Search Results - "SURENDRAN, Sankar"

Parkinson’s disease: oxidative stress and therapeutic approaches by Surendran, Sankar, Rajasankar, Srinivasagam

“…Parkinson’s disease (PD) is a neurodegenerative disorder, caused by reduced levels of catecholamines and oxidative stress. Symptoms seen in the disease include…”
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ISG15 disrupts cytoskeletal architecture and promotes motility in human breast cancer cells by Desai, Shyamal D, Reed, Ryan E, Burks, Julian, Wood, Laurence M, Pullikuth, Ashok K, Haas, Arthur L, Liu, Leroy F, Breslin, Jerome W, Meiners, Sally, Sankar, Surendran

“…The interferon-stimulated gene 15 (ISG15) pathway is highly elevated in breast cancer; however, very little is known about how the ISG15 pathway contributes to…”
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A novel role for ATM in regulating proteasome-mediated protein degradation through suppression of the ISG15 conjugation pathway by Wood, Laurence M, Sankar, Surendran, Reed, Ryan E, Haas, Arthur L, Liu, Leroy F, McKinnon, Peter, Desai, Shyamal D

“…Ataxia Telangiectasia (A-T) is an inherited immunodeficiency disorder wherein mutation of the ATM kinase is responsible for the A-T pathogenesis. Although the…”
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Defective N-Acetylaspartate Catabolism Reduces Brain Acetate Levels and Myelin Lipid Synthesis in Canavan's Disease by Madhavarao, Chikkathur N., Arun, Peethambaran, Moffett, John R., Szucs, Sylvia, Surendran, Sankar, Matalon, Reuben, Garbern, James, Hristova, Diana, Johnson, Anne, Jiang, Wei, M. A. Aryan Namboodiri, Snyder, Solomon H.

“…Canavan's disease (CD) is a fatal, hereditary disorder of CNS development that has been linked to mutations in the gene for the enzyme aspartoacylase (ASPA)…”
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Correction of Kinetic and Stability Defects by Tetrahydrobiopterin in Phenylketonuria Patients with Certain Phenylalanine Hydroxylase Mutations by Erlandsen, Heidi, Pey, Angel L., Gámez, Alejandra, Pérez, Belén, Desviat, Lourdes R., Aguado, Cristina, Koch, Richard, Surendran, Sankar, Tyring, Stephen, Matalon, Reuben, Scriver, Charles R., Ugarte, Magdalena, Martínez, Aurora, Stevens, Raymond C., Beutler, Ernest

“…Phenylketonuria patients harboring a subset of phenylalanine hydroxylase (PAH) mutations have recently shown normalization of blood phenylalanine levels upon…”
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Altered expression of neuronal nitric oxide synthase in the duodenum longitudinal muscle–myenteric plexus of obesity induced diabetes mouse: Implications on enteric neurodegeneration by Surendran, Sankar, Kondapaka, Sudhir B.

“…Type 2 diabetes caused by obesity shows autonomic neuropathy. Molecular mechanism involved in enteric neurodegeneration is not clear. Neuronal nitric oxide…”
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Aspartoacylase Deficiency in the White Matter of Human Immunodeficiency Virus Encephalitis: Novel Mechanism in Axonal Damage by Surendran, Sankar, Rajasankar, Srinivasagam

“…Aspartoacylase/aminoacylase II (ASPA/ACY II) is mainly synthesized in oligodendrocytes to contribute in myelin synthesis. Although axonal damage is seen in the…”
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Expression of calpastatin, minopontin, NIPSNAP1, rabaptin-5 and neuronatin in the phenylketonuria (PKU) mouse brain: Possible role on cognitive defect seen in PKU by Surendran, Sankar, Tyring, Stephen K., Matalon, Reuben

