Search Results - "SUGASAWA, Kaoru"
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Molecular mechanisms of DNA damage recognition for mammalian nucleotide excision repair
Published in DNA repair (01-08-2016)“…For faithful DNA repair, it is crucial for cells to locate lesions precisely within the vast genome. In the mammalian global genomic nucleotide excision repair…”
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The xeroderma pigmentosum pathway: Decision tree analysis of DNA quality
Published in DNA repair (15-07-2011)“…The nucleotide excision repair (NER) system is a fundamental cellular stress response that uses only a handful of DNA binding factors, mutated in the…”
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Tripartite DNA Lesion Recognition and Verification by XPC, TFIIH, and XPA in Nucleotide Excision Repair
Published in Molecular cell (17-09-2015)“…Transcription factor IIH (TFIIH) is essential for both transcription and nucleotide excision repair (NER). DNA lesions are initially detected by NER factors…”
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Two-Step Recognition of DNA Damage for Mammalian Nucleotide Excision Repair: Directional Binding of the XPC Complex and DNA Strand Scanning
Published in Molecular cell (25-11-2009)“…For mammalian nucleotide excision repair (NER), DNA lesions are recognized in at least two steps involving detection of unpaired bases by the XPC protein…”
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5
FANCD2 is a target for caspase 3 during DNA damage-induced apoptosis
Published in FEBS letters (16-10-2014)“…•FANCD2 is a target for caspase 3 during apoptosis.•FANCD2 cleavage does not depend on the mono-ubiquitylation and FA core complex.•Caspase-resistant FANCD2…”
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PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1
Published in The Journal of cell biology (15-10-2012)“…The WD40-repeat protein DDB2 is essential for efficient recognition and subsequent removal of ultraviolet (UV)-induced DNA lesions by nucleotide excision…”
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PRDM14 promotes active DNA demethylation through the ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells
Published in Development (Cambridge) (15-01-2014)“…Ten-eleven translocation (TET) proteins oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC)…”
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Functional impacts of the ubiquitin–proteasome system on DNA damage recognition in global genome nucleotide excision repair
Published in Scientific reports (12-11-2020)“…The ubiquitin–proteasome system (UPS) plays crucial roles in regulation of various biological processes, including DNA repair. In mammalian global genome…”
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UV-induced ubiquitylation of XPC complex, the UV-DDB-ubiquitin ligase complex, and DNA repair
Published in Journal of Molecular Histology (01-09-2006)“…The DNA nucleotide excision repair (NER) system is our major defense against carcinogenesis. Defects in NER are associated with several human genetic disorders…”
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Human SIRT2 and SIRT3 deacetylases function in DNA homologous recombinational repair
Published in Genes to cells : devoted to molecular & cellular mechanisms (01-05-2021)“…SIRT2 and SIRT3 protein deacetylases maintain genome integrity and stability. However, their mechanisms for maintaining the genome remain unclear. To examine…”
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Identification of novel mutations and reassignment of archival xeroderma pigmentosum group C cell strains from Japanese patients
Published in Journal of dermatology (01-03-2023)Get full text
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Mechanism and regulation of DNA damage recognition in nucleotide excision repair
Published in Genes and environment (25-01-2019)“…Nucleotide excision repair (NER) is a versatile DNA repair pathway, which can remove an extremely broad range of base lesions from the genome. In mammalian…”
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Differential requirements for the EF-hand domains of human centrin 2 in primary ciliogenesis and nucleotide excision repair
Published in Journal of cell science (01-10-2019)“…Centrin 2 is a small conserved calcium-binding protein that localizes to the centriolar distal lumen in human cells. It is required for efficient primary…”
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Fluorescence-microscopy-based assay assessing regulatory mechanisms of global genome nucleotide excision repair in cultured cells
Published in STAR protocols (15-09-2023)“…It remains uncertain how global genome nucleotide excision repair (GG-NER) efficiently removes various helix distorting DNA lesions in the cell nucleus. Here,…”
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UV-Induced Ubiquitylation of XPC Protein Mediated by UV-DDB-Ubiquitin Ligase Complex
Published in Cell (06-05-2005)“…The xeroderma pigmentosum group C (XPC) protein complex plays a key role in recognizing DNA damage throughout the genome for mammalian nucleotide excision…”
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Tyrosyl-DNA phosphodiesterases are involved in mutagenic events at a ribonucleotide embedded into DNA in human cells
Published in PloS one (31-12-2020)“…Ribonucleoside triphosphates are often incorporated into genomic DNA during DNA replication. The accumulation of unrepaired ribonucleotides is associated with…”
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FANCD2 Binds CtIP and Regulates DNA-End Resection during DNA Interstrand Crosslink Repair
Published in Cell reports (Cambridge) (22-05-2014)“…The Fanconi anemia (FA) pathway is critically involved in the maintenance of hematopoietic stem cells and the suppression of carcinogenesis. A key FA protein,…”
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Crystal structure of the nucleosome containing ultraviolet light-induced cyclobutane pyrimidine dimer
Published in Biochemical and biophysical research communications (26-02-2016)“…The cyclobutane pyrimidine dimer (CPD) is induced in genomic DNA by ultraviolet (UV) light. In mammals, this photolesion is primarily induced within…”
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Structural basis of pyrimidine-pyrimidone (6–4) photoproduct recognition by UV-DDB in the nucleosome
Published in Scientific reports (17-11-2015)“…UV-DDB, an initiation factor for the nucleotide excision repair pathway, recognizes 6–4PP lesions through a base flipping mechanism. As genomic DNA is almost…”
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Polymorphism of apyrimidinic DNA structures in the nucleosome
Published in Scientific reports (31-01-2017)“…Huge amounts (>10,000/day) of apurinic/apyrimidinic (AP) sites are produced in genomes, but their structures in chromatin remain undetermined. We determined…”
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