Search Results - "SWAAB, Dick F"

Sexual differentiation of the human brain: Relation to gender identity, sexual orientation and neuropsychiatric disorders by Bao, Ai-Min, Swaab, Dick F

“…Research highlights ► Gender identity and sexual orientation are permanently programmed in the fetal brain. ► Testosterone in the fetal stage determines sexual…”
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The human histaminergic system in neuropsychiatric disorders by Shan, Ling, Bao, Ai-Min, Swaab, Dick F

“…Highlights • Neuronal histamine production shows a diurnal rhythm, but not in neurodegeneration. • The histaminergic system shows alterations in various…”
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Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling by Korecka, Joanna A, van Kesteren, Ronald E, Blaas, Eva, Spitzer, Sonia O, Kamstra, Jorke H, Smit, August B, Swaab, Dick F, Verhaagen, Joost, Bossers, Koen

“…Multiple genetic and environmental factors play a role in the development and progression of Parkinson's disease (PD). The main neuropathological hallmark of…”
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Activated wake systems in narcolepsy type 1 by Shan, Ling, Linssen, Suzan, Harteman, Zoe, den Dekker, Fleur, Shuker, Lamis, Balesar, Rawien, Breesuwsma, Nicole, Anink, Jasper, Zhou, Jingru, Lammers, Gert Jan, Swaab, Dick F, Fronczek, Rolf

“…Narcolepsy type 1 (NT1) is assumed to be caused solely by a lack of hypocretin (orexin) neurotransmission. Recently, however, we found an 88% reduction in…”
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Alteration of the microRNA network during the progression of Alzheimer's disease by Lau, Pierre, Bossers, Koen, Janky, Rekin's, Salta, Evgenia, Frigerio, Carlo Sala, Barbash, Shahar, Rothman, Roy, Sierksma, Annerieke S. R., Thathiah, Amantha, Greenberg, David, Papadopoulou, Aikaterini S., Achsel, Tilmann, Ayoubi, Torik, Soreq, Hermona, Verhaagen, Joost, Swaab, Dick F., Aerts, Stein, De Strooper, Bart

“…An overview of miRNAs altered in Alzheimer's disease (AD) was established by profiling the hippocampus of a cohort of 41 late‐onset AD (LOAD) patients and 23…”
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Hypocretin (orexin) loss in Alzheimer's disease by Fronczek, Rolf, van Geest, Sarita, Frölich, Marijke, Overeem, Sebastiaan, Roelandse, Freek W.C, Lammers, Gert Jan, Swaab, Dick F

“…Abstract Sleep disturbances in Alzheimer's disease (AD) patients are associated with the severity of dementia and are often the primary reason for…”
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Disease stage-dependent changes in brain levels and neuroprotective effects of neuroactive steroids in Parkinson's disease by Luchetti, Sabina, Liere, Philippe, Pianos, Antoine, Verwer, Ronald W.H., Sluiter, Arja, Huitinga, Inge, Schumacher, Michael, Swaab, Dick F., Mason, Matthew R.J.

“…Neuroactive steroids are known neuroprotective agents and neurotransmitter regulators. We previously found that expression of the enzymes synthesizing…”
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Disturbance and strategies for reactivation of the circadian rhythm system in aging and Alzheimer’s disease by Wu, Ying-Hui, Swaab, Dick F

“…Abstract Circadian rhythm disturbances, such as sleep disorders, are frequently seen in aging and are even more pronounced in Alzheimer’s disease (AD)…”
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Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy by Thannickal, Thomas C, John, Joshi, Shan, Ling, Swaab, Dick F, Wu, Ming-Fung, Ramanathan, Lalini, McGregor, Ronald, Chew, Keng-Tee, Cornford, Marcia, Yamanaka, Akihiro, Inutsuka, Ayumu, Fronczek, Rolf, Lammers, Gert Jan, Worley, Paul F, Siegel, Jerome M

“…The changes in brain function that perpetuate opiate addiction are unclear. In our studies of human narcolepsy, a disease caused by loss of…”
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Abnormal retinoid and TrkB signaling in the prefrontal cortex in mood disorders by Qi, Xin-Rui, Zhao, Jun, Liu, Ji, Fang, Hui, Swaab, Dick F, Zhou, Jiang-Ning

“…The prefrontal cortex shows structural and functional alterations in mood disorders. Retinoid signaling, brain-derived neurotrophic factor (BDNF), and its…”
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Distribution of the Immune Inhibitory Molecules CD200 and CD200R in the Normal Central Nervous System and Multiple Sclerosis Lesions Suggests Neuron-Glia and Glia-Glia Interactions by Koning, Nathalie, Swaab, Dick F, Hoek, Robert M, Huitinga, Inge

