Search Results - "STYS, Peter"

Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis by Trapp, Bruce D, PhD, Stys, Peter K, MD

“…Summary Multiple sclerosis (MS), an inflammatory demyelinating disease, is a major cause of neurological disability in young adults in the developed world…”
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Ferroptosis Mediates Cuprizone-Induced Loss of Oligodendrocytes and Demyelination by Jhelum, Priya, Santos-Nogueira, Eva, Teo, Wulin, Haumont, Alice, Lenoël, Isadora, Stys, Peter K, David, Samuel

“…Multiple sclerosis (MS) is a chronic demyelinating disease of the CNS. Cuprizone (CZ), a copper chelator, is widely used to study demyelination and…”
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Mechanisms of glutamate toxicity in multiple sclerosis: biomarker and therapeutic opportunities by Macrez, Richard, PhD, Stys, Peter K, MD, Vivien, Denis, Prof, Lipton, Stuart A, MD, Docagne, Fabian, Dr

“…Summary Research advances support the idea that excessive activation of the glutamatergic pathway plays an important part in the pathophysiology of multiple…”
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Metabolic injury to axons and myelin by Tsutsui, Shigeki, Stys, Peter K.

“…CNS white matter, the collection of axons and supporting glia of the mammalian CNS, makes up close to 50% of the human brain by volume. Interruption of vital…”
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Inefficient clearance of myelin debris by microglia impairs remyelinating processes by Lampron, Antoine, Larochelle, Antoine, Laflamme, Nathalie, Préfontaine, Paul, Plante, Marie-Michèle, Sánchez, Maria Gabriela, Yong, V Wee, Stys, Peter K, Tremblay, Marie-Ève, Rivest, Serge

“…An imbalance between remyelinating and demyelinating rates underlies degenerative processes in demyelinating diseases such as multiple sclerosis. An optimal…”
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Myelocortical multiple sclerosis: a new disease subtype? by Stys, Peter K

“…Traditional teaching paints multiple sclerosis as a neuroinflammatory disorder of the CNS, in which recurrent bouts of T-cell-driven inflammatory demyelination…”
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Immunosenescence of microglia and macrophages: impact on the ageing central nervous system by Rawji, Khalil S, Mishra, Manoj K, Michaels, Nathan J, Rivest, Serge, Stys, Peter K, Yong, V Wee

“…Ageing of the central nervous system results in a loss of both grey and white matter, leading to cognitive decline. Additional injury to both the grey and…”
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White matter injury: Ischemic and nonischemic by Fern, Robert F., Matute, Carlos, Stys, Peter K.

“…Ischemic pathologies of white matter (WM) include a large proportion of stroke and developmental lesions while multiple sclerosis (MS) is the archetype…”
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Plasma Neurofilament Light: A Marker of Neurodegeneration in Mild Behavioral Impairment by Naude, James P, Gill, Sascha, Hu, Sophie, McGirr, Alexander, Forkert, Nils D, Monchi, Oury, Stys, Peter K, Smith, Eric E, Ismail, Zahinoor

“…Assessing neuropsychiatric symptoms (NPS) in older adults is important for determining dementia risk. Mild behavioral impairment (MBI) is an at-risk state for…”
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Amyloid dye pairs as spectral sensors for enhanced detection and differentiation of misfolded proteins by Stepanchuk, Anastasiia A., Stys, Peter K.

“…Protein misfolding with subsequent formation of cross-β-sheet-rich fibrils is a well-known pathological hallmark of various neurodegenerative conditions,…”
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Will the real multiple sclerosis please stand up? by Stys, Peter K., Zamponi, Gerald W., van Minnen, Jan, Geurts, Jeroen J. G.

“…Multiple sclerosis (MS) is generally considered to be an autoimmune, inflammatory disease. In this provocative Perspective, Stys and colleagues propose that…”
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Multi-target-directed phenol-triazole ligands as therapeutic agents for Alzheimer's disease by Jones, Michael R, Mathieu, Emilie, Dyrager, Christine, Faissner, Simon, Vaillancourt, Zavier, Korshavn, Kyle J, Lim, Mi Hee, Ramamoorthy, Ayyalusamy, Wee Yong, V, Tsutsui, Shigeki, Stys, Peter K, Storr, Tim

“…Alzheimer's disease (AD) is a multifactorial disease that is characterized by the formation of intracellular neurofibrillary tangles and extracellular…”
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Mechanisms of lysophosphatidylcholine‐induced demyelination: A primary lipid disrupting myelinopathy by Plemel, Jason R., Michaels, Nathan J., Weishaupt, Nina, Caprariello, Andrew V., Keough, Michael B., Rogers, James A., Yukseloglu, Aran, Lim, Jaehyun, Patel, Vikas V., Rawji, Khalil S., Jensen, Samuel K., Teo, Wulin, Heyne, Belinda, Whitehead, Shawn N., Stys, Peter K., Yong, V. Wee

“…For decades lysophosphatidylcholine (LPC, lysolecithin) has been used to induce demyelination, without a clear understanding of its mechanisms. LPC is an…”
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Mechanisms of axonal injury: internodal nanocomplexes and calcium deregulation by Stirling, David P, Stys, Peter K

“…Axonal degeneration causes morbidity in many neurological conditions including stroke, neurotrauma and multiple sclerosis. The limited ability of central…”
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Quantitation of Tissue Amyloid via Fluorescence Spectroscopy Using Controlled Concentrations of Thioflavin-S by MacKeigan, Tatiana P, Morgan, Megan L, Stys, Peter K

“…Amyloids are misfolded proteins that aggregate into fibrillar structures, the accumulation of which is associated with the pathogenesis of many…”
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Axonal and myelinic pathology in 5xFAD Alzheimer's mouse spinal cord by Chu, Tak-Ho, Cummins, Karen, Sparling, Joseph S, Tsutsui, Shigeki, Brideau, Craig, Nilsson, K Peter R, Joseph, Jeffrey T, Stys, Peter K

“…As an extension of the brain, the spinal cord has unique properties which could allow us to gain a better understanding of CNS pathology. The brain and cord…”
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The molecular physiology of the axo-myelinic synapse by Micu, Ileana, Plemel, Jason R., Lachance, Celia, Proft, Juliane, Jansen, Andrew J., Cummins, Karen, van Minnen, Jan, Stys, Peter K.

“…Myelinated axons efficiently transmit information over long distances. The apposed myelin sheath confers favorable electrical properties, but restricts access…”
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Label-free assessment of myelin status using birefringence microscopy by Morgan, Megan Lynn, Brideau, Craig, Teo, Wulin, Caprariello, Andrew Vincent, Stys, Peter K.

“…•Myelin birefringence can be exploited to rapidly and non-destructively examine white matter integrity in tissue sections.•Birefringence imaging reliably…”
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Remyelination after spinal cord injury: is it a target for repair? by Plemel, Jason R, Keough, Michael B, Duncan, Greg J, Sparling, Joseph S, Yong, V Wee, Stys, Peter K, Tetzlaff, Wolfram

“…After spinal cord injury (SCI) there is prolonged and dispersed oligodendrocyte cell death that is responsible for widespread demyelination. To regenerate this…”
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Spectral focusing-based stimulated Raman scattering microscopy using compact glass blocks for adjustable dispersion by Gagnon, Justin R, Allen, Christian Harry, Trudel, Dominique, Leblond, Frederic, Stys, Peter K, Brideau, Craig, Murugkar, Sangeeta

“…Spectral focusing is a well-established technique for increasing spectral resolution in coherent Raman scattering microscopy. However, current methods for…”
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