Search Results - "SUGAWARA Tohru"

A single allele of the hsa-miR-302/367 cluster maintains human pluripotent stem cells by Sugawara, Tohru, Kawamoto, Yuki, Kawasaki, Tomoyuki, Umezawa, Akihiro, Akutsu, Hidenori

“…In a diploid organism, two alleles from a single genetic locus are expressed to generate a normal phenotype. Heterozygous deleterious mutation causes a…”
Get full text

The hsa-miR-302 cluster controls ectodermal differentiation of human pluripotent stem cell via repression of DAZAP2 by Sugawara, Tohru, Miura, Takumi, Kawasaki, Tomoyuki, Umezawa, Akihiro, Akutsu, Hidenori

“…Recent studies have revealed that microRNAs (miRNAs, miRs) are important for self-renewal, differentiation, and cellular reprogramming of somatic cells into…”
Get full text

Using piggyBac transposon gene expression vectors to transfect Zscan5b gene into mouse pluripotent stem cells by Yamada, Mitsutoshi, Sugawara, Tohru, Usami, Shinju, Nakanishi, Rina, Akustu, Hidenori

“…We recently demonstrated that the zygotic gene Zscan5b is involved in maintaining the genomic integrity of pluripotent stem cells (PSCs) during mitosis and…”
Get full text

Correlation between nuptial colors and visual sensitivities tuned by opsins leads to species richness in sympatric Lake Victoria cichlid fishes by Miyagi, Ryutaro, Terai, Yohey, Aibara, Mitsuto, Sugawara, Tohru, Imai, Hiroo, Tachida, Hidenori, Mzighani, Semvua Isa, Okitsu, Takashi, Wada, Akimori, Okada, Norihiro

“…Reproductive isolation that prevents interspecific hybridization between closely related coexisting species maintains sympatric species diversity. One of the…”
Get full text

Eco-geographical diversification of bitter taste receptor genes (TAS2Rs) among subspecies of chimpanzees (Pan troglodytes) by Hayakawa, Takashi, Sugawara, Tohru, Go, Yasuhiro, Udono, Toshifumi, Hirai, Hirohisa, Imai, Hiroo

“…Chimpanzees (Pan troglodytes) have region-specific difference in dietary repertoires from East to West across tropical Africa. Such differences may result from…”
Get full text

Divergent selection on opsins drives incipient speciation in Lake Victoria cichlids by Terai, Yohey, Seehausen, Ole, Sasaki, Takeshi, Takahashi, Kazuhiko, Mizoiri, Shinji, Sugawara, Tohru, Sato, Tetsu, Watanabe, Masakatsu, Konijnendijk, Nellie, Mrosso, Hillary D J, Tachida, Hidenori, Imai, Hiroo, Shichida, Yoshinori, Okada, Norihiro

“…Divergent natural selection acting on ecological traits, which also affect mate choice, is a key element of ecological speciation theory, but has not…”
Get full text

Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons by Shi, Yingxiao, Hung, Shu-Ting, Rocha, Gabriel, Lin, Shaoyu, Linares, Gabriel R, Staats, Kim A, Seah, Carina, Wang, Yaoming, Chickering, Michael, Lai, Jesse, Sugawara, Tohru, Sagare, Abhay P, Zlokovic, Berislav V, Ichida, Justin K

“…Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease with diverse etiologies. Therefore, the identification of common disease mechanisms and…”
Get full text

Epigenetic-scale comparison of human iPSCs generated by retrovirus, Sendai virus or episomal vectors by Nishino, Koichiro, Arai, Yoshikazu, Takasawa, Ken, Toyoda, Masashi, Yamazaki-Inoue, Mayu, Sugawara, Tohru, Akutsu, Hidenori, Nishimura, Ken, Ohtaka, Manami, Nakanishi, Mahito, Umezawa, Akihiro

“…Human induced pluripotent stem cells (iPSCs) are established by introducing several reprogramming factors, such as OCT3/4, SOX2, KLF4, c-MYC. Because of their…”
Get full text

Xenogeneic-free defined conditions for derivation and expansion of human embryonic stem cells with mesenchymal stem cells by Akutsu, Hidenori, Machida, Masakazu, Kanzaki, Seiichi, Sugawara, Tohru, Ohkura, Takashi, Nakamura, Naoko, Yamazaki-Inoue, Mayu, Miura, Takumi, Vemuri, Mohan C., Rao, Mahendra S., Miyado, Kenji, Umezawa, Akihiro

“…The potential applications of human embryonic stem cells (hESCs) in regenerative medicine and developmental research have made stem cell biology one of the…”
Get full text

β-catenin functions pleiotropically in differentiation and tumorigenesis in mouse embryo-derived stem cells by Okumura, Noriko, Akutsu, Hidenori, Sugawara, Tohru, Miura, Takumi, Takezawa, Youki, Hosoda, Akihiro, Yoshida, Keiichi, Ichida, Justin K, Yamada, Mitsutoshi, Hamatani, Toshio, Kuji, Naoaki, Miyado, Kenji, Yoshimura, Yasunori, Umezawa, Akihiro

“…The canonical Wnt/β-catenin signaling pathway plays a crucial role in the maintenance of the balance between proliferation and differentiation throughout…”
Get full text

