Search Results - "SWAIRJO, Manal A"

Structural basis of Qng1-mediated salvage of the micronutrient queuine from queuosine-5'-monophosphate as the biological substrate by Hung, Shr-Hau, Elliott, Gregory I, Ramkumar, Thakku R, Burtnyak, Lyubomyr, McGrenaghan, Callum J, Alkuzweny, Sana, Quaiyum, Samia, Iwata-Reuyl, Dirk, Pan, Xiaobei, Green, Brian D, Kelly, Vincent P, de Crécy-Lagard, Valérie, Swairjo, Manal A

“…Eukaryotic life benefits from-and ofttimes critically relies upon-the de novo biosynthesis and supply of vitamins and micronutrients from bacteria. The…”
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Structure and mechanism of a bacterial t6A biosynthesis system by Luthra, Amit, Swinehart, William, Bayooz, Susan, Phan, Phuc, Stec, Boguslaw, Iwata-Reuyl, Dirk, Swairjo, Manal A

“…Abstract The universal N(6)-threonylcarbamoyladenosine (t6A) modification at position 37 of ANN-decoding tRNAs is central to translational fidelity. In…”
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Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens by Yuan, Yifeng, Zallot, Rémi, Grove, Tyler L., Payan, Daniel J., Martin-Verstraete, Isabelle, Šepić, Sara, Balamkundu, Seetharamsingh, Neelakandan, Ramesh, Gadi, Vinod K., Liu, Chuan-Fa, Swairjo, Manal A., Dedon, Peter C., Almo, Steven C., Gerlt, John A., de Crécy-Lagard, Valérie

“…Queuosine (Q) is a complex tRNA modification widespread in eukaryotes and bacteria that contributes to the efficiency and accuracy of protein synthesis…”
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Predicting the capsid architecture of phages from metagenomic data by Lee, Diana Y., Bartels, Caitlin, McNair, Katelyn, Edwards, Robert A., Swairjo, Manal A., Luque, Antoni

“…[Display omitted] Tailed phages are viruses that infect bacteria and are the most abundant biological entities on Earth. Their ecological, evolutionary, and…”
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Diversity of Archaeosine Synthesis in Crenarchaeota by Phillips, Gabriela, Swairjo, Manal A, Gaston, Kirk W, Bailly, Marc, Limbach, Patrick A, Iwata-Reuyl, Dirk, de Crécy-Lagard, Valérie

“…Archaeosine (G+) is found at position 15 of many archaeal tRNAs. In Euryarchaeota, the G+ precursor, 7-cyano-7-deazaguanine (preQ0), is inserted into tRNA by…”
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Zinc-Independent Folate Biosynthesis: Genetic, Biochemical, and Structural Investigations Reveal New Metal Dependence for GTP Cyclohydrolase IB by SANKARAN, Banumathi, BONNETT, Shilah A, SWAIRJO, Manal A, SHAH, Kinjal, GABRIEL, Scott, REDDY, Robert, SCHIMMEL, Paul, RODIONOV, Dmitry A, DE CRECY-LAGARD, Valérie, HELMANN, John D, IWATA-REUYL, Dirk

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Discovery and Characterization of an Amidinotransferase Involved in the Modification of Archaeal tRNA by Phillips, Gabriela, Chikwana, Vimbai M., Maxwell, Adrienne, El-Yacoubi, Basma, Swairjo, Manal A., Iwata-Reuyl, Dirk, de Crécy-Lagard, Valérie

“…The presence of the 7-deazaguanosine derivative archaeosine (G+) at position 15 in tRNA is one of the diagnostic molecular characteristics of the Archaea. The…”
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From Cyclohydrolase to Oxidoreductase: Discovery of Nitrile Reductase Activity in a Common Fold by Van Lanen, Steven G., Reader, John S., Swairjo, Manal A., de Crécy-Lagard, Valérie, Lee, Bobby, Iwata-Reuyl, Dirk, Benkovic, Stephen J.

“…The enzyme YkvM from Bacillus subtilis was identified previously along with three other enzymes (YkvJKL) in a bioinformatics search for enzymes involved in the…”
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Discovery of a New Prokaryotic Type I GTP Cyclohydrolase Family by El Yacoubi, Basma, Bonnett, Shilah, Anderson, Jessica N., Swairjo, Manal A., Iwata-Reuyl, Dirk, de Crécy-Lagard, Valérie

“…GTP cyclohydrolase I (GCYH-I) is the first enzyme of the de novo tetrahydrofolate biosynthetic pathway present in bacteria, fungi, and plants, and encoded in…”
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YrdC exhibits properties expected of a subunit for a tRNA threonylcarbamoyl transferase by Harris, Kimberly A, Jones, Victoria, Bilbille, Yann, Swairjo, Manal A, Agris, Paul F

