Search Results - "SUEYOSHI, Tatsuya"

Nuclear receptor phosphorylation in xenobiotic signal transduction by Negishi, Masahiko, Kobayashi, Kaoru, Sakuma, Tsutomu, Sueyoshi, Tatsuya

“…Nuclear pregnane X receptor (PXR, NR1I2) and constitutive active/androstane receptor (CAR, NR1I3) are nuclear receptors characterized in 1998 by their…”
Get full text

Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling by Mutoh, Shingo, Sobhany, Mack, Moore, Rick, Perera, Lalith, Pedersen, Lee, Sueyoshi, Tatsuya, Negishi, Masahiko

“…Phenobarbital is a central nervous system depressant that also indirectly activates nuclear receptor constitutive active androstane receptor (CAR), which…”
Get more information

Nuclear Pregnane X Receptor Cross-talk with FoxA2 to Mediate Drug-induced Regulation of Lipid Metabolism in Fasting Mouse Liver by Nakamura, Kouichi, Moore, Rick, Negishi, Masahiko, Sueyoshi, Tatsuya

“…Upon drug activation, the nuclear pregnane X receptor (PXR) regulates not only hepatic drug but also energy metabolism. Using Pxr–/– mice, we have now…”
Get full text

Phosphorylated Nuclear Receptor CAR Forms a Homodimer To Repress Its Constitutive Activity for Ligand Activation by Shizu, Ryota, Osabe, Makoto, Perera, Lalith, Moore, Rick, Sueyoshi, Tatsuya, Negishi, Masahiko

“…The nuclear receptor CAR (NR1I3) regulates hepatic drug and energy metabolism as well as cell fate. Its activation can be a critical factor in drug-induced…”
Get full text

CAR requires Gadd45β to promote phenobarbital-induced mouse liver tumors in early stage by Hori, Takeshi, Yokobori, Kosuke, Moore, Rick, Negishi, Masahiko, Sueyoshi, Tatsuya

“…Phenobarbital (PB) is an archetypal substance used as a mouse hepatocellular carcinoma (HCC) promotor in established experimental protocols. Our previous…”
Get full text

Nuclear receptor CAR-ERα signaling regulates the estrogen sulfotransferase gene in the liver by Yi, MyeongJin, Fashe, Muluneh, Arakawa, Shingo, Moore, Rick, Sueyoshi, Tatsuya, Negishi, Masahiko

“…Estrogen sulfotransferase (SULT1E1) inactivates estrogen and regulates its metabolic homeostats. Whereas SULT1E1 is expressed low in the liver of adult mice,…”
Get full text

A phosphorylation-deficient mutant of retinoid X receptor α at Thr 167 alters fasting response and energy metabolism in mice by Sueyoshi, Tatsuya, Sakuma, Tsutomu, Shindo, Sawako, Fashe, Muluneh, Kanayama, Tomohiko, Ray, Manas, Moore, Rick, Negishi, Masahiko

“…Retinoid X receptor α (RXRα) has a conserved phosphorylation motif at threonine 162 (humans) and threonine 167 (mice) within the DNA-binding domain. Here we…”
Get full text

Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays by Kojima, Hiroyuki, Sata, Fumihiro, Takeuchi, Shinji, Sueyoshi, Tatsuya, Nagai, Tadanori

“…Abstract The nuclear receptor, pregnane X receptor (PXR), is a ligand-dependent transcription factor that regulates genes involved in xenobiotic metabolism…”
Get full text

Dephosphorylation of Threonine 38 Is Required for Nuclear Translocation and Activation of Human Xenobiotic Receptor CAR (NR1I3) by Mutoh, Shingo, Osabe, Makoto, Inoue, Kaoru, Moore, Rick, Pedersen, Lee, Perera, Lalith, Rebolloso, Yvette, Sueyoshi, Tatsuya, Negishi, Masahiko

“…Upon activation by therapeutics, the nuclear xenobiotic/ constitutive active/androstane receptor (CAR) regulates various liver functions ranging from drug…”
Get full text

Relationship between early physical activity after total knee arthroplasty and postoperative physical function: are these related? by Takamura, Daisuke, Iwata, Kentaro, Sueyoshi, Tatsuya, Yasuda, Tadashi, Moriyama, Hideki

