Search Results - "SURMACZ, Eva"

Leptin and Adiponectin: Emerging Therapeutic Targets in Breast Cancer by Surmacz, Eva

“…Obesity is a recognized risk factor for breast cancer development and poorer response to therapy. Two major fat tissue-derived adipokines, leptin and…”
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Leptin and cancer by Garofalo, Cecilia, Surmacz, Eva

“…The prevalence of obesity has markedly increased over the past two decades, especially in the industrialized countries. While the impact of excess body weight…”
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Editorial: Obesity and cancer: update on etiology, molecular biomarkers and biotargets, clinical strategies, and epidemiology by Surmacz, Eva, Guarnotta, Valentina, Reagan, Michaela Ruth

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Growth factor receptors as therapeutic targets: strategies to inhibit the insulin-like growth factor I receptor by Surmacz, Eva

“…Neoplastic transformation is often related to abnormal activation of growth factor receptors and their signaling pathways. The concept of targeting specific…”
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Editorial: Adiponectin: Friend or Foe? Toward Understanding the Complexities of Adiponectin Biology and Challenges in Pharmaceutical Development by Surmacz, Eva, Fiaschi, Tania

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Design and development of a peptide-based adiponectin receptor agonist for cancer treatment by Otvos, Jr, Laszlo, Haspinger, Eva, La Russa, Francesca, Maspero, Federica, Graziano, Patrizia, Kovalszky, Ilona, Lovas, Sandor, Nama, Kaushik, Hoffmann, Ralf, Knappe, Daniel, Cassone, Marco, Wade, John, Surmacz, Eva

“…Adiponectin, a fat tissue-derived adipokine, exhibits beneficial effects against insulin resistance, cardiovascular disease, inflammatory conditions, and…”
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Increased Expression of Leptin and the Leptin Receptor as a Marker of Breast Cancer Progression: Possible Role of Obesity-Related Stimuli by GAROFALO, Cecilia, KODA, Mariusz, CASCIO, Sandra, SULKOWSKA, Mariola, KANCZUGA-KODA, Luiza, GOLASZEWSKA, Jolanta, RUSSO, Antonio, SULKOWSKI, Stanislaw, SURMACZ, Eva

“…Purpose: Recent in vitro studies suggested that the autocrine leptin loop might contribute to breast cancer development by enhancing cell growth and survival…”
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Leptin Interferes with the Effects of the Antiestrogen ICI 182,780 in MCF-7 Breast Cancer Cells by GAROFALO, Cecilia, SISCI, Diego, SURNLACZ, Eva

“…Purpose: Obesity is a risk factor for breast cancer development in postmenopausal women and correlates with shorter disease-free and overall survival in breast…”
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Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects by Ferla, Rita, Bonomi, Maria, Otvos, Jr, Laszlo, Surmacz, Eva

“…Leptin is a pleiotropic hormone whose mitogenic and angiogenic activity has been implicated in the development and progression of several malignancies,…”
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Overexpression of the obesity hormone leptin in human colorectal cancer by Koda, Mariusz, Sulkowska, Mariola, Kanczuga-Koda, Luiza, Surmacz, Eva, Sulkowski, Stanislaw

“…Background: Leptin is an adipocyte-derived neurohormone, high levels of which are found in obese individuals. Leptin controls energy expenditure, acting in the…”
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Function of the IGF-I receptor in breast cancer by Surmacz, E

“…The insulin-like growth factor-I receptor (IGF-IR) is a transmembrane tyrosine kinase regulating various biological processes such as proliferation, survival,…”
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Insulin-dependent leptin expression in breast cancer cells by Bartella, Viviana, Cascio, Sandra, Fiorio, Elena, Auriemma, Alessandra, Russo, Antonio, Surmacz, Eva

“…Pathologic conditions associated with hyperinsulinemia, such as obesity, metabolic syndrome, and diabetes, seem to increase the risk of breast cancer. Here, we…”
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Crosstalk between IGF signaling and steroid hormone receptors in breast cancer by Sisci, Diego, Surmacz, Eva

“…Breast cancer development and progression is regulated by crosstalk between steroid hormones (SHs) (e.g., estrogens, progestins and androgens) and growth…”
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Expression of angiogenic regulators, VEGF and leptin, is regulated by the EGF/PI3K/STAT3 pathway in colorectal cancer cells by Cascio, Sandra, Ferla, Rita, D'Andrea, Aleco, Gerbino, Aldo, Bazan, Viviana, Surmacz, Eva, Russo, Antonio

“…Both leptin and vascular endothelial growth factor (VEGF) are growth and angiogenic cytokines that are upregulated in different types of cancer and have been…”
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Exploring leptin antagonism in ophthalmic cell models by Scolaro, Laura, Parrino, Cristina, Coroniti, Roberta, Otvos, Jr, Laszlo, Surmacz, Eva

“…Emerging evidence suggests that angiogenic and pro-inflammatory cytokine leptin might be implicated in ocular neovascularization. However, the potential of…”
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Obesity hormone leptin induces growth and interferes with the cytotoxic effects of 5-fluorouracil in colorectal tumor stem cells by Bartucci, Monica, Svensson, Susanne, Ricci-Vitiani, Lucia, Dattilo, Rosanna, Biffoni, Mauro, Signore, Michele, Ferla, Rita, De Maria, Ruggero, Surmacz, Eva

“…The incidence of colon cancer has increased in developed countries, possibly due to sedentary lifestyle and high caloric diet. Experimental and epidemiological…”
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Relationships between hypoxia markers and the leptin system, estrogen receptors in human primary and metastatic breast cancer: effects of preoperative chemotherapy by Koda, Mariusz, Kanczuga-Koda, Luiza, Sulkowska, Mariola, Surmacz, Eva, Sulkowski, Stanislaw

“…Tumor hypoxia is marked by enhanced expression of hypoxia-inducible factor-alpha (HIF-1alpha) and glucose transporter-1 (Glut-1). Hypoxic conditions have also…”
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Leptin/HER2 crosstalk in breast cancer: in vitro study and preliminary in vivo analysis by Fiorio, Elena, Mercanti, Anna, Terrasi, Marianna, Micciolo, Rocco, Remo, Andrea, Auriemma, Alessandra, Molino, Annamaria, Parolin, Veronica, Di Stefano, Bruno, Bonetti, Franco, Giordano, Antonio, Cetto, Gian Luigi, Surmacz, Eva

“…Obesity in postmenopausal women is associated with increased breast cancer risk, development of more aggressive tumors and resistance to certain anti-breast…”
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Insulin-like Growth Factor 1 Differentially Regulates Estrogen Receptor-dependent Transcription at Estrogen Response Element and AP-1 Sites in Breast Cancer Cells by Cascio, Sandra, Bartella, Viviana, Garofalo, Cecilia, Russo, Antonio, Giordano, Antonio, Surmacz, Eva

“…Cross-talk between insulin-like growth factor 1 (IGF-1) and estrogen receptor α (ER) regulates gene expression in breast cancer cells, but the underlying…”
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Functional analysis of the ‐2548G/A leptin gene polymorphism in breast cancer cells by Terrasi, Marianna, Fiorio, Elena, Mercanti, Anna, Koda, Mariusz, Moncada, Camilo A., Sulkowski, Stanislaw, Merali, Salim, Russo, Antonio, Surmacz, Eva

“…Leptin is overexpressed in human breast tumors and is produced by breast cancer cells in response to obesity‐related stimuli. The leptin promoter polymorphism…”
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