "SWIETACH, P"

Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells by Dovmark, T H, Saccomano, M, Hulikova, A, Alves, F, Swietach, P

“…Glycolytic cancer cells produce large quantities of lactate that must be removed to sustain metabolism in the absence of oxidative phosphorylation. The only…”
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New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation by Swietach, P, Hulikova, A, Vaughan-Jones, R D, Harris, A L

“…In this review, we discuss the role of the tumour-associated carbonic anhydrase isoform IX (CAIX) in the context of pH regulation. We summarise recent…”
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S0859, an N‐cyanosulphonamide inhibitor of sodium‐bicarbonate cotransport in the heart by Ch'En, F F‐T, Villafuerte, F C, Swietach, P, Cobden, P M, Vaughan‐Jones, R D

“…Background and purpose: Intracellular pH (pHi) in heart is regulated by sarcolemmal H+‐equivalent transporters such as Na+‐H+ exchange (NHE) and Na+‐HCO3 −…”
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A mathematical model of the murine ventricular myocyte: a data-driven biophysically based approach applied to mice overexpressing the canine NCX isoform by Li, L, Niederer, S A, Idigo, W, Zhang, Y H, Swietach, P, Casadei, B, Smith, N P

“…Mathematical modeling of Ca(2+) dynamics in the heart has the potential to provide an integrated understanding of Ca(2+)-handling mechanisms. However, many…”
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The importance of carbonic anhydrase II in red blood cells during exposure of chicken embryos to CO2 by Everaert, N, Willemsen, H, Hulikova, A, Brown, H, Decuypere, E, Swietach, P, Bruggeman, V

“…Abstract The importance of carbonic anhydrase (CA) during exposure of chicken embryos to CO2 during the second half of incubation was investigated. The protein…”
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Measuring and Modeling Chloride-Hydroxyl Exchange in the Guinea-Pig Ventricular Myocyte by Niederer, S.A., Swietach, P., Wilson, D.A., Smith, N.P., Vaughan-Jones, R.D.

“…Protons are powerful modulators of cardiac function. Their intracellular concentration is regulated by sarcolemmal ion transporters that export or import H…”
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Spatial aspects of intracellular pH regulation in heart muscle by Vaughan-Jones, Richard D., Spitzer, Kenneth W., Swietach, Pawel

“…Intracellular pH (pH i) is an important modulator of cardiac function. Because it is readily influenced by metabolic processes, pH i is controlled…”
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Elevated propionate signalling drives Pde9a overexpression and contractile dysfunction through increased histone acetylation and propionylation by Park, KC, Crump, NT, Hulikova, A, Ford, KL, Louwman, N, Carnicer, R, Hauton, D, Koschinski, A, Mccullagh, J, Zaccolo, M, Krywawych, S, Milne, TA, Swietach, P

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The Spatial Distribution of Nitric Oxide‐evoked cGMP Can Produce Biphasic Effects on Na + /H + Exchanger‐1 Activity in the Rat Ventricular Myocyte by Richards, M, Paterson, D, Vaughan‐Jones, R, Swietach, P

“…Abstract only We investigated the effects of nitric oxide (NO)‐signalling on Na + /H + Exchanger (NHE1), the principal H + ‐extruding protein in ventricular…”
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2161Redox-mediated PKA-RIalpha localisation to the lysosome inhibits myocardial calcium release and robustly reduces myocardial injury by Simon, J N, Vrellaku, B, Monterisi, S, Chu, S, Rawlings, N, Lomas, O, Marchal, G A, Waithe, D, Gajendragadkar, P, Jayaram, R, Channon, K, Swietach, P, Zaccolo, M, Eaton, P, Casadei, B

“…Abstract Background Kinase oxidation is a critical signalling mechanism through which changes in the intracellular redox state alter cardiac function. In the…”
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Iron-deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity by Chung, Yu Jin, Luo, Antao, Park, Kyung Chan, Loonat, Aminah A, Lakhal-Littleton, Samira, Robbins, Peter A, Swietach, Pawel

“…Iron deficiency is present in ~50% of heart failure (HF) patients. Large multicenter trials have shown that treatment of iron deficiency with i.v. iron…”
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Functional diversity of electrogenic Na+–HCO3− cotransport in ventricular myocytes from rat, rabbit and guinea pig by Yamamoto, Taku, Swietach, Pawel, Rossini, Alessandra, Loh, Shih‐Hurng, Vaughan‐Jones, Richard D., Spitzer, Kenneth W.

“…The Na+–HCO3− cotransporter (NBC) is an important sarcolemmal acid extruder in cardiac muscle. The characteristics of NBC expressed functionally in heart are…”
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Experimental Generation and Computational Modeling of Intracellular pH Gradients in Cardiac Myocytes by Swietach, Pawel, Leem, Chae-Hun, Spitzer, Kenneth W., Vaughan-Jones, Richard D.

“…It is often assumed that pH i is spatially uniform within cells. A double-barreled microperfusion system was used to apply solutions of weak acid (acetic acid,…”
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Extracellular Acidification Elicits Spatially and Temporally Distinct Ca super(2+) Signals by Huang, W-C, Swietach, P, Vaughan-Jones, R D, Ansorge, O, Glitsch, MD

“…Extracellular acidification accompanies neoplastic transformation of tissues and increases with tumor aggressiveness [1, 2]. The intracellular signaling…”
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The importance of carbonic anhydrase II in red blood cells during exposure of chicken embryos to C02 by EVERAERT, N, WILLEMSEN, H, HULIKOVA, A, BROWN, H, DECUYPERE, E, SWIETACH, P, BRUGGEMAN, V

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The importance of carbonic anhydrase II in red blood cells during exposure of chicken embryos to CO 2 by Everaert, N., Willemsen, H., Hulikova, A., Brown, H., Decuypere, E., Swietach, P., Bruggeman, V.

“…The importance of carbonic anhydrase (CA) during exposure of chicken embryos to CO 2 during the second half of incubation was investigated. The protein…”
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Differentiation impairs low pH-induced Ca super(2) super(+) signaling and ERK phosphorylation in granule precursor tumour cells by Huang, W C, Swietach, P, Vaughan-Jones, R D, Glitsch, MD

“…Extracellular acidification is a hallmark of a number of debilitating pathologies including cancer, ischemia and inflammation. We have recently shown that in…”
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Intracellular proton mobility and buffering power in cardiac ventricular myocytes from rat, rabbit, and guinea pig by Zaniboni, Massimiliano, Swietach, Pawel, Rossini, Alessandra, Yamamoto, Taku, Spitzer, Kenneth W, Vaughan-Jones, Richard D

“…Intracellular pH (pHi) is an important modulator of cardiac function. The spatial regulation of pH within the cytoplasm depends, in part, on intracellular H+…”
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Relationship between intracellular pH and proton mobility in rat and guinea-pig ventricular myocytes by Pawel Swietach, Richard D Vaughan-Jones

“…Intracellular H + ion mobility in eukaryotic cells is low because of intracellular buffering. We have investigated whether H i + mobility varies with pH i . A…”
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Spatial Regulation of Intracellular pH in the Ventricular Myocyte by SWIETACH, PAWEL, VAUGHAN-JONES, RICHARD D.

“…: In the cardiac myocyte, an adequate intracellular proton mobility is necessary for coupling sarcolemmal proton transport to bulk cytoplasm during…”
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