Search Results - "STRESEMANN, Carlo"

Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine by Stresemann, Carlo, Lyko, Frank

“…The cytosine analogues 5‐azacytosine (azacytidine) and 2′‐deoxy‐5‐azacytidine (decitabine) are the currently most advanced drugs for epigenetic cancer…”
Get full text

Methylation of Human MicroRNA Genes in Normal and Neoplastic Cells by Weber, Barbara, Stresemann, Carlo, Brueckner, Bodo, Lyko, Frank

“…MicroRNAs (miRNAs) are small RNA molecules that control gene expression by inhibition of protein translation or by degradation of cognate target mRNAs. Even…”
Get full text

EZH2 Inhibition Blocks Multiple Myeloma Cell Growth through Upregulation of Epithelial Tumor Suppressor Genes by Hernando, Henar, Gelato, Kathy A, Lesche, Ralf, Beckmann, Georg, Koehr, Silke, Otto, Saskia, Steigemann, Patrick, Stresemann, Carlo

“…Multiple myeloma is a plasma cell malignancy characterized by marked heterogeneous genomic instability including frequent genetic alterations in epigenetic…”
Get full text

Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines by STRESEMANN, Carlo, BRUECKNER, Bodo, MUSCH, Tanja, STOPPER, Helga, LYKO, Frank

“…DNA methyltransferase inhibitors represent promising new drugs for cancer therapies. The first of these compounds (5-azacytidine, Vidaza) has recently been…”
Get full text

Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer by Reynoird, Nicolas, Mazur, Pawel K, Stellfeld, Timo, Flores, Natasha M, Lofgren, Shane M, Carlson, Scott M, Brambilla, Elisabeth, Hainaut, Pierre, Kaznowska, Ewa B, Arrowsmith, Cheryl H, Khatri, Purvesh, Stresemann, Carlo, Gozani, Or, Sage, Julien

“…Pancreatic ductal adenocarcinoma (PDAC) is a lethal form of cancer with few therapeutic options. We found that levels of the lysine methyltransferase SMYD2…”
Get full text

A miniaturized mode-of-action profiling platform enables high throughput characterization of the molecular and cellular dynamics of EZH2 inhibition by Falkenstern, Lilia, Georgi, Victoria, Bunse, Stefanie, Badock, Volker, Husemann, Manfred, Roehn, Ulrike, Stellfeld, Timo, Fitzgerald, Mark, Ferrara, Steven, Stöckigt, Detlef, Stresemann, Carlo, Hartung, Ingo V., Fernández-Montalván, Amaury

“…The market approval of Tazemetostat (TAZVERIK) for the treatment of follicular lymphoma and epithelioid sarcoma has established “enhancer of zeste homolog 2”…”
Get full text

Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2 by Eggert, Erik, Hillig, Roman C, Koehr, Silke, Stöckigt, Detlef, Weiske, Jörg, Barak, Naomi, Mowat, Jeffrey, Brumby, Thomas, Christ, Clara D, ter Laak, Antonius, Lang, Tina, Fernandez-Montalvan, Amaury E, Badock, Volker, Weinmann, Hilmar, Hartung, Ingo V, Barsyte-Lovejoy, Dalia, Szewczyk, Magdalena, Kennedy, Steven, Li, Fengling, Vedadi, Masoud, Brown, Peter J, Santhakumar, Vijayaratnam, Arrowsmith, Cheryl H, Stellfeld, Timo, Stresemann, Carlo

“…Protein lysine methyltransferases have recently emerged as a new target class for the development of inhibitors that modulate gene transcription or signaling…”
Get full text

Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia by Brzezinka, Krzysztof, Nevedomskaya, Ekaterina, Lesche, Ralf, Steckel, Michael, Eheim, Ashley L, Haegebarth, Andrea, Stresemann, Carlo

“…The chromosomal rearrangements of the mixed-lineage leukemia gene MLL (KMT2A) have been extensively characterized as a potent oncogenic driver in leukemia. For…”
Get full text

Azacytidine causes complex DNA methylation responses in myeloid leukemia by Stresemann, Carlo, Bokelmann, Imke, Mahlknecht, Ulrich, Lyko, Frank

“…Aberrant DNA methylation patterns play an important role in the pathogenesis of hematologic malignancies. The DNA methyltransferase inhibitors azacytidine and…”
Get full text

Identification of Small Molecules that Modulate Mutant p53 Condensation by Lemos, Clara, Schulze, Luise, Weiske, Joerg, Meyer, Hanna, Braeuer, Nico, Barak, Naomi, Eberspächer, Uwe, Werbeck, Nicolas, Stresemann, Carlo, Lange, Martin, Lesche, Ralf, Zablowsky, Nina, Juenemann, Katrin, Kamburov, Atanas, Luh, Laura Martina, Leissing, Thomas Markus, Mortier, Jeremie, Steckel, Michael, Steuber, Holger, Eis, Knut, Eheim, Ashley, Steigemann, Patrick

“…Structural mutants of p53 induce global p53 protein destabilization and misfolding, followed by p53 protein aggregation. First evidence indicates that p53 can…”
Get full text

Human concentrative nucleoside transporter 1-mediated uptake of 5-azacytidine enhances DNA demethylation by Rius, Maria, Stresemann, Carlo, Keller, Daniela, Brom, Manuela, Schirrmacher, Esther, Keppler, Dietrich, Lyko, Frank

“…The DNA methyltransferase inhibitors 5-azacytidine (5-azaCyd) and 5-aza-2′-deoxycytidine have found increasing use for the treatment of myeloid leukemias and…”
Get full text

