Search Results - "SUGIHARA, HIROSADA"

Novel Non-Peptide Fibrinogen Receptor Antagonists. 1. Synthesis and Glycoprotein IIb-IIIa Antagonistic Activities of 1,3,4-Trisubstituted 2-Oxopiperazine Derivatives Incorporating Side-Chain Functions of the RGDF Peptide by Sugihara, Hirosada, Fukushi, Hideto, Miyawaki, Toshio, Imai, Yumi, Terashita, Zen-ichi, Kawamura, Masaki, Fujisawa, Yukio, Kita, Shunbun

“…Based on the lead tetrapeptide RGDF, two possible non-peptide glycoprotein (GP) IIb-IIIa antagonists possessing an (S)-2-oxopiperazine-3-acetic acid moiety as…”
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Novel Non-Peptide GPIIb/IIIa Antagonists: Synthesis and Biological Activities of 2-[4-[2-(4-Amidinobenzoylamino)-2-(substituted)acetyl]-3-(2-methoxy-2-oxoethyl)-2-oxopiperazinyl]acetic Acids by KITAMURA, Shuji, FUKUSHI, Hideto, MIYAWAKI, Toshio, KAWAMURA, Masaki, TERASHITA, Zen-ichi, SUGIHARA, Hirosada, NAKA, Takehiko

“…To improve the in vitro and in vivo potency of our first low molecular weight GPIIb/IIIa antagonist 1 (TAK-029), a series of…”
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Synthesis and Platelet-Activating Factor (PAF)-Antagonistic Activities of Trisubstituted Piperazine Derivatives by FUKUSHI, Hideto, MABUCHI, Hiroshi, TERASHITA, Zen-ichi, NISHIKAWA, Kohei, SUGIHARA, Hirosada

“…2- or 3-Substituted 1-(2, 3-dimethoxy-6, 7-dihydro-5H-benzocyclohepten-8-ylcarbonyl)-4-(3, 4, 5-trimethoxybenzoyl)- and 4-(3, 4, 5-trimethoxybenzyl)piperazines…”
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Synthesis and Platelet-Activating Factor (PAF)-Antagonistic Activities of 1, 4-Disubstituted Piperazine Derivatives by FUKUSHI, Hideto, MABUCHI, Hiroshi, ITOH, Katsumi, TERASHITA, Zen-ichi, NISHIKAWA, Kohei, SUGIHARA, Hirosada

“…During the screening of novel platelet-activating factor (PAF) antagonists, we found that 1-(6-methoxy-3, 4-dihydro-2-naphthoyl)-4-(3, 4,…”
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Studies on antianaphylactic agents. 5. Synthesis of 3-(1H-tetrazol-5-yl)chromones, a new series of antiallergic substances by Nohara, Akira, Kuriki, Hisashi, Saijo, Taketoshi, Sugihara, Hirosada, Kanno, Morio, Sanno, Yasushi

“…A number of 3-(1H-tetrazol-5-yl)chromones were synthesized and found to have antiallergic activity in the rat passive cutaneous anaphylaxis (PCA) test. These…”
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Synthesis and Angiotensin Converting Enzyme-Inhibitory Activity of N-((1S)-1-Carboxy-5-(4-piperidyl)pentyl)-L-alanine Derivatives by KORI, Masakuni, ITOH, Katsumi, INADA, Yoshiyuki, KATOH, Takeshi, SUMINO, Yasuhiro, NISHIKAWA, Kohei, SUGIHARA, Hirosada

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Synthesis and Angiotensin Converting Enzyme Inhibitory Activity of 1, 5-Benzothiazepine and 1, 5-Benzoxazepine Derivatives. I by ITOH, KATSUMI, KORI, MASAKUNI, INADA, YOSHIYUKI, NISHIKAWA, KOHEI, KAWAMATSU, YUTAKA, SUGIHARA, HIROSADA

“…The design and synthesis of new structural types of angiotensin converting enzyme (ACE) inhibitors, (R)-3-amino-4-oxo-2, 3, 4, 5-tetrahydro-1,…”
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1, 5-Benzoxathiepin Derivatives. I. Synthesis and Reaction of 1, 5-Benzoxathiepin Derivatives by SUGIHARA, HIROSADA, MABUCHI, HIROSHI, KAWAMATSU, YUTAKA

“…Methyl 3-oxo-3, 4-dihydro-2H-1, 5-benzoxathiepin-4-carboxylates (3a-f) were synthesized by regioselective Dieckmann reaction of methyl…”
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An Improved Synthesis of the New Angiotensin Converting Enzyme Inhibitor CV-5975 via a Chemoenzymatic Process by KORI, MASAKUNI, ITOH, KATSUMI, SUGIHARA, HIROSADA

“…A chemoenzymatic synthesis of the new angiotensin converting enzyme inhibitor CV-5975 (1) is described. The optically active key intermediate for the synthesis…”
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Synthesis and Angiotensin Converting Enzyme-Inhibitory Activity of 1, 5-Benzothiazepine and 1, 5-Benzoxazepine Derivatives. III by ITOH, KATSUMI, KORI, MASAKUNI, INADA, YOSHIYUKI, NISHIKAWA, KOHEI, KAWAMATSU, YUTAKA, SUGIHARA, HIROSADA

