Search Results - "STREETS, J"

Polycystin-1 regulates ARHGAP35-dependent centrosomal RhoA activation and ROCK signaling by Streets, Andrew J, Prosseda, Philipp P, Ong, Albert Cm

“…Mutations in PKD1 (encoding for polycystin-1 [PC1]) are found in 80%-85% of patients with autosomal dominant polycystic kidney disease (ADPKD). We tested the…”
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Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation by Streets, Andrew J, Wessely, Oliver, Peters, Dorien J M, Ong, Albert C M

“…Mutations in PKD1 (85%) or PKD2 (15%) account for almost all cases of autosomal dominant polycystic kidney disease (ADPKD). The ADPKD proteins, termed as…”
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Identification, Characterization, and Localization of a Novel Kidney Polycystin-1-Polycystin-2 Complex by Newby, Linda J., Streets, Andrew J., Zhao, Yan, Harris, Peter C., Ward, Christopher J., Ong, Albert C.M.

“…The functions of the two proteins defective in autosomal dominant polycystic kidney disease, polycystin-1 and polycystin-2, have not been fully clarified, but…”
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Protein kinase D-mediated phosphorylation of polycystin-2 (TRPP2) is essential for its effects on cell growth and calcium channel activity by Streets, Andrew J, Needham, Andrew J, Gill, Sharonjit K, Ong, Albert C M

“…PKD2 is mutated in 15% of patients with autosomal dominant polycystic kidney disease. The PKD2 protein, polycystin-2 or TRPP2, is a nonselective Ca2+-permeable…”
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Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localization of polycystin-2 in vivo and in vitro by Streets, Andrew J., Moon, David J., Kane, Michelle E., Obara, Tomoko, Ong, Albert C.M.

“…PKD2 is mutated in 15% of patients with autosomal dominant polycystic kidney disease. Polycystin-2 (PC2), the PKD2 protein, is a non-selective Ca2+-permeable…”
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The complex care of a torture survivor in the United States: The case of Joshua by Berthold, S Megan, Polatin, Peter, Mollica, Richard, Higson-Smith, Craig, Streets, Frederick J, Kelly, Caitrin M, Lavelle, James

“…Torture is an assault on the physical and mental health of an individual, impacting the lives of survivors and their families.The survivor's interpersonal…”
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Love: A philosophy of pastoral care and counselling by Streets, Frederick J.

“…This article explored the meaning of love as an ethical principle and the aim of providing pastoral counselling and care. The author, inspired by the work of…”
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Identification and Functional Characterization of an N-terminal Oligomerization Domain for Polycystin-2 by Feng, Shuang, Okenka, Genevieve M., Bai, Chang-Xi, Streets, Andrew J., Newby, Linda J., DeChant, Brett T., Tsiokas, Leonidas, Obara, Tomoko, Ong, Albert C.M.

“…Autosomal dominant polycystic kidney disease (ADPKD), the most common inherited cause of kidney failure, is caused by mutations in either PKD1 (85%) or PKD2…”
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Activation of TRPP2 through mDia1-dependent voltage gating by Bai, Chang-Xi, Kim, Sehyun, Li, Wei-Ping, Streets, Andrew J, Ong, Albert C M, Tsiokas, Leonidas

“…The TRPP2 cation channel is directly responsible for ∼15% of all cases of autosomal dominant polycystic kidney disease. However, the mechanisms underlying…”
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Functional analysis of pkd1 transgenic lines reveals a direct role for polycystin-1 in mediating cell-cell adhesion by STREETS, Andrew J, NEWBY, Linda J, O'HARE, Michael J, BUKANOV, Nikolay O, IBRAGHIMOV-BESKROVNAYA, Oxana, ONG, Albert C. M

“…The PKD1 protein, polycystin-1, is a large transmembrane protein of uncertain function and topology. To study the putative functions of polycystin-1,…”
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Community-based participatory research with Black people and Black scientists: the power and the promise by Breland-Noble, Alfiee, Streets, Frederick J, Jordan, Ayana

