Search Results - "SUDMEIER, James L"

Chemical and Biological Evaluation of Dipeptidyl Boronic Acid Proteasome Inhibitors for Use in Prodrugs and Pro-Soft Drugs Targeting Solid Tumors by Milo, Lawrence J, Lai, Jack H, Wu, Wengen, Liu, Yuxin, Maw, Hlaing, Li, Youhua, Jin, Zhiping, Shu, Ying, Poplawski, Sarah E, Wu, Yong, Sanford, David G, Sudmeier, James L, Bachovchin, William W

“…Bortezomib, a dipeptidyl boronic acid and potent inhibitor of the 26S proteasome, is remarkably effective against multiple myeloma (MM) but not against solid…”
Get full text

Pro-Soft Val-boroPro: A Strategy for Enhancing in Vivo Performance of Boronic Acid Inhibitors of Serine Proteases by Poplawski, Sarah E, Lai, Jack H, Sanford, David G, Sudmeier, Wengen Wu, James L, Bachovchin, William W

“…Val-boroPro, 1, is a potent, but relatively nonspecific inhibitor of the prolyl peptidases. It has antihyperglycemic activity from inhibition of DPPIV but also…”
Get full text

Measurement of NH Bond Lengths by Fast Magic-Angle Spinning Solid-State NMR Spectroscopy:  A New Method for the Quantification of Hydrogen Bonds by Zhao, Xin, Sudmeier, James L, Bachovchin, William W, Levitt, Malcolm H

Get full text

A Low-Barrier Hydrogen Bond in the Catalytic Triad of Serine Proteases? Theory Versus Experiment by Ash, Elissa L., Sudmeier, James L., De Fabo, Edward C., Bachovchin, William W.

“…Cleland and Kreevoy recently advanced the idea that a special type of hydrogen bond (H-bond), termed a low-barrier hydrogen bond (LBHB), may account for the…”
Get full text

Analyses of the Interaction between the Origin Binding Domain from Simian Virus 40 T Antigen and Single-Stranded DNA Provide Insights into DNA Unwinding and Initiation of DNA Replication by REESE, Danielle K, MEINKE, Gretchen, KUMAR, Anuradha, MOINE, Stephanie, CHEN, Kathleen, SUDMEIER, James L, BACHOVCHIN, William, BOHM, Andrew, BULLOCK, Peter A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Identification of Selective and Potent Inhibitors of Fibroblast Activation Protein and Prolyl Oligopeptidase by Poplawski, Sarah E, Lai, Jack H, Li, Youhua, Jin, Zhiping, Liu, Yuxin, Wu, Wengen, Wu, Yong, Zhou, Yuhong, Sudmeier, James L, Sanford, David G, Bachovchin, William W

“…Fibroblast activation protein (FAP) is a serine protease selectively expressed on reactive stromal fibroblasts of epithelial carcinomas. It is widely believed…”
Get full text

α-Lytic protease can exist in two separately stable conformations with different His57 mobilities and catalytic activities by Haddad, Kristin Coffman, Sudmeier, James L, Bachovchin, Daniel A, Bachovchin, William W

“…α-Lytic protease is a bacterial serine protease widely studied as a model system of enzyme catalysis. Here we report that lyophilization induces a structural…”
Get full text

A General Method for Making Peptide Therapeutics Resistant to Serine Protease Degradation: Application to Dipeptidyl Peptidase IV Substrates by Heard, Kathryn R, Wu, Wengen, Li, Youhua, Zhao, Peng, Woznica, Iwona, Lai, Jack H, Beinborn, Martin, Sanford, David G, Dimare, Matthew T, Chiluwal, Amrita K, Peters, Diane E, Whicher, Danielle, Sudmeier, James L, Bachovchin, William W

“…Bioactive peptides have evolved to optimally fulfill specific biological functions, a fact which has long attracted attention for their use as therapeutic…”
Get full text

Dipeptide Boronic Acid Inhibitors of Dipeptidyl Peptidase IV: Determinants of Potency and in Vivo Efficacy and Safety by Connolly, Beth A, Sanford, David G, Chiluwal, Amrita K, Healey, Sarah E, Peters, Diane E, Dimare, Matthew T, Wu, Wengen, Liu, Yuxin, Maw, Hlaing, Zhou, Yuhong, Li, Youhua, Jin, Zhiping, Sudmeier, James L, Lai, Jack H, Bachovchin, William W

“…Dipeptidyl peptidase IV (DPP-IV; E.C. 3.4.14.5), a serine protease that degrades the incretin hormones GLP-1 and GIP, is now a validated target for the…”
Get full text

