Search Results - "SUGIYAMA, Fumihiro"

Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition by Honda, Akira, Miyazaki, Teruo, Iwamoto, Junichi, Hirayama, Takeshi, Morishita, Yukio, Monma, Tadakuni, Ueda, Hajime, Mizuno, Seiya, Sugiyama, Fumihiro, Takahashi, Satoru, Ikegami, Tadashi

“…The bile acid (BA) composition in mice is substantially different from that in humans. Chenodeoxycholic acid (CDCA) is an end product in the human liver;…”
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Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress by Yagishita, Yoko, Uruno, Akira, Fukutomi, Toshiaki, Saito, Ritsumi, Saigusa, Daisuke, Pi, Jingbo, Fukamizu, Akiyoshi, Sugiyama, Fumihiro, Takahashi, Satoru, Yamamoto, Masayuki

“…The relationship between loss of hypothalamic function and onset of diabetes mellitus remains elusive. Therefore, we generated a targeted oxidative-stress…”
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Forward-genetics analysis of sleep in randomly mutagenized mice by Funato, Hiromasa, Miyoshi, Chika, Fujiyama, Tomoyuki, Kanda, Takeshi, Sato, Makito, Wang, Zhiqiang, Ma, Jing, Nakane, Shin, Tomita, Jun, Ikkyu, Aya, Kakizaki, Miyo, Hotta-Hirashima, Noriko, Kanno, Satomi, Komiya, Haruna, Asano, Fuyuki, Honda, Takato, Kim, Staci J., Harano, Kanako, Muramoto, Hiroki, Yonezawa, Toshiya, Mizuno, Seiya, Miyazaki, Shinichi, Connor, Linzi, Kumar, Vivek, Miura, Ikuo, Suzuki, Tomohiro, Watanabe, Atsushi, Abe, Manabu, Sugiyama, Fumihiro, Takahashi, Satoru, Sakimura, Kenji, Hayashi, Yu, Liu, Qinghua, Kume, Kazuhiko, Wakana, Shigeharu, Takahashi, Joseph S., Yanagisawa, Masashi

“…Sleep is conserved from invertebrates to vertebrates, and is tightly regulated in a homeostatic manner. The molecular and cellular mechanisms that determine…”
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Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis by Ohmi, Yuhsuke, Ise, Wataru, Harazono, Akira, Takakura, Daisuke, Fukuyama, Hidehiro, Baba, Yoshihiro, Narazaki, Masashi, Shoda, Hirofumi, Takahashi, Nobunori, Ohkawa, Yuki, Ji, Shuting, Sugiyama, Fumihiro, Fujio, Keishi, Kumanogoh, Atsushi, Yamamoto, Kazuhiko, Kawasaki, Nana, Kurosaki, Tomohiro, Takahashi, Yoshimasa, Furukawa, Koichi

“…Rheumatoid arthritis (RA)-associated IgG antibodies such as anti-citrullinated protein antibodies (ACPAs) have diverse glycosylation variants; however, key…”
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A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice by Honda, Takato, Fujiyama, Tomoyuki, Miyoshi, Chika, Ikkyu, Aya, Hotta-Hirashima, Noriko, Kanno, Satomi, Mizuno, Seiya, Sugiyama, Fumihiro, Takahashi, Satoru, Funato, Hiromasa, Yanagisawa, Masashi

“…Sleep is an evolutionally conserved behavior from vertebrates to invertebrates. The molecular mechanisms that determine daily sleep amounts and the neuronal…”
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The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells by Miyagi, Satoru, Sroczynska, Patrycja, Kato, Yuko, Nakajima-Takagi, Yaeko, Oshima, Motohiko, Rizq, Ola, Takayama, Naoya, Saraya, Atsunori, Mizuno, Seiya, Sugiyama, Fumihiro, Takahashi, Satoru, Matsuzaki, Yumi, Christensen, Jesper, Helin, Kristian, Iwama, Atsushi

“…Recurrent inactivating mutations have been identified in the X-linked plant homeodomain finger protein 6 (PHF6) gene, encoding a chromatin-binding…”
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SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice by Asano, Fuyuki, Kim, Staci J, Fujiyama, Tomoyuki, Miyoshi, Chika, Hotta-Hirashima, Noriko, Asama, Nodoka, Iwasaki, Kanako, Kakizaki, Miyo, Mizuno, Seiya, Mieda, Michihiro, Sugiyama, Fumihiro, Takahashi, Satoru, Shi, Shoi, Hirano, Arisa, Funato, Hiromasa, Yanagisawa, Masashi

