Search Results - "SUGASAWA, Kaoru"

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  1. 1

    Molecular mechanisms of DNA damage recognition for mammalian nucleotide excision repair by Sugasawa, Kaoru

    Published in DNA repair (01-08-2016)
    “…For faithful DNA repair, it is crucial for cells to locate lesions precisely within the vast genome. In the mammalian global genomic nucleotide excision repair…”
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  2. 2

    The xeroderma pigmentosum pathway: Decision tree analysis of DNA quality by Naegeli, Hanspeter, Sugasawa, Kaoru

    Published in DNA repair (15-07-2011)
    “…The nucleotide excision repair (NER) system is a fundamental cellular stress response that uses only a handful of DNA binding factors, mutated in the…”
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  3. 3

    Tripartite DNA Lesion Recognition and Verification by XPC, TFIIH, and XPA in Nucleotide Excision Repair by Li, Chia-Lung, Golebiowski, Filip M., Onishi, Yuki, Samara, Nadine L., Sugasawa, Kaoru, Yang, Wei

    Published in Molecular cell (17-09-2015)
    “…Transcription factor IIH (TFIIH) is essential for both transcription and nucleotide excision repair (NER). DNA lesions are initially detected by NER factors…”
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  4. 4

    Two-Step Recognition of DNA Damage for Mammalian Nucleotide Excision Repair: Directional Binding of the XPC Complex and DNA Strand Scanning by Sugasawa, Kaoru, Akagi, Jun-ichi, Nishi, Ryotaro, Iwai, Shigenori, Hanaoka, Fumio

    Published in Molecular cell (25-11-2009)
    “…For mammalian nucleotide excision repair (NER), DNA lesions are recognized in at least two steps involving detection of unpaired bases by the XPC protein…”
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  5. 5

    FANCD2 is a target for caspase 3 during DNA damage-induced apoptosis by Sakai, Wataru, Sugasawa, Kaoru

    Published in FEBS letters (16-10-2014)
    “…•FANCD2 is a target for caspase 3 during apoptosis.•FANCD2 cleavage does not depend on the mono-ubiquitylation and FA core complex.•Caspase-resistant FANCD2…”
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    Functional impacts of the ubiquitin–proteasome system on DNA damage recognition in global genome nucleotide excision repair by Sakai, Wataru, Yuasa-Sunagawa, Mayumi, Kusakabe, Masayuki, Kishimoto, Aiko, Matsui, Takeshi, Kaneko, Yuki, Akagi, Jun-ichi, Huyghe, Nicolas, Ikura, Masae, Ikura, Tsuyoshi, Hanaoka, Fumio, Yokoi, Masayuki, Sugasawa, Kaoru

    Published in Scientific reports (12-11-2020)
    “…The ubiquitin–proteasome system (UPS) plays crucial roles in regulation of various biological processes, including DNA repair. In mammalian global genome…”
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  9. 9

    UV-induced ubiquitylation of XPC complex, the UV-DDB-ubiquitin ligase complex, and DNA repair by Sugasawa, Kaoru

    Published in Journal of Molecular Histology (01-09-2006)
    “…The DNA nucleotide excision repair (NER) system is our major defense against carcinogenesis. Defects in NER are associated with several human genetic disorders…”
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  10. 10

    Human SIRT2 and SIRT3 deacetylases function in DNA homologous recombinational repair by Yasuda, Takeshi, Takizawa, Kazuya, Ui, Ayako, Hama, Michio, Kagawa, Wataru, Sugasawa, Kaoru, Tajima, Katsushi

    “…SIRT2 and SIRT3 protein deacetylases maintain genome integrity and stability. However, their mechanisms for maintaining the genome remain unclear. To examine…”
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    Mechanism and regulation of DNA damage recognition in nucleotide excision repair by Kusakabe, Masayuki, Onishi, Yuki, Tada, Haruto, Kurihara, Fumika, Kusao, Kanako, Furukawa, Mari, Iwai, Shigenori, Yokoi, Masayuki, Sakai, Wataru, Sugasawa, Kaoru

    Published in Genes and environment (25-01-2019)
    “…Nucleotide excision repair (NER) is a versatile DNA repair pathway, which can remove an extremely broad range of base lesions from the genome. In mammalian…”
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  13. 13

    Differential requirements for the EF-hand domains of human centrin 2 in primary ciliogenesis and nucleotide excision repair by Khouj, Ebtissal M, Prosser, Suzanna L, Tada, Haruto, Chong, Weng Man, Liao, Jung-Chi, Sugasawa, Kaoru, Morrison, Ciaran G

