Search Results - "SUGIYAMA, Eiji"

Wwp2 maintains cartilage homeostasis through regulation of Adamts5 by Mokuda, Sho, Nakamichi, Ryo, Matsuzaki, Tokio, Ito, Yoshiaki, Sato, Tempei, Miyata, Kohei, Inui, Masafumi, Olmer, Merissa, Sugiyama, Eiji, Lotz, Martin, Asahara, Hiroshi

“…The WW domain-containing protein 2 ( Wwp2 ) gene, the host gene of miR-140, codes for the Wwp2 protein, which is an HECT-type E3 ubiquitin ligases abundantly…”
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Angiotensin-converting Enzyme 2, a SARS-CoV-2 Receptor, Is Upregulated by Interleukin 6 through STAT3 Signaling in Synovial Tissues by Mokuda, Sho, Tokunaga, Tadahiro, Masumoto, Junya, Sugiyama, Eiji

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In-Source Fragmentation of Phenethylamines by Electrospray Ionization Mass Spectrometry: Toward Highly Sensitive Quantitative Analysis of Monoamine Neurotransmitters by Asakawa, Daiki, Mizuno, Hajime, Sugiyama, Eiji, Todoroki, Kenichiro

“…Electrospray ionization mass spectrometry (ESI-MS) is widely used to analyze biomolecules, which are usually detected as protonated and cation-adducted…”
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Fragmentation study of tryptophan-derived metabolites induced by electrospray ionization mass spectrometry for highly sensitive analysis by Asakawa, Daiki, Mizuno, Hajime, Sugiyama, Eiji, Todoroki, Kenichiro

“…Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is interfaced with electrospray ionization (ESI), which generally produces intact gas-phase ions of…”
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Bioanalytical methods for therapeutic monoclonal antibodies and antibody–drug conjugates: A review of recent advances and future perspectives by Todoroki, Kenichiro, Mizuno, Hajime, Sugiyama, Eiji, Toyo’oka, Toshimasa

“…•Current bioanalytical methods for therapeutic mAbs and ADCs were summarized.•Three (bottom-up, top-down, and middle-down) proteomics approaches were…”
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Study of Substituted Phenethylamine Fragmentation Induced by Electrospray Ionization Mass Spectrometry and Its Application for Highly Sensitive Analysis of Neurotransmitters in Biological Samples by Asakawa, Daiki, Sugiyama, Eiji, Mizuno, Hajime, Todoroki, Kenichiro

“…Although liquid chromatography–tandem mass spectrometry (LC–MS/MS) equipped with electrospray ionization (ESI) is widely employed for metabolite analysis,…”
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Analysis of the intracellular localization of amiodarone using live single-cell mass spectrometry by Yahata, Kenji, Mizuno, Hajime, Sugiyama, Eiji, Todoroki, Kenichiro

“…•Analysis of intracellular localization of amiodarone using live single-cell mass spectrometry.•Localization of amiodarone to lipid droplets and vacuole…”
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Precolumn derivatization LC/MS method for observation of efficient hydrogen sulfide supply to the kidney via d-cysteine degradation pathway by Sugiyama, Eiji, Higashi, Toru, Nakamura, Mao, Mizuno, Hajime, Toyo’oka, Toshimasa, Todoroki, Kenichiro

“…d-Cysteine (d-Cys) is metabolized to hydrogen sulfide (H2S) by d-amino acid oxidase (DAO)/3-mercaptopyruvate sulfurtransferase pathway. The pathway is required…”
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Simultaneous determination of all aminobutyric acids by chiral derivatization and liquid chromatography-tandem mass spectrometry by Sugiyama, Eiji, Nakamura, Mao, Mizuno, Hajime, Furusho, Aogu, Todoroki, Kenichiro

“…Aminobutyric acids include eight structural or stereoisomers that exhibit a wide range of biological activities. Recent evidence on some low abundant isomers…”
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Tandem Mass Spectrometry Imaging Reveals Distinct Accumulation Patterns of Steroid Structural Isomers in Human Adrenal Glands by Takeo, Emi, Sugiura, Yuki, Uemura, Tatsuki, Nishimoto, Koshiro, Yasuda, Masanori, Sugiyama, Eiji, Ohtsuki, Sumio, Higashi, Tatsuya, Nishikawa, Tetsuo, Suematsu, Makoto, Fukusaki, Eiichiro, Shimma, Shuichi

“…Visualizing tissue distribution of steroid hormones is a promising application of MALDI mass spectrometry imaging (MSI). On-tissue chemical derivatization…”
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Patient satisfaction, preferences, expectations, characteristics, and impact of suboptimal control of rheumatoid arthritis: A subgroup analysis of Japanese patients from a large international cohort study (SENSE) by Kawahito, Yutaka, Takakubo, Yuya, Morinobu, Akio, Matsubara, Naoko, Nagy, Orsolya, Sugiyama, Eiji

