Search Results - "STOPECK, A. T"

Incidence, risk factors, and outcomes of osteonecrosis of the jaw: integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases by Saad, F., Brown, J.E., Van Poznak, C., Ibrahim, T., Stemmer, S.M., Stopeck, A.T., Diel, I.J., Takahashi, S., Shore, N., Henry, D.H., Barrios, C.H., Facon, T., Senecal, F., Fizazi, K., Zhou, L., Daniels, A., Carrière, P., Dansey, R.

“…Osteonecrosis of the jaw (ONJ) has been reported in patients receiving bisphosphonates for metastatic bone disease. ONJ incidence, risk factors, and outcomes…”
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Immunotherapy of Advanced Malignancy by Direct Gene Transfer of an Interleukin-2 DNA/DMRIE/DOPE Lipid Complex: Phase I/II Experience by GALANIS, E, HERSH, E. M, FORSCHER, C, SONDAK, V. K, LEWIS, B. D, UNGER, E. C, O'DRISCOLL, M, SELK, L, RUBIN, J, STOPECK, A. T, GONZALEZ, R, BURCH, P, SPIER, C, AKPORIAYE, E. T, RINEHART, J. J, EDMONSON, J, SOBOL, R. E

“…We have completed a phase I study, followed by three phase I/II studies, in patients with metastatic melanoma, renal cell carcinoma (RCC), and sarcoma in order…”
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Effect of denosumab versus zoledronic acid in preventing skeletal-related events in patients with bone metastases by baseline characteristics by Lipton, A, Fizazi, K, Stopeck, A.T, Henry, D.H, Smith, M.R, Shore, N, Martin, M, Vadhan-Raj, S, Brown, J.E, Richardson, G.E, Saad, F, Yardley, D.A, Zhou, K, Balakumaran, A, Braun, A

“…Abstract Background Analyses of phase III trials showed that denosumab was superior to zoledronic acid (ZA) in preventing skeletal-related events (SREs)…”
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Phase I study of direct gene transfer of an allogeneic histocompatibility antigen, HLA-B7, in patients with metastatic melanoma by Stopeck, A T, Hersh, E M, Akporiaye, E T, Harris, D T, Grogan, T, Unger, E, Warneke, J, Schluter, S F, Stahl, S

“…To determine the safety, toxicity, and efficacy of direct intratumoral injection of an allogeneic major histocompatibility complex (MHC) class I gene, HLA-B7,…”
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Prevalence of depression in adults with haemophilia by Iannone, M., Pennick, L., Tom, A., Cui, H., Gilbert, M., Weihs, K., Stopeck, A. T.

“…Summary Multiple factors place adults with haemophilia at risk for depression. Health outcomes can be compromised in depressed patients secondary to increased…”
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Prevalence and risk factors associated with decreased bone mineral density in patients with haemophilia by GERSTNER, G., DAMIANO, M. L., TOM, A., WORMAN, C., SCHULTZ, W., RECHT, M., STOPECK, A. T.

“…Osteoporosis in adult males is an under‐recognized problem. Patients with haemophilia have several predisposing factors for developing decreased bone mineral…”
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Cytokine regulation of low density lipoprotein receptor gene transcription in HepG2 cells by STOPECK, A. T, NICHOLSON, A. C, MANCINI, F. P, HAJJAR, D. P

“…Elevated plasma levels of cytokines have been demonstrated in inflammatory, malignant, and infectious diseases. These disease states are often associated with…”
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Advances in the biological therapy and gene therapy of malignant disease by Hersh, E M, Stopeck, A T

“…Biological and gene therapy of cancer have become important components of clinical cancer research. Advances in this area are based on evidence for the…”
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Antigen-Driven Oligoclonal Expansion of Tumor-Infiltrating B Cells in Infiltrating Ductal Carcinoma of the Breast by Coronella, Julia A, Spier, Catherine, Welch, Matthew, Trevor, Katrina T, Stopeck, Alison T, Villar, Hugo, Hersh, Evan M

“…The objective of this study was to determine whether tumor-infiltrating B cells (TIL-B) of infiltrating ductal carcinoma (IDC) of the breast represent a…”
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Recent advances in the treatment of malignant melanoma with gene therapy by Hersh, E M, Stopeck, A T

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Construction of new amplifier expression vectors for high levels of IL-2 gene expression by Tsang, T C, Brailey, J L, Vasanwala, F H, Wu, R S, Liu, F, Clark, P R, Meade-Tollin, L, Luznick, L, Stopeck, A T, Akporiaye, E T, Harris, D T

