Search Results - "SUMMER, ROSS"

Cellular Metabolism in Lung Health and Disease by Liu, Gang, Summer, Ross

“…The lung is often overlooked as a metabolically active organ, yet biochemical studies have long demonstrated that glucose utilization surpasses that of many…”
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Surfactant Lipids at the Host-Environment Interface. Metabolic Sensors, Suppressors, and Effectors of Inflammatory Lung Disease by Fessler, Michael B, Summer, Ross S

“…The lipid composition of pulmonary surfactant is unlike that of any other body fluid. This extracellular lipid reservoir is also uniquely susceptible by virtue…”
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Time to personalize the treatment of anti-MDA-5 associated lung disease by Lake, Michael, George, Gautam, Summer, Ross

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Acute Exacerbation of Interstitial Lung Disease as a Sequela of COVID-19 Pneumonia by Fonseca, Mario, Summer, Ross, Roman, Jesse

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Activation of the mTORC1/PGC-1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium by Summer, Ross, Shaghaghi, Hoora, Schriner, DeLeila, Roque, Willy, Sales, Dominic, Cuevas-Mora, Karina, Desai, Vilas, Bhushan, Alok, Ramirez, Maria I, Romero, Freddy

“…Cellular senescence is a biological process by which cells lose their capacity to proliferate yet remain metabolically active. Although originally considered a…”
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COVID-19 treatment combinations and associations with mortality in a large multi-site healthcare system by Coppock, Dagan, Baram, Michael, Chang, Anna Marie, Henwood, Patricia, Kubey, Alan, Summer, Ross, Zurlo, John, Li, Michael, Hess, Bryan

“…During the early months of the COVID-19 pandemic, mortality associated with the disease declined in the United States. The standard of care for pharmacological…”
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The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: novel target for fibrosis therapy by Fang, Feng, Liu, Lei, Yang, Yang, Tamaki, Zenshiro, Wei, Jun, Marangoni, Roberta G, Bhattacharyya, Swati, Summer, Ross S, Ye, Boping, Varga, John

“…Fibrosis in scleroderma is associated with collagen deposition and myofibroblast accumulation. Peroxisome proliferator activated receptor gamma (PPAR-γ), a…”
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Adiponectin Promotes Macrophage Polarization toward an Anti-inflammatory Phenotype by Ohashi, Koji, Parker, Jennifer L., Ouchi, Noriyuki, Higuchi, Akiko, Vita, Joseph A., Gokce, Noyan, Pedersen, Anette Amstrup, Kalthoff, Christoph, Tullin, Søren, Sams, Anette, Summer, Ross, Walsh, Kenneth

“…It is established that the adipocyte-derived cytokine adiponectin protects against cardiovascular and metabolic diseases, but the effect of this adipokine on…”
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MicroRNA-638 is highly expressed in human vascular smooth muscle cells and inhibits PDGF-BB-induced cell proliferation and migration through targeting orphan nuclear receptor NOR1 by Li, Pan, Liu, Yan, Yi, Bing, Wang, Guokun, You, Xiaohua, Zhao, Xianxian, Summer, Ross, Qin, Yongwen, Sun, Jianxin

“…Aberrant vascular smooth muscle cell (VSMC) proliferation and migration contribute significantly to the development of vascular pathologies, such as…”
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Racial and ethnic disparities in antifibrotic therapy in idiopathic pulmonary fibrosis by Zhao, Joy, Fares, Joseph, George, Gautam, Maheu, Arlene, Loizidis, Giorgos, Roman, Jesse, Kramer, Daniel, Li, Michael, Summer, Ross

“…Racial disparities have been documented in care of many respiratory diseases but little is known about the impact of race on the treatment of interstitial lung…”
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Circulating metabolic profile in idiopathic pulmonary fibrosis: data from the IPF-PRO Registry by Summer, Ross, Todd, Jamie L, Neely, Megan L, Lobo, L Jason, Namen, Andrew, Newby, L Kristin, Shafazand, Shirin, Suliman, Sally, Hesslinger, Christian, Keller, Sascha, Leonard, Thomas B, Palmer, Scott M, Ilkayeva, Olga, Muehlbauer, Michael J, Newgard, Christopher B, Roman, Jesse

“…The circulating metabolome, reflecting underlying cellular processes and disease biology, has not been fully characterized in patients with idiopathic…”
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Alcohol-induced lipid dysregulation impairs glycolytic responses to LPS in alveolar macrophages by Slovinsky, William S, Shaghaghi, Hoora, Para, Rachel, Romero, Freddy, Summer, Ross

“…AbstractSeveral conditions are marked by increased susceptibility to, and enhanced severity of, bacterial infections. Alcohol use disorder, one of these…”
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Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies by Takemura, Yukihiro, Ouchi, Noriyuki, Shibata, Rei, Aprahamian, Tamar, Kirber, Michael T, Summer, Ross S, Kihara, Shinji, Walsh, Kenneth

“…Obesity and type 2 diabetes are associated with chronic inflammation. Adiponectin is an adipocyte-derived hormone with antidiabetic and antiinflammatory…”
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Lipid Uptake by Alveolar Macrophages Drives Fibrotic Responses to Silica Dust by Hou, Xiaomin, Summer, Ross, Chen, Ziying, Tian, Ying, Ma, Jingjing, Cui, Jie, Hao, Xiaohui, Guo, Lingli, Xu, Hong, Wang, Hongli, Liu, Heliang

“…Silicosis is a common occupational disease and represents a significant contributor to respiratory morbidity and mortality worldwide. Lipid-laden macrophages,…”
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Design of the STRIVE-IPF trial- study of therapeutic plasma exchange, rituximab, and intravenous immunoglobulin for acute exacerbations of idiopathic pulmonary fibrosis by Kulkarni, Tejaswini, Criner, Gerard J, Kass, Daniel J, Rosas, Ivan O, Scholand, Mary Beth, Dilling, Daniel F, Summer, Ross, Duncan, Steven R

“…Acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) affect a significant proportion of patients with IPF. There are limited data to inform…”
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Retraction Note: Obesity-induced adipokine imbalance impairs mouse pulmonary vascular endothelial function and primes the lung for injury by Shah, Dilip, Romero, Freddy, Duong, Michelle, Wang, Nadan, Paudyal, Bishnuhari, Suratt, Benjamin T., Kallen, Caleb B., Sun, Jianxin, Zhu, Ying, Walsh, Kenneth, Summer, Ross

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The involvement of GM-CSF deficiencies in parallel pathways of pulmonary alveolar proteinosis and the alcoholic lung by Slovinsky, William S., Romero, Freddy, Sales, Dominic, Shaghaghi, Hoora, Summer, Ross

“…Chronic alcohol consumption renders the lung more susceptible to infections by disrupting essential alveolar macrophage functions. Emerging evidence suggests…”
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Obesity paradox? by Summer, Ross S

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Hermansky-Pudlak syndrome-2 alters mitochondrial homeostasis in the alveolar epithelium of the lung by Cuevas-Mora, Karina, Roque, Willy, Shaghaghi, Hoora, Gochuico, Bernadette R, Rosas, Ivan O, Summer, Ross, Romero, Freddy

“…Mitochondrial dysfunction has emerged as an important player in the pathogenesis of idiopathic pulmonary fibrosis (IPF), a common cause of idiopathic…”
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Moving senolytics closer to the clinic in IPF by Kramer, Daniel, George, Gautam, Summer, Ross

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