Search Results - "SUTHERLAND, L R"

The prognostic and predictive value of serum CA19.9 in pancreatic cancer by Humphris, J.L., Chang, D.K., Johns, A.L., Scarlett, C.J., Pajic, M., Jones, M.D., Colvin, E.K., Nagrial, A., Chin, V.T., Chantrill, L.A., Samra, J.S., Gill, A.J., Kench, J.G., Merrett, N.D., Das, A., Musgrove, E.A., Sutherland, R.L., Biankin, A.V.

“…Current staging methods for pancreatic cancer (PC) are inadequate, and biomarkers to aid clinical decision making are lacking. Despite the availability of the…”
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A role for GATA-2 in transition to an aggressive phenotype in prostate cancer through modulation of key androgen-regulated genes by Böhm, M, Locke, W J, Sutherland, R L, Kench, J G, Henshall, S M

“…GATA-2, a member of the GATA family of transcription factors, is involved in androgen receptor (AR) signaling, however, little is known regarding its role in…”
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Adjuvant chemotherapy in elderly patients with pancreatic cancer by Nagrial, A M, Chang, D K, Nguyen, N Q, Johns, A L, Chantrill, L A, Humphris, J L, Chin, V T, Samra, J S, Gill, A J, Pajic, M, Pinese, M, Colvin, E K, Scarlett, C J, Chou, A, Kench, J G, Sutherland, R L, Horvath, L G, Biankin, A V

“…Background: Adjuvant chemotherapy improves survival for patients with resected pancreatic cancer. Elderly patients are under-represented in Phase III clinical…”
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Prediction of outcome of early ER+ breast cancer is improved using a biomarker panel, which includes Ki-67 and p53 by Millar, E K A, Graham, P H, McNeil, C M, Browne, L, O'Toole, S A, Boulghourjian, A, Kearsley, J H, Papadatos, G, Delaney, G, Fox, C, Nasser, E, Capp, A, Sutherland, R L

“…Background: The aim of this study is to determine whether immunohistochemical (IHC) assessment of Ki67 and p53 improves prognostication of oestrogen…”
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Estrogen and antiestrogen regulation of cell cycle progression in breast cancer cells by Doisneau-Sixou, S F, Sergio, C M, Carroll, J S, Hui, R, Musgrove, E A, Sutherland, R L

“…The central involvement of estrogen in the development of the mammary gland and in the genesis of breast cancer has lent impetus to studies of the links…”
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Cyclin D1b protein expression in breast cancer is independent of cyclin D1a and associated with poor disease outcome by Millar, E K A, Dean, J L, McNeil, C M, O'Toole, S A, Henshall, S M, Tran, T, Lin, J, Quong, A, Comstock, C E S, Witkiewicz, A, Musgrove, E A, Rui, H, LeMarchand, L, Setiawan, V W, Haiman, C A, Knudsen, K E, Sutherland, R L, Knudsen, E S

“…Aberrant expression of cyclin D1 protein is a common feature of breast cancer. However, the CCND1 gene encodes two gene products, cyclin D1a and cyclin D1b,…”
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A distinct molecular profile associated with mucinous epithelial ovarian cancer by HEINZELMANN-SCHWARZ, V. A, GARDINER-GARDEN, M, FINK, D, HACKER, N. F, SUTHERLAND, R. L, O'BRIEN, P. M, HENSHALL, S. M, SCURRY, J. P, SCOLYER, R. A, SMITH, A. N, BALI, A, VANDEN BERGH, P, BARON-HAY, S, SCOTT, C

“…Mucinous epithelial ovarian cancers (MOC) are clinically and morphologically distinct from the other histological subtypes of ovarian cancer. To determine the…”
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Role of endoplasmic reticulum stress induction by the plant toxin, persin, in overcoming resistance to the apoptotic effects of tamoxifen in human breast cancer cells by McCloy, R A, Shelley, E J, Roberts, C G, Boslem, E, Biden, T J, Nicholson, R I, Gee, J M, Sutherland, R L, Musgrove, E A, Burgess, A, Butt, A J

“…Background: Persin is a plant toxin that displays synergistic cytotoxicity with tamoxifen in human breast cancer cell lines. Here, we examined the ability of…”
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Collagen and calcium-binding EGF domains 1 is frequently inactivated in ovarian cancer by aberrant promoter hypermethylation and modulates cell migration and survival by Barton, C A, Gloss, B S, Qu, W, Statham, A L, Hacker, N F, Sutherland, R L, Clark, S J, O'Brien, P M

“…Background: Collagen and calcium-binding EGF domains 1 (CCBE1) is an uncharacterised gene that has down-regulated expression in breast cancer. As CCBE1 maps to…”
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Promoter methylation of the mutated in colorectal cancer gene is a frequent early event in colorectal cancer by KOHONEN-CORISH, M. R. J, SIGGLEKOW, N. D, YOUNG, J, LEGGETT, B. A, JASS, J. R, SUTHERLAND, R. L, SUSANTO, J, CHAPUIS, P. H, BOKEY, E. L, DENT, O. F, CHAN, C, LIN, B. P. C, SENG, T. J, LAIRD, P. W

