Search Results - "SUGIYAMA, YUICHI"

Transporter or membrane barriers effects on hepatic clearance (the extended clearance equation) models and the need for scaling for IVIVE by Sugiyama, Yuichi

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S9.1 - Albumin-mediated hepatic uptake of organic anion transport polypeptide substrates by Sugiyama, Yuichi

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Preincubation-dependent and long-lasting inhibition of organic anion transporting polypeptide (OATP) and its impact on drug-drug interactions by Shitara, Yoshihisa, Sugiyama, Yuichi

“…Preincubation with cyclosporin A (CsA), a potent inhibitor of organic anion transporting polypeptide 1B1 (OATP1B1) and OATP1B3, enhanced its inhibitory effects…”
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Phase 0/microdosing approaches: time for mainstream application in drug development? by Burt, Tal, Young, Graeme, Lee, Wooin, Kusuhara, Hiroyuki, Langer, Oliver, Rowland, Malcolm, Sugiyama, Yuichi

“…Phase 0 approaches — which include microdosing — evaluate subtherapeutic exposures of new drugs in first-in-human studies known as exploratory clinical trials…”
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Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions by Shitara, Yoshihisa, Sugiyama, Yuichi

“…3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are widely used for the treatment of hypercholesterolemia. Their efficacy in…”
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In vitro-in vivo Extrapolation of Transporter-mediated Clearance in the Liver and Kidney by Kusuhara, Hiroyuki, Sugiyama, Yuichi

“…Transporter govern drug movement into and out of tissues, thereby playing an important role in drug disposition in plasma and to the site of action. The…”
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Post-translational regulation of the major drug transporters in the families of organic anion transporters and organic anion–transporting polypeptides by Lee, Wooin, Ha, Jeong-min, Sugiyama, Yuichi

“…The organic anion transporters (OATs) and organic anion–transporting polypeptides (OATPs) belong to the solute carrier (SLC) transporter superfamily and play…”
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Involvement of Multiple Transporters in the Hepatobiliary Transport of Rosuvastatin by KITAMURA, Satoshi, MAEDA, Kazuya, YI WANG, SUGIYAMA, Yuichi

“…Rosuvastatin is an HMG-CoA reductase inhibitor and one of the most hydrophilic among the commercially available statins. It is efficiently accumulated in the…”
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Drug transporters: Starring roles in new drug discovery and development by Sugiyama, Yuichi

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Perspectives of xenobiotics science in Asia Pacific community: Xenobiotic metabolism and transporters – Importance of translational and reverse-translation research by Sugiyama, Yuichi

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Cluster Gauss‐Newton method for a quick approximation of profile likelihood: With application to physiologically‐based pharmacokinetic models by Aoki, Yasunori, Sugiyama, Yuichi

“…Physiologically‐based pharmacokinetic (PBPK) models can be challenging to work with because they can have too many parameters to identify from observable data…”
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Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone by Kodaira, Hiroshi, Kusuhara, Hiroyuki, Ushiki, Junko, Fuse, Eiichi, Sugiyama, Yuichi

“…A synergistic effect of P-glycoprotein (P-gp)/Abcb1a and breast cancer resistance protein (Bcrp)/Abcg2 was reported to limit the brain penetration of their…”
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Experimental and Modeling Evidence Supporting the Trans -Inhibition Mechanism for Preincubation Time-Dependent, Long-Lasting Inhibition of Organic Anion Transporting Polypeptide 1B1 by Cyclosporine A by Izumi, Saki, Nozaki, Yoshitane, Lee, Wooin, Sugiyama, Yuichi

“…Cyclosporine A (CsA) and rifampin are potent inhibitors of organic anion transporting polypeptide (OATP) 1B1 and are widely used to assess the risk for…”
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Investigation of the impact of substrate selection on in vitro organic anion transporting polypeptide 1B1 inhibition profiles for the prediction of drug-drug interactions by Izumi, Saki, Nozaki, Yoshitane, Maeda, Kazuya, Komori, Takafumi, Takenaka, Osamu, Kusuhara, Hiroyuki, Sugiyama, Yuichi

“…The risk assessment of organic anion transporting polypeptide (OATP) 1B1-mediated drug-drug interactions (DDIs) is an indispensable part of drug development…”
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Impact of Genetic Polymorphisms of Transporters on the Pharmacokinetic, Pharmacodynamic and Toxicological Properties of Anionic Drugs by Maeda, Kazuya, Sugiyama, Yuichi

“…As the importance of drug transporters in the clinical pharmacokinetics of drugs is recognized, genetic polymorphisms of drug transporters have emerged as one…”
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Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug‐Drug Interaction Evaluation: Perspectives From the International Transporter Consortium by Chu, Xiaoyan, Liao, Mingxiang, Shen, Hong, Yoshida, Kenta, Zur, Arik A., Arya, Vikram, Galetin, Aleksandra, Giacomini, Kathleen M., Hanna, Imad, Kusuhara, Hiroyuki, Lai, Yurong, Rodrigues, David, Sugiyama, Yuichi, Zamek‐Gliszczynski, Maciej J., Zhang, Lei

“…Drug transporters can govern the absorption, distribution, metabolism, and excretion of substrate drugs and endogenous substances. Investigations to examine…”
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Influence of Transporter Polymorphisms on Drug Disposition and Response: A Perspective From the International Transporter Consortium by Yee, Sook Wah, Brackman, Deanna J., Ennis, Elizabeth A., Sugiyama, Yuichi, Kamdem, Landry K., Blanchard, Rebecca, Galetin, Aleksandra, Zhang, Lei, Giacomini, Kathleen M.

“…Advances in genomic technologies have led to a wealth of information identifying genetic polymorphisms in membrane transporters, specifically how these…”
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Predicting In Vivo Target Occupancy (TO) Profiles via Physiologically Based Pharmacokinetic–TO Modeling of Warfarin Pharmacokinetics in Blood: Importance of Low Dose Data and Prediction of Stereoselective Target Interactions by Lee, Wooin, Kim, Min-Soo, Kim, Jiyoung, Aoki, Yasunori, Sugiyama, Yuichi

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Consideration of albumin-mediated hepatic uptake for highly protein-bound anionic drugs: Bridging the gap of hepatic uptake clearance between in vitro and in vivo by Miyauchi, Seiji, Kim, Soo-Jin, Lee, Wooin, Sugiyama, Yuichi

“…The accuracy in predicting in vivo hepatic clearance of drugs from in vitro data (often termed as in vitro-to-in vivo extrapolation, IVIVE) has improved in…”
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When to consider intra-target microdosing: physiologically based pharmacokinetic modeling approach to quantitatively identify key factors for observing target engagement by Aoki, Yasunori, Rowland, Malcom, Sugiyama, Yuichi

“…Intra-Target Microdosing (ITM), integral to Phase 0 clinical studies, offers a novel approach in drug development, effectively bridging the gap between…”
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