Search Results - "SUGIYAMA, Akira"

Dendrite fragmentation induced by massive-like δ–γ transformation in Fe–C alloys by Yasuda, Hideyuki, Morishita, Kohei, Nakatsuka, Noriaki, Nishimura, Tomohiro, Yoshiya, Masato, Sugiyama, Akira, Uesugi, Kentaro, Takeuchi, Akihisa

“…Dendrite arm fragmentation is considered in solidification structure tailoring. Time-resolved and in situ imaging using synchrotron radiation X-rays allows the…”
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Long-term administration of recombinant canstatin prevents adverse cardiac remodeling after myocardial infarction by Sugiyama, Akira, Ito, Rumi, Okada, Muneyoshi, Yamawaki, Hideyuki

“…Myocardial infarction (MI) still remains a leading cause of mortality throughout the world. An adverse cardiac remodeling, such as hypertrophy and fibrosis, in…”
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Preventive Effect of Canstatin against Ventricular Arrhythmia Induced by Ischemia/Reperfusion Injury: A Pilot Study by Sugiyama, Akira, Shimizu, Yurie, Okada, Muneyoshi, Otani, Kosuke, Yamawaki, Hideyuki

“…Ventricular arrhythmia induced by ischemia/reperfusion (I/R) injury is a clinical problem in reperfusion therapies for acute myocardial infarction. Ca overload…”
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Pathophysiological roles of canstatin on myofibroblasts after myocardial infarction in rats by Sugiyama, Akira, Okada, Muneyoshi, Yamawaki, Hideyuki

“…Myofibroblasts play an important role during remodeling process after myocardial infarction through proliferation, migration, production and degradation of…”
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Endostatin Stimulates Proliferation and Migration of Myofibroblasts Isolated from Myocardial Infarction Model Rats by Sugiyama, Akira, Hirano, Yuka, Okada, Muneyoshi, Yamawaki, Hideyuki

“…Myofibroblasts contribute to the healing of infarcted areas after myocardial infarction through proliferation, migration, and production of extracellular…”
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Fetal nuchal edema and developmental anomalies caused by gene mutations in mice by Sugiyama, Akira, Hirashima, Masanori

“…Fetal nuchal edema, a subcutaneous accumulation of extracellular fluid in the fetal neck, is detected as increased nuchal translucency (NT) by ultrasonography…”
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Cathepsin S degrades arresten and canstatin in infarcted area after myocardial infarction in rats by SUGIYAMA, Akira, MITSUI, Ayaka, OKADA, Muneyoshi, YAMAWAKI, Hideyuki

“…The basement membrane surrounding cardiomyocytes is mainly composed of α1 and α2 chain of type IV collagen. Arresten and canstatin are fragments of…”
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Asymmetric Synthesis of Tertiary α -Hydroxyketones by Enantioselective Decarboxylative Chlorination and Subsequent Nucleophilic Substitution by Kam, Mei Kee, Sugiyama, Akira, Kawanishi, Ryouta, Shibatomi, Kazutaka

“…Chiral tertiary α-hydroxyketones were synthesized with high enantiopurity by asymmetric decarboxylative chlorination and subsequent nucleophilic substitution…”
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Pathological complete remission of relapsed tumor by photo‐activating antibody–mimetic drug conjugate treatment by Kaneko, Yudai, Yamatsugu, Kenzo, Yamashita, Takefumi, Takahashi, Kazuki, Tanaka, Toshiya, Aki, Sho, Tatsumi, Toshifumi, Kawamura, Takeshi, Miura, Mai, Ishii, Masazumi, Ohkubo, Kei, Osawa, Tsuyoshi, Kodama, Tatsuhiko, Ishikawa, Shumpei, Tsukagoshi, Masanobu, Chansler, Michael, Sugiyama, Akira, Kanai, Motomu, Katoh, Hiroto

“…Antibody–mimetic drug conjugate is a novel noncovalent conjugate consisting of an antibody‐mimetic recognizing a target molecule on the cancer cell surface and…”
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Decreased Expression of Canstatin in Rat Model of Monocrotaline-Induced Pulmonary Arterial Hypertension: Protective Effect of Canstatin on Right Ventricular Remodeling by Sugiyama, Akira, Kaisho, Maina, Okada, Muneyoshi, Otani, Kosuke, Yamawaki, Hideyuki

“…Pulmonary arterial hypertension (PAH) is a progressive disease which causes right ventricular (RV) failure. Canstatin, a C-terminal fragment of type IV…”
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Nucleic acid–triggered tumoral immunity propagates pH‐selective therapeutic antibodies through tumor‐driven epitope spreading by Furuya, Genta, Katoh, Hiroto, Atsumi, Shinichiro, Hashimoto, Itaru, Komura, Daisuke, Hatanaka, Ryo, Senga, Shogo, Hayashi, Shuto, Akita, Shoji, Matsumura, Hirofumi, Miura, Akihiro, Mita, Hideaki, Nakakido, Makoto, Nagatoishi, Satoru, Sugiyama, Akira, Suzuki, Ryohei, Konishi, Hiroki, Yamamoto, Asami, Abe, Hiroyuki, Hiraoka, Nobuyoshi, Aoki, Kazunori, Kato, Yasumasa, Seto, Yasuyuki, Yoshimura, Chihoko, Miyadera, Kazutaka, Tsumoto, Kouhei, Ushiku, Tetsuo, Ishikawa, Shumpei

