Search Results - "SULLIVAN, William J"

Lysine Acetylation Is Widespread on Proteins of Diverse Function and Localization in the Protozoan Parasite Toxoplasma gondii by Jeffers, Victoria, Sullivan, William J., Jr

“…While histone proteins are the founding members of lysine acetylation substrates, it is now clear that hundreds of other proteins can be acetylated in multiple…”
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A latent ability to persist: differentiation in Toxoplasma gondii by Jeffers, Victoria, Tampaki, Zoi, Kim, Kami, Sullivan, William J.

“…A critical factor in the transmission and pathogenesis of Toxoplasma gondii is the ability to convert from an acute disease-causing, proliferative stage…”
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Transcriptional repression by ApiAP2 factors is central to chronic toxoplasmosis by Radke, Joshua B, Worth, Danielle, Hong, David, Huang, Sherri, Sullivan, Jr, William J, Wilson, Emma H, White, Michael W

“…Tachyzoite to bradyzoite development in Toxoplasma is marked by major changes in gene expression resulting in a parasite that expresses a new repertoire of…”
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Mechanisms of Toxoplasma gondii persistence and latency by Sullivan, William J., Jeffers, Victoria

“…Abstract Toxoplasma gondii is an obligate intracellular protozoan parasite that causes opportunistic disease, particularly in immunocompromised individuals…”
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Translation initiation factor eIF1.2 promotes Toxoplasma stage conversion by regulating levels of key differentiation factors by Wang, Fengrong, Holmes, Michael J., Hong, Hea Jin, Thaprawat, Pariyamon, Kannan, Geetha, Huynh, My-Hang, Schultz, Tracey L., Licon, M. Haley, Lourido, Sebastian, Dong, Wenzhao, Brito Querido, Jailson, Sullivan, William J., O’Leary, Seán E., Carruthers, Vern B.

“…The parasite Toxoplasma gondii persists in its hosts by converting from replicating tachyzoites to latent bradyzoites housed in tissue cysts. The molecular…”
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Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii by Augusto, Leonardo, Amin, Parth H, Wek, Ronald C, Sullivan, Jr, William J

“…Toxoplasma gondii is a prevalent protozoan parasite that can infect any nucleated cell but cannot replicate outside of its host cell. Toxoplasma is auxotrophic…”
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Bromodomains in Protozoan Parasites: Evolution, Function, and Opportunities for Drug Development by Jeffers, Victoria, Yang, Chunlin, Huang, Sherri, Sullivan, Jr, William J

“…Parasitic infections remain one of the most pressing global health concerns of our day, affecting billions of people and producing unsustainable economic…”
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Doxycycline alters metabolism and proliferation of human cell lines by Ahler, Ethan, Sullivan, William J, Cass, Ashley, Braas, Daniel, York, Autumn G, Bensinger, Steven J, Graeber, Thomas G, Christofk, Heather R

“…The tetracycline antibiotics are widely used in biomedical research as mediators of inducible gene expression systems. Despite many known effects of…”
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A transcriptional network required for bradyzoite development in Toxoplasma gondii is dispensable for recrudescent disease by Sokol-Borrelli, Sarah L., Reilly, Sarah M., Holmes, Michael J., Orchanian, Stephanie B., Massmann, Mackenzie D., Sharp, Katherine G., Cabo, Leah F., Alrubaye, Hisham S., Martorelli Di Genova, Bruno, Lodoen, Melissa B., Sullivan, William J., Boyle, Jon P.

“…Identification of regulators of Toxoplasma gondii bradyzoite development and cyst formation is the most direct way to address the importance of parasite…”
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ApiAP2 transcription factor restricts development of the Toxoplasma tissue cyst by Radke, Joshua B., Lucas, Olivier, De Silva, Erandi K., Ma, YanFen, Sullivan, William J., Weiss, Louis M., Llinas, Manuel, White, Michael W.