“…Community-based participatory research (CBPR) is a collaborative approach that involves active participation and input from members of the community on all…”
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Measurements of the magnetic form factor of the proton in the timelike region at large momentum transfer by Ambrogiani, M., Bagnasco, S., Baldini, W., Bettoni, D., Borreani, G., Buzzo, A., Calabrese, R., Cester, R., Dalpiaz, P., Fan, X., Garzoglio, G., Gollwitzer, K. E., Hahn, A., Jin, S., Kasper, J., Lasio, G., Lo Vetere, M., Luppi, E., Maas, P., Macrì, M., Mandelkern, M., Marchetto, F., Marinelli, M., Marsh, W., Martini, M., Menichetti, E., Mussa, R., Obertino, M. M., Pallavicini, M., Pastrone, N., Patrignani, C., Pedlar, T. K., Peoples, J., Pordes, S., Robutti, E., Rosen, J., Rumerio, P., Santroni, A., Savrié, M., Schultz, J., Seth, K. K., Stancari, G., Stancari, M., Streets, J., Tomaradze, A., Werkema, S., Zioulas, G.

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The Sorting Nexin 3 Retromer Pathway Regulates the Cell Surface Localization and Activity of a Wnt-Activated Polycystin Channel Complex by Feng, Shuang, Streets, Andrew J, Nesin, Vasyl, Tran, Uyen, Nie, Hongguang, Onopiuk, Marta, Wessely, Oliver, Tsiokas, Leonidas, Ong, Albert C M

“…Autosomal dominant polycystic kidney disease (ADPKD) is caused by inactivating mutations in (85%) or (15%). The ADPKD proteins encoded by these genes,…”
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Helix pomatia agglutinin lectin‐binding oligosaccharides of aggressive breast cancer by Dwek, Miriam V., Ross, Heidi A., Streets, Andrew J., Brooks, Susan A., Adam, Elizabeth, Titcomb, Ann, Woodside, Jayne V., Schumacher, Udo, Leathem, Anthony J.

“…Predicting long‐term outcome after breast‐cancer diagnosis remains problematic, particularly for patients with clinically small, axillary lymph node‐ negative…”
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The association of urinary epidermal growth factors with ADPKD disease severity and progression by Harskamp, Laura R, Perez-Gomez, Maria Vanessa, Heida, Judith E, Engels, Gerwin E, van Goor, Harry, van den Heuvel, Marius C, Streets, Andrew J, Ong, Albert C M, Ortiz, Alberto, Gansevoort, Ron T

“…ABSTRACT Background The epidermal growth factor receptor (EGFR) pathway is involved in kidney tissue repair and growth. Preclinical interventional data and…”
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A high throughput zebrafish chemical screen reveals ALK5 and non-canonical androgen signalling as modulators of the pkd2−/− phenotype by Metzner, A., Griffiths, J. D., Streets, A. J., Markham, E., Philippou, T., Van Eeden, F. J. M., Ong, A. C. M.

“…Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic cause of end-stage renal failure in humans and results from germline…”
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Parallel microarray profiling identifies ErbB4 as a determinant of cyst growth in ADPKD and a prognostic biomarker for disease progression by Streets, Andrew J, Magayr, Tajdida A, Huang, Linghong, Vergoz, Laura, Rossetti, Sandro, Simms, Roslyn J, Harris, Peter C, Peters, Dorien J M, Ong, Albert C M

“…Autosomal dominant polycystic kidney disease (ADPKD) is the fourth most common cause of end-stage renal disease. The disease course can be highly variable and…”
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The Polycystin-1, Lipoxygenase, and α-Toxin Domain Regulates Polycystin-1 Trafficking by Xu, Yaoxian, Streets, Andrew J, Hounslow, Andrea M, Tran, Uyen, Jean-Alphonse, Frederic, Needham, Andrew J, Vilardaga, Jean-Pierre, Wessely, Oliver, Williamson, Michael P, Ong, Albert C M

“…Mutations in polycystin-1 (PC1) give rise to autosomal dominant polycystic kidney disease, an important and common cause of kidney failure. Despite its medical…”
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Preaching in the New Millennium: Celebrating the Tercentennial of Yale University by Streets, Frederick J

“…In this collection of sermons, fifteen distinguished religious leaders reflect upon the moral, social, and political nature of our time. The sermons originated…”
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The cAMP Signaling Pathway and Direct Protein Kinase A Phosphorylation Regulate Polycystin-2 (TRPP2) Channel Function by Cantero, María del Rocío, Velázquez, Irina F., Streets, Andrew J., Ong, Albert C.M., Cantiello, Horacio F.

“…Polycystin-2 (PC2) is a TRP-type, Ca2+-permeable non-selective cation channel that plays an important role in Ca2+ signaling in renal and non-renal cells. The…”
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