“…The post-transcriptional nucleoside modifications of tRNA's anticodon domain form the loop structure and dynamics required for effective and accurate…”
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Protection of the Queuosine Biosynthesis Enzyme QueF from Irreversible Oxidation by a Conserved Intramolecular Disulfide by Mohammad, Adeba, Bon Ramos, Adriana, Lee, Bobby W K, Cohen, Spencer W, Kiani, Maryam K, Iwata-Reuyl, Dirk, Stec, Boguslaw, Swairjo, Manal A

“…QueF enzymes catalyze the nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of the nitrile group of 7-cyano-7-deazaguanine (preQ₀) to…”
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Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis by Yang, Xiang-Lei, Otero, Francella J, Ewalt, Karla L, Liu, Jianming, Swairjo, Manal A, Köhrer, Caroline, RajBhandary, Uttam L, Skene, Robert J, McRee, Duncan E, Schimmel, Paul

“…Aminoacylation of tRNA is the first step of protein synthesis. Here, we report the co‐crystal structure of human tryptophanyl‐tRNA synthetase and tRNATrp. This…”
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Fluorescent fatty acid transfer from bovine serum albumin to phospholipid vesicles: collision or diffusion mediated uptake by Elmadhoun, Bassam M, Swairjo, Manal A, Burczynski, Frank J

“…The extent of palmitate uptake by hepatocytes is dependent upon the surface charge of the extracellular binding protein. Specifically, hepatocyte uptake is…”
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Conformational communication mediates the reset step in t6A biosynthesis by Luthra, Amit, Paranagama, Naduni, Swinehart, William, Bayooz, Susan, Phan, Phuc, Quach, Vanessa, Schiffer, Jamie M, Stec, Boguslaw, Iwata-Reuyl, Dirk, Swairjo, Manal A

“…Abstract The universally conserved N6-threonylcarbamoyladenosine (t6A) modification of tRNA is essential for translational fidelity. In bacteria, t6A…”
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Breaking Sieve for Steric Exclusion of a Noncognate Amino Acid from Active Site of a tRNA Synthetase by Swairjo, Manal A., Schimmel, Paul R.

“…The genetic code is fixed in aminoacylation reactions catalyzed by aminoacyl-tRNA synthetases. Amino acid discrimination occurs at two sites: one for amino…”
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7-Deazaguanines in DNA: functional and structural elucidation of a DNA modification system by Gedara, Samanthi Herath, Wood, Evan, Gustafson, Andrew, Liang, Cui, Hung, Shr-Hau, Savage, Joshua, Phan, Phuc, Luthra, Amit, de Crécy-Lagard, Valérie, Dedon, Peter, Swairjo, Manal A, Iwata-Reuyl, Dirk

“…Abstract The modified nucleosides 2′-deoxy-7-cyano- and 2′-deoxy-7-amido-7-deazaguanosine (dPreQ0 and dADG, respectively) recently discovered in DNA are the…”
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Specificity in the biosynthesis of the universal tRNA nucleoside N6-threonylcarbamoyl adenosine (t6A)-TsaD is the gatekeeper by Swinehart, William, Deutsch, Christopher, Sarachan, Kathryn L, Luthra, Amit, Bacusmo, Jo Marie, de Crécy-Lagard, Valérie, Swairjo, Manal A, Agris, Paul F, Iwata-Reuyl, Dirk

“…N6-threonylcarbamoyl adenosine (t6A) is a nucleoside modification found in all kingdoms of life at position 37 of tRNAs decoding ANN codons, which functions in…”
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Structure-based design of guanosine analogue inhibitors targeting GTP cyclohydrolase IB towards a new class of antibiotics by Samaan, George N., Paranagama, Naduni, Haque, Ayesha, Hecht, David A., Swairjo, Manal A., Purse, Byron W.

“…[Display omitted] GTP cyclohydrolase (GCYH-I) is an enzyme in the folate biosynthesis pathway that has not been previously exploited as an antibiotic target,…”
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Mechanism and catalytic strategy of the prokaryotic-specific GTP cyclohydrolase-IB by Paranagama, Naduni, Bonnett, Shilah A, Alvarez, Jonathan, Luthra, Amit, Stec, Boguslaw, Gustafson, Andrew, Iwata-Reuyl, Dirk, Swairjo, Manal A

“…Guanosine 5'-triphosphate (GTP) cyclohydrolase-I (GCYH-I) catalyzes the first step in folic acid biosynthesis in bacteria and plants, biopterin biosynthesis in…”
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Specificity in the biosynthesis of the universal tRNA nucleoside N 6 -threonylcarbamoyl adenosine (t 6 A)-TsaD is the gatekeeper by Swinehart, William, Deutsch, Christopher, Sarachan, Kathryn L, Luthra, Amit, Bacusmo, Jo Marie, de Crécy-Lagard, Valérie, Swairjo, Manal A, Agris, Paul F, Iwata-Reuyl, Dirk

“…-threonylcarbamoyl adenosine (t A) is a nucleoside modification found in all kingdoms of life at position 37 of tRNAs decoding ANN codons, which functions in…”
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