Synthesis and Chemical Modification of 3, 3-Dimethyl-1H, 3H-furo[4, 3-b][1, 5]benzothiazepin-1-one

Heating of 3-(2-aminophenylthio)-2-methoxycarbonyl-4-methyl-2-penten-4-olide with triethylamine hydrochloride gave 3, 3-dimethyl-1H, 3H-furo[4, 3-b][1, 5]benzothiazepin-1-one. Some chemical modifications of the product including [2+2]cycloaddition and 1, 3-dipolar cycloaddition to the imino group in...

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Bibliographic Details
Published in:	Chemical & pharmaceutical bulletin Vol. 43; no. 10; pp. 1643 - 1646
Main Authors:	MATSUO, Keizo, SUNAGO, Masayo, OKUTANI, Natsue, TAKAGI, Tatsuko, NAKAMOTO, Hiromi, KOBAYASHI, Mariko
Format:	Journal Article
Language:	English
Published:	Tokyo The Pharmaceutical Society of Japan 1995 Maruzen Japan Science and Technology Agency
Subjects:	1, 3-dipolar cycloaddition 1H, 3H-furobenzothiazepin-1-one [1, 2, 4]oxadiazolo-fused heterocycle [2+2]cycloaddition Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Organic chemistry Preparations and properties β-lactam Cycloaddition Oxygen sulfur nitrogen heterocycle Lactam Lactone Aromatic compound Tricyclic compound Chemical synthesis
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Summary:	Heating of 3-(2-aminophenylthio)-2-methoxycarbonyl-4-methyl-2-penten-4-olide with triethylamine hydrochloride gave 3, 3-dimethyl-1H, 3H-furo[4, 3-b][1, 5]benzothiazepin-1-one. Some chemical modifications of the product including [2+2]cycloaddition and 1, 3-dipolar cycloaddition to the imino group in the product were performed.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.43.1643