Search Results - "STRUCK, Joachim"
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Adrenomedullin in heart failure: pathophysiology and therapeutic application
Published in European journal of heart failure (01-02-2019)“…Adrenomedullin (ADM) is a peptide hormone first discovered in 1993 in pheochromocytoma. It is synthesized by endothelial and vascular smooth muscle cells and…”
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Selenoprotein-P Deficiency Predicts Cardiovascular Disease and Death
Published in Nutrients (09-08-2019)“…Selenoprotein-P (SELENOP) is the main carrier of selenium to target organs and reduces tissue oxidative stress both directly and by delivering selenium to…”
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Assessment of Conventional Cardiovascular Risk Factors and Multiple Biomarkers for the Prediction of Incident Heart Failure and Atrial Fibrillation
Published in Journal of the American College of Cardiology (16-11-2010)“…Objectives The purpose of this study was to assess the predictive accuracy of conventional cardiovascular risk factors for incident heart failure and atrial…”
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Assay for the Measurement of Copeptin, a Stable Peptide Derived from the Precursor of Vasopressin
Published in Clinical chemistry (Baltimore, Md.) (01-01-2006)“…Arginine vasopressin (AVP) is a key regulator of water balance, but its instability makes reliable measurement difficult and precludes routine use. We present…”
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Plasma Copeptin, A Unifying Factor behind the Metabolic Syndrome
Published in The journal of clinical endocrinology and metabolism (01-07-2011)“…Context: Arginine vasopressin (AVP) is known to affect liver glycogenolysis, insulin, and glucagon secretion and pituitary ACTH release. We previously showed…”
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Effects of the Humanized Anti-Adrenomedullin Antibody Adrecizumab (HAM8101) on Vascular Barrier Function and Survival in Rodent Models of Systemic Inflammation and Sepsis
Published in Shock (Augusta, Ga.) (01-12-2018)“…PURPOSE:Adrenomedullin (ADM) is an important regulator of endothelial barrier function during sepsis. Administration of a murine antibody targeted against the…”
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Circulating Biologically Active Adrenomedullin (bio-ADM) Predicts Hemodynamic Support Requirement and Mortality During Sepsis
Published in Chest (01-08-2017)“…The biological role of adrenomedullin (ADM), a hormone involved in hemodynamic homeostasis, is controversial in sepsis because administration of either the…”
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Selenoprotein P Deficiency and Risk of Mortality and Rehospitalization in Acute Heart Failure
Published in Journal of the American College of Cardiology (20-08-2019)“…Selenium is a nutrient with antioxidant effects and thus is protective against cardiovascular disease (1), as demonstrated by a meta-analysis revealing a…”
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Genetic vasopressin 1b receptor variance in overweight and diabetes mellitus
Published in European journal of endocrinology (01-01-2016)“…ObjectiveRecently, imbalance in the vasopressin (AVP) system, measured as elevated levels of copeptin (the C-terminal part of the AVP pro-hormone) in plasma,…”
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Procalcitonin after cardiac arrest – An indicator of severity of illness, ischemia-reperfusion injury and outcome
Published in Resuscitation (01-06-2013)“…Abstract Aim To investigate serial serum concentrations of procalcitonin (PCT) and C-reactive protein (CRP) in patients treated with mild hypothermia after…”
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Circulating Biologically Active Adrenomedullin Predicts Organ Failure and Mortality in Sepsis
Published in Annals of laboratory medicine (01-09-2019)“…Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Biologically active adrenomedullin (bio-ADM) is an emerging…”
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Plasma Copeptin and the Risk of Diabetes Mellitus
Published in Circulation (New York, N.Y.) (18-05-2010)“…Animal studies suggest that the arginine vasopressin system may play a role in glucose metabolism, but data from humans are limited. We analyzed plasma…”
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Proenkephalin a 119-159 (penKid) - a novel biomarker for acute kidney injury in sepsis: an observational study
Published in BMC emergency medicine (28-11-2019)“…Sepsis is a leading cause of death worldwide and a major challenge for physicians to predict and manage. Proenkephalin A 119-159 (penKid) is a reliable…”
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Changes in Plasma Copeptin, the C-Terminal Portion of Arginine Vasopressin during Water Deprivation and Excess in Healthy Subjects
Published in The journal of clinical endocrinology and metabolism (01-10-2007)“…Context: The measurement of arginine vasopressin (AVP) is often cumbersome because it is unstable with a short half-life time. AVP is derived from a larger…”
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Elevated Soluble Urokinase Plasminogen Activator Receptor and Proenkephalin Serum Levels Predict the Development of Acute Kidney Injury after Cardiac Surgery
Published in International journal of molecular sciences (31-07-2017)“…Acute kidney injury (AKI) develops in up to 40% of patients after cardiac surgery. The soluble urokinase plasminogen activator receptor (suPAR) has been…”
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Increased concentrations of bioactive adrenomedullin subsequently to angiotensin‐receptor/neprilysin‐inhibitor treatment in chronic systolic heart failure
Published in British journal of clinical pharmacology (01-03-2021)“…Aims The clinically investigated rationale for neprilysin (NEP)‐inhibition by angiotensinreceptor‐NEPinhibitor (ARNi) therapy is to induce elevations in…”
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Comparison of Copeptin, B-Type Natriuretic Peptide, and Amino-Terminal Pro-B-Type Natriuretic Peptide in Patients With Chronic Heart Failure
Published in Journal of the American College of Cardiology (22-07-2008)“…Comparison of Copeptin, B-Type Natriuretic Peptide, and Amino-Terminal Pro-B-Type Natriuretic Peptide in Patients With Chronic Heart Failure: Prediction of…”
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Proenkephalin Predicts Organ Failure, Renal Replacement Therapy, and Mortality in Patients With Sepsis
Published in Annals of laboratory medicine (01-11-2020)“…Kidney failure occurs frequently and is associated with high mortality during sepsis. Proenkephalin (PENK) is an emerging biomarker of kidney function. We…”
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Plasma Carboxy-Terminal Provasopressin (Copeptin): A Novel Marker of Insulin Resistance and Metabolic Syndrome
Published in The journal of clinical endocrinology and metabolism (01-07-2009)“…Context: Stress-mediated hypothalamic-pituitary-adrenal axis activation, regulated by arginine vasopressin (AVP), may have a role in the pathophysiology of…”
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Copeptin, C-reactive protein, and procalcitonin as prognostic biomarkers in acute exacerbation of COPD
Published in Chest (01-04-2007)“…A novel approach to estimate the severity of COPD exacerbation and predict its outcome is the use of biomarkers. We assessed circulating levels of copeptin,…”
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