Search Results - "SVENSSON, C. I"

A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder by Sellgren, C M, Kegel, M E, Bergen, S E, Ekman, C J, Olsson, S, Larsson, M, Vawter, M P, Backlund, L, Sullivan, P F, Sklar, P, Smoller, J W, Magnusson, P K E, Hultman, C M, Walther-Jallow, L, Svensson, C I, Lichtenstein, P, Schalling, M, Engberg, G, Erhardt, S, Landén, M

“…Elevated cerebrospinal fluid (CSF) levels of the glia-derived N -methyl- D -aspartic acid receptor antagonist kynurenic acid (KYNA) have consistently been…”
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Mammalian target of rapamycin in spinal cord neurons mediates hypersensitivity induced by peripheral inflammation by Norsted Gregory, E, Codeluppi, S, Gregory, J.A, Steinauer, J, Svensson, C.I

“…Abstract mTOR, the mammalian target of rapamycin, is a serine–threonine kinase known to regulate cell proliferation and growth. mTOR has also been implicated…”
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Spinal glial TLR4‐mediated nociception and production of prostaglandin E2 and TNF by Saito, O, Svensson, CI, Buczynski, MW, Wegner, K, Hua, X‐Y, Codeluppi, S, Schaloske, RH, Deems, RA, Dennis, EA, Yaksh, TL

“…Background and purpose:  Toll‐like receptor 4 (TLR4) expressed on spinal microglia and astrocytes has been suggested to play an important role in the…”
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Distribution of transmembrane AMPA receptor regulatory protein (TARP) isoforms in the rat spinal cord by Larsson, M, Agalave, N, Watanabe, M, Svensson, C.I

“…Highlights • The TARP isoforms γ-2, γ-3, γ-4, γ-7 and γ-8 were detected in the rat spinal cord. • γ-4, γ-7 and γ-8 showed distinct laminar distribution in the…”
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Inflammation-induced GluA1 trafficking and membrane insertion of Ca2+ permeable AMPA receptors in dorsal horn neurons is dependent on spinal tumor necrosis factor, PI3 kinase and protein kinase A by Wigerblad, G., Huie, J.R., Yin, H.Z., Leinders, M., Pritchard, R.A., Koehrn, F.J., Xiao, W.-H., Bennett, G.J., Huganir, R.L., Ferguson, A.R., Weiss, J.H., Svensson, C.I., Sorkin, L.S.

“…Peripheral inflammation induces sensitization of nociceptive spinal cord neurons. Both spinal tumor necrosis factor (TNF) and neuronal membrane insertion of…”
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The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation by Park, H.J., Sandor, K., McQueen, J., Woller, S.A., Svensson, C.I., Corr, M., Yaksh, T.L.

“…Background Glucose‐6‐phosphate isomerase and collagen type II antibody‐induced arthritis models (K/BxN and CAIA, respectively) have an inflammatory and a…”
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Spinal release of tumour necrosis factor activates c-Jun N-terminal kinase and mediates inflammation-induced hypersensitivity by Bas, D.B., Abdelmoaty, S., Sandor, K., Codeluppi, S., Fitzsimmons, B., Steinauer, J., Hua, X.Y., Yaksh, T.L., Svensson, C.I.

“…Background Mounting evidence points to individual contributions of tumour necrosis factor‐alpha (TNF) and the c‐Jun N‐terminal kinase (JNK) pathway to the…”
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Spinal phospholipase A2 in inflammatory hyperalgesia : Role of the small, secretory phospholipase A2 by SVENSSON, C. I, LUCAS, K. K, HUA, X.-Y, POWELL, H. C, DENNIS, E. A, YAKSH, T. L

“…Current work emphasizes that peripheral tissue injury and inflammation results in a heightened sensitivity to subsequent noxious input (hyperalgesia) that is…”
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Spinal Astrocytes in Pain Processing: Non-Neuronal Cells as Therapeutic Targets by Svensson, Camilla I, Brodin, Ernst

“…The treatment of chronic inflammatory and neuropathic pain is a major concern, and the need for new more effective analgesics with less adverse effects is…”
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Autoantibodies to citrullinated proteins induce joint pain independent of inflammation via a chemokine-dependent mechanism by Wigerblad, Gustaf, Bas, Duygu B, Fernades-Cerqueira, Cátia, Krishnamurthy, Akilan, Nandakumar, Kutty Selva, Rogoz, Katarzyna, Kato, Jungo, Sandor, Katalin, Su, Jie, Jimenez-Andrade, Juan Miguel, Finn, Anja, Bersellini Farinotti, Alex, Amara, Khaled, Lundberg, Karin, Holmdahl, Rikard, Jakobsson, Per-Johan, Malmström, Vivianne, Catrina, Anca I, Klareskog, Lars, Svensson, Camilla I

“…An interesting and so far unexplained feature of chronic pain in autoimmune disease is the frequent disconnect between pain and inflammation. This is…”
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Tumor Necrosis Factor-alpha Induces Mechanical Allodynia after Spinal Nerve Ligation by Activation of p38 MAPK in Primary Sensory Neurons by Schafers, Maria, Svensson, Camilla I, Sommer, Claudia, Sorkin, Linda S

“…Tumor necrosis factor-alpha (TNF) is implicated in the initiation of neuropathic pain. In vitro, TNF activates p38 mitogen-activated kinase. Accordingly, we…”
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Collagen antibody-induced arthritis evokes persistent pain with spinal glial involvement and transient prostaglandin dependency by Bas, Duygu B., Su, Jie, Sandor, Katalin, Agalave, Nilesh M., Lundberg, Johanna, Codeluppi, Simone, Baharpoor, Azar, Nandakumar, Kutty S., Holmdahl, Rikard, Svensson, Camilla I.