“…The success of IL-2 gene therapy in cancer is in part dependent on the development of high level IL-2 gene expression vectors. Currently, expression vectors…”
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Effects of SU5416, a small molecule tyrosine kinase receptor inhibitor, on FLT3 expression and phosphorylation in patients with refractory acute myeloid leukemia by O’Farrell, Anne-Marie, Yuen, Helene A, Smolich, Beverly, Hannah, Alison L, Louie, Sharianne G, Hong, Weiru, Stopeck, Alison T, Silverman, Lewis R, Lancet, Jeffrey E, Karp, Judith E, Albitar, Maher, Cherrington, Julie M, Giles, Francis J

“…Acute myeloid leukemia (AML) is associated with dysregulated hematopoietic cell proliferation and increased bone marrow angiogenesis, each regulated by…”
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Loss of B7.2 (CD86) and Intracellular Adhesion Molecule 1 (CD54) Expression Is Associated with Decreased Tumor-infiltrating T Lymphocytes in Diffuse B-cell Large-cell Lymphoma by STOPECK, Alison T, GESSNER, Andrea, MILLER, Thomas P, HERSH, Evan M, JOHNSON, Cynthia S, HAIYAN CUI, FRUTIGER, Yvette, GROGAN, Thomas M

“…Tumor-infiltrating CD8+ T-lymphocytes (T-TILs) are thought to be relevant to immunosurveillance of several tumor types including B-cell non-Hodgkin’s lymphoma…”
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Studies of direct intratumoral gene transfer using cationic lipid-complexed plasmid DNA by Clark, P R, Stopeck, A T, Ferrari, M, Parker, S E, Hersh, E M

“…Cationic lipid-mediated gene transfer is a safe and effective means of delivering potent immunomodulatory cytokines directly into tumors. This approach avoids…”
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Denosumab for the prevention of symptomatic skeletal events (SSEs) in patients with bone-metastatic breast cancer: A comparison with skeletal-related events (SREs) by Body, J.-J., von Moos, R., Lipton, A., Martin, M., Diel, I., Steger, G., Tonkin, K., de Boer, R., Radcliffe, H.-S., Niepel, D., Stopeck, A.T.

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Polycations and cationic lipids enhance adenovirus transduction and transgene expression in tumor cells by Clark, P R, Stopeck, A T, Brailey, J L, Wang, Q, McArthur, J, Finer, M H, Hersh, E M

“…Replication-deficient adenovirus vectors are efficient vehicles for delivering therapeutic genes into mammalian cells. However, the high doses required to…”
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Plasmid DNA gene therapy: studies with the human interleukin-2 gene in tumor cells in vitro and in the murine B16 melanoma model in vivo by Parker, S E, Khatibi, S, Margalith, M, Anderson, D, Yankauckas, M, Gromkowski, S H, Latimer, T, Lew, D, Marquet, M, Manthorpe, M, Hobart, P, Hersh, E, Stopeck, A T, Norman, J

“…The plasmid DNA vector pVCL-1102 containing the coding sequence for the human IL-2 gene was evaluated for expression in tumor cells in vitro and in vivo. In…”
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Cationic Lipid Gene Transfer of an IL-2 Transgene Leads to Activation of Natural Killer Cells in a SCID Mouse Human Tumor Xenograft by Clark, Paul R., Stopeck, Alison T., Parker, Suezanne E., Hersh, Evan M.

“…Natural killer (NK) cells play an important role in combating infectious and malignant diseases and interleukin-2 (IL-2) has been shown to promote…”
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Abstract P1-11-24: Aromatase inhibitors and bone health in women 75 and older treated for early stage breast cancer by Baer, L, Chaudhry, B, Kudelka, A, Cohen, J, Stopeck, AT

“…Abstract Introduction: Breast cancer is the most common cancer in women. In estrogen receptor positive breast cancers aromatase inhibitors (AI) are a common…”
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Abstract P1-11-22: Aromatase inhibitors are significantly better tolerated by early stage breast cancer patients 75 or older and with significantly lower early discontinuation rate by Chaudhry, B, Baer, L, Kudelka, A, Cohen, J, Stopeck, AT

“…Abstract Introduction: Breast cancer is the most common cancer in women. In postmenopausal women with early stage estrogen receptor positive breast cancer,…”
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