Search Results - "SUMMERS, David K"

Bacterial Metabolite Indole Modulates Incretin Secretion from Intestinal Enteroendocrine L Cells by Chimerel, Catalin, Emery, Edward, Summers, David K., Keyser, Ulrich, Gribble, Fiona M., Reimann, Frank

“…It has long been speculated that metabolites, produced by gut microbiota, influence host metabolism in health and diseases. Here, we reveal that indole,…”
Get full text

The indole pulse: a new perspective on indole signalling in Escherichia coli by Gaimster, Hannah, Cama, Jehangir, Hernández-Ainsa, Silvia, Keyser, Ulrich F, Summers, David K

“…Indole has diverse signalling roles, including modulation of biofilm formation, virulence and stress responses. Changes are induced by indole concentrations of…”
Get full text

Inhibition of indole production increases the activity of quinolone antibiotics against E. coli persisters by Zarkan, Ashraf, Matuszewska, Marta, Trigg, Stephen B., Zhang, Meng, Belgami, Daaniyah, Croft, Cameron, Liu, Junyan, El-Ouisi, Sawssen, Greenhalgh, Jack, Duboff, James S., Rahman, Taufiq, Summers, David K.

“…Persisters are a sub-population of genetically sensitive bacteria that survive antibiotic treatment by entering a dormant state. The emergence of persisters…”
Get full text

Importance of the Genetic Diversity within the Mycobacterium tuberculosis Complex for the Development of Novel Antibiotics and Diagnostic Tests of Drug Resistance by Köser, Claudio U, Feuerriegel, Silke, Summers, David K, Archer, John A C, Niemann, Stefan

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Efficient Production of Active Polyhydroxyalkanoate Synthase in Escherichia coli by Coexpression of Molecular Chaperones by THOMSON, Nicholas M, SAIKA, Azusa, USHIMARU, Kazunori, SANGIAMBUT, Smith, TSUGE, Takeharu, SUMMERS, David K, SIVANIAH, Easan

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Impact of fgd1 and ddn Diversity in Mycobacterium tuberculosis Complex on In Vitro Susceptibility to PA-824 by Feuerriegel, Silke, Köser, Claudio U, Baù, Davide, Rüsch-Gerdes, Sabine, Summers, David K, Archer, John A. C, Marti-Renom, Marc A, Niemann, Stefan

“…PA-824 is a promising drug candidate for the treatment of tuberculosis (TB). It is in phase II clinical trials as part of the first newly designed regimen…”
Get full text

Efficient 3‐Hydroxybutyrate Production by Quiescent Escherichia coli Microbial Cell Factories is Facilitated by Indole‐Induced Proteomic and Metabolomic Changes by Thomson, Nicholas M., Shirai, Tomokazu, Chiapello, Marco, Kondo, Akihiko, Mukherjee, Krishna J., Sivaniah, Easan, Numata, Keiji, Summers, David K.

“…The authors show that quiescent (Q‐Cell) Escherichia coli cultures can maintain metabolic activity in the absence of growth for up to 24 h, leading to four…”
Get full text

Local and Universal Action: The Paradoxes of Indole Signalling in Bacteria by Zarkan, Ashraf, Liu, Junyan, Matuszewska, Marta, Gaimster, Hannah, Summers, David K.

“…Indole is a signalling molecule produced by many bacterial species and involved in intraspecies, interspecies, and interkingdom signalling. Despite the…”
Get full text

Efficient molecular weight control of bacterially synthesized polyesters by alcohol supplementation by Thomson, Nicholas M., Hiroe, Ayaka, Tsuge, Takeharu, Summers, David K., Sivaniah, Easan

“…The bacterial plastic poly(3‐hydroxybutyrate) (PHB) has many practical applications but its commercial potential is presently limited, partly due to the…”
Get full text

Frequency and diversity of small cryptic plasmids in the genus Rahnella by Rozhon, Wilfried, Petutschnig, Elena, Khan, Mamoona, Summers, David K, Poppenberger, Brigitte

“…Rahnella is a widely distributed genus belonging to the Enterobacteriaceae and frequently present on vegetables. Although Rahnella has interesting…”
Get full text

Polymorphisms in Isoniazid and Prothionamide Resistance Genes of the Mycobacterium tuberculosis Complex by Projahn, Michaela, Köser, Claudio U, Homolka, Susanne, Summers, David K, Archer, John A C, Niemann, Stefan

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Indole prevents Escherichia coli cell division by modulating membrane potential by Chimerel, Catalin, Field, Christopher M., Piñero-Fernandez, Silvia, Keyser, Ulrich F., Summers, David K.

“…Indole is a bacterial signalling molecule that blocks E. coli cell division at concentrations of 3–5mM. We have shown that indole is a proton ionophore and…”
Get full text

Indole signalling contributes to the stable maintenance of Escherichia coli multicopy plasmids by Chant, Eleanor L, Summers, David K

“…The efficient transmission of multicopy plasmids to daughter cells at division requires that a high copy number is maintained. Plasmid multimers depress copy…”
Get full text

Overview of errors in the reference sequence and annotation of Mycobacterium tuberculosis H37Rv, and variation amongst its isolates by Köser, Claudio U., Niemann, Stefan, Summers, David K., Archer, John A.C.

“…Since its publication in 1998, the genome sequence of the Mycobacterium tuberculosis H37Rv laboratory strain has acted as the cornerstone for the study of…”
Get full text

Indole Pulse Signalling Regulates the Cytoplasmic pH of E. coli in a Memory-Like Manner by Zarkan, Ashraf, Caño-Muñiz, Santiago, Zhu, Jinbo, Al Nahas, Kareem, Cama, Jehangir, Keyser, Ulrich F., Summers, David K.

“…Bacterial cells are critically dependent upon pH regulation. Here we demonstrate that indole plays a critical role in the regulation of the cytoplasmic pH of…”
Get full text

The Effect of Bacterial Signal Indole on the Electrical Properties of Lipid Membranes by Chimerel, Catalin, Murray, Andrew J., Oldewurtel, Enno R., Summers, David K., Keyser, Ulrich F.

“…Indole is an important biological signalling molecule produced by many Gram positive and Gram negative bacterial species, including Escherichia coli. Here we…”
Get full text

Indole modifies the central carbon flux in the anaerobic metabolism of Escherichia coli: application to the production of hydrogen and other metabolites by De Leon-Rodriguez, Antonio, Caño-Muñiz, Santiago L., Liu, Junyan, Summers, David K.

“…•Indole affects the anaerobic metabolism of E. coli.•Indole induces quiescent cells in anaerobic conditions.•Indole changes the composition of anaerobic…”
Get full text

Indole generates quiescent and metabolically active Escherichia coli cultures by Chen, Chih-Chin, Walia, Rupali, Mukherjee, Krishna J., Mahalik, Subhashree, Summers, David K.

“…An inherent problem with bacterial cell factories used to produce recombinant proteins or metabolites is that resources are channeled into unwanted biomass as…”
Get full text

Indole inhibition of ColE1 replication contributes to stable plasmid maintenance by Field, Christopher M., Summers, David K.

“…► ColE1 plasmid dimers cause increased indole production. ► To effectively resolve dimers, plasmid replication must be stopped. ► Indole inhibits plasmid…”
Get full text

The Quiescent-Cell Expression System for Protein Synthesis in Escherichia coli by ROWE, D. C. D, SUMMERS, D. K

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text