Search Results - "SWAIDANI, Shadi"

TRAF Regulation of IL-17 Cytokine Signaling by Swaidani, Shadi, Liu, Caini, Zhao, Junjie, Bulek, Katarzyna, Li, Xiaoxia

“…Tumor necrosis factor receptor (TNFR)-associated factors or (TRAFs) are important mediators of Interleukin-17 (IL-17) cytokine signaling and contribute to…”
Get full text

Direct and Differential Suppression of Myeloid-Derived Suppressor Cell Subsets by Sunitinib Is Compartmentally Constrained by KO, Jennifer S, RAYMAN, Patricia, IRELAND, Joanna, SWAIDANI, Shadi, GEQIANG LI, BUNTING, Kevin D, RINI, Brian, FINKE, James H, COHEN, Peter A

“…The antiangiogenic drug sunitinib is a receptor tyrosine kinase inhibitor with significant, yet not curative, therapeutic effects in metastatic renal cell…”
Get full text

Epithelium: the interplay between innate and Th2 immunity by Bulek, Katarzyna, Swaidani, Shadi, Aronica, Mark, Li, Xiaoxia

“…Mucosal epithelium functions not only as a physical barrier, but also as a regulator of innate and adaptive immune responses against foreign substances and…”
Get full text

Act1, a U-box E3 ubiquitin ligase for IL-17 signaling by Liu, Caini, Qian, Wen, Qian, Youcun, Giltiay, Natalia V, Lu, Yi, Swaidani, Shadi, Misra, Saurav, Deng, Li, Chen, Zhijian J, Li, Xiaoxia

“…Interleukin-17 (IL-17), a proinflammatory cytokine mainly produced by cells of the T helper 17 (T(H)17) lineage, is required for host defense against bacterial…”
Get more information

The Critical Role of Epithelial-Derived Act1 in IL-17- and IL-25-Mediated Pulmonary Inflammation by Swaidani, Shadi, Bulek, Katarzyna, Kang, Zizhen, Liu, Caini, Lu, Yi, Yin, Weiguo, Aronica, Mark, Li, Xiaoxia

“…IL-25 initiates, promotes, and augments Th2 immune responses. In this study, we report that Act1, a key component in IL-17-mediated signaling, is an essential…”
Get full text

The Essential Role of Single Ig IL-1 Receptor-Related Molecule/Toll IL-1R8 in Regulation of Th2 Immune Response by Bulek, Katarzyna, Swaidani, Shadi, Qin, Jinzhong, Lu, Yi, Gulen, Muhammet F, Herjan, Tomasz, Min, Booki, Kastelein, Robert A, Aronica, Mark, Kosz-Vnenchak, Magdalena, Li, Xiaoxia

“…A novel cytokine IL-33, an IL-1 family member, signals via ST2 receptor and promotes Th2 responses, through the activation of NF-kappaB and MAP kinases…”
Get full text

Immunotherapy with IL12 and PD1/CTLA4 inhibition is effective in advanced ovarian cancer and associates with reversal of myeloid cell-induced immunosuppression by Pavicic, Paul G., Rayman, Patricia A., Swaidani, Shadi, Rupani, Amit, Makarov, Vladimir, Tannenbaum, Charles S., Edwards, Robert P., Vlad, Anda M., Diaz-Montero, C. Marcela, Mahdi, Haider

“…The tumor microenvironment (TME) in ovarian cancer (OC) is characterized by immune suppression, due to an abundance of suppressive immune cells populations. To…”
Get full text

TSG-6 Protein Is Crucial for the Development of Pulmonary Hyaluronan Deposition, Eosinophilia, and Airway Hyperresponsiveness in a Murine Model of Asthma by Swaidani, Shadi, Cheng, Georgiana, Lauer, Mark E., Sharma, Manisha, Mikecz, Katalin, Hascall, Vincent C., Aronica, Mark A.

“…Hyaluronan (HA) deposition is often correlated with mucosal inflammatory responses, where HA mediates both protective and pathological responses. By modifying…”
Get full text

Epithelial Cell-Specific Act1 Adaptor Mediates Interleukin-25-Dependent Helminth Expulsion through Expansion of Lin−c-Kit+ Innate Cell Population by Kang, Zizhen, Swaidani, Shadi, Yin, Weiguo, Wang, Chenhui, Barlow, Jillian L., Gulen, Muhammet Fatih, Bulek, Katarzyna, Do, Jeong-su, Aronica, Mark, McKenzie, Andrew N.J., Min, Booki, Li, Xiaoxia

“…Interleukin-25 (IL-25 or IL-17E), a member of the structurally related IL-17 family, functions as an important mediator of T helper 2 cell-type (type 2)…”
Get full text

Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Amplifies Hyaluronan Synthesis by Airway Smooth Muscle Cells by Lauer, Mark E., Cheng, Georgiana, Swaidani, Shadi, Aronica, Mark A., Weigel, Paul H., Hascall, Vincent C.

