Search Results - "SUSSMAN, Mark A"

BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation by Lampert, Mark A., Orogo, Amabel M., Najor, Rita H., Hammerling, Babette C., Leon, Leonardo J., Wang, Bingyan J., Kim, Taeyong, Sussman, Mark A., Gustafsson, Åsa B.

“…Cell-based therapies represent a very promising strategy to repair and regenerate the injured heart to prevent progression to heart failure. To date, these…”
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Enhanced Effect of Combining Human Cardiac Stem Cells and Bone Marrow Mesenchymal Stem Cells to Reduce Infarct Size and to Restore Cardiac Function After Myocardial Infarction by WILLIAMS, Adam R, HATZISTERGOS, Konstantinos E, HARE, Joshua M, ADDICOTT, Benjamin, MCCALL, Fred, CARVALHO, Decio, SUNCION, Viky, MORALES, Azorides R, DA SILVA, Jose, SUSSMAN, Mark A, HELDMAN, Alan W

“…Because mesenchymal stem cells (MSCs) induce proliferation and differentiation of c-kit(+) cardiac stem cells (CSCs) in vivo and in vitro, we hypothesized that…”
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Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure by Thomas, Robert L, Roberts, David J, Kubli, Dieter A, Lee, Youngil, Quinsay, Melissa N, Owens, Jarvis B, Fischer, Kimberlee M, Sussman, Mark A, Miyamoto, Shigeki, Gustafsson, Åsa B

“…Myeloid cell leukemia-1 (MCL-1) is an anti-apoptotic BCL-2 protein that is up-regulated in several human cancers. MCL-1 is also highly expressed in myocardium,…”
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Empowering Adult Stem Cells for Myocardial Regeneration by Mohsin, Sadia, Siddiqi, Sailay, Collins, Brett, Sussman, Mark A

“…Treatment strategies for heart failure remain a high priority for ongoing research due to the profound unmet need in clinical disease coupled with lack of…”
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Cardiac tissue engineering therapeutic products to enhance myocardial contractility by Broughton, Kathleen M., Sussman, Mark A.

“…Researchers continue to develop therapeutic products for the repair and replacement of myocardial tissue that demonstrates contractility equivalent to normal…”
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Hrd1 and ER-Associated Protein Degradation, ERAD, Are Critical Elements of the Adaptive ER Stress Response in Cardiac Myocytes by Doroudgar, Shirin, Völkers, Mirko, Thuerauf, Donna J, Khan, Mohsin, Mohsin, Sadia, Respress, Jonathan L, Wang, Wei, Gude, Natalie, Müller, Oliver J, Wehrens, Xander H.T, Sussman, Mark A, Glembotski, Christopher C

“…RATIONALE:Hydroxymethyl glutaryl-coenzyme A reductase degradation protein 1 (Hrd1) is an endoplasmic reticulum (ER)-transmembrane E3 ubiquitin ligase that has…”
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Pim1 Kinase Overexpression Enhances ckit+ Cardiac Stem Cell Cardiac Repair Following Myocardial Infarction in Swine by Kulandavelu, Shathiyah, PhD, Karantalis, Vasileios, MD, Fritsch, Julia, BS, Hatzistergos, Konstantinos E., PhD, Loescher, Viky Y., MD, McCall, Frederic, BS, Wang, Bo, MD, Bagno, Luiza, PhD, Golpanian, Samuel, MD, Wolf, Ariel, BS, Grenet, Justin, BS, Williams, Adam, MD, Kupin, Aaron, Rosenfeld, Aaron, Mohsin, Sadia, PhD, Sussman, Mark A., PhD, Morales, Azorides, MD, Balkan, Wayne, PhD, Hare, Joshua M., MD

“…Abstract Background Pim1 kinase plays an important role in cell division, survival, and commitment of precursor cells towards a myocardial lineage, and…”
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Enhancing myocardial repair with CardioClusters by Monsanto, Megan M., Wang, Bingyan J., Ehrenberg, Zach R., Echeagaray, Oscar, White, Kevin S., Alvarez, Roberto, Fisher, Kristina, Sengphanith, Sharon, Muliono, Alvin, Gude, Natalie A., Sussman, Mark A.

“…Cellular therapy to treat heart failure is an ongoing focus of intense research, but progress toward structural and functional recovery remains modest…”
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Myocardial AKT: the omnipresent nexus by Sussman, Mark A, Völkers, Mirko, Fischer, Kimberlee, Bailey, Brandi, Cottage, Christopher T, Din, Shabana, Gude, Natalie, Avitabile, Daniele, Alvarez, Roberto, Sundararaman, Balaji, Quijada, Pearl, Mason, Matt, Konstandin, Mathias H, Malhowski, Amy, Cheng, Zhaokang, Khan, Mohsin, McGregor, Michael

“…One of the greatest examples of integrated signal transduction is revealed by examination of effects mediated by AKT kinase in myocardial biology. Positioned…”
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Signal transducers and activators of transcription-3/pim1 axis plays a critical role in the pathogenesis of human pulmonary arterial hypertension by Paulin, Roxane, Courboulin, Audrey, Meloche, Jolyane, Mainguy, Vincent, Dumas de la Roque, Eric, Saksouk, Nehmé, Côté, Jacques, Provencher, Steeve, Sussman, Mark A, Bonnet, Sébastien

“…Pulmonary artery hypertension (PAH) is a proliferative disorder associated with enhanced pulmonary artery smooth muscle cell proliferation and suppressed…”
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Myocardial Regeneration for Humans　― Modifying Biology and Manipulating Evolution by Broughton, Kathleen M., Sussman, Mark A.

