Search Results - "STOEHR, OLIVER"

Liver adapts mitochondrial function to insulin resistant and diabetic states in mice by Franko, Andras, von Kleist-Retzow, Jürgen-Christoph, Neschen, Susanne, Wu, Moya, Schommers, Philipp, Böse, Marlen, Kunze, Alexander, Hartmann, Ursula, Sanchez-Lasheras, Carmen, Stoehr, Oliver, Huntgeburth, Michael, Brodesser, Susanne, Irmler, Martin, Beckers, Johannes, de Angelis, Martin Hrabé, Paulsson, Mats, Schubert, Markus, Wiesner, Rudolf J

“…Background & Aims To determine if diabetic and insulin-resistant states cause mitochondrial dysfunction in liver or if there is long term adaptation of…”
Get full text

1632-P: Effects of MTOR Signaling in Muscle-Specific Irs1/2 Knockout Mice by STOEHR, OLIVER, COPPS, KYLE D., TAO, RONGYA, WHITE, MORRIS F.

“…Disruption of Irs1 and Irs2 expression in skeletal and cardiac muscle (MDKO mice) caused death from dilated cardiomyopathy within the first 30 days of life…”
Get full text

Metabolic Dysfunction within Brown Adipose Tissue and Skeletal Muscle Caused by Complete Hepatic Insulin Resistance Is Reversible by FGF-21 Treatment by STOEHR, OLIVER, TAO, RONGYA, COPPS, KYLE D., WHITE, MORRIS F.

“…Hepatic Irs1/Irs2 double knockout mice (LDKO) developed severe systemic insulin resistance, glucose intolerance, and dysregulated gluconeogenesis and…”
Get full text

Hepatic Insulin Signaling Regulates Hepatokines to Coordinate Energy Expenditure and Weight Gain through Irs2 in Sim1 Neurons by TAO, RONGYA, COPPS, KYLE D., STOEHR, OLIVER, WHITE, ORRIS F.

“…Insulin resistance is the underlying cause of type 2 diabetes; however, insulin resistance might also be a feed-back mechanism to protect cells and tissues…”
Get full text

1835-P: Deletion of Insulin Receptor Substrate 2 in AGRP Neurons Causes Beta-Cell Dysfunction by TAO, RONGYA, COPPS, KYLE D., WHITE, MORRIS F., STOEHR, OLIVER

“…In humans, type 2 diabetes progresses when beta-cells fail to compensate peripheral insulin resistance. Insulin receptor substrate (IRS) proteins mediate a…”
Get full text

282-LB: Dysregulated FGF21 Links Hepatic Insulin Resistance to Dysfunctional BAT by STOEHR, OLIVER, TAO, RONGYA, COPPS, KYLE D., WHITE, MORRIS F.

“…LDKO (hepatic Irs1/Irs2 double knockout) mice show a severe diabetic phenotype owing to the impaired communication of the insulin resistant liver throughout…”
Get full text

Neuronal IGF‐1 resistance reduces Aβ accumulation and protects against premature death in a model of Alzheimer's disease by Freude, Susanna, Hettich, Moritz M., Schumann, Christina, Stöhr, Oliver, Koch, Linda, Köhler, Christoph, Udelhoven, Michael, Leeser, Uschi, Müller, Marita, Kubota, Naoto, Kadowaki, Takashi, Krone, Wilhelm, Schroder, Hannsjörg, Brüning, Jens C., Schubert, Markus

“…ABSTRACT Alzheimer's disease (AD) is characterized by progressive neurodegeneration leading to loss of cognitive abilities and ultimately to death. Postmortem…”
Get full text

Bezafibrate Improves Insulin Sensitivity and Metabolic Flexibility in STZ-Induced Diabetic Mice by Franko, Andras, Huypens, Peter, Neschen, Susanne, Irmler, Martin, Rozman, Jan, Rathkolb, Birgit, Neff, Frauke, Prehn, Cornelia, Dubois, Guillaume, Baumann, Martina, Massinger, Rebecca, Gradinger, Daniel, Przemeck, Gerhard K H, Repp, Birgit, Aichler, Michaela, Feuchtinger, Annette, Schommers, Philipp, Stöhr, Oliver, Sanchez-Lasheras, Carmen, Adamski, Jerzy, Peter, Andreas, Prokisch, Holger, Beckers, Johannes, Walch, Axel K, Fuchs, Helmut, Wolf, Eckhard, Schubert, Markus, Wiesner, Rudolf J, Hrabě de Angelis, Martin

“…Bezafibrate (BEZ), a pan activator of peroxisome proliferator-activated receptors (PPARs), has been generally used to treat hyperlipidemia for decades…”
Get full text

Chronic peripheral hyperinsulinemia has no substantial influence on tau phosphorylation in vivo by Becker, Katrin, Freude, Susanna, Zemva, Johanna, Stöhr, Oliver, Krone, Wilhelm, Schubert, Markus

“…► 15% high fat diet induces hyperinsulinemia without altering glucose tolerance. ► Chronic hyperinsulinemia does not alter central Insulin receptor signaling…”
Get full text

Distribution patterns, range size and niche breadth of Austrian endemic plants by Essl, Franz, Staudinger, Markus, Stöhr, Oliver, Schratt-Ehrendorfer, Luise, Rabitsch, Wolfgang, Niklfeld, Harald

“…Endemic species are not a uniform group in terms of range size, habitat preferences, and ecological plasticity. Based on a recent inventory of endemic vascular…”
Get full text

Insulin receptor substrate-1 and -2 mediate resistance to glucose-induced caspase-3 activation in human neuroblastoma cells by Stöhr, Oliver, Hahn, Johann, Moll, Lorna, Leeser, Uschi, Freude, Susanna, Bernard, Corinna, Schilbach, Katharina, Markl, Andreas, Udelhoven, Michael, Krone, Wilhelm, Schubert, Markus

“…Hyperglycemia in patients with type 2 diabetes causes multiple neuronal complications, e.g., diabetic polyneuropathy, cognitive decline, and embryonic neural…”
Get full text

Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer’s disease by Stöhr, Oliver, Schilbach, Katharina, Moll, Lorna, Hettich, Moritz M., Freude, Susanna, Wunderlich, F. Thomas, Ernst, Marianne, Zemva, Johanna, Brüning, Jens C., Krone, Wilhelm, Udelhoven, Michael, Schubert, Markus

“…In brains from patients with Alzheimer’s disease (AD), expression of insulin receptor (IR), insulin-like growth factor-1 receptor (IGF-1R), and insulin…”
Get full text