Search Results - "SUN, Yongnian"

Activity of the HIV-1 Attachment Inhibitor BMS-626529, the Active Component of the Prodrug BMS-663068, against CD4-Independent Viruses and HIV-1 Envelopes Resistant to Other Entry Inhibitors by ZHUFANG LI, NANNAN ZHOU, YONGNIAN SUN, RAY, Neelanjana, LATAILLADE, Max, HANNA, George J, KRYSTAL, Mark

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The Assembly of Ebola Virus Nucleocapsid Requires Virion-Associated Proteins 35 and 24 and Posttranslational Modification of Nucleoprotein by Huang, Yue, Xu, Ling, Sun, Yongnian, Nabel, Gary J

“…Ebola virus encodes seven viral structural and regulatory proteins that support its high rates of replication, but little is known about nucleocapsid assembly…”
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Regulation of the Proinflammatory Effects of Fas Ligand (CD95L) by Chen, Jian-Jun, Sun, Yongnian, Nabel, Gary J.

“…Fas ligand (CD95L) inhibits T cell function in immune-privileged organs such as the eye and testis, yet in most tissues CD95L expression induces potent…”
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In Vitro Cross-Resistance Profile of Nucleoside Reverse Transcriptase Inhibitor (NRTI) BMS-986001 against Known NRTI Resistance Mutations by ZHUFANG LI, TERRY, Brian, LATAILLADE, Max, HANNA, George J, KRYSTAL, Mark, OLDS, William, PROTACK, Tricia, DEMINIE, Carol, MINASSIAN, Beatrice, NOWICKA-SANS, Beata, SUN, Yongnian, DICKER, Ira, HWANG, Carey

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ACH-806, an NS4A Antagonist, Inhibits Hepatitis C Virus Replication by Altering the Composition of Viral Replication Complexes by WENGANG YANG, YONGNIAN SUN, MINGJUN HUANG, XIAOHONG HOU, YONGSEN ZHAO, FABRYCKI, Joanne, DAWEI CHEN, XIANGZHU WANG, AGARWAL, Atul, PHADKE, Avinash, DESHPANDE, Milind

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Regulation of β -Catenin Transformation by the p300 Transcriptional Coactivator by Sun, Yongnian, Kolligs, Frank T., Hottiger, Michael O., Mosavin, Rashid, Fearon, Eric R., Nabel, Gary J.

“…The β -catenin protein plays a critical role in embryonic development and mature tissue homeostasis through its effects on E-cadherin-mediated cell adhesion…”
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Hepatitis C Virus (HCV) NS5B Nonnucleoside Inhibitors Specifically Block Single-Stranded Viral RNA Synthesis Catalyzed by HCV Replication Complexes In Vitro by Yang, Wengang, Sun, Yongnian, Phadke, Avinash, Deshpande, Milind, Huang, Mingjun

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On Ternary Complex Stability in Protein Degradation: In Silico Molecular Glue Binding Affinity Calculations by Weiss, Dahlia R., Bortolato, Andrea, Sun, Yongnian, Cai, Xianmei, Lai, Chon, Guo, Sixuan, Shi, Lihong, Shanmugasundaram, Veerabahu

“…Molecular glues are small molecules that simultaneously bind to two proteins, creating a chemically induced protein–protein interface. CELMoDs (cereblon E3…”
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Comprehensive characterization and optimization of Caco-2 cells enabled the development of a miniaturized 96-well permeability assay by Cai, Xianmei, Patel, Shivani, Huang, Chunli, Paiva, Anthony, Sun, Yongnian, Barker, Gregory, Weller, Harold, Shou, Wilson

“…Assessment of compound permeability through a Caco-2 cell monolayer is a well-accepted model to evaluate its permeability potential and transporter…”
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GSK3732394: a Multi-specific Inhibitor of HIV Entry by Wensel, David, Sun, Yongnian, Davis, Jonathan, Li, Zhufang, Zhang, Sharon, McDonagh, Thomas, Langley, David, Mitchell, Tracy, Tabruyn, Sebastien, Nef, Patrick, Cockett, Mark, Krystal, Mark

“…Long-acting antiretrovirals could provide a useful alternative to daily oral therapy for HIV-1-infected individuals. Building on a bi-specific molecule with…”
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Discovery and Characterization of a Novel CD4-Binding Adnectin with Potent Anti-HIV Activity by Wensel, David, Sun, Yongnian, Li, Zhufang, Zhang, Sharon, Picarillo, Caryn, McDonagh, Thomas, Fabrizio, David, Cockett, Mark, Krystal, Mark, Davis, Jonathan

“…A novel fibronectin-based protein (Adnectin) HIV-1 inhibitor was generated using selection. This inhibitor binds to human CD4 with a high affinity (3.9 nM) and…”
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Mechanistic investigation of liver injury induced by BMS-932481, an experimental ɣ-secretase modulator by Zhuo, Xiaoliang, Howell, Brett A, Shen, Hong, Woodhead, Jeffrey L, Mosure, Kathy, Zhang, Yueping, Scialis, Renato J, Iyer, Ramaswamy, Sun, Yongnian, Boy, Kenneth M, Lentz, Kimberley A, Denton, R Rex, Soars, Matthew G, Johnson, Benjamin M, Humphreys, W Griffith