“…Mammals exhibit circadian cycles of sleep and wakefulness under the control of the suprachiasmatic nucleus (SCN), such as the strong arousal phase-locked to…”
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Efficient induction of proximity-dependent labelling by biotin feeding in BMAL1-BioID knock-in mice by Murata, Kazuya, Mimura, Asuka, Suzuki, Hayate, Mikami, Natsuki, Hamada, Yuko, Kato, Kanako, Iki, Natsumi, Ishida, Miyuki, Daitoku, Yoko, Tanimoto, Yoko, Okiyoneda, Tsukasa, Fujiyama, Tomoyuki, Dinh, Tra Thi Huong, Mizuno, Seiya, Sugiyama, Fumihiro

“…Abstract Proximity-dependent biotin identification (BioID) is a useful method to identify unknown protein–protein interactions. Few reports have described…”
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Mast4 determines the cell fate of MSCs for bone and cartilage development by Kim, Pyunggang, Park, Jinah, Lee, Dong-Joon, Mizuno, Seiya, Shinohara, Masahiro, Hong, Chang Pyo, Jeong, Yealeen, Yun, Rebecca, Park, Hyeyeon, Park, Sujin, Yang, Kyung-Min, Lee, Min-Jung, Jang, Seung Pil, Kim, Hyun-Yi, Lee, Seung-Jun, Song, Sun U., Park, Kyung-Soon, Tanaka, Mikako, Ohshima, Hayato, Cho, Jin Won, Sugiyama, Fumihiro, Takahashi, Satoru, Jung, Han-Sung, Kim, Seong-Jin

“…Mesenchymal stromal cells (MSCs) differentiation into different lineages is precisely controlled by signaling pathways. Given that protein kinases play a…”
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Role of Anti‐Fractalkine Antibody in Suppression of Joint Destruction by Inhibiting Migration of Osteoclast Precursors to the Synovium in Experimental Arthritis by Hoshino‐Negishi, Kana, Ohkuro, Masayoshi, Nakatani, Tomoya, Kuboi, Yoshikazu, Nishimura, Miyuki, Ida, Yoko, Kakuta, Jungo, Hamaguchi, Akiko, Kumai, Minoru, Kamisako, Tsutomu, Sugiyama, Fumihiro, Ikeda, Wataru, Ishii, Naoto, Yasuda, Nobuyuki, Imai, Toshio

“…Objective To elucidate the role of the fractalkine (FKN)/CX3CR1 pathway in joint destruction in rheumatoid arthritis. Methods We examined the effect of…”
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In vitro and in vivo functions of T cells produced in complemented thymi of chimeric mice generated by blastocyst complementation by Yamazaki, Kazuto, Kubara, Kenji, Ishii, Satoko, Li, Peng, Dairiki, Ryo, Hihara, Taro, Ishizuka, Yuta, Izumi, Yukina, Kumai, Minoru, Kamisako, Tsutomu, Ishizaki, Hiroyoshi, Sato, Hideyuki, Masaki, Hideki, Mizuno, Naoaki, Mitsuhashi, Kaoru, Ito, Masashi, Hamanaka, Sanae, Yamaguchi, Tomoyuki, Watanabe, Motoo, Sugiyama, Fumihiro, Nakauchi, Hiromitsu

“…Blastocyst complementation is an intriguing way of generating humanized animals for organ preparation in regenerative medicine and establishing novel models…”
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Transcriptomic Evaluation of Pulmonary Fibrosis-Related Genes: Utilization of Transgenic Mice with Modifying p38 Signal in the Lungs by Matsuda, Shuichi, Kim, Jun-Dal, Sugiyama, Fumihiro, Matsuo, Yuji, Ishida, Junji, Murata, Kazuya, Nakamura, Kanako, Namiki, Kana, Sudo, Tatsuhiko, Kuwaki, Tomoyuki, Hatano, Masahiko, Tatsumi, Koichiro, Fukamizu, Akiyoshi, Kasuya, Yoshitoshi

“…Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing lung disease that is caused by the dysregulation of alveolar epithelial type II cells (AEC II)…”
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Birth of mice from meiotically arrested spermatocytes following biparental meiosis in halved oocytes by Ogonuki, Narumi, Kyogoku, Hirohisa, Hino, Toshiaki, Osawa, Yuki, Fujiwara, Yasuhiro, Inoue, Kimiko, Kunieda, Tetsuo, Mizuno, Seiya, Tateno, Hiroyuki, Sugiyama, Fumihiro, Kitajima, Tomoya S, Ogura, Atsuo