“…Cellular differentiation leading to formation of the bradyzoite tissue cyst stage is the underlying cause of chronic toxoplasmosis. Consequently, mechanisms…”
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Genome-wide localization of histone variants in Toxoplasma gondii implicates variant exchange in stage-specific gene expression by Nardelli, Sheila C, Silmon de Monerri, Natalie C, Vanagas, Laura, Wang, Xiaonan, Tampaki, Zoi, Sullivan, Jr, William J, Angel, Sergio O, Kim, Kami

“…Toxoplasma gondii is a protozoan parasite that differentiates from acute tachyzoite stages to latent bradyzoite forms in response to environmental cues that…”
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Guanabenz Reverses a Key Behavioral Change Caused by Latent Toxoplasmosis in Mice by Reducing Neuroinflammation by Martynowicz, Jennifer, Augusto, Leonardo, Wek, Ronald C, Boehm, 2nd, Stephen L, Sullivan, Jr, William J

“…is an intracellular parasite that has infected one-third of humans. The infection is permanent because the replicative form (tachyzoite) converts into a latent…”
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Host sensing and signal transduction during Toxoplasma stage conversion by Augusto, Leonardo, Wek, Ronald C., Sullivan, William J.

“…The intracellular parasite Toxoplasma gondii infects nucleated cells in virtually all warm‐blooded vertebrates, including one‐third of the human population…”
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Histone variant H2B.Z acetylation is necessary for maintenance of Toxoplasma gondii biological fitness by Vanagas, Laura, Muñoz, Daniela, Cristaldi, Constanza, Ganuza, Agustina, Nájera, Rosario, Bonardi, Mabel C., Turowski, Valeria R., Guzman, Fanny, Deng, Bin, Kim, Kami, Sullivan, William J., Angel, Sergio O.

“…Through regulation of DNA packaging, histone proteins are fundamental to a wide array of biological processes. A variety of post-translational modifications…”
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mRNA cap-binding protein eIF4E1 is a novel regulator of Toxoplasma gondii latency by Holmes, Michael J, Bastos, Matheus S, Dey, Vishakha, Severo, Vanessa, Wek, Ronald C, Sullivan, Jr, William J

“…The protozoan parasite causes serious opportunistic disease due to its ability to persist in patients as latent tissue cysts. The molecular mechanisms…”
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Translational Control in the Latency of Apicomplexan Parasites by Holmes, Michael J., Augusto, Leonardo da Silva, Zhang, Min, Wek, Ronald C., Sullivan, William J.

“…Apicomplexan parasites Toxoplasma gondii and Plasmodium spp. use latent stages to persist in the host, facilitate transmission, and thwart treatment of…”
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PK4, a eukaryotic initiation factor 2α(eIF2α) kinase, is essential for the development of the erythrocytic cycle of Plasmodium by Zhang, Min, Mishra, Satish, Sakthivel, Ramanavelan, Rojas, Margarito, Ranjan, Ravikant, Sullivan, William J. Jr, Fontoura, Beatriz M. A, Ménard, Robert, Dever, Thomas E, Nussenzweig, Victor

“…In response to environmental stresses, the mammalian serine threonine kinases PERK, GCN2, HRI, and PKR phosphorylate the regulatory serine 51 of the eukaryotic…”
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Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency by Zhang, Min, Gallego-Delgado, Julio, Fernandez-Arias, Cristina, Waters, Norman C., Rodriguez, Ana, Tsuji, Moriya, Wek, Ronald C., Nussenzweig, Victor, Sullivan, William J.

“…Artemisinin and its derivatives (ARTs) are frontline antimalarial drugs. However, ART monotherapy is associated with a high frequency of recrudescent…”
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TgIF2K-B Is an eIF2α Kinase in Toxoplasma gondii That Responds to Oxidative Stress and Optimizes Pathogenicity by Augusto, Leonardo, Martynowicz, Jennifer, Amin, Parth H, Carlson, Kenneth R, Wek, Ronald C, Sullivan, Jr, William J

“…is an obligate intracellular parasite that persists in its vertebrate hosts in the form of dormant tissue cysts, which facilitate transmission through…”
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m6A RNA methylation facilitates pre-mRNA 3’-end formation and is essential for viability of Toxoplasma gondii by Holmes, Michael J, Padgett, Leah R, Bastos, Matheus S, Sullivan, William J

“…Toxoplasma gondii is an obligate intracellular parasite that can cause serious opportunistic disease in the immunocompromised or through congenital infection…”
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