“…Cardiovascular disease remains the leading cause of death worldwide and developing novel therapies to treat and cure the disease remains a high priority in the…”
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Cardiomyocyte cell cycle dynamics and proliferation revealed through cardiac-specific transgenesis of fluorescent ubiquitinated cell cycle indicator (FUCCI) by Alvarez, Roberto, Wang, Bingyan J., Quijada, Pearl J., Avitabile, Daniele, Ho, Thi, Shaitrit, Maya, Chavarria, Monica, Firouzi, Fareheh, Ebeid, David, Monsanto, Megan M., Navarrete, Natalie, Moshref, Maryam, Siddiqi, Sailay, Broughton, Kathleen M., Bailey, Barbara A., Gude, Natalie A., Sussman, Mark A.

“…Understanding and manipulating the cardiomyocyte cell cycle has been the focus of decades of research, however the ultimate goal of activating mitotic activity…”
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Enhancement of Myocardial Regeneration Through Genetic Engineering of Cardiac Progenitor Cells Expressing Pim-1 Kinase by FISCHER, Kimberlee M, COTTAGE, Christopher T, WEITAO WU, SHABANA DIN, GUDE, Natalie A, AVITABILE, Daniele, QUIJADA, Pearl, COLLINS, Brett L, FRANSIOLI, Jenna, SUSSMAN, Mark A

“…Despite numerous studies demonstrating the efficacy of cellular adoptive transfer for therapeutic myocardial regeneration, problems remain for donated cells…”
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Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation by Din, Shabana, Mason, Matthew, Völkers, Mirko, Johnson, Bevan, Cottage, Christopher T., Wang, Zeping, Joyo, Anya Y., Quijada, Pearl, Erhardt, Peter, Magnuson, Nancy S., Konstandin, Mathias H., Sussman, Mark A.

“…Mitochondrial morphological dynamics affect the outcome of ischemic heart damage and pathogenesis. Recently, mitochondrial fission protein dynamin-related…”
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Mechanistic Target of Rapamycin Complex 2 Protects the Heart From Ischemic Damage by Völkers, Mirko, Konstandin, Mathias H, Doroudgar, Shirin, Toko, Haruhiro, Quijada, Pearl, Din, Shabana, Joyo, Anya, Ornelas, Luis, Samse, Kaitleen, Thuerauf, Donna J, Gude, Natalie, Glembotski, Christopher C, Sussman, Mark A

“…BACKGROUND—The mechanistic target of rapamycin (mTOR) comprises 2 structurally distinct multiprotein complexes, mTOR complexes 1 and 2 (mTORC1 and mTORC2)…”
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Activation of the Unfolded Protein Response in Infarcted Mouse Heart and Hypoxic Cultured Cardiac Myocytes by Thuerauf, Donna J, Marcinko, Marie, Gude, Natalie, Rubio, Marta, Sussman, Mark A, Glembotski, Christopher C

“…Endoplasmic reticulum (ER) stresses that reduce ER protein folding activate the unfolded protein response (UPR). One effector of the UPR is the transcription…”
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Cardiac Stem Cell Hybrids Enhance Myocardial Repair by Quijada, Pearl, Salunga, Hazel T, Hariharan, Nirmala, Cubillo, Jonathan D, El-Sayed, Farid G, Moshref, Maryam, Bala, Kristin M, Emathinger, Jacqueline M, De La Torre, Andrea, Ormachea, Lucia, Alvarez, Roberto, Gude, Natalie A, Sussman, Mark A

“…RATIONALE:Dual cell transplantation of cardiac progenitor cells (CPCs) and mesenchymal stem cells (MSCs) after infarction improves myocardial repair and…”
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Fibronectin Is Essential for Reparative Cardiac Progenitor Cell Response After Myocardial Infarction by Konstandin, Mathias H, Toko, Haruhiro, Gastelum, Grady M, Quijada, Pearl, De La Torre, Andrea, Quintana, Mercedes, Collins, Brett, Din, Shabana, Avitabile, Daniele, Völkers, Mirko, Gude, Natalie, Fässler, Reinhard, Sussman, Mark A

“…RATIONALE:Adoptive transfer of cardiac progenitor cells (CPCs) has entered clinical application, despite limited mechanistic understanding of the endogenous…”
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Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1 by Völkers, Mirko, Toko, Haruhiro, Doroudgar, Shirin, Din, Shabana, Quijada, Pearl, Joyo, Anya Y., Ornelas, Luis, Joyo, Eri, Thuerauf, Donna J., Konstandin, Mathias H., Gude, Natalie, Glembotski, Christopher C., Sussman, Mark A.

“…Mechanistic target of rapamycin complex 1 (mTORC1), necessary for cellular growth, is regulated by intracellular signaling mediating inhibition of mTORC1…”
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Rac1-Induced Connective Tissue Growth Factor Regulates Connexin 43 and N-Cadherin Expression in Atrial Fibrillation by Adam, Oliver, MD, Lavall, Daniel, MS, Theobald, Katharina, MS, Hohl, Mathias, PhD, Grube, Markus, PhD, Ameling, Sabine, MS, Sussman, Mark A., PhD, Rosenkranz, Stephan, MD, PhD, Kroemer, Heyo K., PhD, Schäfers, Hans-Joachim, MD, Böhm, Michael, MD, Laufs, Ulrich, MD

“…Objectives We studied the signal transduction of atrial structural remodeling that contributes to the pathogenesis of atrial fibrillation (AF). Background…”
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