Search Results - "STRASSLE, B. W"

Inhibition of osteoclasts prevents cartilage loss and pain in a rat model of degenerative joint disease by Strassle, B.W, Mark, L, Leventhal, L, Piesla, M.J, Jian Li, X, Kennedy, J.D, Glasson, S.S, Whiteside, G.T

“…Summary Objective To investigate the relationship between efficacy of a bisphosphonate, pain and extent of joint damage in the monosodium iodoacetate (MIA)…”
Get full text

Hyperpolarization-activated cyclic nucleotide-gated channel mRNA and protein expression in large versus small diameter dorsal root ganglion neurons: Correlation with hyperpolarization-activated current gating by Kouranova, E.V, Strassle, B.W, Ring, R.H, Bowlby, M.R, Vasilyev, D.V

“…Abstract Hyperpolarization-activated cyclic nucleotide-gated channels (HCN) are responsible for the functional hyperpolarization-activated current ( Ih ) in…”
Get full text

Species‐specific in vitro pharmacological effects of the cannabinoid receptor 2 (CB2) selective ligand AM1241 and its resolved enantiomers by Bingham, B, Jones, P G, Uveges, A J, Kotnis, S, Lu, P, Smith, V A, Sun, S‐C, Resnick, L, Chlenov, M, He, Y, Strassle, B W, Cummons, T A, Piesla, M J, Harrison, J E, Whiteside, G T, Kennedy, J D

“…Background and purpose: Racemic (R,S) AM1241 is a cannabinoid receptor 2 (CB2)‐selective aminoalkylindole with antinociceptive efficacy in animal pain models…”
Get full text

Modulation of A-type potassium channels by a family of calcium sensors by Rhodes, Kenneth J, An, W. Frank, Bowlby, Mark R, Betty, Maria, Cao, Jie, Ling, Huai-Ping, Mendoza, Grace, Hinson, Joseph W, Mattsson, Karen I, Strassle, Brian W, Trimmer, James S

“…In the brain and heart, rapidly inactivating (A-type) voltage-gated potassium (Kv) currents operate at subthreshold membrane potentials to control the…”
Get full text

WAY‐318068: a novel, potent and selective noradrenaline re‐uptake inhibitor with activity in rodent models of pain and depression by Whiteside, GT, Dwyer, JM, Harrison, JE, Beyer, CE, Cummons, T, Manzino, L, Mark, L, Johnston, GH, Strassle, BW, Adedoyin, A, Lu, P, Piesla, MJ, Pulicicchio, CM, Erve, JCL, Platt, BJ, Hughes, ZA, Rogers, KE, Deecher, DC, Trybulski, EJ, Kennedy, JD, Zhang, P, Leventhal, L

“…Background and purpose:  Antidepressants, which raise the CNS concentrations of 5‐HT and noradrenaline, are frequently used in the treatment of chronic pain;…”
Get full text

Generation and characterization of subtype-specific monoclonal antibodies to K+ channel α- and β-subunit polypeptides by BEKELE-ARCURI, Z, MATOS, M. F, MANGANAS, L, STRASSLE, B. W, MONAGHAN, M. M, RHODES, K. J, TRIMMER, J. S

“…Molecular characterization of mammalian voltage-sensitive K+ channel genes and their expression became possible with the cloning of the Shaker locus of…”
Get full text

Species‐specific in vitro pharmacological effects of the cannabinoid receptor 2 (CB2) selective ligand AM1241 and its resolved enantiomers by Bingham, B, Jones, P G, Uveges, A J, Kotnis, S, Lu, P, Smith, V A, Sun, S‐C, Resnick, L, Chlenov, M, He, Y, Strassle, B W, Cummons, T A, Piesla, M J, Harrison, J E, Whiteside, G T, Kennedy, J D

“…British Journal of Pharmacology (2007) 151, 1137; doi:10.1038/sj.bjp.0707378…”
Get full text

KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain by Rhodes, Kenneth J, Carroll, Karen I, Sung, M Amy, Doliveira, Lisa C, Monaghan, Michael M, Burke, Sharon L, Strassle, Brian W, Buchwalder, Lynn, Menegola, Milena, Cao, Jie, An, W Frank, Trimmer, James S

“…Voltage-gated potassium (Kv) channels from the Kv4, or Shal-related, gene family underlie a major component of the A-type potassium current in mammalian…”
Get full text

Light and electron microscopic analysis of KChIP and Kv4 localization in rat cerebellar granule cells by Strassle, Brian W., Menegola, Milena, Rhodes, Kenneth J., Trimmer, James S.

“…Potassium channels are key determinants of neuronal excitability. We recently identified KChIPs as a family of calcium binding proteins that coassociate and…”
Get full text

Association and colocalization of the Kvbeta1 and Kvbeta2 beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel complexes by Rhodes, K J, Strassle, B W, Monaghan, M M, Bekele-Arcuri, Z, Matos, M F, Trimmer, J S

“…The differential expression and association of cytoplasmic beta-subunits with pore-forming alpha-subunits may contribute significantly to the complexity and…”
Get full text

Association and colocalization of the Kv beta 1 and Kv beta 2 beta -subunits with Kv1 alpha -subunits in mammalian brain K super(+) channel complexes by Rhodes, K J, Strassle, B W, Monaghan, M M, Bekele-Arcuri, Z, Matos, M F, Trimmer, J S

“…The differential expression and association of cytoplasmic beta -subunits with pore-forming alpha -subunits may contribute significantly to the complexity and…”
Get full text

Generation and characterization of subtype-specific monoclonal antibodies to K super(+) channel alpha - and beta -subunit polypeptides by Bekele-Arcuri, Z, Matos, M F, Manganas, L, Strassle, B W, Monaghan, M M, Rhodes, K J, Trimmer, J S

“…Molecular characterization of mammalian voltage-sensitive K super(+) channel genes and their expression became possible with the cloning of the Shaker locus of…”
Get full text