“…A seires of (R)-3-amino-4-oxo-2, 3, 4, 5-tetrahydro-1, 5-benzothiazepine-5-acetic acids (8) and (S)-3-amino-4-oxo-2, 3, 4, 5-tetrahydro-1,…”
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Synthesis and Angiotensin converting Enzyme Inhibitory Activity of 1, 5-Benzothiazepine and 1, 5-Benzoxazepine Derivatives. II by ITOH, KATSUMI, KORI, MASAKUNI, INADA, YOHIYUKI, NISHIKAWA, KOHEI, KAWAMATSU, YUTAKA, SUGIHARA, HIROSADA

“…A series of (R)-3-amino-4-oxo-2, 3, 4, 5-tetrahydro-1, 5-benzothiazepine-5-acetic acids (4 and 13)and (S)-3-amino-4-oxo-2, 3, 4, 5-tetrahydro-1,…”
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1, 5-Benzoxathiepin Derivatives. II. Synthesis and Serotonin S2-Receptor-Blocking Activity of Aminoalkyl-Substituted 3, 4-Dihydro-2H-1, 5-benzoxathiepin-3-ols and Related Compounds by SUGIHARA, HIROSADA, MABUCHI, HIROSHI, HIRATA, MINORU, IMAMOTO, TETSUJI, KAWAMATSU, YUTAKA

“…Novel 1, 5-benzoxathiepin derivatives, 3, 4-dihydro-2H-1, 5-benzoxathiepin-3-ols with an aminoalkyl group at the 2-, 3- or 4-position, were synthesized and…”
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Stereoselective Synthesis of cis-and trans-3-Amino-4-chromanols by SUGIHARA, HIROSADA, SANNO, YASUSHI

“…3-Alkylamino-(cis-1a-c) and trans-1a-c), 7-hydroxy-3-isopropylamino-(cis-1d and trans-1d), 7, 8-dihydroxy-3-isopropylamino-(cis-1e and trans-1e) and 6,…”
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Spirocyclopropane Compounds. I. Synthesis and Reactivity of Spiro [cyclopropane-1, 2'-[2H] indol]-3'(1'H)-ones by KAWADA, MITSURU, KAWANO, YASUHIKO, SUGIHARA, HIROSADA, TAKEI, SABURO, IMADA, ISUKE

“…A spirocompound, 1'-acetylspiro [cyclopropane-1, 2'-[2H] indol]-3'(1'H)-one (III-1), was synthesized from anthranilic acid in three steps, which involve the…”
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Spirocyclopropane compounds. III. Synthesis of spiro(benzofuran-2(3H),1'-cyclopropan)-3-ones for evaluation as gastric antisecretory and antiulcer agents by KAWADA, MITSURU, WATANABE, MASAZUMI, OKAMOTO, KAYOKO, SUGIHARA, HIROSADA, HIRATA, TAKEO, MAKI, YOSHITAKA, IMADA, ISUKE, SANNO, YASUSHI

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Spirocyclopropane Compounds. II. Synthesis and Biological Activities of Spiro [cyclopropane-1, 2'-[2H] indol]-3'(1'H)-ones by KAWADA, MITSURU, SUGIHARA, HIROSADA, MIKAMI, IWAO, KAWAI, KIYOHISA, KUZUNA, SEIJI, NOGUCHI, SHUNSAKU, SANNO, YASUSHI

“…Spiro [cyclopropane-1, 2'-[2H] indol]-3'(1'H)-ones with various substituents on the benzene ring and at the 1'-position were synthesized. Investigation of…”
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(R)-3-((S)-1-carboxy-5-(4-piperidyl)pentyl)amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid (CV-5975): A new potent and long-lasting inhibitor of angiotensin converting enzyme by INADA, Yoshiyuki, ITOH, Katsumi, KAMIYA, Kazuhide, SUGIHARA, Hirosada, NISHIKAWA, Kohei

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Stereoselective Syntheses of cis- and trans-2-Alkylamino-1, 2, 3, 4-tetrahydro-1-naphthalenols by Acid-catalyzed Ring Opening of 1, 2-N-Alkylimino-1, 2, 3, 4-tetrahydronaphthalenes by SUGIHARA, HIROSADA, UKAWA, KIYOSHI, MIYAKE, AKIO, SANNO, YASUSHI

“…5- or 7-Substituted cis- and trans-2-tert-butylamino-6-hydroxy-1, 2, 3, 4-tetrahydro-1-naphthalenols (cis-29-cis-32) and (trans-30-trans-35) were synthesized…”
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Syntheses of conformationally Rigid Catecholamine Derivatives by OKA, YOSHIKAZU, MOTOHASHI, MICHIO, SUGIHARA, HIROSADA, MIYASHITA, OSAMU, ITOH, KATSUMI, NISHIKAWA, MASAO, YURUGI, SHOJIRO

“…2-Amino-5, 6-dihydroxy-1, 2, 3, 4-tetrahydro-1-naphthalenol (1), 5, 6-dihydroxy-2-methylamino-1, 2, 3, 4-tetrahydro-1-naphthalenol (2) and 5,…”
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Syntheses of 1, 2-N-Alkylimino-1, 2, 3, 4-tetrahydronaphthalene Derivatives and Preparation of Ring Closed Analog of Salbutamol as a New β-Adrenoceptor Agent by SUGIHARA, HIROSADA, UKAWA, KIYOSHI, MIYAKE, AKIO, ITOH, KATSUMI, SANNO, YASUSHI

“…A method for preparing 5-substituted 2-tertiary-alkylamino-6-hydroxy-1, 2, 3, 4-tetrahydro-1-naphthalenols was described. The method involves the preparation…”
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