Search Results - "STRICKLEY, R. G"

Solubilizing excipients in oral and injectable formulations by Strickley, Robert G

“…A review of commercially available oral and injectable solution formulations reveals that the solubilizing excipients include water-soluble organic solvents…”
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Parenteral formulations of small molecules therapeutics marketed in the United States (1999). Part III by Strickley, R G

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Solubilization and stabilization of an anti-HIV thiocarbamate, NSC 629243, for parenteral delivery, using extemporaneous emulsions by STRICKLEY, R. G, ANDERSON, B. D

“…The O-alkyl-N-aryl thiocarbamate, I, (2-chloro-5-[[(1-methyl-ethoxy)thioxomethyl]amino]benzoic acid, 1-methylethylester, NSC 629243, also known as Uniroyal…”
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Preformulation salt selection. Physical property comparisons of the tris(hydroxymethyl)aminomethane (THAM) salts of four analgesic/antiinflammatory agents with the sodium salts and the free acids by GU, L, STRICKLEY, R. G

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Solid-state stability of human insulin. II. Effect of water on reactive intermediate partitioning in lyophiles from pH 2-5 solutions: stabilization against covalent dimer formation by Strickley, R G, Anderson, B D

“…Previous studies have established that at low pH human insulin decomposition proceeds through a two-step mechanism involving rate-limiting intramolecular…”
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Solid-state stability of human insulin I. Mechanism and the effect of water on the kinetics of degradation in lyophiles from pH 2-5 solutions by STRICKLEY, R. G, ANDERSON, B. D

“…Previous studies have established that in aqueous solution at low pH human insulin decomposition proceeds through a cyclic anhydride intermediate leading to…”
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Drug-excipient incompatibility studies of the dipeptide angiotensin-converting enzyme inhibitor, moexipril hydrochloride : dry powder vs wet granulation by LEO GU, STRICKLEY, R. G, LI-HUA CHI, CHOWHAN, Z. T

“…The drug-excipient incompatibility screen for moexipril hydrochloride (1) using various isothermal stress methods is reported herein. It was found that most of…”
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Diketopiperazine formation, hydrolysis, and epimerization of the new dipeptide angiotensin-converting enzyme inhibitor RS-10085 by GU, L, STRICKLEY, R. G

“…The degradation kinetics, products, and mechanisms of RS-10085(1), 2-[2-(1-ethoxycarbonyl)-3-phenylpropyl]amino-1-oxopropyl]-6,7-…”
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An unexpected pH effect on the stability of moexipril lyophilized powder by STRICKLEY, R. G, VISOR, G. C, LIN, L.-H, GU, L

“…Because of the limited stability of moexipril (RS-10085; 1) in aqueous solution, lyophilized parenteral formulations were evaluated as a function of pH in this…”
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Preformulation stability studies of the new dipeptide angiotensin-converting enzyme inhibitor RS-10029 by GU, L, STRICKLEY, R. G

“…The degradation kinetics, products, and mechanisms of RS-10029 (2), 2-[2-[(1-carboxylic acid)-3-phenylpropyl]amino-1-oxopropyl] 6,7-dimethoxy-…”
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Parenteral formulations of small molecules therapeutics marketed in the United States (1999)--Part I by Strickley, R G

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Pediatric drugs--a review of commercially available oral formulations by Strickley, Robert G, Iwata, Quynh, Wu, Sylvia, Dahl, Terrence C

“…Pediatric oral formulations can be quite scientifically challenging to develop and the prerequisites for both a measurable dosage form to administer based upon…”
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High-performance liquid chromatographic (HPLC) and HPLC-mass spectrometric (MS) analysis of the degradation of the luteinizing hormone-releasing hormone (LH-RH) antagonist RS-26306 in aqueous solution by Strickley, R G, Brandl, M, Chan, K W, Straub, K, Gu, L

“…The kinetics of the degradation of an LH-RH antagonist, RS-26306,1, in aqueous solution from pH 1 to pH 11 were studied by reverse-phase HPLC. The pH-rate…”
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Parenteral formulation development for the positive inotropic agent RS-82856: solubility and stability enhancement through complexation and lyophilization by Visor, G C, Lin, L H, Benjamin, E, Strickley, R G, Gu, L

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High-performance liquid chromatographic (HPLC) and HPLC-mass spectrometric (MS) analysis of the degradation of th eluteinizin hormone-releasing hormone (LH-RH) antagonist RS-26306 in queous solution by STRICKLEY, R. G, BRANDL, M, CHAN, K. W, STRAUB, K, GU, L

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