Search Results - "STONE, JENNIFER S."

A brief history of hair cell regeneration research and speculations on the future by Rubel, Edwin W., Furrer, Stephanie A., Stone, Jennifer S.

“…Millions of people worldwide suffer from hearing and balance disorders caused by loss of the sensory hair cells that convert sound vibrations and head…”
Get full text

Vascular endothelial growth factor is required for regeneration of auditory hair cells in the avian inner ear by Wan, Liangcai, Lovett, Michael, Warchol, Mark E., Stone, Jennifer S.

“…Hair cells in the auditory organ of the vertebrate inner ear are the sensory receptors that convert acoustic stimuli into electrical signals that are conveyed…”
Get full text

Inhibition of Notch activity promotes nonmitotic regeneration of hair cells in the adult mouse utricles by Lin, Vincent, Golub, Justin S, Nguyen, Tot Bui, Hume, Clifford R, Oesterle, Elizabeth C, Stone, Jennifer S

“…The capacity of adult mammals to regenerate sensory hair cells is not well defined. To explore early steps in this process, we examined reactivation of a…”
Get full text

Large basolateral processes on type II hair cells are novel processing units in mammalian vestibular organs by Pujol, Rémy, Pickett, Sarah B., Nguyen, Tot Bui, Stone, Jennifer S.

“…ABSTRACT Sensory receptors in the vestibular system (hair cells) encode head movements and drive central motor reflexes that control gaze, body movements, and…”
Get full text

Bone morphogenetic protein 4 antagonizes hair cell regeneration in the avian auditory epithelium by Lewis, Rebecca M., Keller, Jesse J., Wan, Liangcai, Stone, Jennifer S.

“…Permanent hearing loss is often a result of damage to cochlear hair cells, which mammals are unable to regenerate. Non-mammalian vertebrates such as birds…”
Get full text

Hair cell regeneration in the avian auditory epithelium by Stone, Jennifer S, Cotanche, Douglas A

“…Regeneration of sensory hair cells in the mature avian inner ear was first described just over 20 years ago. Since then, it has been shown that many other…”
Get full text

Atoh1 expression defines activated progenitors and differentiating hair cells during avian hair cell regeneration by Cafaro, Jon, Lee, Gi Soo, Stone, Jennifer S.

“…In the avian inner ear, nonsensory supporting cells give rise to new sensory hair cells through two distinct processes: mitosis and direct…”
Get full text

Atoh1 expression and function during auditory hair cell regeneration in post-hatch chickens by Lewis, Rebecca M., Hume, Clifford R., Stone, Jennifer S.

“…Loss of hair cells in humans leads to irreversible hearing deficits, since auditory hair cells are not replaced. In contrast, hair cells are regenerated in the…”
Get full text

Sensorineural correlates of failed functional recovery after natural regeneration of vestibular hair cells in adult mice by Jáuregui, Emmanuel J, Scheinman, Kelli L, Bibriesca Mejia, Ingrid K, Pruett, Lindsay, Zaini, Hannah, Finkbeiner, Connor, Phillips, Jonathan A, Gantz, Jay A, Nguyen, Tot Bui, Phillips, James O, Stone, Jennifer S

“…Vestibular hair cells (HCs) are mechanoreceptors that sense head motions by modulating the firing rate of vestibular ganglion neurons (VGNs), whose central…”
Get full text

Expression of Prox1 during mouse cochlear development by Bermingham-McDonogh, Olivia, Oesterle, Elizabeth C., Stone, Jennifer S., Hume, Clifford R., Huynh, Huy M., Hayashi, Toshinori

“…We carried out an analysis of the expression of Prox1, a homeodomain transcription factor, during mouse inner ear development with particular emphasis on the…”
Get full text

Inner ear supporting cells: Rethinking the silent majority by Wan, Guoqiang, Corfas, Gabriel, Stone, Jennifer S.

“…•Supporting cells are required for cell patterning, planar cell polarity, and synaptogenesis in developing sensory epithelia.•In mature sensory epithelia,…”
Get full text

Development and regeneration of vestibular hair cells in mammals by Burns, Joseph C., Stone, Jennifer S.

“…Vestibular sensation is essential for gaze stabilization, balance, and perception of gravity. The vestibular receptors in mammals, Type I and Type II hair…”
Get full text

Aminoglycoside Damage and Hair Cell Regeneration in the Chicken Utricle by Scheibinger, Mirko, Ellwanger, Daniel C., Corrales, C. Eduardo, Stone, Jennifer S., Heller, Stefan

Get full text

The transcription factor Sox2 is required to maintain the cell type-specific properties and innervation of type II vestibular hair cells in adult mice by Stone, Jennifer S, Pujol, Rémy, Nguyen, Tot Bui, Cox, Brandon C

“…The sense of balance relies on vestibular hair cells, which detect head motions. Mammals have two types of vestibular hair cell, I and II, with unique…”
Get full text

The Differentiation Status of Hair Cells That Regenerate Naturally in the Vestibular Inner Ear of the Adult Mouse by González-Garrido, Antonia, Pujol, Rémy, López-Ramírez, Omar, Finkbeiner, Connor, Eatock, Ruth Anne, Stone, Jennifer S

“…Aging, disease, and trauma can lead to loss of vestibular hair cells and permanent vestibular dysfunction. Previous work showed that, following acute…”
Get full text

Hair cell replacement in adult mouse utricles after targeted ablation of hair cells with diphtheria toxin by Golub, Justin S, Tong, Ling, Ngyuen, Tot B, Hume, Cliff R, Palmiter, Richard D, Rubel, Edwin W, Stone, Jennifer S

“…We developed a transgenic mouse to permit conditional and selective ablation of hair cells in the adult mouse utricle by inserting the human diphtheria toxin…”
Get full text

Development of hair cell phenotype and calyx nerve terminals in the neonatal mouse utricle by Warchol, Mark E., Massoodnia, Roxanna, Pujol, Remy, Cox, Brandon C., Stone, Jennifer S.

“…The vestibular organs of reptiles, birds, and mammals possess Type I and Type II sensory hair cells, which have distinct morphologies, physiology, and…”
Get full text

Atoh1 is required in supporting cells for regeneration of vestibular hair cells in adult mice by Hicks, Kelli L., Wisner, Serena R., Cox, Brandon C., Stone, Jennifer S.

“…In amniotes, head movements are encoded by two types of vestibular hair cells (type I and type II) with unique morphology, physiology, and innervation. After…”
Get full text

Cellular Studies of Auditory Hair Cell Regeneration in Birds by Stone, Jennifer S., Rubel, Edwin W

“…A decade ago it was discovered that mature birds are able to regenerate hair cells, the receptors for auditory perception. This surprising finding generated…”
Get full text

Sox2 is required in supporting cells for normal levels of vestibular hair cell regeneration in adult mice by Ciani Berlingeri, Amanda N., Pujol, Rémy, Cox, Brandon C., Stone, Jennifer S.

“…•We deleted Sox2 from vestibular supporting cells in adult mice prior to hair cell damage.•We found that Sox2 is required in supporting cells for normal levels…”
Get full text