Search Results - "SUCKLING, K. E"

Legumain and cathepsin-L expression in human unstable carotid plaque by Mattock, K.L, Gough, P.J, Humphries, J, Burnand, K, Patel, L, Suckling, K.E, Cuello, F, Watts, C, Gautel, M, Avkiran, M, Smith, A

“…Abstract Objective The cysteine protease, legumain, is thought to have a role in the processing and activation of proteases such as cathepsin-L, which have…”
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Role of acyl-CoA: cholesterol acyltransferase in cellular cholesterol metabolism by Suckling, K E, Stange, E F

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Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase: a potential new risk factor for coronary artery disease by Caslake, M J, Packard, C J, Suckling, K E, Holmes, S D, Chamberlain, P, Macphee, C H

“…A specific and robust immunoassay for the lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), platelet-activating factor acetylhydrolase, is described for…”
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The Peroxisome Proliferator-activated Receptor δ Promotes Lipid Accumulation in Human Macrophages by Vosper, Helen, Patel, Lisa, Graham, Tracey L., Khoudoli, Guennadi A., Hill, Alexander, Macphee, Colin H., Pinto, Ivan, Smith, Stephen A., Suckling, Keith E., Wolf, C. Roland, Palmer, Colin N.A.

“…The peroxisome proliferator-activated receptors (PPARs) are a family of fatty acid-activated transcription factors which control lipid homeostasis and cellular…”
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Animal models of human lipid metabolism by Suckling, K E, Jackson, B

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Cholesterol lowering and bile acid excretion in the hamster with cholestyramine treatment by Suckling, K E, Benson, G M, Bond, B, Gee, A, Glen, A, Haynes, C, Jackson, B

“…Cholestyramine was administered to hamsters at 6 doses in the diet for 1 week. Plasma cholesterol, LDL + VLDL cholesterol and HDL cholesterol were measured…”
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Emerging strategies for the treatment of atherosclerosis as seen from the patent literature by Suckling, K E

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Time-course studies by neutron solution scattering and biochemical assays of the aggregation of human low-density lipoprotein during Cu2+-induced oxidation by Meyer, D F, Mayans, M O, Groot, P H E, Suckling, K E, Bruckdorfer, K R, Perkins, S J

“…The oxidative modification of low-density lipoproteins (LDL) is recognized to be a key event in the development of atherosclerotic plaques on artery walls. The…”
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Effect of probucol on serum lipids, atherosclerosis and toxicology in fat-fed LDL receptor deficient mice by Benson, G.Martin, Schiffelers, Raymond, Nicols, Charlotte, Latcham, Judy, Vidgeon-Hart, Martin, Toseland, C.D.Nigel, Suckling, Keith E, Groot, Pieter H.E

“…Although numerous transgenic mouse models for atherosclerosis have been developed recently, little is known about their response to hypolipidaemic or…”
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SR-12813 lowers plasma cholesterol in beagle dogs by decreasing cholesterol biosynthesis by Berkhout, Theo A, Simon, Helen M, Jackson, Brian, Yates, John, Pearce, Nigel, Groot, Pieter H.E, Bentzen, Craig, Niesor, Eric, Kerns, William D, Suckling, Keith E

“…SR-12813 inhibits cholesterol biosynthesis in Hep G2 cells via an enhanced degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. Here we…”
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Polydeoxycholate in human and hamster feces : a major product of cholate metabolism by BENSON, G. M, HASKINS, N. J, ECKERS, C, MOORE, P. J, REID, D. G, MITCHELL, R. C, SUNIL WAGHMARE, SUCKLING, K. E

“…Fecal bile acid excretion is one of the two major routes by which cholesterol is eliminated from the body, fecal cholesterol being the other. During their…”
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Synthesis and coenzyme A-dependent esterification of cholesterol in rat intestinal epithelium. Differences in cellular localization and mechanisms of regulation by Stange, E F, Suckling, K E, Dietschy, J M

“…The current studies were undertaken to characterize the localization and regulation of cholesterol synthesis and acyl-CoA:cholesterol acyltransferase activity…”
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SK&F 97426-A: a novel bile acid sequestrant with higher affinities and slower dissociation rates for bile acids in vitro than cholestyramine by Benson, G M, Alston, D R, Hickey, D M, Jaxa-Chamiec, A A, Whittaker, C M, Haynes, C, Glen, A, Blanchard, S, Cresswell, S R, Suckling, K E

“…SK&F 97426-A is a novel bile acid sequestrant that is threefold more potent than cholestyramine at increasing bile acid excretion in the hamster. SK&F 97426-A…”
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Cholesterol synthesis in vivo and in vitro in the WHHL rabbit, an animal with defective low density lipoprotein receptors by Dietschy, J M, Kita, T, Suckling, K E, Goldstein, J L, Brown, M S

“…These studies were undertaken to measure rates of synthesis of digitonin-precipitable sterols in vivo and in vitro in control rabbits (New Zealand (NZ)…”
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The effect of cyclic AMP analogues and glucagon on cholesteryl ester synthesis and hydrolysis in cultured hamster hepatocytes by Hoang, Van-Quyen, Suckling, Keith E., Cho-Chui, Y.S., M. Botham, Kathleen

“…Two cyclic AMP analogues, 8-chloro cyclic AMP and 8-(4 ehlorophenylthio) cyclic AMP, were found to increase the incorporation of [ 3H]oleate into cholereryl…”
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Cholesterol metabolism in the adrenal cortex by Boyd, G S, McNamara, B, Suckling, K E, Tocher, D R

“…Adrenal cortical mitochondria contain a mixed function oxidase capable of converting cholesterol to pregnenolone; this enzyme requires NADPH, oxygen and…”
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Inhibition of cholesterol 7 alpha-hydroxylase by an antibody to a male-specific form of cytochrome P-450 from subfamily P450IIC by Eldredge, E R, Jackson, B, Suckling, K E, Wolf, C R

“…The absence of antibodies to cholesterol 7 alpha-hydroxylase (EC 1.14.13.17), the rate-determining enzyme for bile acid synthesis, has significantly…”
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Regulation of acyl-coA: cholesterol acyltransferase by Suckling, K E

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Time-course studies by neutron solution scattering and biochemical assays of the aggregation of human low-density lipoprotein during Cu(2+)-induced oxidation by Meyer, D F, Mayans, M O, Groot, P H, Suckling, K E, Bruckdorfer, K R, Perkins, S J

“…The oxidative modification of low-density lipoproteins (LDL) is recognized to be a key event in the development of atherosclerotic plaques on artery walls. The…”
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The effect of dibutyryl cyclic AMP on the uptake of taurocholic acid by isolated rat liver cells by Botham, K M, Suckling, K E

“…The effect of dibutyryl cyclic AMP on the uptake of taurocholic acid by isolated rat hepatocytes was studied. In the presence of low levels (10-100 microM) of…”
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