“…BACKGROUNDPhysical activity is associated with physical function; however, the relationship between early physical activity after total knee arthroplasty (TKA)…”
Get full text

Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers by Faucette, Stephanie R, Zhang, Tong-Cun, Moore, Rick, Sueyoshi, Tatsuya, Omiecinski, Curtis J, LeCluyse, Edward L, Negishi, Masahiko, Wang, Hongbing

“…Both the human pregnane X receptor (hPXR) and constitutive androstane receptor (hCAR) are capable of regulating CYP3A4 and CYP2B6 gene expression. However, the…”
Get more information

Twenty-Five-Years and Greater, Results After Nonmodular Cemented Total Knee Arthroplasty by Ritter, Merrill A., Keating, E. Michael, Sueyoshi, Tatsuya, Davis, Kenneth E., Barrington, John W., Emerson, Roger H.

“…Total knee arthroplasty (TKA) has been shown to be very successful with long-term follow-ups. But there are no reports showing prosthesis survival at 25-30…”
Get full text

Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor by Faucette, Stephanie R, Sueyoshi, Tatsuya, Smith, Cornelia M, Negishi, Masahiko, Lecluyse, Edward L, Wang, Hongbing

“…Accumulated evidence suggests that cross-talk between the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) results in shared…”
Get more information

Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes by Sueyoshi, Tatsuya, Li, Linhao, Wang, Hongbing, Moore, Rick, Kodavanti, Prasada Rao S, Lehmler, Hans-Joachim, Negishi, Masahiko, Birnbaum, Linda S

“…Polybrominated diphenyl ether BDE-47 (2,2',4,4'-tetrabromodiphenyl ether) is a thyroid hormone disruptor in mice; hepatic induction of various metabolic…”
Get full text

Conditional deletion of Tgfbr2 in hypertrophic chondrocytes delays terminal chondrocyte differentiation by Sueyoshi, Tatsuya, Yamamoto, Koji, Akiyama, Haruhiko

“…Transforming growth factor β (Tgfb) signaling plays an important role in endochondral ossification. Previous studies of mice in which the Tgfb type II receptor…”
Get full text

Cytoplasmic Localization of Pregnane X Receptor and Ligand-dependent Nuclear Translocation in Mouse Liver by Squires, E James, Sueyoshi, Tatsuya, Negishi, Masahiko

“…The pregnane X receptor (PXR) plays an important role in the response to xenobiotics and endogenous toxins. We have used a specific anti-PXR antibody in the…”
Get full text

Phenobarbital Induces SLC13A5 Expression through Activation of PXR but Not CAR in Human Primary Hepatocytes by Li, Zhihui, Li, Linhao, Heyward, Scott, Men, Shuaiqian, Xu, Meishu, Sueyoshi, Tatsuya, Wang, Hongbing

“…Phenobarbital (PB), a widely used antiepileptic drug, is known to upregulate the expression of numerous drug-metabolizing enzymes and transporters in the liver…”
Get full text

The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor by Li, Linhao, Chen, Tao, Stanton, Joseph D, Sueyoshi, Tatsuya, Negishi, Masahiko, Wang, Hongbing

“…As a promiscuous xenobiotic sensor, the constitutive androstane receptor (CAR; NR1I3) regulates the expression of multiple drug-metabolizing enzymes and…”
Get more information

The Nuclear Orphan Receptor CAR-Retinoid X Receptor Heterodimer Activates the Phenobarbital-Responsive Enhancer Module of the CYP2B Gene by Honkakoski, Paavo, Zelko, Igor, Sueyoshi, Tatsuya, Negishi, Masahiko

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Vertebroplasty Using Allograft Bone Chips with Posterior Instrumented Fusion in the Treatment of Osteoporotic Vertebral Fractures with Neurological Deficits by Masuda, Soichiro, Onishi, Eijiro, Ota, Satoshi, Fujita, Satoshi, Sueyoshi, Tatsuya, Hashimura, Takumi, Yasuda, Tadashi

“…Introduction: In general, osteoporotic vertebral fractures with neurological deficits require surgery. However, the ideal surgical method remains…”
Get full text