Search Results - "SUGIYAMA, Tomoyasu"

Finding new roles of classic biomolecular condensates in the nucleus: Lessons from fission yeast by Sugiyama, Tomoyasu

“…Decades have passed since the initial discovery of membrane-less nuclear compartments, commonly called nuclear bodies or nuclear condensates. These…”
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Effects of the anti-inflammatory drug celecoxib on cell death signaling in human colon cancer by Maruyama, Ryuto, Kiyohara, Yuki, Kudo, Yasuhiro, Sugiyama, Tomoyasu

“…The anti-inflammatory drug celecoxib, the only inhibitor of cyclooxygenase-2 (COX-2) with anticancer activity, is used to treat rheumatoid arthritis and can…”
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The fission yeast MTREC complex targets CUTs and unspliced pre-mRNAs to the nuclear exosome by Zhou, Yang, Zhu, Jianguo, Schermann, Géza, Ohle, Corina, Bendrin, Katja, Sugioka-Sugiyama, Rie, Sugiyama, Tomoyasu, Fischer, Tamás

“…Cryptic unstable transcripts (CUTs) are rapidly degraded by the nuclear exosome. However, the mechanism by which they are recognized and targeted to the…”
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Red1 promotes the elimination of meiosis-specific mRNAs in vegetatively growing fission yeast by Sugiyama, Tomoyasu, Sugioka-Sugiyama, Rie

“…Meiosis‐specific mRNAs are transcribed in vegetative fission yeast, and these meiotic mRNAs are selectively removed from mitotic cells to suppress meiosis…”
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Deep Learning of Phase-Contrast Images of Cancer Stem Cells Using a Selected Dataset of High Accuracy Value Using Conditional Generative Adversarial Networks by Zhang, Zaijun, Ishihata, Hiroaki, Maruyama, Ryuto, Kasai, Tomonari, Kameda, Hiroyuki, Sugiyama, Tomoyasu

“…Artificial intelligence (AI) technology for image recognition has the potential to identify cancer stem cells (CSCs) in cultures and tissues. CSCs play an…”
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Comprehensive analysis of heterochromatin- and RNAi-mediated epigenetic control of the fission yeast genome by Grewal, Shiv I S, Cam, Hugh P, Sugiyama, Tomoyasu, Chen, Ee Sin, Chen, Xi, FitzGerald, Peter C

“…The organization of eukaryotic genomes into distinct structural and functional domains is important for the regulation and transduction of genetic information…”
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Untimely expression of gametogenic genes in vegetative cells causes uniparental disomy by Folco, H. Diego, Chalamcharla, Venkata R., Sugiyama, Tomoyasu, Thillainadesan, Gobi, Zofall, Martin, Balachandran, Vanivilasini, Dhakshnamoorthy, Jothy, Mizuguchi, Takeshi, Grewal, Shiv I. S.

“…Uniparental disomy in fission yeast is triggered by aberrant expression of gametogenic genes in vegetative cells, and is associated with the activation of…”
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RNAi-Mediated Targeting of Heterochromatin by the RITS Complex by Verdel, André, Jia, Songtao, Gerber, Scott, Sugiyama, Tomoyasu, Gygi, Steven, Shiv I. S. Grewal, Moazed, Danesh

“…RNA interference (RNAi) is a widespread silencing mechanism that acts at both the posttranscriptional and transcriptional levels. Here, we describe the…”
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Deep Learning of Cancer Stem Cell Morphology Using Conditional Generative Adversarial Networks by Aida, Saori, Okugawa, Junpei, Fujisaka, Serena, Kasai, Tomonari, Kameda, Hiroyuki, Sugiyama, Tomoyasu

“…Deep-learning workflows of microscopic image analysis are sufficient for handling the contextual variations because they employ biological samples and have…”
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SHREC, an Effector Complex for Heterochromatic Transcriptional Silencing by Sugiyama, Tomoyasu, Cam, Hugh P., Sugiyama, Rie, Noma, Ken-ichi, Zofall, Martin, Kobayashi, Ryuji, Grewal, Shiv I.S.

