Search Results - "STUARD, S. B"

Mechanism-based inactivation of mouse hepatic cytochrome P4502B enzymes by amine metabolites of musk xylene by LEHMAN-MCKEEMAN, L. D, JOHNSON, D. R, CAUDILL, D, STUARD, S. B

“…Musk xylene (2,4,6-trinitro-1-t-butylxylene; MX) is a synthetic nitromusk perfume ingredient that induces and inhibits mouse cytochrome P4502B (CYP2B) enzymes…”
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Computerized image analysis of morphologically transformed and nontransformed syrian hamster embryo (SHE) cell colonies : application to objective SHE cell transformation assay scoring by RIDDER, G. M, STUARD, S. B, KERCKAERT, G. A, CODY, D. B, LEBOEUF, R. A, ISFORT, R. J

“…We have developed an automated image analysis system that provides comparable classification of morphologically transformed SHE cell colonies to the current…”
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A 20-month olestra feeding study in dogs by Miller, K W, Wood, F E, Stuard, S B, Alden, C L

“…Three groups of beagle dogs (five/sex/group) were fed olestra, a mixture of octa-, hepta- and hexa-esters of sucrose formed with long-chain fatty acids, at 0,…”
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Induction of protein phosphorylation, protein synthesis, immediate-early-gene expression and cellular proliferation by intracellular pH modulation : implications for the role of hydrogen ions in signal transduction by ISFORT, R. J, CODY, D. B, ASQUITH, T. N, RIDDER, G. M, STUARD, S. B, LEBOEUF, R. A

“…In Syrian hamster embryo cells, intracellular acidification (but not alkalization) results in proliferation, immediate-early-gene expression and tyrosine…”
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The safety of ethyl oleate is supported by a 91-day feeding study in rats by Bookstaff, Robert C, Stuard, Sharon B, Ward, Susan R, Pesik, Patricia K.McKee, Henwood, Susan M

“…The purpose of this study was to determine the safety of ethyl oleate (EO) in a 91-day feeding study in Sprague–Dawley rats. EO was mixed into AIN-93G purified…”
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Dosimetry considerations for in vivo and in vitro test data and a novel surrogate iTTC approach for read-across based on metabolites by Blackburn, K.L., Ellison, C.A., Stuard, S.B., Wu, S.

“…In the context of REACH and the EU ban on animal testing of cosmetic ingredients, development, adoption and acceptance of non-animal methods is urgent…”
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The combination of epidermal growth factor and transforming growth factor-beta induces novel phenotypic changes in mouse liver stem cell lines by Isfort, R J, Cody, D B, Stuard, S B, Randall, C J, Miller, C, Ridder, G M, Doersen, C J, Richards, W G, Yoder, B K, Wilkinson, J E, Woychik, R P

“…Mouse liver stem cell (oval cell) lines were investigated in order to determine the role which two families of growth and differentiation factors (GDFs),…”
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Characterization of the Effects of Musk Ketone on Mouse Hepatic Cytochrome P450 Enzymes by Stuard, Sharon B., Caudill, Douglas, Lehman-Mckeeman, Lois D.

“…Nitroaromatic musks, including musk ketone (MK; 2,6-dimethyl-3,5-dinitro-4-t-butylacetophenone), are chemicals used as perfume ingredients in household…”
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Induction of mouse cytochrome P450 2B enzymes by amine metabolites of musk xylene: Contribution of microsomal enzyme induction to the hepatocarcinogenicity of musk xylene by Lehman-McKeeman, Lois D., Stuard, Sharon B., Caudill, Douglas, Johnson, David R.

“…Musk xylene (MX) is a synthetic nitromusk perfume ingredient that, although uniformly negative in genotoxicity testing, causes liver tumors in B6C3F1 mice. MX…”
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Calcium Functions as a Transcriptional and Mitogenic Repressor in Syrian Hamster Embryo Cells: Roles of Intracellular pH and Calcium in Controlling Embryonic Cell Differentiation and Proliferation by Isfort, Robert J., Cody, David B., Stuard, Sharon B., Ridder, Gregg M., LeBoeuf, Robert A.

“…We have investigated the role played by the growth and differentiation factor (GDF)-induced calcium ion second messenger signal in the control of cellular…”
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Examination of Tetrachlorosalicylanilide (TCSA) Photoallergy Using In Vitro Photohapten-Modified Langerhans Cell-Enriched Epidermal Cells by Gerberick, G Frank, Ryan, Cindy A, Von Bargen, Edward C, Stuard, Sharon B, Ridder, Gregg M

“…Lymphocytes from BALB/c mice photosensitized in vivo to tetrachlorosalicylanilide (TCSA) were investigated to determine whether they could be stimulated to…”
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Modulation of the platelet-derived-growth-factor-induced calcium signal by extracellular/intracellular pH in Syrian hamster embryo cells. Implications for the role of calcium in mitogenic signalling by Isfort, R J, Stuard, S B, Cody, D B, Ridder, G M, LeBoeuf, R A

“…Studies have been performed to understand the interactions and the role which intracellular calcium and intracellular pH have in mediating mitogen-stimulated…”
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Computerized image analysis of morphologically transformed and nontransformed Syrian hamster embryo (SHE) cell colonies: Application to objective SHE cell transformation assay scoring by Ridder, G M, Stuard, S B, Kerckaert, G A, Cody, D B, LeBoeuf, R A, Isfort, R J

“…We have developed an automated image analysis system that provides comparable classification of morphologically transformed SHE cell colonies to the current…”
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