Zscan5b Deficiency Impairs DNA Damage Response and Causes Chromosomal Aberrations during Mitosis by Ogawa, Seiji, Yamada, Mitsutoshi, Nakamura, Akihiro, Sugawara, Tohru, Nakamura, Akari, Miyajima, Shoko, Harada, Yuichirou, Ooka, Reina, Okawa, Ryuichiro, Miyauchi, Jun, Tsumura, Hideki, Yoshimura, Yasunori, Miyado, Kenji, Akutsu, Hidenori, Tanaka, Mamoru, Umezawa, Akihiro, Hamatani, Toshio

“…Zygotic genome activation (ZGA) begins after fertilization and is essential for establishing pluripotency and genome stability. However, it is unclear how ZGA…”
Get full text

Parallelism of Amino Acid Changes at the RH1 Affecting Spectral Sensitivity among Deep-Water Cichlids from Lakes Tanganyika and Malawi by Sugawara, Tohru, Terai, Yohey, Imai, Hiroo, Turner, George F., Koblmüller, Stephan, Sturmbauer, Christian, Shichida, Yoshinori, Okada, Norihiro, Ohta, Tomoko

“…Many examples of the appearance of similar traits in different lineages are known during the evolution of organisms. However, the underlying genetic mechanisms…”
Get full text

Development and Application of a Solution-Phase Automated Synthesizer, ‘ChemKonzert’ by Machida, Kazuhiro, Hirose, Yoichiro, Fuse, Shinichiro, Sugawara, Tohru, Takahashi, Takashi

“…In this paper we describe the development of a fully-automated solution-phase synthesizer, ‘ChemKonzert’ that can be used to prepare a wide variety of organic…”
Get full text

Generation of primitive neural stem cells from human fibroblasts using a defined set of factors by Miura, Takumi, Sugawara, Tohru, Fukuda, Atsushi, Tamoto, Ryo, Kawasaki, Tomoyuki, Umezawa, Akihiro, Akutsu, Hidenori

“…In mice, leukemia inhibitory factor (LIF)-dependent primitive neural stem cells (NSCs) have a higher neurogenic potential than bFGF-dependent definitive NSCs…”
Get full text

Identification of non-taster Japanese macaques for a specific bitter taste by Suzuki, Nami, Sugawara, Tohru, Matsui, Atsushi, Go, Yasuhiro, Hirai, Hirohisa, Imai, Hiroo

“…Bitter taste perception evolved as a key detection mechanism against the ingestion of bioactive substances, and is mediated by TAS2R gene family members in…”
Get full text

Natural selection of the rhodopsin gene during the adaptive radiation of East African Great Lakes cichlid fishes by Sugawara, Tohru, Terai, Yohey, Okada, Norihiro

Get full text

Polymorphisms in the GPCRs of primates and the genetic database on the individual primates in the Primate Research Institute by Imai, Hiroo, Sugawara, Tohru, Go, Yasuhiro, Matsui, Atsushi, Nishimura, Osamu, Inoue, Eiji, Murayama, Miho, Hirai, Hirohisa, Agata, Kiyokazu, Matsuzawa, Tetsuro

Get full text

S3-5 Commonality of speciation by sensory drive revealed by its signatures in Lake Victoria cichlid fishes by TERAI Yohey, MIYAGI Ryutaro, MIZOIRI Shinji, MZIGHANI Semvua I, AIBARA Mitsuto, OKITSU Takashi, WADA Akimori, SUGAWARA Tohru, IMAI Hiroo, OKADA Norihiro

Get full text

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance by Zhao, Zhen, Sagare, Abhay P, Ma, Qingyi, Halliday, Matthew R, Kong, Pan, Kisler, Kassandra, Winkler, Ethan A, Ramanathan, Anita, Kanekiyo, Takahisa, Bu, Guojun, Owens, Nelly Chuqui, Rege, Sanket V, Si, Gabriel, Ahuja, Ashim, Zhu, Donghui, Miller, Carol A, Schneider, Julie A, Maeda, Manami, Maeda, Takahiro, Sugawara, Tohru, Ichida, Justin K, Zlokovic, Berislav V

“…Zhao et al . report that brain vessels have a major role in clearing Alzheimer's disease–related toxin Aβ from brain and show that PICALM gene product and its…”
Get full text

Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons by Shi, Yingxiao, Lin, Shaoyu, Staats, Kim A, Li, Yichen, Chang, Wen-Hsuan, Hung, Shu-Ting, Hendricks, Eric, Linares, Gabriel R, Wang, Yaoming, Son, Esther Y, Wen, Xinmei, Kisler, Kassandra, Wilkinson, Brent, Menendez, Louise, Sugawara, Tohru, Woolwine, Phillip, Huang, Mickey, Cowan, Michael J, Ge, Brandon, Koutsodendris, Nicole, Sandor, Kaitlin P, Komberg, Jacob, Vangoor, Vamshidhar R, Senthilkumar, Ketharini, Hennes, Valerie, Seah, Carina, Nelson, Amy R, Cheng, Tze-Yuan, Lee, Shih-Jong J, August, Paul R, Chen, Jason A, Wisniewski, Nicholas, Hanson-Smith, Victor, Belgard, T Grant, Zhang, Alice, Coba, Marcelo, Grunseich, Chris, Ward, Michael E, van den Berg, Leonard H, Pasterkamp, R Jeroen, Trotti, Davide, Zlokovic, Berislav V, Ichida, Justin K

“…Human ALS/FTD patient iPSC-derived neurons are used to uncover mechanisms by which C9ORF72 mutations cause neurodegeneration. An intronic GGGGCC repeat…”
Get full text