“…Important roles of humoral tumor immunity are often pointed out; however, precise profiles of dominant antigens and developmental mechanisms remain elusive. We…”
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Five doses of the mRNA vaccination potentially suppress ancestral-strain stimulated SARS-CoV2-specific cellular immunity: a cohort study from the Fukushima vaccination community survey, Japan by Tani, Yuta, Takita, Morihito, Wakui, Masatoshi, Saito, Hiroaki, Nishiuchi, Takamitsu, Zhao, Tianchen, Yamamoto, Chika, Kawamura, Takeshi, Sugiyama, Akira, Nakayama, Aya, Kaneko, Yudai, Kodama, Tatsuhiko, Shinaha, Ryuzaburo, Tsubokura, Masaharu

“…The bivalent mRNA vaccine is recommended to address coronavirus disease variants, with additional doses suggested for high-risk groups. However, the…”
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Development of X-ray Imaging for Observing Solidification of Carbon Steels by Yasuda, Hideyuki, Nagira, Tomoya, Yoshiya, Masato, Nakatsuka, Noriaki, Sugiyama, Akira, Uesugi, Kentaro, Umetani, Keiji

“…Time-resolved X-ray imaging of dendritic solidification for pure Fe and carbon steels with sufficient spatial and time resolutions has been developed for the…”
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SARS-CoV-2 spike protein antibody titers after the fourth dose of BNT162b2 vaccine among Japanese patients undergoing hemodialysis: a single-center study by Watanabe, Shun, Sawano, Toyoaki, Saito, Hiroaki, Ozaki, Akihiko, Wakui, Masatoshi, Zhao, Tianchen, Yamamoto, Chika, Kobashi, Yurie, Kawamura, Takeshi, Sugiyama, Akira, Nakayama, Aya, Kaneko, Yudai, Shimmura, Hiroaki, Tsubokura, Masaharu

“…Patients undergoing hemodialysis are particularly vulnerable to severe outcomes of SARS-CoV-2 infection, with mortality rates higher than that of the general…”
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Cupid and Psyche system for the diagnosis and treatment of advanced cancer by SUGIYAMA, Akira, KAWAMURA, Takeshi, TANAKA, Toshiya, DOI, Hirofumi, YAMASHITA, Takefumi, SHINODA, Keiko, FUJITANI, Hideaki, YAMATSUGU, Kenzo, SHIMIZU, Yohei, TATSUMI, Toshifumi, TAKAHASHI, Kazuki, KANAI, Motomu, MIZOHATA, Eiichi, KAWATO, Tatsuya, DOI, Takefumi, INOUE, Tsuyoshi, KODAMA, Tatsuhiko

“…In advanced cancer patients, malignant cells invade and disseminate within normal cells and develop resistance to therapy with additional genetic mutations,…”
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Humoral immunity after second dose of BNT162b2 vaccine in Japanese communities: an observational cross-sectional study, Fukushima Vaccination Community Survey by Kobashi, Yurie, Kawamura, Takeshi, Shimazu, Yuzo, Zhao, Tianchen, Sugiyama, Akira, Nakayama, Aya, Kaneko, Yudai, Nishikawa, Yoshitaka, Omata, Fumiya, Takita, Morihito, Yamamoto, Chika, Yoshida, Makoto, Kosaka, Makoto, Murayama, Anju, Sugiura, Sota, Tanaka, Manato, Kawashima, Moe, Uchi, Yuna, Shindo, Joji, Oikawa, Tomoyoshi, Shibuya, Kenji, Kodama, Tatsuhiko, Tsubokura, Masaharu

“…To reveal waning humoral immunity after second dose BNT162b2 vaccinations in a rural Japanese community and determine factors affecting antibody titers. We…”
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New Insights into the Role of Basement Membrane-Derived Matricryptins in the Heart by Okada, Muneyoshi, Imoto, Keisuke, Sugiyama, Akira, Yasuda, Jumpei, Yamawaki, Hideyuki

“…The extracellular matrix (ECM), which contributes to structural homeostasis as well as to the regulation of cellular function, is enzymatically cleaved by…”
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Yb:YAG thin-disk chirped pulse amplification laser system for intense terahertz pulse generation by Ochi, Yoshihiro, Nagashima, Keisuke, Maruyama, Momoko, Tsubouchi, Masaaki, Yoshida, Fumiko, Kohno, Nanase, Mori, Michiaki, Sugiyama, Akira

“…We have developed a 1 kHz repetition picosecond laser system dedicated for intense terahertz (THz) pulse generation. The system comprises a chirped pulse…”
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Mutations for decreasing the immunogenicity and maintaining the function of core streptavidin by Yumura, Kyohei, Ui, Mihoko, Doi, Hirofumi, Hamakubo, Takao, Kodama, Tatsuhiko, Tsumoto, Kouhei, Sugiyama, Akira

“…The defining property of core streptavidin (cSA) is not only its high binding affinity for biotin but also its pronounced thermal and chemical stability…”
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Antibody mimetic drug conjugate manufactured by high-yield Escherichia coli expression and non-covalent binding system by Yamatsugu, Kenzo, Katoh, Hiroto, Yamashita, Takefumi, Takahashi, Kazuki, Aki, Sho, Tatsumi, Toshifumi, Kaneko, Yudai, Kawamura, Takeshi, Miura, Mai, Ishii, Masazumi, Ohkubo, Kei, Osawa, Tsuyoshi, Kodama, Tatsuhiko, Ishikawa, Shumpei, Kanai, Motomu, Sugiyama, Akira

“…Antibody-drug conjugates (ADCs) are a major therapeutic tool for the treatment of advanced cancer. Malignant cells in advanced cancer often display multiple…”
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