Search Results - "SUTTON, Steven W"

Brain α7 Nicotinic Acetylcholine Receptor Assembly Requires NACHO by Gu, Shenyan, Matta, Jose A., Lord, Brian, Harrington, Anthony W., Sutton, Steven W., Davini, Weston B., Bredt, David S.

“…Nicotine exerts its behavioral and additive actions through a family of brain nicotinic acetylcholine receptors (nAChRs). Enhancing α7-type nAChR signaling…”
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Oxysterols direct B-cell migration through EBI2 by Liu, Changlu, Yang, Xia V., Wu, Jiejun, Kuei, Chester, Mani, Neelakandha S., Zhang, Li, Yu, Jingxue, Sutton, Steven W., Qin, Ning, Banie, Homayon, Karlsson, Lars, Sun, Siquan, Lovenberg, Timothy W.

“…EBI2 receptors revealed as oxysterols The EBI2 receptor (Epstein–Barr virus-induced gene 2, also known as GPR183) was recently shown to be linked to autoimmune…”
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Lactate Inhibits Lipolysis in Fat Cells through Activation of an Orphan G-protein-coupled Receptor, GPR81 by Liu, Changlu, Wu, Jiejun, Zhu, Jessica, Kuei, Chester, Yu, Jingxue, Shelton, Jonathan, Sutton, Steven W., Li, Xiaorong, Yun, Su Jin, Mirzadegan, Taraneh, Mazur, Curt, Kamme, Fredrik, Lovenberg, Timothy W.

“…Lactic acid is a well known metabolic by-product of intense exercise, particularly under anaerobic conditions. Lactate is also a key source of energy and an…”
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Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation by Soroosh, Pejman, Wu, Jiejun, Xue, Xiaohua, Song, Jiao, Sutton, Steven W., Sablad, Marciano, Yu, Jingxue, Nelen, Marina I., Liu, Xuejun, Castro, Glenda, Luna, Rosa, Crawford, Shelby, Banie, Homayon, Dandridge, Rose A., Deng, Xiaohu, Bittner, Anton, Kuei, Chester, Tootoonchi, Mandana, Rozenkrants, Natasha, Herman, Krystal, Gao, Jingjin, Yang, Xia V., Sachen, Kacey, Ngo, Karen, Fung-Leung, Wai-Ping, Nguyen, Steven, de Leon-Tabaldo, Aimee, Blevitt, Jonathan, Zhang, Yan, Cummings, Maxwell D., Rao, Tadimeti, Mani, Neelakandha S., Liu, Changlu, McKinnon, Murray, Milla, Marcos E., Fourie, Anne M., Sun, Siquan

“…The RAR-related orphan receptor gamma t (RORγt) is a nuclear receptor required for generating IL-17–producing CD4 ⁺ Th17 T cells, which are essential in host…”
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Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat by Dugovic, Christine, Shelton, Jonathan E, Aluisio, Leah E, Fraser, Ian C, Jiang, Xiaohui, Sutton, Steven W, Bonaventure, Pascal, Yun, Sujin, Li, Xiaorong, Lord, Brian, Dvorak, Curt A, Carruthers, Nicholas I, Lovenberg, Timothy W

“…Orexins are peptides produced by lateral hypothalamic neurons that exert a prominent role in the maintenance of wakefulness by activating orexin-1 (OX1R) and…”
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Distribution of relaxin-3 and RXFP3 within arousal, stress, affective, and cognitive circuits of mouse brain by Smith, Craig M., Shen, Pei-Juan, Banerjee, Avantika, Bonaventure, Pascal, Ma, Sherie, Bathgate, Ross A.D., Sutton, Steven W., Gundlach, Andrew L.

“…Relaxin‐3 (RLN3) and its native receptor, relaxin family peptide 3 receptor (RXFP3), constitute a newly identified neuropeptide system enriched in mammalian…”
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Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity by Douglass, John D., Zhou, Yin Xiu, Wu, Amy, Zadrogra, John A., Gajda, Angela M., Lackey, Atreju I., Lang, Wensheng, Chevalier, Kristen M., Sutton, Steven W., Zhang, Sui-Po, Flores, Christopher M., Connelly, Margery A., Storch, Judith

“…Monoacylglycerol lipase (MGL) is a ubiquitously expressed enzyme that catalyzes the hydrolysis of monoacylglycerols (MGs) to yield FFAs and glycerol. MGL…”
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Modulation of Hippocampal Theta Oscillations and Spatial Memory by Relaxin-3 Neurons of the Nucleus Incertus by Ma, Sherie, Olucha-Bordonau, Francisco E, Hossain, M. Akhter, Lin, Feng, Kuei, Chester, Liu, Changlu, Wade, John D, Sutton, Steven W, Nunez, Angel, Gundlach, Andrew L

“…Hippocampal theta rhythm is thought to underlie learning and memory, and it is well established that "pacemaker" neurons in medial septum (MS) modulate theta…”
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Erratum: Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity by Douglass, John D., Zhou, Yin Xiu, Wu, Amy, Zadroga, John A., Gajda, Angela M., Lackey, Atreju I., Lang, Wensheng, Chevalier, Kristen M., Sutton, Steven W., Zhang, Sui-Po, Flores, Christopher M., Connelly, Margery A., Storch, Judith

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Metabolic and Neuroendocrine Responses to RXFP3 Modulation in the Central Nervous System by Sutton, Steven W., Shelton, Jonathan, Smith, Craig, Williams, John, Yun, Sujin, Motley, Timothy, Kuei, Chester, Bonaventure, Pascal, Gundlach, Andrew, Liu, Changlu, Lovenberg, Timothy

“…Neuroanatomical studies have shown relaxin‐3 neurons, primarily found in the rodent nucleus incertus (NI), project widely into a large number of areas…”
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Chimeric, mutant orexin receptors show key interactions between orexin receptors, peptides and antagonists by Tran, Da-Thao, Bonaventure, Pascal, Hack, Michael, Mirzadegan, Taraneh, Dvorak, Curt, Letavic, Michael, Carruthers, Nicholas, Lovenberg, Timothy, Sutton, Steven W.