    Published in Journal of cell science (01-10-2019)
    “…Centrin 2 is a small conserved calcium-binding protein that localizes to the centriolar distal lumen in human cells. It is required for efficient primary…”
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  14. 14

    Fluorescence-microscopy-based assay assessing regulatory mechanisms of global genome nucleotide excision repair in cultured cells by Kusakabe, Masayuki, Sugasawa, Kaoru

    Published in STAR protocols (15-09-2023)
    “…It remains uncertain how global genome nucleotide excision repair (GG-NER) efficiently removes various helix distorting DNA lesions in the cell nucleus. Here,…”
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  15. 15

    UV-Induced Ubiquitylation of XPC Protein Mediated by UV-DDB-Ubiquitin Ligase Complex by Sugasawa, Kaoru, Okuda, Yuki, Saijo, Masafumi, Nishi, Ryotaro, Matsuda, Noriyuki, Chu, Gilbert, Mori, Toshio, Iwai, Shigenori, Tanaka, Keiji, Tanaka, Kiyoji, Hanaoka, Fumio

    Published in Cell (06-05-2005)
    “…The xeroderma pigmentosum group C (XPC) protein complex plays a key role in recognizing DNA damage throughout the genome for mammalian nucleotide excision…”
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  16. 16

    Tyrosyl-DNA phosphodiesterases are involved in mutagenic events at a ribonucleotide embedded into DNA in human cells by Takeishi, Ayuna, Kogashi, Hiroyuki, Odagiri, Mizuki, Sasanuma, Hiroyuki, Takeda, Shunichi, Yasui, Manabu, Honma, Masamitsu, Suzuki, Tetsuya, Kamiya, Hiroyuki, Sugasawa, Kaoru, Ura, Kiyoe, Sassa, Akira

    Published in PloS one (31-12-2020)
    “…Ribonucleoside triphosphates are often incorporated into genomic DNA during DNA replication. The accumulation of unrepaired ribonucleotides is associated with…”
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  17. 17

    FANCD2 Binds CtIP and Regulates DNA-End Resection during DNA Interstrand Crosslink Repair by Unno, Junya, Itaya, Akiko, Taoka, Masato, Sato, Koichi, Tomida, Junya, Sakai, Wataru, Sugasawa, Kaoru, Ishiai, Masamichi, Ikura, Tsuyoshi, Isobe, Toshiaki, Kurumizaka, Hitoshi, Takata, Minoru

    Published in Cell reports (Cambridge) (22-05-2014)
    “…The Fanconi anemia (FA) pathway is critically involved in the maintenance of hematopoietic stem cells and the suppression of carcinogenesis. A key FA protein,…”
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  18. 18

    Crystal structure of the nucleosome containing ultraviolet light-induced cyclobutane pyrimidine dimer by Horikoshi, Naoki, Tachiwana, Hiroaki, Kagawa, Wataru, Osakabe, Akihisa, Matsumoto, Syota, Iwai, Shigenori, Sugasawa, Kaoru, Kurumizaka, Hitoshi

    “…The cyclobutane pyrimidine dimer (CPD) is induced in genomic DNA by ultraviolet (UV) light. In mammals, this photolesion is primarily induced within…”
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  19. 19

    Structural basis of pyrimidine-pyrimidone (6–4) photoproduct recognition by UV-DDB in the nucleosome by Osakabe, Akihisa, Tachiwana, Hiroaki, Kagawa, Wataru, Horikoshi, Naoki, Matsumoto, Syota, Hasegawa, Mayu, Matsumoto, Naoyuki, Toga, Tatsuya, Yamamoto, Junpei, Hanaoka, Fumio, Thomä, Nicolas H., Sugasawa, Kaoru, Iwai, Shigenori, Kurumizaka, Hitoshi

    Published in Scientific reports (17-11-2015)
    “…UV-DDB, an initiation factor for the nucleotide excision repair pathway, recognizes 6–4PP lesions through a base flipping mechanism. As genomic DNA is almost…”
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  20. 20

    Polymorphism of apyrimidinic DNA structures in the nucleosome by Osakabe, Akihisa, Arimura, Yasuhiro, Matsumoto, Syota, Horikoshi, Naoki, Sugasawa, Kaoru, Kurumizaka, Hitoshi

    Published in Scientific reports (31-01-2017)
    “…Huge amounts (>10,000/day) of apurinic/apyrimidinic (AP) sites are produced in genomes, but their structures in chromatin remain undetermined. We determined…”
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