“…Objective Pain is one of the most debilitating symptoms reported by rheumatoid arthritis (RA) patients. While the collagen antibody–induced arthritis (CAIA)…”
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Olfactory exposure to males, including men, causes stress and related analgesia in rodents by Sorge, Robert E, Martin, Loren J, Isbester, Kelsey A, Sotocinal, Susana G, Rosen, Sarah, Tuttle, Alexander H, Wieskopf, Jeffrey S, Acland, Erinn L, Dokova, Anastassia, Kadoura, Basil, Leger, Philip, Mapplebeck, Josiane C S, McPhail, Martina, Delaney, Ada, Wigerblad, Gustaf, Schumann, Alan P, Quinn, Tammie, Frasnelli, Johannes, Svensson, Camilla I, Sternberg, Wendy F, Mogil, Jeffrey S

“…The presence of male experimenters induces stress and stress-induced analgesia, affecting behavioral assays in mice. We found that exposure of mice and rats to…”
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Spinal glial TLR4‐mediated nociception and production of prostaglandin E 2 and TNF by Saito, O, Svensson, CI, Buczynski, MW, Wegner, K, Hua, X‐Y, Codeluppi, S, Schaloske, RH, Deems, RA, Dennis, EA, Yaksh, TL

“…Background and purpose:  Toll‐like receptor 4 (TLR4) expressed on spinal microglia and astrocytes has been suggested to play an important role in the…”
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The spinal phospholipase-cyclooxygenase-prostanoid cascade in nociceptive processing by Svensson, Camilla I, Yaksh, Tony L

“…Intrathecal phospholipase A2 (PLA2) and cyclooxygenase-2 (COX-2), but not COX-1, inhibitors attenuate facilitated pain states generated by peripheral…”
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Activation of p38 mitogen‐activated protein kinase in spinal microglia is a critical link in inflammation‐induced spinal pain processing by Svensson, Camilla I., Marsala, Martin, Westerlund, Anna, Calcutt, Nigel A., Campana, Wendy M., Freshwater, Jason D., Catalano, Rosanne, Feng, Ying, Protter, Andrew A., Scott, Brian, Yaksh, Tony L.

“…We examined the effect of p38 mitogen‐activated protein kinase (MAPK) inhibitors in models of nociception and correlated this effect with localization and…”
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Cross-centre replication of suppressed burrowing behaviour as an ethologically relevant pain outcome measure in the rat: a prospective multicentre study by Wodarski, Rachel, Delaney, Ada, Ultenius, Camilla, Morland, Rosie, Andrews, Nick, Baastrup, Catherine, Bryden, Luke A., Caspani, Ombretta, Christoph, Thomas, Gardiner, Natalie J., Huang, Wenlong, Kennedy, Jeffrey D., Koyama, Suguru, Li, Dominic, Ligocki, Marcin, Lindsten, Annika, Machin, Ian, Pekcec, Anton, Robens, Angela, Rotariu, Sanziana M., Voß, Sabrina, Segerdahl, Marta, Stenfors, Carina, Svensson, Camilla I., Treede, Rolf-Detlef, Uto, Katsuhiro, Yamamoto, Kazumi, Rutten, Kris, Rice, Andrew S.C.

“…Burrowing, an ethologically relevant rodent behaviour, has been proposed as a novel outcome measure to assess the global impact of pain in rats. In a…”
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Inhibition of spinal cytosolic phospholipase A(2) expression by an antisense oligonucleotide attenuates tissue injury-induced hyperalgesia by Kim, D H, Fitzsimmons, B, Hefferan, M P, Svensson, C I, Wancewicz, E, Monia, B P, Hung, G, Butler, M, Marsala, M, Hua, X-Y, Yaksh, T L

“…Activation of the spinal phospholipase A(2) (PLA(2)) -cyclooxygenase (COX) -prostaglandin signaling pathway is widely implicated in nociceptive processing…”
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Autoantibodies Hurt: Transfer of Patient-Derived CASPR2 Antibodies Induces Neuropathic Pain in Mice by Hunt, Matthew A., Nascimento, Diana S.M., Bersellini Farinotti, Alex, Svensson, Camilla I.

“…In this issue of Neuron, Dawes et al. (2018) show that CASPR2 antibodies (Abs) isolated from patients bind specifically to primary afferent cell bodies and…”
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Injury type-specific calcium channel alpha 2 delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin by Luo, Z D, Calcutt, N A, Higuera, E S, Valder, C R, Song, Y-H, Svensson, C I, Myers, R R

“…The calcium channel alpha2delta-1 subunit is a structural subunit important for functional calcium channel assembly. In vitro studies have shown that this…”
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