“…We tested the hypothesis that the artificial addition of heavy chains from inter-α-inhibitor to hyaluronan (HA), by adding recombinant TSG-6 (TNF-stimulated…”
Get full text

Nitrotyrosine Proteome Survey in Asthma Identifies Oxidative Mechanism of Catalase Inactivation by Ghosh, Sudakshina, Janocha, Allison J, Aronica, Mark A, Swaidani, Shadi, Comhair, Suzy A. A, Xu, Weiling, Zheng, Lemin, Kaveti, Suma, Kinter, Michael, Hazen, Stanley L, Erzurum, Serpil C

“…Reactive oxygen species and reactive nitrogen species produced by epithelial and inflammatory cells are key mediators of the chronic airway inflammation of…”
Get full text

Myeloid-cell-specific role of Gasdermin D in promoting lung cancer progression in mice by Traughber, C. Alicia, Deshpande, Gauravi M., Neupane, Kalash, Bhandari, Nilam, Khan, Mariam R., McMullen, Megan R., Swaidani, Shadi, Opoku, Emmanuel, Muppala, Santoshi, Smith, Jonathan D., Nagy, Laura E., Gulshan, Kailash

“…The activities of the NLRP3 and AIM2 inflammasomes and Gasdermin D (GsdmD) are implicated in lung cancer pathophysiology but it’s not clear if their…”
Get full text

Resveratrol As a Novel Treatment for Recurrent Epistaxis in SMAD4+ Hereditary Hemorrhagic Telangiectasia by Gill, Shahbegh, Swaidani, Shadi, Parambil, Joseph, McCrae, Keith R.

“…Introduction Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant disorder characterized by the development of arteriovenous malformations or…”
Get full text

Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis by Bulek, Katarzyna, Zhao, Junjie, Liao, Yun, Rana, Nitish, Corridoni, Daniele, Antanaviciute, Agne, Chen, Xing, Wang, Han, Qian, Wen, Miller-Little, William A, Swaidani, Shadi, Tang, Fangqiang, Willard, Belinda B, McCrae, Keith, Kang, Zizhen, Dubyak, George R, Cominelli, Fabio, Simmons, Alison, Pizarro, Theresa T, Li, Xiaoxia

“…Gasdermin D (GSDMD) induces pyroptosis via the pore-forming activity of its N-terminal domain, cleaved by activated caspases associated with the release of…”
Get full text

“HIT”ing back against NETs by Swaidani, Shadi, McCrae, Keith R.

Get full text

Tissue Factor (TF) Is Upregulated in Tumor-Bearing Mice Treated with Immune Checkpoint Inhibitor (ICI) by Shim, Young Jun, Hisada, Yohei, Swaidani, Shadi, Pavicic, Paul, Khorana, Alok A, Diaz-Montero, Marcela, Mackman, Nigel, McCrae, Keith R.

Get full text

Immune Checkpoint Inhibitors (ICI) Promote Neutrophil-Platelet Aggregate and NET Formation in Tumor-Bearing Mice by Shim, Young Jun, Rayman, Pat, Pavicic, Paul, Swaidani, Shadi, Khorana, Alok A, Diaz-Montero, Marcela, McCrae, Keith R.

Get full text

Hyaluronan Rafts on Airway Epithelial Cells by Abbadi, Amina, Lauer, Mark, Swaidani, Shadi, Wang, Aimin, Hascall, Vincent

“…Many cells, including murine airway epithelial cells, respond to a variety of inflammatory stimuli by synthesizing leukocyte-adhesive hyaluronan (HA) cables…”
Get full text

Cytokine Profiling in Antiphospholipid Syndrome Demonstrates Persistent Immune Dysregulation and a Procoagulant Phenotype by Hubben, Anne K, Bazeley, Peter, Swaidani, Shadi, Alarabi, Ahmed, Kulkarni, Paresh P, Shim, Young Jun, Palihati, Maierdan, Barnard, John, McCrae, Keith R.

“…Background: The antiphospholipid syndrome (APS) is an autoimmune thromboinflammatory disease characterized by thrombosis and the persistent detection of…”
Get full text

Abundance of B Cell Receptors Harboring Elongated Polytyrosine and Polyserine Rich Motifs within Their Heavy Chain CDR3 Distinguishes Catastrophic and Antiphospholipid Syndrome by Swaidani, Shadi, Chaturvedi, Shruti, Pan, Xiang-Zuo, Brodsky, Robert, Wen, Renren, Khorana, Alok A, McCrae, Keith R.

“…Antiphospholipid syndrome (APS) is defined by arterial and/or venous thrombosis and/or pregnancy morbidity along with persistent circulating antiphospholipid…”
Get full text