Search Results - "STOKER, Tammy E."

High-throughput screening and chemotype-enrichment analysis of ToxCast phase II chemicals evaluated for human sodium-iodide symporter (NIS) inhibition by Wang, Jun, Hallinger, Daniel R., Murr, Ashley S., Buckalew, Angela R., Lougee, Ryan R., Richard, Ann M., Laws, Susan C., Stoker, Tammy E.

“…In support of the Endocrine Disruptor Screening Program (EDSP), the U.S.EPA's Office of Research and Development (ORD) is developing high-throughput screening…”
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The Effects of Triclosan on Puberty and Thyroid Hormones in Male Wistar Rats by Zorrilla, Leah M., Gibson, Emily K., Jeffay, Susan C., Crofton, Kevin M., Setzer, Woodrow R., Cooper, Ralph L., Stoker, Tammy E.

“…Triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol) is a potent antibacterial and antifungal compound that is widely used in personal care products, plastics,…”
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The effect of triclosan on the uterotrophic response to extended doses of ethinyl estradiol in the weanling rat by Louis, Gwendolyn W., Hallinger, Daniel R., Stoker, Tammy E.

“…► We characterize EE and TCS co-exposure effects on uterine growth. ► We study changes in uterine epithelial cell height and EE-regulated mRNA levels. ► TCS…”
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Thyroid hormone action controls multiple components of cell junctions at the ventricular zone in the newborn rat brain by O'Shaughnessy, Katherine L, McMichael, Benjamin D, Sasser, Aubrey L, Bell, Kiersten S, Riutta, Cal, Ford, Jermaine L, Stoker, Tammy E, Grindstaff, Rachel D, Pandiri, Arun R, Gilbert, Mary E

“…Thyroid hormone (TH) action controls brain development in a spatiotemporal manner. Previously, we demonstrated that perinatal hypothyroidism led to formation…”
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Atrazine and reproductive function: mode and mechanism of action studies by Cooper, Ralph L., Laws, Susan C., Das, Parikshit C., Narotsky, Michael G., Goldman, Jerome M., Lee Tyrey, E., Stoker, Tammy E.

“…Atrazine, a chlorotriazine herbicide, is used to control annual grasses and broadleaf weeds. In this review, we summarize our laboratory's work evaluating the…”
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The effects of simazine, a chlorotriazine herbicide, on pubertal development in the female Wistar rat by Zorrilla, Leah M., Gibson, Emily K., Stoker, Tammy E.

“…Chlorotriazine herbicides, such as atrazine and its metabolites, have been shown to target the neuroendocrine regulation of male and female reproductive…”
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The effects of prenatal exposure to atrazine on pubertal and postnatal reproductive indices in the female rat by Davis, Lori K., Murr, Ashley S., Best, Deborah S., Fraites, Melanie J.P., Zorrilla, Leah M., Narotsky, Michael G., Stoker, Tammy E., Goldman, Jerome M., Cooper, Ralph L.

“…Atrazine (ATR) is an herbicide that exerts negative reproductive effects. We examined the effects of vehicle or ATR (1, 5, 20 and 100 mg/kg-d), administered to…”
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Evaluating Chemicals for Thyroid Disruption: Opportunities and Challenges with in Vitro Testing and Adverse Outcome Pathway Approaches by Noyes, Pamela D, Friedman, Katie Paul, Browne, Patience, Haselman, Jonathan T, Gilbert, Mary E, Hornung, Michael W, Barone, Jr, Stan, Crofton, Kevin M, Laws, Susan C, Stoker, Tammy E, Simmons, Steven O, Tietge, Joseph E, Degitz, Sigmund J

“…Extensive clinical and experimental research documents the potential for chemical disruption of thyroid hormone (TH) signaling through multiple molecular…”
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Gestational atrazine exposure: Effects on male reproductive development and metabolite distribution in the dam, fetus, and neonate by Fraites, Melanie J.P., Narotsky, Michael G., Best, Deborah S., Stoker, Tammy E., Davis, Lori K., Goldman, Jerome M., Hotchkiss, Michelle G., Klinefelter, Gary R., Kamel, Alaa, Qian, Yaorong, Podhorniak, Lynda, Cooper, Ralph L.

“…Few studies have investigated the long-term effects of atrazine (ATR) following in utero exposure. We evaluated the effects of gestational exposure of Sprague…”
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Triclosan Exposure Modulates Estrogen-Dependent Responses in the Female Wistar Rat by Stoker, Tammy E., Gibson, Emily K., Zorrilla, Leah M.