“…Phenylketonuria (PKU) is an inborn error of amino acid metabolism. Phenylalanine hydroxylase (PAH) deficiency results in accumulation of phenylalanine (Phe) in…”
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Absence-Like and Tonic Seizures in Aspartoacylase/Attractin Double-Mutant Mice by GOHMA, Hiroshi, KURAMOTO, Takashi, MATALON, Reuben, SURENDRAN, Sankar, TYRING, Stephen, KITADA, Kazuhiro, SASA, Masashi, SERIKAWA, Tadao

“…The Spontaneously Epileptic Rat (SER), a double-mutant for tremor and zitter mutations, shows spontaneous occurrences of absence-like and tonic seizures…”
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Aspartoacylase gene knockout in the mouse: Impact on reproduction by Surendran, Sankar, Szucs, Sylvia, Tyring, Stephen K., Matalon, Reuben

“…Canavan disease (CD) is an autosomal recessive disorder caused by aspartoacylase (ASPA) gene mutations resulting enzyme deficiency. The homozygous knockout…”
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Upregulation of N-acetylaspartic acid resulting nitric oxide toxicity induces aspartoacylase mutations and protein interaction to cause pathophysiology seen in Canavan disease by Surendran, Sankar

“…Summary Aspartoacylase (ASPA) converts N-acetylaspartic acid into aspartate and acetate. In Canavan disease (CD), N-acetylaspartic acid (NAA) is found to be…”
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Ashwagandha leaf extract: A potential agent in treating oxidative damage and physiological abnormalities seen in a mouse model of Parkinson's disease by RajaSankar, Srinivasagam, Manivasagam, Thamilarasan, Surendran, Sankar

“…Parkinson's disease (PD) is a neurodegenerative disorder that leads to impairment of balance and coordination. Therapy for the disease is still under…”
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Upregulation of N-acetylaspartic acid alters inflammation, transcription and contractile associated protein levels in the stomach and smooth muscle contractility by Surendran, Sankar

“…N -acetylaspartic acid (NAA) is converted into aspartate and acetate by aspartoacylase. Abnormal levels of the enzyme leads to accumulation of NAA and these…”
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Upregulation of N-acetylaspartic Acid Induces Oxidative Stress to Contribute in Disease Pathophysiology by Surendran, Sankar, Bhatnagar, Maheep

“…N-acetylaspartic acid (NAA) is predominantly present in brain and also present in lower amount in peripheral organs. The role of NAA in pathophysiology is…”
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Neurochemistry of Metabolic Diseases – Lysosomal Storage Diseases, Phenylketonuria & Canavan Disease

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Aspartoacylase gene knockout results in severe vacuolation in the white matter and gray matter of the spinal cord in the mouse by Surendran, Sankar, Campbell, Gerald A., Tyring, Stephen K., Matalon, Reuben

“…Canavan disease (CD) is a neurodegenerative disorder characterized by the spongy degeneration of the white matter of the brain. Aspartoacylase (ASPA) gene…”
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Withania somnifera root extract improves catecholamines and physiological abnormalities seen in a Parkinson's disease model mouse by RajaSankar, Srinivasagam, Manivasagam, Thamilarasan, Sankar, Venkatachalam, Prakash, Seppan, Muthusamy, Rathinasamy, Krishnamurti, Arumugam, Surendran, Sankar

“…Withania somnifera root extract (Ws)/Ashwagandha/Indian ginseng is a traditional herbal medicine, used over 4000 years in India, shown to have effect on neural…”
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Upregulation of aspartoacylase seen in diabetes is due to advanced glycation end-products by Surendran, Sankar

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Arginine stimulates cdx2-transformed intestinal epithelial cell migration via a mechanism requiring both nitric oxide and phosphorylation of p70 S6 kinase by Rhoads, J Marc, Liu, Yuying, Niu, Xiaomei, Surendran, Sankar, Wu, Guoyao

“…In intestinal cells, arginine (Arg) is 1 of the 2 most potent amino acid activators of p70(s6k), a key regulator of 5'- terminal oligopyrimidine mRNA…”
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Fas (CD95) alters neuronal nitric oxide synthase expression to contribute in diabetic gastroparesis by Surendran, Sankar

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