“…BMS-932481 was designed to modulate ɣ-secretase activity to produce shorter and less amyloidogenic peptides, potentially averting liabilities associated with…”
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A Novel gp41-Binding Adnectin with Potent Anti-HIV Activity Is Highly Synergistic when Linked to a CD4-Binding Adnectin by Wensel, David, Sun, Yongnian, Davis, Jonathan, Li, Zhufang, Zhang, Sharon, McDonagh, Thomas, Fabrizio, David, Cockett, Mark, Krystal, Mark

“…The N17 region of gp41 in HIV-1 is the most conserved region in gp160. mRNA selection technologies were used to identify an adnectin that binds to this region…”
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Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage by Nowicka-Sans, Beata, Protack, Tricia, Lin, Zeyu, Li, Zhufang, Zhang, Sharon, Sun, Yongnian, Samanta, Himadri, Terry, Brian, Liu, Zheng, Chen, Yan, Sin, Ny, Sit, Sing-Yuen, Swidorski, Jacob J, Chen, Jie, Venables, Brian L, Healy, Matthew, Meanwell, Nicholas A, Cockett, Mark, Hanumegowda, Umesh, Regueiro-Ren, Alicia, Krystal, Mark, Dicker, Ira B

“…BMS-955176 is a second-generation human immunodeficiency virus type 1 (HIV-1) maturation inhibitor (MI). A first-generation MI, bevirimat, showed clinical…”
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Distinct Biology of Kaposi’s Sarcoma-Associated Herpesvirus from Primary Lesions and Body Cavity Lymphomas by Friborg, Jr, J, Kong, W P, Flowers, C C, Flowers, S L, Sun, Y, Foreman, K E, Nickoloff, B J, Nabel, G J

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Pharmacodynamics‐based approach for efficacious human dose projection of BMS‐986260, a small molecule transforming growth factor beta receptor 1 inhibitor by Parrish, Karen E., Swanson, Jesse, Cheng, Lihong, Luk, Emily, Stetsko, Paul, Smalley, James, Shu, Yue‐Zhong, Huang, Jinwen, Pabalan, Jonathan G., Sun, Yongnian, Zvyaga, Tatyana, Cvijic, Mary Ellen, Burke, James, Borzilleri, Robert, Murtaza, Anwar, Augustine, Karen, Yang, Zheng

“…Transforming growth factor beta (TGF‐β) is a pleiotropic cytokine that has a wide array of biological effects. For decades, tumor biology implicated TGF‐β as…”
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Inhibitors of Human Immunodeficiency Virus Type 1 (HIV-1) Attachment. 12. Structure–Activity Relationships Associated with 4‑Fluoro-6-azaindole Derivatives Leading to the Identification of 1‑(4-Benzoylpiperazin-1-yl)-2-(4-fluoro-7-[1,2,3]triazol-1-yl‑1H‑pyrrolo[2,3‑c]pyridin-3-yl)ethane-1,2-dione (BMS-585248) by Regueiro-Ren, Alicia, Xue, Qiufen M, Swidorski, Jacob J, Gong, Yi-Fei, Mathew, Marina, Parker, Dawn D, Yang, Zheng, Eggers, Betsy, D’Arienzo, Celia, Sun, Yongnian, Malinowski, Jacek, Gao, Qi, Wu, Dedong, Langley, David R, Colonno, Richard J, Chien, Caly, Grasela, Dennis M, Zheng, Ming, Lin, Pin-Fang, Meanwell, Nicholas A, Kadow, John F

“…A series of highly potent HIV-1 attachment inhibitors with 4-fluoro-6-azaindole core heterocycles that target the viral envelope protein gp120 has been…”
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Pyrazolo-Piperidines Exhibit Dual Inhibition of CCR5/CXCR4 HIV Entry and Reverse Transcriptase by Cox, Bryan D, Prosser, Anthony R, Sun, Yongnian, Li, Zhufang, Lee, Sangil, Huang, Ming B, Bond, Vincent C, Snyder, James P, Krystal, Mark, Wilson, Lawrence J, Liotta, Dennis C

“…We report novel anti-HIV-1 agents with combined dual host–pathogen pharmacology. Lead compound 3, composed of a pyrazole-piperidine core, exhibits three…”
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Antiviral Inhibition of the HIV-1 Capsid Protein by Tang, Chun, Loeliger, Erin, Kinde, Isaac, Kyere, Samson, Mayo, Keith, Barklis, Eric, Sun, Yongnian, Huang, Mingjun, Summers, Michael F

“…During the assembly stage of the human immunodeficiency virus (HIV) replication cycle, several thousand copies of the viral Gag polyprotein associate at the…”
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Increased sensitivity of HIV variants selected by attachment inhibitors to broadly neutralizing antibodies by Zhou, Nannan, Fan, Li, Ho, Hsu-Tso, Nowicka-Sans, Beata, Sun, Yongnian, Zhu, Yingjie, Hu, Yanhua, McAuliffe, Brian, Rose, Burt, Fang, Hua, Wang, Tao, Kadow, John, Krystal, Mark, Alexander, Louis, Colonno, Richard, Lin, Pin-Fang

“…Abstract Treatment with HIV attachment inhibitors (AIs) can select for escape mutants throughout the viral envelope. We report on three such mutations: F423Y…”
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