“…CD200 is a membrane glycoprotein that suppresses immune activity via its receptor, CD200R. CD200-CD200R interactions have recently been considered to…”
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Vulnerability and resilience to Alzheimer's disease: early life conditions modulate neuropathology and determine cognitive reserve by Lesuis, Sylvie L, Hoeijmakers, Lianne, Korosi, Aniko, de Rooij, Susanne R, Swaab, Dick F, Kessels, Helmut W, Lucassen, Paul J, Krugers, Harm J

“…Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a high prevalence among the elderly and a huge personal and societal impact. Recent…”
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Increased pituitary adenylate cyclase-activating polypeptide in the central bed nucleus of the stria terminalis in mood disorders in men by Slabe, Zala, Pechler, Gwyneth A., van Heerikhuize, Joop, Samuels, Benjamin A., Živin, Marko, Zorović, Maja, Swaab, Dick F.

“…The mood disorders major depressive disorder (MDD) and bipolar disorder (BD) are highly prevalent worldwide. Women are more vulnerable to these…”
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Histamine-4 receptor antagonist ameliorates Parkinson-like pathology in the striatum by Fang, Qiuyuan, Xicoy, Helena, Shen, Junqing, Luchetti, Sabina, Dai, Di, Zhou, Pei, Qi, Xin-Rui, Martens, Gerard J.M., Huitinga, Inge, Swaab, Dick F., Liu, Chunqing, Shan, Ling

“…•Upregulation of H4R in the top functional category for human Parkinson’s disease (PD).•A H4R antagonist (JNJ) normalized the number of nigrostriatal…”
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The stress system in the human brain in depression and neurodegeneration by Swaab, Dick F, Bao, Ai-Min, Lucassen, Paul J

“…Corticotropin-releasing hormone (CRH) plays a central role in the regulation of the hypothalamic-pituitary-adrenal (HPA)-axis, i.e., the final common pathway…”
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The concept of resilience to Alzheimer's Disease: current definitions and cellular and molecular mechanisms by de Vries, Luuk E, Huitinga, Inge, Kessels, Helmut W, Swaab, Dick F, Verhaagen, Joost

“…Some individuals are able to maintain their cognitive abilities despite the presence of significant Alzheimer's Disease (AD) neuropathological changes. This…”
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Histamine H1 receptor deletion in cholinergic neurons induces sensorimotor gating ability deficit and social impairments in mice by Cheng, Li, Xu, Cenglin, Wang, Lu, An, Dadao, Jiang, Lei, Zheng, Yanrong, Xu, Yixin, Wang, Yi, Wang, Yujing, Zhang, Kuo, Wang, Xiaodong, Zhang, Xiangnan, Bao, Aimin, Zhou, Yudong, Yang, Jingyu, Duan, Shumin, Swaab, Dick F., Hu, Weiwei, Chen, Zhong

“…Negative symptoms in schizophrenia strongly contribute to poor functional outcomes, however its pathogenesis is still unclear. Here, we found that histamine H…”
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Alterations of melatonin receptors MT1 and MT2 in the hypothalamic suprachiasmatic nucleus during depression by Wu, Ying-Hui, Ursinus, Jeanine, Zhou, Jiang-Ning, Scheer, Frank A.J.L, Ai-Min, Bao, Jockers, Ralf, van Heerikhuize, Joop, Swaab, Dick F

“…Abstract Background The pineal hormone melatonin regulates circadian rhythms, largely by feedback on the central biological clock of the brain, the…”
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Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease by Bossers, Koen, Wirz, Kerstin T.S., Meerhoff, Gideon F., Essing, Anke H.W., van Dongen, Jeroen W., Houba, Pieter, Kruse, Chris G., Verhaagen, Joost, Swaab, Dick F.

“…Using the Braak staging for neurofibrillary changes as an objective indicator of the progression of Alzheimer's disease, we have performed a systematic search…”
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Neurosteroid biosynthetic pathways changes in prefrontal cortex in Alzheimer's disease by Luchetti, Sabina, Bossers, Koen, Van de Bilt, Saskia, Agrapart, Vincent, Morales, Rafael Ramirez, Frajese, Giovanni Vanni, Swaab, Dick F

“…Abstract Expression of the genes for enzymes involved in neurosteroid biosynthesis was studied in human prefrontal cortex (PFC) in the course of Alzheimer's…”
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