“…The mutated in colorectal cancer (MCC) gene is in close linkage with the adenomatous polyposis coli (APC) gene on chromosome 5, in a region of frequent loss of…”
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BAG-1 overexpression attenuates luminal apoptosis in MCF-10A mammary epithelial cells through enhanced RAF-1 activation by Anderson, L R, Sutherland, R L, Butt, A J

“…Although the multi-functional, prosurvival protein, Bcl-2-associated anthanogene 1 (BAG-1) is frequently overexpressed in breast cancers, its role in the…”
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Identification of PUMA as an estrogen target gene that mediates the apoptotic response to tamoxifen in human breast cancer cells and predicts patient outcome and tamoxifen responsiveness in breast cancer by Roberts, C G, Millar, E K A, O'Toole, S A, McNeil, C M, Lehrbach, G M, Pinese, M, Tobelmann, P, McCloy, R A, Musgrove, E A, Sutherland, R L, Butt, A J

“…Recognition of the pivotal role of estrogen in the aetiology of breast cancer has led to the development of antiestrogens (AE), such as tamoxifen (TAM) as…”
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Oral contraceptive use and smoking are risk factors for relapse in Crohn's disease by Timmer, Antje, Sutherland ,‡, Lloyd R., Martin §, Francois

“…Background & Aims: Lifestyle factors have been shown to influence prognosis in Crohn's disease. The purpose of this study was to prospectively assess the…”
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Dynamic Lasing from All-Organic Two-Dimensional Photonic Crystals by Jakubiak, R., Tondiglia, V. P., Natarajan, L. V., Sutherland, R. L., Lloyd, P., Bunning, T. J., Vaia, R. A.

“…Optically pumped lasing of pyrromethene 597 in 2D columnar photonic crystals (PCs) derived from holographic polymer‐dispersed liquid crystals (LCs, see Figure)…”
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Prognostic significance of DNA repair proteins MLH1, MSH2 and MGMT expression in non-small-cell lung cancer and precursor lesions by Cooper, W A, Kohonen-Corish, M R J, Chan, C, Kwun, S Y, McCaughan, B, Kennedy, C, Sutherland, R L, Lee, C-S

“…Aims:  To investigate the role of DNA repair proteins and their prognostic significance in non‐small‐cell lung cancer (NSCLC). Methods and results:  A…”
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The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitro by O'Brien, P M, Davies, M J, Scurry, J P, Smith, A N, Barton, C A, Henderson, M J, Saunders, D N, Gloss, B S, Patterson, K I, Clancy, J L, Heinzelmann-Schwarz, V A, Scolyer, R A, Zeng, Y, Williams, E D, Scurr, L, DeFazio, A, Quinn, D I, Watts, C K W, Hacker, N F, Henshall, S M, Sutherland, R L

“…Despite a high initial response rate to first-line platinum/paclitaxel chemotherapy, most women with epithelial ovarian cancer relapse with recurrent disease…”
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Lack of effect of intravenous administration on time to respond to azathioprine for steroid-treated Crohn's disease by Sandborn, William J., Tremaine, William J., Wolf, Douglas C., Targan, Stephan R., Sninsky, Charles A., Sutherland, Lloyd R., Hanauer, Stephen B., McDonald, John W.D., Feagan, Brian G., Fedorak, Richard N., Isaacs, Kim L., Pike, M.Gennette, Mays, Dennis C., Lipsky, James J., Gordon, Susan, Kleoudis, Christi S., Murdock, Robert H.

“…Background & Aims: Azathioprine is effective for Crohn's disease but acts slowly. A loading dose may decrease the time to response. Methods: A…”
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The influence of surfactant in reflective HPDLC gratings by Klosterman, J., Natarajan, L.V., Tondiglia, V.P., Sutherland, R.L., White, T.J., Guymon, C.A., Bunning, T.J.

“…The use of highly functional acrylate monomers (large number of reactive bonds) as the precursor to the polymer-rich phase of holographic polymer-dispersed…”
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Wilms' tumor protein 1: an early target of progestin regulation in T-47D breast cancer cells that modulates proliferation and differentiation by Caldon, C E, Lee, C S L, Sutherland, R L, Musgrove, E A

“…Progesterone regulates the proliferation and differentiation of normal mammary epithelium. In breast cancer cells, progesterone and its synthetic analogs,…”
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Aberrant p16(INK4A) and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma by Biankin, A V, Biankin, S A, Kench, J G, Morey, A L, Lee, C-S, Head, D R, Eckstein, R P, Hugh, T B, Henshall, S M, Sutherland, R L

“…Intraductal papillary mucinous tumours (IPMT) of the pancreas constitute a unique pathological entity with an overall incidence of associated invasive…”
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