Search Results - "SUNDERMANN, Kurt F"

A Highly Stereoselective Synthesis of Epothilone B by White, James D, Carter, Rich G, Sundermann, Kurt F

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Toward Understanding How the Lactone Moiety of Discodermolide Affects Activity by Shaw, Simon J, Sundermann, Kurt F, Burlingame, Mark A, Myles, David C, Freeze, B. Scott, Xian, Ming, Brouard, Ignacio, Smith, Amos B

“…A series of simplified discodermolide analogues have been designed and synthesized in an attempt to understand the role of the lactone ring. These synthetic…”
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Total Synthesis of Epothilone B, Epothilone D, and cis- and trans-9,10-Dehydroepothilone D by White, James D, Carter, Rich G, Sundermann, Kurt F, Wartmann, Markus

“…The phosphonium salt 35, representing one of the two principal subunits of the epothilones, was prepared from propargyl alcohol via heptenone 22. A Wittig…”
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Design, Synthesis, and Evaluation of Carbamate-Substituted Analogues of (+)-Discodermolide by Smith, Amos B, Freeze, B. Scott, LaMarche, Matthew J, Hirose, Tomoyasu, Brouard, Ignacio, Rucker, Paul V, Xian, Ming, Sundermann, Kurt F, Shaw, Simon J, Burlingame, Mark A, Horwitz, Susan Band, Myles, David C

“…The design, syntheses, and biological evaluation of 22 totally synthetic analogues of the potent microtubule-stabilizing agent (+)-discodermolide (1) have been…”
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Design, Synthesis, and Evaluation of Analogues of (+)-14-Normethyldiscodermolide by Smith, Amos B, Freeze, B. Scott, LaMarche, Matthew J, Hirose, Tomoyasu, Brouard, Ignacio, Xian, Ming, Sundermann, Kurt F, Shaw, Simon J, Burlingame, Mark A, Horwitz, Susan Band, Myles, David C

“…The design, syntheses, and biological evaluation of nine totally synthetic analogues of the microtubule-stabilizing agent (+)-14-normethyldiscodermolide (2)…”
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A series of 23,24-dihydrodiscodermolide analogues with simplified lactone regions by Shaw, Simon J., Sundermann, Kurt F., Burlingame, Mark A., Zhang, Dan, Petryka, Joseph, Myles, David C.

“…A collection of seven new 23,24-dihydrodiscodermolide analogues have been synthesized with modifications to the lactone ring, some of which show…”
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Improved Synthesis of Epothilone B Employing Alkylation of an Alkyne for Assembly of Subunits by White, James D, Sundermann, Kurt F, Carter, Rich G

“…A strategy for assembling the two principal modules of epothilone B was developed that merges an allylic bromide with a terminal acetylene to fabricate the…”
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Design, synthesis and cytotoxicity of 7-deoxy aryl discodermolide analogues by BURLINGAME, Mark A, SHAW, Simon J, FREEZE, B. Scott, SMITH, Amos B, SUNDERMANN, Kurt F, DAN ZHANG, PETRYKA, Joseph, MENDOZA, Esteban, FENGHUA LIU, MYLES, David C, LAMARCHE, Matthew J, HIROSE, Tomoyasu

“…A series of 7-deoxy discodermolide analogues in which the lactone fragment 'C' was replaced by aryl substituents were designed, synthesized, and evaluated for…”
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Synthesis, Conformational Analysis, and Bioassay of 9,10-Didehydroepothilone D by White, James D, Sundermann, Kurt F, Wartmann, Markus

“…9,10-Didehydroepothilone D was synthesized, its conformation was studied, and its tubulin polymerization and antiproliferative activity were compared with that…”
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Total Synthesis of Epothilone B, Epothilone D, and cis- and trans-9,10-Dehydroepothilone D  [J. Am. Chem. Soc. 2001, 123, 5407−5413]. by White, James D, Carter, Rich G, Sundermann, Kurt F, Wartmann, Markus

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Fragment Assembly: An Alternative Approach to Generating Complex Polyketides by Shaw, Simon J., Zhang, Dan, Sundermann, Kurt F., Myles, David C.

“…A new approach to the preparation of complex polyketide natural products has been outlined in which the products of biosynthesis are used as starting materials…”
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Synthesis of epothilones and epothilone analogues by Sundermann, Kurt F

“…A convergent synthesis of epothilone B that generates all seven of its asymmetric centers in a completely stereoselective fashion has been completed. Key…”
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