“…Transcriptional gene silencing (TGS) is the mechanism generally thought by which heterochromatin effects silencing. However, recent discovery in fission yeast…”
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Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes by Kimura, Kouichi, Wakamatsu, Ai, Suzuki, Yutaka, Ota, Toshio, Nishikawa, Tetsuo, Yamashita, Riu, Yamamoto, Jun-ichi, Sekine, Mitsuo, Tsuritani, Katsuki, Wakaguri, Hiroyuki, Ishii, Shizuko, Sugiyama, Tomoyasu, Saito, Kaoru, Isono, Yuko, Irie, Ryotaro, Kushida, Norihiro, Yoneyama, Takahiro, Otsuka, Rie, Kanda, Katsuhiro, Yokoi, Takahide, Kondo, Hiroshi, Wagatsuma, Masako, Murakawa, Katsuji, Ishida, Shinichi, Ishibashi, Tadashi, Takahashi-Fujii, Asako, Tanase, Tomoo, Nagai, Keiichi, Kikuchi, Hisashi, Nakai, Kenta, Isogai, Takao, Sugano, Sumio

“…By analyzing 1,780,295 5'-end sequences of human full-length cDNAs derived from 164 kinds of oligo-cap cDNA libraries, we identified 269,774 independent…”
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RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing by Grewal, Shiv I S, Noma, Ken-ichi, Sugiyama, Tomoyasu, Cam, Hugh, Verdel, Andre, Zofall, Martin, Jia, Songtao, Moazed, Danesh

“…RNA interference is a conserved mechanism by which double-stranded RNA is processed into short interfering RNAs (siRNAs) that can trigger both…”
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Conditional Generative Adversarial Networks to Model iPSC-Derived Cancer Stem Cells by Aida, Saori, Kameda, Hiroyuki, Nishisako, Sakae, Kasai, Tomonari, Sato, Atsushi, Sugiyama, Tomoyasu

“…The realization of effective and low-cost drug discovery is imperative to enable people to easily purchase and use medicines when necessary. This paper reports…”
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The Nucleation and Maintenance of Heterochromatin by a Histone Deacetylase in Fission Yeast by Yamada, Takatomi, Fischle, Wolfgang, Sugiyama, Tomoyasu, Allis, C. David, Grewal, Shiv I.S.

“…Posttranslational modifications of histones play an essential role in heterochromatin assembly. Whereas the role of Clr4/Suv39h-mediated methylation of histone…”
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Temporal and Locational Values of Images Affecting the Deep Learning of Cancer Stem Cell Morphology by Hanai, Yumi, Ishihata, Hiroaki, Zhang, Zaijun, Maruyama, Ryuto, Kasai, Tomonari, Kameda, Hiroyuki, Sugiyama, Tomoyasu

“…Deep learning is being increasingly applied for obtaining digital microscopy image data of cells. Well-defined annotated cell images have contributed to the…”
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RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production by Sugiyama, T, Cam, H, Verdel, A, Moazed, D, Grewal, S.I.S

“…In fission yeast, factors involved in the RNA interference (RNAi) pathway including Argonaute, Dicer, and RNA-dependent RNA polymerase are required for…”
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Red5 and three nuclear pore components are essential for efficient suppression of specific mRNAs during vegetative growth of fission yeast by Sugiyama, Tomoyasu, Wanatabe, Nobuyoshi, Kitahata, Eri, Tani, Tokio, Sugioka-Sugiyama, Rie

“…Zinc-finger domains are found in many nucleic acid-binding proteins in both prokaryotes and eukaryotes. Proteins carrying zinc-finger domains have important…”
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Rhn1, a nuclear protein, is required for suppression of meiotic mRNAs in mitotically dividing fission yeast by Sugiyama, Tomoyasu, Sugioka-Sugiyama, Rie, Hada, Kazumasa, Niwa, Ryusuke

“…In the fission yeast Schizosaccharomyces pombe, many meiotic mRNAs are transcribed during mitosis and meiosis and selectively eliminated in mitotic cells…”
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14-3-3 Interacts Directly with and Negatively Regulates Pro-apoptotic Bax by Nomura, Masaya, Shimizu, Shigeomi, Sugiyama, Tomoyasu, Narita, Masashi, Ito, Toshinori, Matsuda, Hikaru, Tsujimoto, Yoshihide

“…The Bcl-2 family of proteins comprises well characterized regulators of apoptosis, consisting of anti-apoptotic members and pro-apoptotic members…”
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The Catalytic-Dependent and -Independent Roles of Lsd1 and Lsd2 Lysine Demethylases in Heterochromatin Formation in Schizosaccharomyces pombe by Marayati, Bahjat F, Tucker, James F, Cerda, David A De La, Hou, Tien-Chi, Chen, Rong, Sugiyama, Tomoyasu, Pease, James B, Zhang, Ke

“…In eukaryotes, heterochromatin plays a critical role in organismal development and cell fate acquisition, through regulating gene expression. The…”
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