“…Orexin receptor antagonists are being investigated as therapeutic agents for insomnia and addictive disorders. In this study the interactions between the…”
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In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependency by Alvarez-Jaimes, Lily, Sutton, Steven W, Nepomuceno, Diane, Motley, S Timothy, Cik, Miroslav, Stocking, Emily, Shoblock, James, Bonaventure, Pascal

“…Recent findings suggest that the relaxin-3 neural network may represent a new ascending arousal pathway able to modulate a range of neural circuits including…”
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Pharmacological characterization of relaxin-3/INSL7 receptors GPCR135 and GPCR142 from different mammalian species by Chen, Jingcai, Kuei, Chester, Sutton, Steven W, Bonaventure, Pascal, Nepomuceno, Diane, Eriste, Elo, Sillard, Rannar, Lovenberg, Timothy W, Liu, Changlu

“…Relaxin-3 has recently been identified as a ligand for two structurally related G-protein-coupled receptors, human GPCR135 and GPCR142. This current study…”
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Anatomical Distribution of Prolactin-Releasing Peptide and Its Receptor Suggests Additional Functions in the Central Nervous System and Periphery by Roland, Barbara L, Sutton, Steven W, Wilson, Sandy J, Luo, Lin, Pyati, Jayashree, Huvar, Rene, Erlander, Mark G, Lovenberg, Timothy W

“…A recently identified neuropeptide with PRL-releasing capabilities binds to and activates a previously known orphan G protein-coupled receptor, GPR10. We…”
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Distribution of G-protein-coupled receptor (GPCR)135 binding sites and receptor mRNA in the rat brain suggests a role for relaxin-3 in neuroendocrine and sensory processing by Sutton, Steven W, Bonaventure, Pascal, Kuei, Chester, Roland, Barbara, Chen, Jingcai, Nepomuceno, Diane, Lovenberg, Timothy W, Liu, Changlu

“…G-protein-coupled receptor 135 (GPCR135), a former orphan GPCR also known as SALPR, has recently been shown to be modulated by relaxin-3 (R3). In addition to…”
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Identification and characterization of select oxysterols as ligands for GPR17 by Harrington, Anthony W., Liu, Changlu, Phillips, Naomi, Nepomuceno, Diane, Kuei, Chester, Chang, Joseph, Chen, Weixuan, Sutton, Steven W., O'Malley, Daniel, Pham, Ly, Yao, Xiang, Sun, Siquan, Bonaventure, Pascal

“…Background and Purpose G‐protein coupled receptor 17 (GPR17) is an orphan receptor involved in the process of myelination, due to its ability to inhibit the…”
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Relaxin-3 receptor (Rxfp3) gene knockout mice display reduced running wheel activity: Implications for role of relaxin-3/RXFP3 signalling in sustained arousal by Hosken, Ihaia T., Sutton, Steven W., Smith, Craig M., Gundlach, Andrew L.

“…•Evidence suggests relaxin-3 can activate RXFP3, but also RXFP1.•Study assessed basal behavioural phenotype of novel Rxfp3 KO mouse line.•Rxfp3 KO mice…”
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GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids L-Tryptophan and L-Phenylalanine by Liu, Changlu, Bonaventure, Pascal, Lee, Grace, Nepomuceno, Diane, Kuei, Chester, Wu, Jiejun, Li, Qingqin, Joseph, Victory, Sutton, Steven W, Eckert, William, Yao, Xiang, Yieh, Lynn, Dvorak, Curt, Carruthers, Nicholas, Coate, Heather, Yun, Sujin, Dugovic, Christine, Harrington, Anthony, Lovenberg, Timothy W

“…GPR139 is an orphan G-protein-coupled receptor expressed in the central nervous system. To identify its physiologic ligand, we measured GPR139 receptor…”
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Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV (μ-TRTX-Hh2a) by Minassian, Natali A., Gibbs, Alan, Shih, Amy Y., Liu, Yi, Neff, Robert A., Sutton, Steven W., Mirzadegan, Tara, Connor, Judith, Fellows, Ross, Husovsky, Matthew, Nelson, Serena, Hunter, Michael J., Flinspach, Mack, Wickenden, Alan D.

“…Voltage-gated sodium channels (VGSCs) are essential to the normal function of the vertebrate nervous system. Aberrant function of VGSCs underlies a variety of…”
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Structure-Based Optimization of Selective and Brain Penetrant CK1δ Inhibitors for the Treatment of Circadian Disruptions by McCarver, Stefan, Hanna, Luke, Samant, Andrew, Thompson, Aaron A., Seierstad, Mark, Saha, Arjun, Wu, Dongpei, Lord, Brian, Sutton, Steven W., Shah, Vishal, Milligan, Cynthia M., Wennerholm, Michelle, Shelton, Jonathan, Lebold, Terry P., Shireman, Brock T.

“…Neuropsychiatric disorders such as major depressive disorders and schizophrenia are often associated with disruptions to the normal 24 h sleep wake cycle…”
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