“…To evaluate treatment satisfaction, disease outcomes, and perspectives of patients with poorly controlled rheumatoid arthritis (RA) treated with conventional…”
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Effect of Porphyromonas gingivalis infection on gut dysbiosis and resultant arthritis exacerbation in mouse model by Hamamoto, Yuta, Ouhara, Kazuhisa, Munenaga, Syuichi, Shoji, Mikio, Ozawa, Tatsuhiko, Hisatsune, Jyunzo, Kado, Isamu, Kajiya, Mikihito, Matsuda, Shinji, Kawai, Toshihisa, Mizuno, Noriyoshi, Fujita, Tsuyoshi, Hirata, Shintaro, Tanimoto, Kotaro, Nakayama, Koji, Kishi, Hiroyuki, Sugiyama, Eiji, Kurihara, Hidemi

“…Background Porphyromonas gingivalis (Pg) infection causes periodontal disease and exacerbates rheumatoid arthritis (RA). It is reported that inoculation of…”
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N-glycan in the variable region of monoclonal ACPA (CCP-Ab1) promotes the exacerbation of experimental arthritis by Kawataka, Masatoshi, Ouhara, Kazuhisa, Kobayashi, Eiji, Shinoda, Koichiro, Tobe, Kazuyuki, Fujimori, Ryousuke, Mizuno, Noriyoshi, Sugiyama, Eiji, Ozawa, Tatsuhiko, Kishi, Hiroyuki

“…Abstract Objectives The variable region of most ACPA IgG molecules in the serum of RA patients carries N-glycan (N-glycanV). To analyse the pathogenicity of…”
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N-terminal peptide fragment constitutes core of amyloid deposition of serum amyloid A: An imaging mass spectrometry study by Shintani-Domoto, Yukako, Sugiura, Yuki, Ogawa, Makiko, Sugiyama, Eiji, Abe, Hiroyuki, Sakatani, Takashi, Ohashi, Ryuji, Ushiku, Tetsuo, Fukayama, Masashi

“…Serum amyloid A (SAA) is an acute phase protein, which undergoes structural changes and deposits in the extracellular matrix, causing organ damage. Systemic AA…”
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Recurrent triple-negative breast cancer (TNBC) tissues contain a higher amount of phosphatidylcholine (32:1) than non-recurrent TNBC tissues by Hosokawa, Yuko, Masaki, Noritaka, Takei, Shiro, Horikawa, Makoto, Matsushita, Shoko, Sugiyama, Eiji, Ogura, Hiroyuki, Shiiya, Norihiko, Setou, Mitsutoshi

“…Triple-negative breast cancer (TNBC) is one of the breast cancer subtype that displays a high risk of early recurrence and short overall survival. Improvement…”
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Ammonium Sulfate Improves Detection of Hydrophilic Quaternary Ammonium Compounds through Decreased Ion Suppression in Matrix-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry by Sugiyama, Eiji, Masaki, Noritaka, Matsushita, Shoko, Setou, Mitsutoshi

“…Hydrophilic quaternary ammonium compounds (QACs) include derivatives of carnitine (Car) or choline, which are known to have essential bioactivities. Here we…”
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Metabolites for monitoring symptoms and predicting remission in patients with depression who received electroconvulsive therapy: a pilot study by Uchida, Takahito, Sugiura, Yuki, Sugiyama, Eiji, Maeda, Rae, Tanaka, Kenji F., Suematsu, Makoto, Mimura, Masaru, Uchida, Hiroyuki

“…The lack of biomarkers to monitor and predict the efficacy of electroconvulsive therapy (ECT) has hindered its optimal use. To establish metabolomic markers…”
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Oral administration of bovine lactoferrin suppresses the progression of rheumatoid arthritis in an SKG mouse model by Yanagisawa, Shunryou, Nagasaki, Karin, Chea, Chanbora, Ando, Toshinori, Ayuningtyas, Nurina Febriyanti, Inubushi, Toshihiro, Ishikado, Atsushi, Imanaka, Hiromichi, Sugiyama, Eiji, Takahashi, Ichiro, Miyauchi, Mutsumi, Takata, Takashi

“…Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammatory bone destruction in which tumor necrosis factor alpha (TNF-α) plays a key…”
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Capsule endoscopy findings reflect the gastrointestinal conditions of patients with systemic sclerosis by Iio, Sumio, Oka, Shiro, Tanaka, Shinji, Sumioka, Akihiko, Tsuboi, Akiyoshi, Nojima, Takaki, Hirata, Shintaro, Matsuo, Yoshimi, Sugiyama, Eiji, Hide, Michihiro, Arihiro, Koji, Chayama, Kazuaki

“…Systemic sclerosis (SSc) is characterized by fibrosis of the skin and various internal organs. However, there is limited knowledge concerning small-bowel…”
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Glycosphingolipid metabolic reprogramming drives neural differentiation by Russo, Domenico, Della Ragione, Floriana, Rizzo, Riccardo, Sugiyama, Eiji, Scalabrì, Francesco, Hori, Kei, Capasso, Serena, Sticco, Lucia, Fioriniello, Salvatore, De Gregorio, Roberto, Granata, Ilaria, Guarracino, Mario R, Maglione, Vittorio, Johannes, Ludger, Bellenchi, Gian Carlo, Hoshino, Mikio, Setou, Mitsutoshi, D'Esposito, Maurizio, Luini, Alberto, D'Angelo, Giovanni

“…Neural development is accomplished by differentiation events leading to metabolic reprogramming. Glycosphingolipid metabolism is reprogrammed during neural…”
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