“…Microinjection of spermatozoa or spermatids into oocytes is a major choice for infertility treatment. However, the use of premeiotic spermatocytes has never…”
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Efficient production of large deletion and gene fragment knock-in mice mediated by genome editing with Cas9-mouse Cdt1 in mouse zygotes by Mizuno-Iijima, Saori, Ayabe, Shinya, Kato, Kanako, Matoba, Shogo, Ikeda, Yoshihisa, Dinh, Tra Thi Huong, Le, Hoai Thu, Suzuki, Hayate, Nakashima, Kenichi, Hasegawa, Yoshikazu, Hamada, Yuko, Tanimoto, Yoko, Daitoku, Yoko, Iki, Natsumi, Ishida, Miyuki, Ibrahim, Elzeftawy Abdelaziz Elsayed, Nakashiba, Toshiaki, Hamada, Michito, Murata, Kazuya, Miwa, Yoshihiro, Okada-Iwabu, Miki, Iwabu, Masato, Yagami, Ken-ichi, Ogura, Atsuo, Obata, Yuichi, Takahashi, Satoru, Mizuno, Seiya, Yoshiki, Atsushi, Sugiyama, Fumihiro

“…•Novel CRISPR-Cas vectors with a Cas9 fused to a part of mouse Cdt1.•Nuclear localisation of Cdt1-fused Cas9 in mammalian cells and embryos.•High efficiency in…”
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Generation and Characterization of a Cell Type-Specific, Inducible Cre-Driver Line to Study Olfactory Processing by Koldaeva, Anzhelika, Zhang, Cary, Huang, Yu-Pei, Reinert, Janine Kristin, Mizuno, Seiya, Sugiyama, Fumihiro, Takahashi, Satoru, Soliman, Taha, Matsunami, Hiroaki, Fukunaga, Izumi

“…In sensory systems of the brain, mechanisms exist to extract distinct features from stimuli to generate a variety of behavioral repertoires. These often…”
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Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice by Yamazaki, Hiromi, Kasai, Shuya, Mimura, Junsei, Ye, Peng, Inose-Maruyama, Atsushi, Tanji, Kunikazu, Wakabayashi, Koichi, Mizuno, Seiya, Sugiyama, Fumihiro, Takahashi, Satoru, Sato, Tsubasa, Ozaki, Taku, Cavener, Douglas R, Yamamoto, Masayuki, Itoh, Ken

“…Amino acids exert many biological functions, serving as allosteric regulators and neurotransmitters, as constituents in proteins and as nutrients…”
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Cardioprotective Effect of Apelin-13 on Cardiac Performance and Remodeling in End-Stage Heart Failure by Koguchi, Wataru, Kobayashi, Naohiko, Takeshima, Hiroshi, Ishikawa, Mayuko, Sugiyama, Fumihiro, Ishimitsu, Toshihiko

“…Background: Apelin and its cognate G protein-coupled receptor, APJ, constitute a signaling pathway with a positive inotropic effect on cardiac function…”
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Regional random mutagenesis driven by multiple sgRNAs and diverse on-target genome editing events to identify functionally important elements in non-coding regions by Morimoto, Kento, Suzuki, Hayate, Kuno, Akihiro, Daitoku, Yoko, Tanimoto, Yoko, Kato, Kanako, Murata, Kazuya, Sugiyama, Fumihiro, Mizuno, Seiya

“…Functional regions that regulate biological phenomena are interspersed throughout eukaryotic genomes. The most definitive approach for identifying such regions…”
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Null mutation of exocyst complex component 3-like does not affect vascular development in mice by Takashima, Satsuki, Okamura, Eiichi, Ichiyama, Yusuke, Nishi, Kiyoto, Shimizu, Akio, Watanabe, Chisato, Muto, Masanaga, Matsumoto, Shoma, Tsukiyama-Fujii, Setsuko, Tsukiyama, Tomoyuki, Ogita, Hisakazu, Nishi, Eiichiro, Ohji, Masahito, Sugiyama, Fumihiro, Takahashi, Satoru, Mizuno, Seiya, Mizutani, Ken-ichi, Ema, Masatsugu

“…Exocyst is an octameric protein complex implicated in exocytosis. The exocyst complex is highly conserved among mammalian species, but the physiological…”
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DAJIN enables multiplex genotyping to simultaneously validate intended and unintended target genome editing outcomes by Kuno, Akihiro, Ikeda, Yoshihisa, Ayabe, Shinya, Kato, Kanako, Sakamoto, Kotaro, Suzuki, Sayaka R, Morimoto, Kento, Wakimoto, Arata, Mikami, Natsuki, Ishida, Miyuki, Iki, Natsumi, Hamada, Yuko, Takemura, Megumi, Daitoku, Yoko, Tanimoto, Yoko, Dinh, Tra Thi Huong, Murata, Kazuya, Hamada, Michito, Muratani, Masafumi, Yoshiki, Atsushi, Sugiyama, Fumihiro, Takahashi, Satoru, Mizuno, Seiya

“…Genome editing can introduce designed mutations into a target genomic site. Recent research has revealed that it can also induce various unintended events such…”
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