“…Triclosan is an antimicrobial found in personal care and sanitizing products, such as soaps, toothpaste, and hair products. There have been recent concerns for…”
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High-Throughput Screening of ToxCast PFAS Chemical Library for Potential Inhibitors of the Human Sodium Iodide Symporter by Stoker, Tammy E., Wang, Jun, Murr, Ashley S., Bailey, Jarod R., Buckalew, Angela R.

“…Over the past decade, there has been increased concern for environmental chemicals that can target various sites within the hypothalamic–pituitary–thyroid axis…”
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High-Throughput Screening and Quantitative Chemical Ranking for Sodium-Iodide Symporter Inhibitors in ToxCast Phase I Chemical Library by Wang, Jun, Hallinger, Daniel R, Murr, Ashley S, Buckalew, Angela R, Simmons, Steven O, Laws, Susan C, Stoker, Tammy E

“…Thyroid uptake of iodide via the sodium-iodide symporter (NIS) is the first step in the biosynthesis of thyroid hormones that are critical for health and…”
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Ammonium perchlorate: serum dosimetry, neurotoxicity, and resilience of the neonatal rat thyroid system by Gilbert, Mary E, Hassan, Iman, O’Shaughnessy, Katherine L, Wood, Carmen, Stoker, Tammy E, Riutta, Cal, Ford, Jermaine L

“…Abstract The environmental contaminant perchlorate impairs the synthesis of thyroid hormones by reducing iodine uptake into the thyroid gland. Despite this…”
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Evaluation of potential sodium-iodide symporter (NIS) inhibitors using a secondary Fischer rat thyroid follicular cell (FRTL-5) radioactive iodide uptake (RAIU) assay by Buckalew, Angela R., Wang, Jun, Murr, Ashley S., Deisenroth, Chad, Stewart, Wendy M., Stoker, Tammy E., Laws, Susan C.

“…The Fischer rat thyroid follicular cell line (FRTL-5) endogenously expresses the sodium-iodide symporter (NIS) and has been used to identify environmental…”
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Development of a screening approach to detect thyroid disrupting chemicals that inhibit the human sodium iodide symporter (NIS) by Hallinger, Daniel R., Murr, Ashley S., Buckalew, Angela R., Simmons, Steven O., Stoker, Tammy E., Laws, Susan C.

“…The U.S. EPA's Endocrine Disruptor Screening Program aims to use high-throughput assays and computational toxicology models to screen and prioritize chemicals…”
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Endocrine-Disrupting Chemicals: Prepubertal Exposures and Effects on Sexual Maturation and Thyroid Function in the Male Rat. A Focus on the EDSTAC Recommendations by Stoker, Tammy E., Parks, Louise G., Gray, L. Earl, Cooper, Ralph L.

“…Puberty in mammalian species is a period of rapid interactive endocrine and morphological changes. Therefore, it is not surprising that exposure to a variety…”
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An optimized radioimmunoassay for quantification of total serum thyroxine (T4) in fetal, neonatal, and pregnant rats by O'Shaughnessy, Katherine L., Hotchkiss, Michelle G., Buckalew, Angela K., Murr, Ashley S., Gilbert, Mary E., Stoker, Tammy E.

“…Identifying xenobiotics that interrupt the thyroid axis has significant public health implications, given that thyroid hormones are required for brain…”
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Effects of chronic exposure to triclosan on reproductive and thyroid endpoints in the adult Wistar female rat by Louis, Gwendolyn W., Hallinger, Daniel R., Braxton, M. Janay, Kamel, Alaa, Stoker, Tammy E.

“…Triclosan (TCS), an antibacterial, has been shown to be an endocrine disruptor in the rat. Previously, subchronic TCS treatment to female rats was found to…”
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Developmental Exposure to a Commercial PBDE Mixture, DE-71: Neurobehavioral, Hormonal, and Reproductive Effects by Kodavanti, Prasada Rao S., Coburn, Cary G., Moser, Virginia C., MacPhail, Robert C., Fenton, Suzanne E., Stoker, Tammy E., Rayner, Jennifer L., Kannan, Kurunthachalam, Birnbaum, Linda S.

“…Developmental effects of polybrominated diphenyl ethers (PBDEs) have been suspected due to their structural similarities to polychlorinated biphenyls (PCBs)…”
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Expanded high-throughput screening and chemotype-enrichment analysis of the phase II: e1k ToxCast library for human sodium-iodide symporter (NIS) inhibition by Wang, Jun, Richard, Ann M., Murr, Ashley S., Buckalew, Angela R., Lougee, Ryan R., Shobair, Mahmoud, Hallinger, Daniel R., Laws, Susan C., Stoker, Tammy E.

“…The sodium-iodide symporter (NIS) mediates the uptake of iodide into the thyroid. Inhibition of NIS function by xenobiotics has been demonstrated to suppress…”
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