Search Results - "STRICKER, Stefan H"

Epigenetic regulation of neural lineage elaboration: Implications for therapeutic reprogramming by Stricker, Stefan H., Götz, Magdalena

“…The vulnerability of the mammalian brain is mainly due to its limited ability to generate new neurons once fully matured. Direct conversion of non-neuronal…”
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DNA-Methylation: Master or Slave of Neural Fate Decisions? by Stricker, Stefan H, Götz, Magdalena

“…The pristine formation of complex organs depends on sharp temporal and spatial control of gene expression. Therefore, epigenetic mechanisms have been…”
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Targeted removal of epigenetic barriers during transcriptional reprogramming by Baumann, Valentin, Wiesbeck, Maximilian, Breunig, Christopher T., Braun, Julia M., Köferle, Anna, Ninkovic, Jovica, Götz, Magdalena, Stricker, Stefan H.

“…Master transcription factors have the ability to direct and reverse cellular identities, and consequently their genes must be subject to particular…”
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Selfish mutations dysregulating RAS-MAPK signaling are pervasive in aged human testes by Maher, Geoffrey J, Ralph, Hannah K, Ding, Zhihao, Koelling, Nils, Mlcochova, Hana, Giannoulatou, Eleni, Dhami, Pawan, Paul, Dirk S, Stricker, Stefan H, Beck, Stephan, McVean, Gilean, Wilkie, Andrew O M, Goriely, Anne

“…Mosaic mutations present in the germline have important implications for reproductive risk and disease transmission. We previously demonstrated a phenomenon…”
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CRISPR Tools for Physiology and Cell State Changes: Potential of Transcriptional Engineering and Epigenome Editing by Breunig, Christopher T, Köferle, Anna, Neuner, Andrea M, Wiesbeck, Maximilian F, Baumann, Valentin, Stricker, Stefan H

“…Given the large amount of genome-wide data that have been collected during the last decades, a good understanding of how and why cells change during…”
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Glioblastoma Stem Cells Respond to Differentiation Cues but Fail to Undergo Commitment and Terminal Cell-Cycle Arrest by Carén, Helena, Stricker, Stefan H., Bulstrode, Harry, Gagrica, Sladjana, Johnstone, Ewan, Bartlett, Thomas E., Feber, Andrew, Wilson, Gareth, Teschendorff, Andrew E., Bertone, Paul, Beck, Stephan, Pollard, Steven M.

“…Glioblastoma (GBM) is an aggressive brain tumor whose growth is driven by stem cell-like cells. BMP signaling triggers cell-cycle exit and differentiation of…”
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Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner by Stricker, Stefan H, Feber, Andrew, Engström, Pär G, Carén, Helena, Kurian, Kathreena M, Takashima, Yasuhiro, Watts, Colin, Way, Michael, Dirks, Peter, Bertone, Paul, Smith, Austin, Beck, Stephan, Pollard, Steven M

“…Epigenetic changes are frequently observed in cancer. However, their role in establishing or sustaining the malignant state has been difficult to determine due…”
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Probing cell identity hierarchies by fate titration and collision during direct reprogramming by Hersbach, Bob A, Fischer, David S, Masserdotti, Giacomo, Deeksha, Mojžišová, Karolina, Waltzhöni, Thomas, Rodriguez‐Terrones, Diego, Heinig, Matthias, Theis, Fabian J, Götz, Magdalena, Stricker, Stefan H

“…Despite the therapeutic promise of direct reprogramming, basic principles concerning fate erasure and the mechanisms to resolve cell identity conflicts remain…”
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One step generation of customizable gRNA vectors for multiplex CRISPR approaches through string assembly gRNA cloning (STAgR) by Breunig, Christopher T, Durovic, Tamara, Neuner, Andrea M, Baumann, Valentin, Wiesbeck, Maximilian F, Köferle, Anna, Götz, Magdalena, Ninkovic, Jovica, Stricker, Stefan H

“…Novel applications based on the bacterial CRISPR system make genetic, genomic, transcriptional and epigenomic engineering widely accessible for the first time…”
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Entering the post-epigenomic age: back to epigenetics by Bultmann, Sebastian, Stricker, Stefan H.

