Search Results - "SUZUKI, Tadashi"

Catabolism of N-glycoproteins in mammalian cells: Molecular mechanisms and genetic disorders related to the processes by Suzuki, Tadashi

“…N-glycans on glycoproteins serve as one of the most important co- and post-translational modifications of proteins, and it has been well established that they…”
Get full text

N-glycanase NGLY1 regulates mitochondrial homeostasis and inflammation through NRF1 by Yang, Kun, Huang, Ryan, Fujihira, Haruhiko, Suzuki, Tadashi, Yan, Nan

“…Mutations in the (N-glycanase 1) gene, encoding an evolutionarily conserved deglycosylation enzyme, are associated with a rare congenital disorder leading to…”
Get full text

Reviewing the Model Core Curriculum for Pharmacy Education and Fundamental Capacities to Become a Pharmacist with a 20-year Perspective on Human Resources Development by Suzuki, Tadashi

“…The model core curriculum for pharmacy education (core curriculum) specifies the basics of 6-year pharmacy education. Pharmacy education is currently being…”
Get full text

The cytoplasmic peptide:N-glycanase (NGLY1) — Structure, expression and cellular functions by Suzuki, Tadashi, Huang, Chengcheng, Fujihira, Haruhiko

“…NGLY1/Ngly1 is a cytosolic peptide:N-glycanase, i.e. de-N-glycosylating enzyme acting on N-glycoproteins in mammals, generating free, unconjugated N-glycans…”
Get full text

Ever-expanding NGLY1 biology by Suzuki, Tadashi, Yoshida, Yukiko

“…Abstract The cytosolic peptide:N-glycanase (PNGase; NGLY1 in humans) is a deglycosylating enzyme that is widely conserved in eukaryotes. This enzyme is…”
Get full text

Assay for the peptide:N-glycanase/NGLY1 and disease-specific biomarkers for diagnosing NGLY1 deficiency by Hirayama, Hiroto, Suzuki, Tadashi

“…Abstract Cytosolic peptide:N-glycanase (NGLY1 in mammals), a highly conserved enzyme in eukaryotes, catalyses the deglycosylation of N-glycans that are…”
Get full text

The cytoplasmic peptide:N-glycanase (Ngly1)-basic science encounters a human genetic disorder by Suzuki, Tadashi

“…Peptide:N-glycanase (PNGase) is a de-N-glycosylating enzyme that cleaves intact N-glycans from glycoproteins/glycopeptides. The activity of the cytoplasmic…”
Get full text

A method for assaying peptide: N-glycanase/N-glycanase 1 activities in crude extracts using an N-glycosylated cyclopeptide by Hirayama, Hiroto, Tachida, Yuriko, Seino, Junichi, Suzuki, Tadashi

“…Abstract Cytosolic peptide: N-glycanase (PNGase; NGLY1), an enzyme responsible for de-glycosylation of N-glycans on glycoproteins, is known to play pivotal…”
Get full text

Functional glycomics: Application to medical science and hepatology by Miyoshi, Eiji, Kamada, Yoshihiro, Suzuki, Tadashi

“…Glycomics refers to the comprehensive analysis of glycans. Recent progress in glycotechnology enables the determination of a variety of biological functions of…”
Get full text

Non-lysosomal degradation pathway for N-linked glycans and dolichol-linked oligosaccharides by Suzuki, Tadashi, Harada, Yoichiro

“…•fOSs and POSs are liberated from dolichol-linked oligosaccharides at the ER membrane.•The cytosol is a site for deglycosylation of misfolded…”
Get full text

Diffusion process in photoreaction of ketoprofen probed by transient grating method by Kashihara, Wataru, Takeyama, Jumpei, Suzuki, Tadashi

“…[Display omitted] •Diffusion dynamics of Ketoprofen (KP) with and without triethylamine (TEA) in methanol was studied by using transient grating…”
Get full text

Propagation Characteristics of kHz Band PLC Signal on MV–LV Distribution System by SUZUKI, TADASHI

“…SUMMARY The kHz band power line communication (PLC) is one of the convincing mediums of the communication system for smart meter reading. Data transmission…”
Get full text

Molecular phylogeny of the genus Fissidens (Fissidentaceae, Bryophyta) and a refinement of the infrageneric classification by Suzuki, Tadashi, Inoue, Yuya, Tsubota, Hiromi

“…[Display omitted] •Three subgera and seven sections are recognized in a moss genus Fissidens based on combined molecular and morphological evidence.•Ancestral…”
Get full text

The Model Core Curriculum for Pharmacy Education to Become a Pharmacist with a 20-year Perspective on Human Resources Development by Hirata, Kazumasa, Suzuki, Tadashi

Get full text

Fluorogenic probes reveal a role of GLUT4 N-glycosylation in intracellular trafficking by Hirayama, Shinya, Hori, Yuichiro, Benedek, Zsolt, Suzuki, Tadashi, Kikuchi, Kazuya

“…Probes based on the photoactive yellow protein tag for monitoring the consequences of glycosylation on GLUT4 traffic reveal that glycosylation is important for…”
Get full text

JF1/B6F1 Ngly1−/− mouse as an isogenic animal model of NGLY1 deficiency by ASAHINA, Makoto, FUJINAWA, Reiko, FUJIHIRA, Haruhiko, MASAHARA-NEGISHI, Yuki, ANDOU, Tomohiro, TOZAWA, Ryuichi, SUZUKI, Tadashi

“…N-Glycanase 1 (NGLY1) deficiency is a congenital disorder caused by mutations in the NGLY1 gene. Because systemic Ngly1−/− mice with a C57BL/6 (B6) background…”
Get full text

Loss of peptide: N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase by Yoshida, Yukiko, Asahina, Makoto, Murakami, Arisa, Kawawaki, Junko, Yoshida, Meari, Fujinawa, Reiko, Iwai, Kazuhiro, Tozawa, Ryuichi, Matsuda, Noriyuki, Tanaka, Keiji, Suzuki, Tadashi

“…Mutations in the human peptide:N-glycanase gene (NGLY1), which encodes a cytosolic de–N-glycosylating enzyme, cause a congenital autosomal recessive disorder…”
Get full text

Cytosolic-free oligosaccharides are predominantly generated by the degradation of dolichol-linked oligosaccharides in mammalian cells by Harada, Yoichiro, Masahara-Negishi, Yuki, Suzuki, Tadashi

“…During asparagine (N)-linked protein glycosylation, eukaryotic cells generate considerable amounts of free oligosaccharides (fOSs) in the cytosol. It is…”
Get full text

Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase gene by Fujihira, Haruhiko, Masahara-Negishi, Yuki, Tamura, Masaru, Huang, Chengcheng, Harada, Yoichiro, Wakana, Shigeharu, Takakura, Daisuke, Kawasaki, Nana, Taniguchi, Naoyuki, Kondoh, Gen, Yamashita, Tadashi, Funakoshi, Yoko, Suzuki, Tadashi

“…The cytoplasmic peptide:N-glycanase (Ngly1 in mammals) is a de-N-glycosylating enzyme that is highly conserved among eukaryotes. It was recently reported that…”
Get full text

N-Glycosylation Is Critical for the Stability and Intracellular Trafficking of Glucose Transporter GLUT4 by Haga, Yoshimi, Ishii, Kumiko, Suzuki, Tadashi

“…The facilitative glucose transporter GLUT4 plays a key role in regulating whole body glucose homeostasis. GLUT4 dramatically changes its distribution upon…”
Get full text