Antiproliferative effects of DNA methyltransferase 3B depletion are not associated with DNA demethylation by Hagemann, Sabine, Kuck, Dirk, Stresemann, Carlo, Prinz, Florian, Brueckner, Bodo, Mund, Cora, Mumberg, Dominik, Sommer, Anette

“…Silencing of genes by hypermethylation contributes to cancer progression and has been shown to occur with increased frequency at specific genomic loci…”
Get full text

The human let-7a-3 locus contains an epigenetically regulated MicroRNA gene with oncogenic function by BRUECKNER, Bodo, STRESEMANN, Carlo, KUNER, Ruprecht, MUND, Cora, MUSCH, Tanja, MEISTER, Michael, SFÜLTMANN, Holger, LYKO, Frank

“…MicroRNAs (miRNAs) are small noncoding RNAs that repress their target mRNAs by complementary base pairing and induction of the RNA interference pathway. It has…”
Get full text

Abstract 4475: SMYD2 inhibitor BAY-598 reveals the giant scaffold AHNAK as a novel multi-methylated substrate by Eggert, Erik, Stellfeld, Timo, Korr, Daniel, Stresemann, Carlo

“…Abstract The SET and MYND domain-containing protein 2 (SMYD2) has been reported to mono-methylate several lysine residues on histone and non-histone proteins…”
Get full text

MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis by Alborzinia, Hamed, Flórez, Andrés F, Kreth, Sina, Brückner, Lena M, Yildiz, Umut, Gartlgruber, Moritz, Odoni, Dorett I, Poschet, Gernot, Garbowicz, Karolina, Shao, Chunxuan, Klein, Corinna, Meier, Jasmin, Zeisberger, Petra, Nadler-Holly, Michal, Ziehm, Matthias, Paul, Franziska, Burhenne, Jürgen, Bell, Emma, Shaikhkarami, Marjan, Würth, Roberto, Stainczyk, Sabine A, Wecht, Elisa M, Kreth, Jochen, Büttner, Michael, Ishaque, Naveed, Schlesner, Matthias, Nicke, Barbara, Stresemann, Carlo, Llamazares-Prada, María, Reiling, Jan H, Fischer, Matthias, Amit, Ido, Selbach, Matthias, Herrmann, Carl, Wölfl, Stefan, Henrich, Kai-Oliver, Höfer, Thomas, Trumpp, Andreas, Westermann, Frank

“…Aberrant expression of MYC transcription factor family members predicts poor clinical outcome in many human cancers. Oncogenic MYC profoundly alters metabolism…”
Get full text

Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling by Graham, Keith, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Naujoks, Jan, Lesche, Ralf, Weiske, Joerg, Kuehnlenz, Julia, Brzezinka, Krzysztof, Potze, Lisette, Zanconato, Francesca, Nicke, Barbara, Montebaur, Anna, Bone, Wilhelm, Golfier, Sven, Kaulfuss, Stefan, Kopitz, Charlotte, Pilari, Sabine, Steuber, Holger, Hayat, Sikander, Kamburov, Atanas, Steffen, Andreas, Schlicker, Andreas, Buchgraber, Philipp, Braeuer, Nico, Font, Nuria Aiguabella, Heinrich, Tobias, Kuhnke, Lara, Nowak-Reppel, Katrin, Stresemann, Carlo, Steigemann, Patrick, Walter, Annette O, Blotta, Simona, Ocker, Matthias, Lakner, Ashley, von Nussbaum, Franz, Mumberg, Dominik, Eis, Knut, Piccolo, Stefano, Lange, Martin

“…This study describes the identification and target deconvolution of small molecule inhibitors of oncogenic Yes-associated protein (YAP1)/TAZ activity with…”
Get more information

Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target by Brzezinka, Krzysztof, Nevedomskaya, Ekaterina, Lesche, Ralf, Haegebarth, Andrea, Ter Laak, Antonius, Fernández-Montalván, Amaury E, Eberspaecher, Uwe, Werbeck, Nicolas D, Moenning, Ursula, Siegel, Stephan, Haendler, Bernard, Eheim, Ashley L, Stresemann, Carlo

“…Inhibiting the interaction of menin with the histone methyltransferase MLL1 (KMT2A) has recently emerged as a novel therapeutic strategy. Beneficial…”
Get full text

Abstract 4973: MYCN mediates cysteine addiction and sensitizes to ferroptosis in cancer cells by Westermann, Frank, Alborzinia, Hamed, Gogolin, Sina, Flórez, Andrés F., Brückner, Lena M., Gartlgruber, Moritz, Hartlieb, Sabine, Dreidax, Daniel, Nadler-Holly, Michal, Ziehm, Matthias, Shao, Chunxuan, Selbach, Matthias, Stresemann, Carlo, Poschet, Gernot, Nicke, Barbara, Wölfl, Stefan, Henrich, Kai O., Höfer, Thomas

“…Abstract Aberrant expression of MYC family members predicts poor clinical outcome in many human cancers. Oncogenic MYC profoundly alters metabolism and…”
Get full text

Quantification of histone H3 Lys27 trimethylation (H3K27me3) by high-throughput microscopy enables cellular large-scale screening for small-molecule EZH2 inhibitors by Luense, Svenja, Denner, Philip, Fernández-Montalván, Amaury, Hartung, Ingo, Husemann, Manfred, Stresemann, Carlo, Prechtl, Stefan

“…EZH2 inhibition can decrease global histone H3 lysine 27 trimethylation (H3K27me3) and thereby reactivates silenced tumor suppressor genes. Inhibition of EZH2…”
Get more information

Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine : The role of epigenetics in carcinogenesis by STRESEMANN, Carlo, LYKO, Frank

Get full text