Identification of Histidine Tautomers in Proteins by 2D 1H/13Cδ2 One-Bond Correlated NMR by Sudmeier, James L, Bradshaw, Elizabeth M, Haddad, Kristin E. Coffman, Day, Regina M, Thalhauser, Craig J, Bullock, Peter A, Bachovchin, William W

“…If the 13Cδ2 chemical shift of neutral (“high pH”) histidine is >122 ppm, primarily Nδ1−H tautomer (2) is indicated; if it is <122 ppm, primarily Nε2−H…”
Get full text

4-Substituted boro-proline dipeptides: Synthesis, characterization, and dipeptidyl peptidase IV, 8, and 9 activities by Wu, Wengen, Liu, Yuxin, Milo, Lawrence J., Shu, Ying, Zhao, Peng, Li, Youhua, Woznica, Iwona, Yu, Gengli, Sanford, David G., Zhou, Yuhong, Poplawski, Sarah E., Connolly, Beth A., Sudmeier, James L., Bachovchin, William W., Lai, Jack H.

“…The boroProline-based dipeptidyl boronic acids were among the first DPP-IV inhibitors identified, and remain the most potent known. We introduced various…”
Get full text

Synthesis and Characterization of Constrained Peptidomimetic Dipeptidyl Peptidase IV Inhibitors:  Amino-Lactam boroAlanines by Lai, Jack H, Wu, Wengen, Zhou, Yuhong, Maw, Hlaing H, Liu, Yuxin, Milo, Lawrence J, Poplawski, Sarah E, Henry, Gillian D, Sudmeier, James L, Sanford, David G, Bachovchin, William W

“…We describe here the epimerization-free synthesis and characterization of a new class of conformationally constrained lactam aminoboronic acid inhibitors of…”
Get full text

Tautomerism, acid‐base equilibria, and H‐bonding of the six histidines in subtilisin BPN′ by NMR by Day, Regina M., Thalhauser, Craig J., Sudmeier, James L., Vincent, Matthew P., Torchilin, Ekaterina V., Sanford, David G., Bachovchin, Christopher W., Bachovchin, William W.

“…We have determined by 15N, 1H, and 13C NMR, the chemical behavior of the six histidines in subtilisin BPN′ and their PMSF and peptide boronic acid complexes in…”
Get full text

Autochelation in Dipeptide Boronic Acids:  pH-Dependent Structures and Equilibria of Asp-boroPro and His-boroPro by NMR Spectroscopy by Sudmeier, James L., Zhou, Yuhong, Lai, Jack H., Maw, Hlaing H., Wu, Wengen, Bachovchin, William W.

“…Many dipeptide boronic acids of the type H2N-X − Y-B(OH)2 are potent protease inhibitors. Interest in these compounds as drugs for cancer, diabetes, and other…”
Get full text

T Antigen Origin-Binding Domain of Simian Virus 40:  Determinants of Specific DNA Binding by Bradshaw, Elizabeth M., Sanford, David G., Luo, Xuelian, Sudmeier, James L., Gurard-Levin, Zachary A., Bullock, Peter A., Bachovchin, William W.

“…To better understand origin recognition and initiation of DNA replication, we have examined by NMR complexes formed between the origin-binding domain of SV40 T…”
Get full text

Unusual 1H NMR chemical shifts support (His) Cɛ1—H⋅⋅⋅O⩵C H-bond: Proposal for reaction-driven ring flip mechanism in serine protease catalysis by Ash, Elissa L., Sudmeier, James L., Day, Regina M., Vincent, Matthew, Torchilin, Ekaterina V., Haddad, Kristin Coffman, Bradshaw, Elizabeth M., Sanford, David G., Bachovchin, William W.

“…13 C-selective NMR, combined with inhibitor perturbation experiments, shows that the C ɛ 1 —H proton of the catalytic histidine in resting α-lytic protease and…”
Get full text

Direct NMR Observation and p K a Determination of the Asp 102 Side Chain in a Serine Protease by Everill, Paul, Sudmeier, James L., Bachovchin, William W.

Get full text

Nuclear magnetic resonance studies of rate and mechanism of stereospecific acid- and base-catalyzed deuterations of .alpha.-hydrogen atoms in ethylenediamine-N,N1-diacetatocobalt(III) chelates by Sudmeier, James L, Occupati, G

Get full text

Nuclear Magnetic Resonance Study of Rate and Mechanism of Exchange Reactions Involving (Ethylenedinitrilo) tetraacetatocadmate(II) by Sudmeier, James L, Reilley, Charles N

Get full text

Proton magnetic resonance studies of pentadenate cobalt(III) aminocarboxylates. Structures and reactions of nitro- and aquo-substituted complexes by Sudmeier, James L, Blackmer, Gary L

Get full text