“…It is undeniably one of the greatest findings in biology that (with some very minor exceptions) every cell in the body possesses the whole genetic information…”
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The Aryl Hydrocarbon Receptor Pathway Defines the Time Frame for Restorative Neurogenesis by Di Giaimo, Rossella, Durovic, Tamara, Barquin, Pablo, Kociaj, Anita, Lepko, Tjasa, Aschenbroich, Sven, Breunig, Christopher T., Irmler, Martin, Cernilogar, Filippo M., Schotta, Gunnar, Barbosa, Joana S., Trümbach, Dietrich, Baumgart, Emily Violette, Neuner, Andrea M., Beckers, Johannes, Wurst, Wolfgang, Stricker, Stefan H., Ninkovic, Jovica

“…Zebrafish have a high capacity to replace lost neurons after brain injury. New neurons involved in repair are generated by a specific set of glial cells, known…”
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Folding makes an imprint by Stricker, Stefan H

“…Imprinted gene clusters are confined genomic regions containing genes with parent-of-origin-dependent transcriptional activity. In this issue of , Loftus and…”
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From profiles to function in epigenomics by Stricker, Stefan H., Köferle, Anna, Beck, Stephan

“…Key Points Many epigenetic approaches contribute to our understanding of gene regulation and cell identity. By pursuing these epigenetic approaches, different…”
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A high-content small molecule screen identifies sensitivity of glioblastoma stem cells to inhibition of polo-like kinase 1 by Danovi, Davide, Folarin, Amos, Gogolok, Sabine, Ender, Christine, Elbatsh, Ahmed M O, Engström, Pär G, Stricker, Stefan H, Gagrica, Sladjana, Georgian, Ana, Yu, Ding, U, Kin Pong, Harvey, Kevin J, Ferretti, Patrizia, Paddison, Patrick J, Preston, Jane E, Abbott, N Joan, Bertone, Paul, Smith, Austin, Pollard, Steven M

“…Glioblastoma multiforme (GBM) is the most common primary brain cancer in adults and there are few effective treatments. GBMs contain cells with molecular and…”
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Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation by Blake, Sophia M, Stricker, Stefan H, Halavach, Hanna, Poetsch, Anna R, Cresswell, George, Kelly, Gavin, Kanu, Nnennaya, Marino, Silvia, Luscombe, Nicholas M, Pollard, Steven M, Behrens, Axel

“…Glioblastoma multiforme (GBM) is the most aggressive human primary brain cancer. Using a Trp53-deficient mouse model of GBM, we show that genetic inactivation…”
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Innate Immune Pathways Promote Oligodendrocyte Progenitor Cell Recruitment to the Injury Site in Adult Zebrafish Brain by Sanchez-Gonzalez, Rosario, Koupourtidou, Christina, Lepko, Tjasa, Zambusi, Alessandro, Novoselc, Klara Tereza, Durovic, Tamara, Aschenbroich, Sven, Schwarz, Veronika, Breunig, Christopher T, Straka, Hans, Huttner, Hagen B, Irmler, Martin, Beckers, Johannes, Wurst, Wolfgang, Zwergal, Andreas, Schauer, Tamas, Straub, Tobias, Czopka, Tim, Trümbach, Dietrich, Götz, Magdalena, Stricker, Stefan H, Ninkovic, Jovica

“…The oligodendrocyte progenitors (OPCs) are at the front of the glial reaction to the traumatic brain injury. However, regulatory pathways steering the OPC…”
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An in vitro ES cell imprinting model shows that imprinted expression of the Igf2r gene arises from an allele-specific expression bias by Latos, Paulina A, Stricker, Stefan H, Steenpass, Laura, Pauler, Florian M, Huang, Ru, Senergin, Basak H, Regha, Kakkad, Koerner, Martha V, Warczok, Katarzyna E, Unger, Christine, Barlow, Denise P

“…Genomic imprinting is an epigenetic process that results in parental-specific gene expression. Advances in understanding the mechanism that regulates imprinted…”
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A downstream CpG island controls transcript initiation and elongation and the methylation state of the imprinted Airn macro ncRNA promoter by Koerner, Martha V, Pauler, Florian M, Hudson, Quanah J, Santoro, Federica, Sawicka, Anna, Guenzl, Philipp M, Stricker, Stefan H, Schichl, Yvonne M, Latos, Paulina A, Klement, Ruth M, Warczok, Katarzyna E, Wojciechowski, Jacek, Seiser, Christian, Kralovics, Robert, Barlow, Denise P

“…A CpG island (CGI) lies at the 5' end of the Airn macro non-protein-coding (nc) RNA that represses the flanking Igf2r promoter in cis on paternally inherited…”
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Editorial overview: Fluidity of cell fates – from reprogramming to repair by Stricker, Stefan H, Berninger, Benedikt, Götz, Magdalena

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Silencing and transcriptional properties of the imprinted Airn ncRNA are independent of the endogenous promoter by Stricker, Stefan H, Steenpass, Laura, Pauler, Florian M, Santoro, Federica, Latos, Paulina A, Huang, Ru, Koerner, Martha V, Sloane, Mathew A, Warczok, Katarzyna E, Barlow, Denise P

“…The Airn macro ncRNA is the master regulator of imprinted expression in the Igf2r imprinted gene cluster where it silences three flanking genes in cis . Airn…”
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