Search Results - "SWENSON, D. H"

Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome by JAMES, S. J, POGRIBNA, M, GAYLOR, D. W, POGRIBNY, I. P, MELNYK, S, HINE, R. J, GIBSON, J. B, PING YI, TAFOYA, D. L, SWENSON, D. H, WILSON, V. L

“…Down syndrome, or trisomy 21, is a complex genetic disease resulting from the presence of 3 copies of chromosome 21. The origin of the extra chromosome is…”
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Reaction of the antitumor antibiotic CC-1065 with DNA. Location of the site of thermally induced strand breakage and analysis of DNA sequence specificity by Reynolds, Vincent L, Molineux, Ian J, Kaplan, David J, Swenson, David H, Hurley, Laurence H

“…CC-1065 is a unique antitumor antibiotic produced by Streptomyces zelensis. The potent cytotoxic effects of this drug are thought to be due to its ability to…”
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Reaction of the Antitumor Antibiotic CC-1065 with DNA: Structure of a DNA Adduct with DNA Sequence Specificity by Hurley, Laurence H., Reynolds, Vincent L., Swenson, David H., Petzold, Gary L., Scahill, Terry A.

“…Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs may react preferentially with…”
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Synthesis and Evaluation of a Boronated Nitroimidazole for Boron Neutron Capture Therapy by Swenson, David H, Laster, Brenda H, Metzger, Robert L

“…We postulated that nitroimidazoles, previously used for radiosensitizing solid tumors, may be interesting templates as carriers of 10B for boron neutron…”
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Protection from 1-cyano-3,4-epithiobutane nephrotoxicity by aminooxyacetic acid and effect on xenobiotic-metabolizing enzymes in male fischer 344 rats by Vansteenhouse, Jan L., Prescott, Judith S., Swenson, David H.

“…1‐Cyano‐3,4‐epithiobutane (CEB), a naturally occurring nitrile derived from cruciferous plants, causes nephrotoxicity and increased renal glutathione (GSH)…”
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An NMR study of the covalent and noncovalent interactions of CC-1065 and DNA by Scahill, Terrence A, Jensen, Randy M, Swenson, David H, Hatzenbuhler, Nicole T, Petzold, Gary, Wierenga, Wendell, Brahme, Nanda D

“…The binding of the antitumor drug CC-1065 has been studied with nuclear magnetic resonance (NMR) spectroscopy. This study involves two parts, the elucidation…”
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CC-1065 (NSC 298223), a novel antitumor agent that interacts strongly with double-stranded DNA by Li, L H, Swenson, D H, Schpok, S L, Kuentzel, S L, Dayton, B D, Krueger, W C

“…CC-1065, a novel antibiotic produced by Streptomyces zelensis, was active against several experimental tumors in vivo and a broad spectrum of human tumor cells…”
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Binding of CC-1065 to poly- and oligonucleotides by Krueger, W C, Li, L H, Moscowitz, A, Prairie, M D, Petzold, G, Swenson, D H

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The binding of CC-1065 to thymidine and deoxyadenosine oligonucleotides and to poly(dA).poly(dT) by Krueger, W C, Duchamp, D J, Li, L H, Moscowitz, A, Petzold, G L, Prairie, M D, Swenson, D H

“…In this work, we report on the binding of the novel antitumor agent CC-1065 to poly(dA).poly(dT) and to mixtures of dA and dT oligomers as determined by…”
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Synthesis of N-(purin-8-yl)arylamines by Swenson, David H, El-Bayoumy, Karam, Shuie, Gong Huey, Hecht, Stephen S, Fiala, Emerich, Kadlubar, Fred F, Freeman, J. Pat

“…Methods for direct synthesis of N-(purin-8-yl)arylamines were investigated. N-(Purin-8-yl)arylamines are adducts from reaction of electrophilic metabolites of…”
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Toxic and vascular nephropathy associated with orotic acid administration in laboratory cats by Dimski, D S, Taylor, H W, Taboada, J, Van Steenhouse, J L, Swenson, D H, Marx, B D

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Evaluation of DNA binding characteristics of some CC-1065 analogs by Swenson, D H, Petzold, G L, Williams, M G, Li, L H, Prairie, M D, Krueger, W C

“…The factors influencing the binding of CC-1065 to DNA were examined using racemic analogs with varying chain lengths. The ability of these agents to bind DNA…”
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Analysis of DNA Adduct,S-[2-(N7-Guanyl)ethyl]glutathione, by Liquid Chromatography/Mass Spectrometry and Liquid Chromatography/Tandem Mass Spectrometry by Huang, Huan, Jemal, Ahmedin, David, Connie, Barker, Steven A., Swenson, David H., Means, Jay C.

“…Sensitive and specific isotope dilution liquid chromatography/mass spectrometry (LC/MS) and liquid chromatography/tandem mass spectrometry (LC/MS/MS) methods…”
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Aflatoxin B1-2,3-dichloride as a model of the active metabolite of aflatoxin B1 in mutagenesis and carcinogenesis by Fahmy, M J, Fahmy, O G, Swenson, D H

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The Salmonella mutagenicity test: evaluation of 29 drug candidates by Aaron, C S, Mazurek, J, Zimmer, D M, Swenson, D H

“…The Salmonella mutagenicity test (Ames assay) is part of the routine screening battery applied to all new drugs at The Upjohn Company. The purpose of this…”
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Identification of the methyl phosphotriester of thymidylyl (3',5')thymidine as a product from reaction of DNA with the carcinogen N-methyl-N-nitrosourea by Swenson, D H, Farmer, P B, Lawley, P D

“…The methyl phosphotriester of thymidylyl(3'-5')thymidine, Tp(Me)T, was obtained as a product of enzymic digestion of N-[14C]methyl-N-nitrosourea-methylated DNA…”
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Note on the determination of chymotrypsin and chymotrypsin inhibitor activity using casein by Kakade, M L, Swenson, D H, Liener, I E

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A comprehensive quantitative analysis of methylated and ethylated DNA using high pressure liquid chromatography by Beranek, D T, Weis, C C, Swenson, D H

“…Methods were developed for the efficient routine degradation and fractionation of ethylated and methylated DNA. Alkylated DNA was hydrolyzed by a neutral…”
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Genotoxicity of tacrine in primary hepatocytes isolated from B6C3F1 mice and aged ad libitum and calorie restricted Fischer 344 rats by Shaddock, J.G., Feuers, R.J., Chou, M.W., Swenson, D.H., Casciano, D.A.

“…Tacrine (1,2,3,4-tetrahydro-9-aminoacridine; THA), a reversible centrally acting anticholinesterase, has been shown to be potentially useful for treatment of…”
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Urinary orotic acid-to-creatinine ratios in cats with hepatic lipidosis by VanSteenhouse, J L, Dimski, D S, Swenson, D H, Taboada, J

“…To determine urinary orotic acid (OA) concentration and evaluate the urinary OA-to-creatinine ratio (OACR) in cats with hepatic lipidosis (HL). 20 cats with HL…”
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